Clinical characteristics of adults with Asperger's Syndrome assessed with self-report questionnaires / Chieko KANAI in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.185-190 Titre : Clinical characteristics of adults with Asperger's Syndrome assessed with self-report questionnaires Type de document : Texte imprimé et/ou numérique Auteurs : Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Haruhisa OTA, Auteur ; Hidenori YAMASUE, Auteur ; Eisuke MATSUSHIMA, Auteur ; Hideki YOKOI, Auteur ; Kazuyuki SHINOHARA, Auteur ; Nobumasa KATO, Auteur Année de publication : 2011 Article en page(s) : p.185-190 Langues : Anglais (eng) Mots-clés : Asperger's-Syndrome Clinical-characteristics Self-report-questionnaires Autism-Spectrum-Quotient-(AQ) Schizotypal-Personality-Questionnaire-(SPQ) Eysenck-Personality-Questionnaire-(EPQ) Index. décimale : PER Périodiques Résumé : Diagnosis of Asperger's Syndrome (AS) in adults is difficult, and clinical sample-based studies that systematically illustrate the clinical characteristics of adult AS patients are needed so that appropriate treatment can be provided. Here we examined the clinical characteristics of AS in 112 adults (median age, 28.0 years [range, 18–52]; 71 men and 41 women: 55 AS group (median age, 27.0 years [range, 18–49]; 36 men and 19 women), 57 control group (median age, 28.0 years [range, 20–52]; 35 men and 22 women) through administration of the Japanese version of the Autism-Spectrum Quotient (AQ) and the Japanese version of the Schizotypal Personality Questionnaire (SPQ), and the Eysenck Personality Questionnaire (EPQ). Scores on the AQ, SPQ, and the ‘Neuroticism’ and ‘Psychoticism’ scores of the EPQ were significantly higher in adults with AS than in controls. The ‘Extraversion’ and ‘Lie’ scores of the EPQ were significantly lower in adults with AS than in controls. The total score of the AQ was correlated with 3 subscale scores (unusual perceptual experiences, odd or eccentric behavior, and suspiciousness) of the SPQ in the AS group, but not in the control group. The findings demonstrated that AQ and other personality scales could be used to elucidate the clinical characteristics of AS in adults. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.03.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] Clinical characteristics of adults with Asperger's Syndrome assessed with self-report questionnaires [Texte imprimé et/ou numérique] / Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Haruhisa OTA, Auteur ; Hidenori YAMASUE, Auteur ; Eisuke MATSUSHIMA, Auteur ; Hideki YOKOI, Auteur ; Kazuyuki SHINOHARA, Auteur ; Nobumasa KATO, Auteur . - 2011 . - p.185-190. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.185-190 Mots-clés : Asperger's-Syndrome Clinical-characteristics Self-report-questionnaires Autism-Spectrum-Quotient-(AQ) Schizotypal-Personality-Questionnaire-(SPQ) Eysenck-Personality-Questionnaire-(EPQ) Index. décimale : PER Périodiques Résumé : Diagnosis of Asperger's Syndrome (AS) in adults is difficult, and clinical sample-based studies that systematically illustrate the clinical characteristics of adult AS patients are needed so that appropriate treatment can be provided. Here we examined the clinical characteristics of AS in 112 adults (median age, 28.0 years [range, 18–52]; 71 men and 41 women: 55 AS group (median age, 27.0 years [range, 18–49]; 36 men and 19 women), 57 control group (median age, 28.0 years [range, 20–52]; 35 men and 22 women) through administration of the Japanese version of the Autism-Spectrum Quotient (AQ) and the Japanese version of the Schizotypal Personality Questionnaire (SPQ), and the Eysenck Personality Questionnaire (EPQ). Scores on the AQ, SPQ, and the ‘Neuroticism’ and ‘Psychoticism’ scores of the EPQ were significantly higher in adults with AS than in controls. The ‘Extraversion’ and ‘Lie’ scores of the EPQ were significantly lower in adults with AS than in controls. The total score of the AQ was correlated with 3 subscale scores (unusual perceptual experiences, odd or eccentric behavior, and suspiciousness) of the SPQ in the AS group, but not in the control group. The findings demonstrated that AQ and other personality scales could be used to elucidate the clinical characteristics of AS in adults. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.03.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

Comparison of white matter integrity between autism spectrum disorder subjects and typically developing individuals: a meta-analysis of diffusion tensor imaging tractography studies / Yuta AOKI in Molecular Autism, (July 2013)  

Public ISBD [article]  inMolecular Autism > (July 2013) . - 17 p. Titre : Comparison of white matter integrity between autism spectrum disorder subjects and typically developing individuals: a meta-analysis of diffusion tensor imaging tractography studies Type de document : Texte imprimé et/ou numérique Auteurs : Yuta AOKI, Auteur ; Osamu ABE, Auteur ; Yasumasa NIPPASHI, Auteur ; Hidenori YAMASUE, Auteur Année de publication : 2013 Article en page(s) : 17 p. Langues : Anglais (eng) Mots-clés : Autistic disorder  Asperger  Brain  Human  Imaging  Pervasive developmental disorder Index. décimale : PER Périodiques Résumé : Background Aberrant brain connectivity, especially with long-distance underconnectivity, has been recognized as a candidate pathophysiology of autism spectrum disorders. However, a number of diffusion tensor imaging studies investigating people with autism spectrum disorders have yielded inconsistent results. Methods To test the long-distance underconnectivity hypothesis, we performed a systematic review and meta-analysis of diffusion tensor imaging studies in subjects with autism spectrum disorder. Diffusion tensor imaging studies comparing individuals with autism spectrum disorders with typically developing individuals were searched using MEDLINE, Web of Science and EMBASE from 1980 through 1 August 2012. Standardized mean differences were calculated as an effect size of the tracts. Results A comprehensive literature search identified 25 relevant diffusion tensor imaging studies comparing autism spectrum disorders and typical development with regions-of-interest methods. Among these, 14 studies examining regions of interest with suprathreshold sample sizes were included in the meta-analysis. A random-effects model demonstrated significant fractional anisotropy reductions in the corpus callosum (P = 0.023, n = 387 (autism spectrum disorders/typically developing individuals: 208/179)), left uncinate fasciculus (P = 0.011, n = 242 (117/125)), and left superior longitudinal fasciculus (P = 0.016, n = 182 (96/86)), and significant increases of mean diffusivity in the corpus callosum (P = 0.006, n = 254 (129/125)) and superior longitudinal fasciculus bilaterally (P = 0.031 and 0.011, left and right, respectively, n = 109 (51/58)), in subjects with autism spectrum disorders compared with typically developing individuals with no significant publication bias. Conclusion The current meta-analysis of diffusion tensor imaging studies in subjects with autism spectrum disorders emphasizes important roles of the superior longitudinal fasciculus, uncinate fasciculus, and corpus callosum in the pathophysiology of autism spectrum disorders and supports the long-distance underconnectivity hypothesis. En ligne : http://dx.doi.org/10.1186/2040-2392-4-25 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] Comparison of white matter integrity between autism spectrum disorder subjects and typically developing individuals: a meta-analysis of diffusion tensor imaging tractography studies [Texte imprimé et/ou numérique] / Yuta AOKI, Auteur ; Osamu ABE, Auteur ; Yasumasa NIPPASHI, Auteur ; Hidenori YAMASUE, Auteur . - 2013 . - 17 p. Langues : Anglais (eng) in Molecular Autism > (July 2013) . - 17 p. Mots-clés : Autistic disorder  Asperger  Brain  Human  Imaging  Pervasive developmental disorder Index. décimale : PER Périodiques Résumé : Background Aberrant brain connectivity, especially with long-distance underconnectivity, has been recognized as a candidate pathophysiology of autism spectrum disorders. However, a number of diffusion tensor imaging studies investigating people with autism spectrum disorders have yielded inconsistent results. Methods To test the long-distance underconnectivity hypothesis, we performed a systematic review and meta-analysis of diffusion tensor imaging studies in subjects with autism spectrum disorder. Diffusion tensor imaging studies comparing individuals with autism spectrum disorders with typically developing individuals were searched using MEDLINE, Web of Science and EMBASE from 1980 through 1 August 2012. Standardized mean differences were calculated as an effect size of the tracts. Results A comprehensive literature search identified 25 relevant diffusion tensor imaging studies comparing autism spectrum disorders and typical development with regions-of-interest methods. Among these, 14 studies examining regions of interest with suprathreshold sample sizes were included in the meta-analysis. A random-effects model demonstrated significant fractional anisotropy reductions in the corpus callosum (P = 0.023, n = 387 (autism spectrum disorders/typically developing individuals: 208/179)), left uncinate fasciculus (P = 0.011, n = 242 (117/125)), and left superior longitudinal fasciculus (P = 0.016, n = 182 (96/86)), and significant increases of mean diffusivity in the corpus callosum (P = 0.006, n = 254 (129/125)) and superior longitudinal fasciculus bilaterally (P = 0.031 and 0.011, left and right, respectively, n = 109 (51/58)), in subjects with autism spectrum disorders compared with typically developing individuals with no significant publication bias. Conclusion The current meta-analysis of diffusion tensor imaging studies in subjects with autism spectrum disorders emphasizes important roles of the superior longitudinal fasciculus, uncinate fasciculus, and corpus callosum in the pathophysiology of autism spectrum disorders and supports the long-distance underconnectivity hypothesis. En ligne : http://dx.doi.org/10.1186/2040-2392-4-25 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

Objective assessment of autism spectrum disorder based on performance in structured interpersonal acting-out tasks with prosodic stability and variability / Keiko OCHI in Autism Research, 17-2 (February 2024)  

Public ISBD [article]  inAutism Research > 17-2 (February 2024) . - p.395-409 Titre : Objective assessment of autism spectrum disorder based on performance in structured interpersonal acting-out tasks with prosodic stability and variability Type de document : Texte imprimé et/ou numérique Auteurs : Keiko OCHI, Auteur ; Masaki KOJIMA, Auteur ; Nobutaka ONO, Auteur ; Miho KURODA, Auteur ; Keiho OWADA, Auteur ; Shigeki SAGAYAMA, Auteur ; Hidenori YAMASUE, Auteur Article en page(s) : p.395-409 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract In this study, we sought to objectively and quantitatively characterize the prosodic features of autism spectrum disorder (ASD) via the characteristics of prosody in a newly developed structured speech experiment. Male adults with high-functioning ASD and age/intelligence-matched men with typical development (TD) were asked to read 29 brief scripts aloud in response to preceding auditory stimuli. To investigate whether (1) highly structured acting-out tasks can uncover the prosodic of difference between those with ASD and TD, and (2) the prosodic stableness and flexibleness can be used for objective automatic assessment of ASD, we compared prosodic features such as fundamental frequency, intensity, and mora duration. The results indicate that individuals with ASD exhibit stable pitch registers or volume levels in some affective vocal-expression scenarios, such as those involving anger or sadness, compared with TD and those with TD. However, unstable prosody was observed in some timing control or emphasis tasks in the participants with ASD. Automatic classification of the ASD and TD groups using a support vector machine (SVM) with speech features exhibited an accuracy of 90.4%. A machine learning-based assessment of the degree of ASD core symptoms using support vector regression (SVR) also had good performance. These results may inform the development of a new easy-to-use assessment tool for ASD core symptoms using recorded audio signals. En ligne : https://doi.org/10.1002/aur.3080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522 [article] Objective assessment of autism spectrum disorder based on performance in structured interpersonal acting-out tasks with prosodic stability and variability [Texte imprimé et/ou numérique] / Keiko OCHI, Auteur ; Masaki KOJIMA, Auteur ; Nobutaka ONO, Auteur ; Miho KURODA, Auteur ; Keiho OWADA, Auteur ; Shigeki SAGAYAMA, Auteur ; Hidenori YAMASUE, Auteur . - p.395-409. Langues : Anglais (eng) in Autism Research > 17-2 (February 2024) . - p.395-409 Index. décimale : PER Périodiques Résumé : Abstract In this study, we sought to objectively and quantitatively characterize the prosodic features of autism spectrum disorder (ASD) via the characteristics of prosody in a newly developed structured speech experiment. Male adults with high-functioning ASD and age/intelligence-matched men with typical development (TD) were asked to read 29 brief scripts aloud in response to preceding auditory stimuli. To investigate whether (1) highly structured acting-out tasks can uncover the prosodic of difference between those with ASD and TD, and (2) the prosodic stableness and flexibleness can be used for objective automatic assessment of ASD, we compared prosodic features such as fundamental frequency, intensity, and mora duration. The results indicate that individuals with ASD exhibit stable pitch registers or volume levels in some affective vocal-expression scenarios, such as those involving anger or sadness, compared with TD and those with TD. However, unstable prosody was observed in some timing control or emphasis tasks in the participants with ASD. Automatic classification of the ASD and TD groups using a support vector machine (SVM) with speech features exhibited an accuracy of 90.4%. A machine learning-based assessment of the degree of ASD core symptoms using support vector regression (SVR) also had good performance. These results may inform the development of a new easy-to-use assessment tool for ASD core symptoms using recorded audio signals. En ligne : https://doi.org/10.1002/aur.3080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522

Task dependent prefrontal dysfunction in persons with Asperger's disorder investigated with multi-channel near-infrared spectroscopy / Akira IWANAMI in Research in Autism Spectrum Disorders, 5-3 (July-September 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-3 (July-September 2011) . - p.1187-1193 Titre : Task dependent prefrontal dysfunction in persons with Asperger's disorder investigated with multi-channel near-infrared spectroscopy Type de document : Texte imprimé et/ou numérique Auteurs : Akira IWANAMI, Auteur ; Yuka OKAJIMA, Auteur ; Haruhisa OTA, Auteur ; Masayuki TANI, Auteur ; Takashi YAMADA, Auteur ; Ryuichiro HASHIMORO, Auteur ; Chieko KANAI, Auteur ; Hiromi WATANABE, Auteur ; Hidenori YAMASUE, Auteur ; Yuki KAWAKUBO, Auteur ; Nobumasa KATO, Auteur Année de publication : 2011 Article en page(s) : p.1187-1193 Langues : Anglais (eng) Mots-clés : Asperger's disorder  PDD  NIRS  Prefrontal dysfunction  Verbal fluency task Index. décimale : PER Périodiques Résumé : Dysfunction of the prefrontal cortex has been previously reported in individuals with Asperger's disorder. In the present study, we used multi-channel near-infrared spectroscopy (NIRS) to detect changes in the oxygenated hemoglobin concentration ([oxy-Hb]) during two verbal fluency tasks. The subjects were 20 individuals with Asperger's disorder and 18 age- and IQ-matched healthy controls. The relative [oxy-Hb] in the prefrontal cortex was measured during the category and letter fluency tasks. The mean total [oxy-Hb] during the category fluency task did not differ significantly between the groups; however, during the letter fluency task, the mean [oxy-Hb] in persons with Asperger's disorder was significantly lower than that in controls. These results suggested task-relevant or task-specific prefrontal dysfunction in persons with Asperger's disorder. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.01.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 [article] Task dependent prefrontal dysfunction in persons with Asperger's disorder investigated with multi-channel near-infrared spectroscopy [Texte imprimé et/ou numérique] / Akira IWANAMI, Auteur ; Yuka OKAJIMA, Auteur ; Haruhisa OTA, Auteur ; Masayuki TANI, Auteur ; Takashi YAMADA, Auteur ; Ryuichiro HASHIMORO, Auteur ; Chieko KANAI, Auteur ; Hiromi WATANABE, Auteur ; Hidenori YAMASUE, Auteur ; Yuki KAWAKUBO, Auteur ; Nobumasa KATO, Auteur . - 2011 . - p.1187-1193. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-3 (July-September 2011) . - p.1187-1193 Mots-clés : Asperger's disorder  PDD  NIRS  Prefrontal dysfunction  Verbal fluency task Index. décimale : PER Périodiques Résumé : Dysfunction of the prefrontal cortex has been previously reported in individuals with Asperger's disorder. In the present study, we used multi-channel near-infrared spectroscopy (NIRS) to detect changes in the oxygenated hemoglobin concentration ([oxy-Hb]) during two verbal fluency tasks. The subjects were 20 individuals with Asperger's disorder and 18 age- and IQ-matched healthy controls. The relative [oxy-Hb] in the prefrontal cortex was measured during the category and letter fluency tasks. The mean total [oxy-Hb] during the category fluency task did not differ significantly between the groups; however, during the letter fluency task, the mean [oxy-Hb] in persons with Asperger's disorder was significantly lower than that in controls. These results suggested task-relevant or task-specific prefrontal dysfunction in persons with Asperger's disorder. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.01.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119

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