Abnormalities in the anterior cingulate cortex associated with attentional and inhibitory control deficits: A neurophysiological study on children with autism spectrum disorders / Agnes S. CHAN in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.254-266 Titre : Abnormalities in the anterior cingulate cortex associated with attentional and inhibitory control deficits: A neurophysiological study on children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Agnes S. CHAN, Auteur ; Virginia C.N. WONG, Auteur ; Yvonne M.Y. HAN, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Connie LEUNG, Auteur Année de publication : 2011 Article en page(s) : p.254-266 Langues : Anglais (eng) Mots-clés : Anterior-cingulate Attention Inhibitory-control EEG Autism Children Index. décimale : PER Périodiques Résumé : Previous studies showed that the anterior cingulate cortex (ACC) is activated when individuals engage in attention and inhibitory control tasks. The present study examined whether ACC activity is associated with behavioral performance of the two tasks. Twenty normal and 20 children with autism spectrum disorders (ASDs) were subjected to neuropsychological assessments on attention and inhibitory control, as well as electroencephalography recording. Children with ASD performed significantly worse than normal children on attention tasks as shown in their poorer performance on the Digit Span test, the greater number of Omission Errors on both the Continuous Performance Test II and the Go/No-Go tasks. They also performed significantly worse than normal children on inhibitory control tasks as shown by the greater number of False Alarms on the Object Recognition and Hong Kong List Learning Test. Their ACC activities, as indicated by relative theta power, were found to be significantly lower than those of normal controls during performance of the Go/No-Go task. Depressed ACC activities were further found to be significantly associated with poorer performance in attention and inhibition. Clinical implications on the use of theta activities in the ACC as an indicator to monitor intervention progress in children with ASD were discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.04.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] Abnormalities in the anterior cingulate cortex associated with attentional and inhibitory control deficits: A neurophysiological study on children with autism spectrum disorders [Texte imprimé et/ou numérique] / Agnes S. CHAN, Auteur ; Virginia C.N. WONG, Auteur ; Yvonne M.Y. HAN, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Connie LEUNG, Auteur . - 2011 . - p.254-266. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.254-266 Mots-clés : Anterior-cingulate Attention Inhibitory-control EEG Autism Children Index. décimale : PER Périodiques Résumé : Previous studies showed that the anterior cingulate cortex (ACC) is activated when individuals engage in attention and inhibitory control tasks. The present study examined whether ACC activity is associated with behavioral performance of the two tasks. Twenty normal and 20 children with autism spectrum disorders (ASDs) were subjected to neuropsychological assessments on attention and inhibitory control, as well as electroencephalography recording. Children with ASD performed significantly worse than normal children on attention tasks as shown in their poorer performance on the Digit Span test, the greater number of Omission Errors on both the Continuous Performance Test II and the Go/No-Go tasks. They also performed significantly worse than normal children on inhibitory control tasks as shown by the greater number of False Alarms on the Object Recognition and Hong Kong List Learning Test. Their ACC activities, as indicated by relative theta power, were found to be significantly lower than those of normal controls during performance of the Go/No-Go task. Depressed ACC activities were further found to be significantly associated with poorer performance in attention and inhibition. Clinical implications on the use of theta activities in the ACC as an indicator to monitor intervention progress in children with ASD were discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.04.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders / Yvonne M.Y. HAN in Research in Autism Spectrum Disorders, 7-6 (June 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-6 (June 2013) . - p.662-674 Titre : Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M. K. LAM, Auteur ; Priscilla M. K. POON, Auteur Article en page(s) : p.662-674 Langues : Anglais (eng) Mots-clés : EEG coherence  Immunologic function  Executive dysfunction  Autism  Children Index. décimale : PER Périodiques Résumé : Previous studies have shown that children with autism spectrum disorders (ASDs) have impaired executive function, disordered neural connectivity, and abnormal immunologic function. The present study examined whether these abnormalities were associated. Seventeen high-functioning (HFA) and 17 low-functioning (LFA) children with ASD, aged 8–17 years, participated voluntarily in the study. The two groups of children were compared on their general intelligence in terms of IQ; executive function as measured by the Hong Kong List Learning Test, D2 Test of Concentration, Five Point Test, Children's Color Trail Test, Tower of California Test, and Go/No-Go task; a non-executive task as measured by the Picture Completion Task; neural connectivity as measured by theta coherence in the anterior and posterior regions; and immunologic function as measured by the level of circulating CD3+ CD8+ suppressor/cytotoxic T lymphocytes in a blood sample. Results on executive function showed that LFA children performed significantly poorer than HFA children as shown on their lower Executive Composite as well as individual executive function scores. However, there was no group difference on the Picture Completion Task. Results on neural connectivity showed that LFA children demonstrated a different pattern of electroencephalography (EEG) coherence from HFA children as shown in the significantly elevated theta coherence in the anterior network, as well as at the left intra-hemispheric (LA-LP) and right-to-left inter-hemisphere (RA-LP) connections of LFA children. In immunologic function, results showed that LFA children had significantly elevated level of suppressor/cytotoxic T lymphocytes (CD3+ CD8+) (p lt; 0.05). In addition, the executive dysfunction, disordered neural connectivity, and abnormal immunologic function were found to be associated. These results provided some initial evidence to support the notion that immunologic factors are associated with neuronal damage, measureable by EEG coherence and manifested as executive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.02.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199 [article] Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders [Texte imprimé et/ou numérique] / Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M. K. LAM, Auteur ; Priscilla M. K. POON, Auteur . - p.662-674. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-6 (June 2013) . - p.662-674 Mots-clés : EEG coherence  Immunologic function  Executive dysfunction  Autism  Children Index. décimale : PER Périodiques Résumé : Previous studies have shown that children with autism spectrum disorders (ASDs) have impaired executive function, disordered neural connectivity, and abnormal immunologic function. The present study examined whether these abnormalities were associated. Seventeen high-functioning (HFA) and 17 low-functioning (LFA) children with ASD, aged 8–17 years, participated voluntarily in the study. The two groups of children were compared on their general intelligence in terms of IQ; executive function as measured by the Hong Kong List Learning Test, D2 Test of Concentration, Five Point Test, Children's Color Trail Test, Tower of California Test, and Go/No-Go task; a non-executive task as measured by the Picture Completion Task; neural connectivity as measured by theta coherence in the anterior and posterior regions; and immunologic function as measured by the level of circulating CD3+ CD8+ suppressor/cytotoxic T lymphocytes in a blood sample. Results on executive function showed that LFA children performed significantly poorer than HFA children as shown on their lower Executive Composite as well as individual executive function scores. However, there was no group difference on the Picture Completion Task. Results on neural connectivity showed that LFA children demonstrated a different pattern of electroencephalography (EEG) coherence from HFA children as shown in the significantly elevated theta coherence in the anterior network, as well as at the left intra-hemispheric (LA-LP) and right-to-left inter-hemisphere (RA-LP) connections of LFA children. In immunologic function, results showed that LFA children had significantly elevated level of suppressor/cytotoxic T lymphocytes (CD3+ CD8+) (p lt; 0.05). In addition, the executive dysfunction, disordered neural connectivity, and abnormal immunologic function were found to be associated. These results provided some initial evidence to support the notion that immunologic factors are associated with neuronal damage, measureable by EEG coherence and manifested as executive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.02.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199

Disordered connectivity associated with memory deficits in children with autism spectrum disorders / Agnes S. CHAN in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.237-245 Titre : Disordered connectivity associated with memory deficits in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Agnes S. CHAN, Auteur ; Yvonne M.Y. HAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Cho Yee TO, Auteur ; Raymond C. K. CHAN, Auteur Année de publication : 2011 Article en page(s) : p.237-245 Langues : Anglais (eng) Mots-clés : Autism EEG Coherence Memory Theta Children Index. décimale : PER Périodiques Résumé : The present study examined the memory performance and cortical connectivity of children with ASD, and investigated whether the memory deficits exhibited by these children were associated with the cortical connectivity. Twenty-one children with ASD and 21 children with normal development (NC), aged 5–14 years, participated in the study. Each child was administered a neuropsychological battery that included the Test of Non-verbal Intelligence (TONI-III), Digit Span test (DS), Rey-Osterrieth Complex Figure Test (Rey-O), and Hong Kong List Learning Test (HKLLT); and an EEG recording session when performing the visual encoding Object Recognition (OR) task. Six neuropsychological measures from the test battery and six EEG coherence measures in the theta band were compared between the children with ASD and normal children. Results indicated that children with ASD performed at comparable levels with normal children in the DS and Rey-O, but were significantly poorer in HKLLT and OR. They also exhibited significantly elevated long-range coherences in the fronto-posterior connections involving the left hemisphere (left anterior–left posterior; left anterior–right posterior). Pearson correlation showed significant negative associations between the anterior–posterior EEG coherences and memory performance. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.04.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] Disordered connectivity associated with memory deficits in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Agnes S. CHAN, Auteur ; Yvonne M.Y. HAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Cho Yee TO, Auteur ; Raymond C. K. CHAN, Auteur . - 2011 . - p.237-245. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.237-245 Mots-clés : Autism EEG Coherence Memory Theta Children Index. décimale : PER Périodiques Résumé : The present study examined the memory performance and cortical connectivity of children with ASD, and investigated whether the memory deficits exhibited by these children were associated with the cortical connectivity. Twenty-one children with ASD and 21 children with normal development (NC), aged 5–14 years, participated in the study. Each child was administered a neuropsychological battery that included the Test of Non-verbal Intelligence (TONI-III), Digit Span test (DS), Rey-Osterrieth Complex Figure Test (Rey-O), and Hong Kong List Learning Test (HKLLT); and an EEG recording session when performing the visual encoding Object Recognition (OR) task. Six neuropsychological measures from the test battery and six EEG coherence measures in the theta band were compared between the children with ASD and normal children. Results indicated that children with ASD performed at comparable levels with normal children in the DS and Rey-O, but were significantly poorer in HKLLT and OR. They also exhibited significantly elevated long-range coherences in the fronto-posterior connections involving the left hemisphere (left anterior–left posterior; left anterior–right posterior). Pearson correlation showed significant negative associations between the anterior–posterior EEG coherences and memory performance. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.04.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

Effects of prefrontal transcranial direct current stimulation on social functioning in autism spectrum disorder: A randomized clinical trial / Yvonne MY HAN in Autism, 27-8 (November 2023)  

Public ISBD [article]  inAutism > 27-8 (November 2023) . - p.2465-2482 Titre : Effects of prefrontal transcranial direct current stimulation on social functioning in autism spectrum disorder: A randomized clinical trial Type de document : Texte imprimé et/ou numérique Auteurs : Yvonne MY HAN, Auteur ; Melody MY CHAN, Auteur ; Caroline KS SHEA, Auteur ; Flora YM MO, Auteur ; Klaire WK YIU, Auteur ; Raymond CK CHUNG, Auteur ; Mei-chun CHEUNG, Auteur ; Agnes S CHAN, Auteur Article en page(s) : p.2465-2482 Mots-clés : ASD  behavior  cognition  RCT  social  tDCS Index. décimale : PER Périodiques Résumé : This triple-arm, double-blind, randomized clinical trial investigated the effect of multisession prefrontal transcranial direct current stimulation (tDCS) on social functioning in individuals with autism spectrum disorder (ASD). A total of 105 individuals (age 14-21?years) diagnosed with ASD were randomized into the active-tDCS, sham-tDCS, and waitlist control groups. The experimental group received 20?min of 1.5?mA tDCS stimulation (cathode: F3; anode: Fp2) for 10?days with concurrent computerized cognitive remediation training. Changes in overall social functioning, social communication, and restricted, repetitive behaviors (RRB) were measured by the Social Responsiveness Scale-2nd edition (SRS-2). Two-level hierarchical linear mixed-model analysis showed significant group*time interactions for SRS-2 total [F(2, 107.09)?=?7.82; p?=?0.001] and RRB [F(2, 90.26)?=?5.62; p?=?0.005] T-scores. When compared with the waitlist control group, the changes in scores were only significant in active-tDCS (SRS-2 total T-score p? En ligne : http://dx.doi.org/10.1177/13623613231169547 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Effects of prefrontal transcranial direct current stimulation on social functioning in autism spectrum disorder: A randomized clinical trial [Texte imprimé et/ou numérique] / Yvonne MY HAN, Auteur ; Melody MY CHAN, Auteur ; Caroline KS SHEA, Auteur ; Flora YM MO, Auteur ; Klaire WK YIU, Auteur ; Raymond CK CHUNG, Auteur ; Mei-chun CHEUNG, Auteur ; Agnes S CHAN, Auteur . - p.2465-2482. in Autism > 27-8 (November 2023) . - p.2465-2482 Mots-clés : ASD  behavior  cognition  RCT  social  tDCS Index. décimale : PER Périodiques Résumé : This triple-arm, double-blind, randomized clinical trial investigated the effect of multisession prefrontal transcranial direct current stimulation (tDCS) on social functioning in individuals with autism spectrum disorder (ASD). A total of 105 individuals (age 14-21?years) diagnosed with ASD were randomized into the active-tDCS, sham-tDCS, and waitlist control groups. The experimental group received 20?min of 1.5?mA tDCS stimulation (cathode: F3; anode: Fp2) for 10?days with concurrent computerized cognitive remediation training. Changes in overall social functioning, social communication, and restricted, repetitive behaviors (RRB) were measured by the Social Responsiveness Scale-2nd edition (SRS-2). Two-level hierarchical linear mixed-model analysis showed significant group*time interactions for SRS-2 total [F(2, 107.09)?=?7.82; p?=?0.001] and RRB [F(2, 90.26)?=?5.62; p?=?0.005] T-scores. When compared with the waitlist control group, the changes in scores were only significant in active-tDCS (SRS-2 total T-score p? En ligne : http://dx.doi.org/10.1177/13623613231169547 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Lymphocyte subset alterations related to executive function deficits and repetitive stereotyped behavior in autism / Yvonne M.Y. HAN in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.486-494 Titre : Lymphocyte subset alterations related to executive function deficits and repetitive stereotyped behavior in autism Type de document : Texte imprimé et/ou numérique Auteurs : Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M.K. LAM, Auteur Année de publication : 2011 Article en page(s) : p.486-494 Langues : Anglais (eng) Mots-clés : Immune-function Neuropsychological-function Autism Index. décimale : PER Périodiques Résumé : Increasing evidence suggests that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASD). The present study examined whether immunological abnormalities are associated with cognitive deficits in children with ASD. Eighteen high-functioning (HFA) and 19 low-functioning (LFA) children with ASD, aged 8–17 years, were assessed on cognitive functioning using IQ tests and executive functions tests including the Five Point test, Children Color Trail-making Test, D2 Test of Concentration, Tower of California Test; Hong Kong List Learning Test, and Go/No-Go test. They were also assessed on autoimmune symptoms, reported by their parents; and immunological measures including T lymphocytes (CD3+), B lymphocytes (CD19+), T helper lymphocytes (CD3+CD4+), suppressor/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) cells (CD3−CD16+ and/or CD56+). LFA children showed greater deficits in executive functions as well as higher levels of total lymphocyte, T lymphocyte and suppressor/cytotoxic T lymphocyte levels than HFA children (all p < 0.05). Their executive functions were also significantly associated with the three lymphocyte levels (all p < 0.05). These findings support the notion that altered immune functions may act on the neural tissues of individuals with ASD, which in turn leads to their cognitive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.06.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] Lymphocyte subset alterations related to executive function deficits and repetitive stereotyped behavior in autism [Texte imprimé et/ou numérique] / Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M.K. LAM, Auteur . - 2011 . - p.486-494. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.486-494 Mots-clés : Immune-function Neuropsychological-function Autism Index. décimale : PER Périodiques Résumé : Increasing evidence suggests that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASD). The present study examined whether immunological abnormalities are associated with cognitive deficits in children with ASD. Eighteen high-functioning (HFA) and 19 low-functioning (LFA) children with ASD, aged 8–17 years, were assessed on cognitive functioning using IQ tests and executive functions tests including the Five Point test, Children Color Trail-making Test, D2 Test of Concentration, Tower of California Test; Hong Kong List Learning Test, and Go/No-Go test. They were also assessed on autoimmune symptoms, reported by their parents; and immunological measures including T lymphocytes (CD3+), B lymphocytes (CD19+), T helper lymphocytes (CD3+CD4+), suppressor/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) cells (CD3−CD16+ and/or CD56+). LFA children showed greater deficits in executive functions as well as higher levels of total lymphocyte, T lymphocyte and suppressor/cytotoxic T lymphocyte levels than HFA children (all p < 0.05). Their executive functions were also significantly associated with the three lymphocyte levels (all p < 0.05). These findings support the notion that altered immune functions may act on the neural tissues of individuals with ASD, which in turn leads to their cognitive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.06.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

Verbal memory deficits in relation to organization strategy in high- and low-functioning autistic children / Mei-chun CHEUNG in Research in Autism Spectrum Disorders, 4-4 (October-December 2010)  

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