Early life stress is associated with default system integrity and emotionality during infancy / Alice M. GRAHAM in Journal of Child Psychology and Psychiatry, 56-11 (November 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1212-1222 Titre : Early life stress is associated with default system integrity and emotionality during infancy Type de document : texte imprimé Auteurs : Alice M. GRAHAM, Auteur ; Jennifer H. PFEIFER, Auteur ; Philip A. FISHER, Auteur ; Samuel CARPENTER, Auteur ; Damien A. FAIR, Auteur Article en page(s) : p.1212-1222 Langues : Anglais (eng) Mots-clés : Functional MRI  infancy  stress  family functioning  brain development Index. décimale : PER Périodiques Résumé : Background Extensive animal research has demonstrated the vulnerability of the brain to early life stress (ELS) with consequences for emotional development and mental health. However, the influence of moderate and common forms of stress on early human brain development is less well-understood and precisely characterized. To date, most work has focused on severe forms of stress, and/or on brain functioning years after stress exposure. Methods In this report we focused on conflict between parents (interparental conflict), a common and relatively moderate form of ELS that is highly relevant for children's mental health outcomes. We used resting state functional connectivity MRI to examine the coordinated functioning of the infant brain (N = 23; 6–12-months-of-age) in the context of interparental conflict. We focused on the default mode network (DMN) due to its well-characterized developmental trajectory and implications for mental health. We further examined DMN strength as a mediator between conflict and infants’ negative emotionality. Results Higher interparental conflict since birth was associated with infants showing stronger connectivity between two core DMN regions, the posterior cingulate cortex (PCC) and the anterior medial prefrontal cortex (aMPFC). PCC to amygdala connectivity was also increased. Stronger PCC-aMPFC connectivity mediated between higher conflict and higher negative infant emotionality. Conclusions The developing DMN may be an important marker for effects of ELS with relevance for emotional development and subsequent mental health. Increasing understanding of the associations between common forms of family stress and emerging functional brain networks has potential to inform intervention efforts to improve mental health outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12409 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Early life stress is associated with default system integrity and emotionality during infancy [texte imprimé] / Alice M. GRAHAM, Auteur ; Jennifer H. PFEIFER, Auteur ; Philip A. FISHER, Auteur ; Samuel CARPENTER, Auteur ; Damien A. FAIR, Auteur . - p.1212-1222. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1212-1222 Mots-clés : Functional MRI  infancy  stress  family functioning  brain development Index. décimale : PER Périodiques Résumé : Background Extensive animal research has demonstrated the vulnerability of the brain to early life stress (ELS) with consequences for emotional development and mental health. However, the influence of moderate and common forms of stress on early human brain development is less well-understood and precisely characterized. To date, most work has focused on severe forms of stress, and/or on brain functioning years after stress exposure. Methods In this report we focused on conflict between parents (interparental conflict), a common and relatively moderate form of ELS that is highly relevant for children's mental health outcomes. We used resting state functional connectivity MRI to examine the coordinated functioning of the infant brain (N = 23; 6–12-months-of-age) in the context of interparental conflict. We focused on the default mode network (DMN) due to its well-characterized developmental trajectory and implications for mental health. We further examined DMN strength as a mediator between conflict and infants’ negative emotionality. Results Higher interparental conflict since birth was associated with infants showing stronger connectivity between two core DMN regions, the posterior cingulate cortex (PCC) and the anterior medial prefrontal cortex (aMPFC). PCC to amygdala connectivity was also increased. Stronger PCC-aMPFC connectivity mediated between higher conflict and higher negative infant emotionality. Conclusions The developing DMN may be an important marker for effects of ELS with relevance for emotional development and subsequent mental health. Increasing understanding of the associations between common forms of family stress and emerging functional brain networks has potential to inform intervention efforts to improve mental health outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12409 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism / Jennifer H. PFEIFER in Journal of Autism and Developmental Disorders, 43-2 (February 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-2 (February 2013) . - p.272-285 Titre : Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism Type de document : texte imprimé Auteurs : Jennifer H. PFEIFER, Auteur ; Junaid S. MERCHANT, Auteur ; Natalie L. COLICH, Auteur ; Leanna M. HERNANDEZ, Auteur ; Jeff D. RUDIE, Auteur ; Mirella DAPRETTO, Auteur Article en page(s) : p.272-285 Langues : (Eng) Mots-clés : Autism  Self  Ventral mPFC  Anterior insula  Middle cingulate cortex  Development Index. décimale : PER Périodiques Résumé : This fMRI study investigated neural responses while making appraisals of self and other, across the social and academic domains, in children and adolescents with and without autism spectrum disorders (ASD). Compared to neurotypical youth, those with ASD exhibited hypoactivation of ventromedial prefrontal cortex during self-appraisals. Responses in middle cingulate cortex (MCC) and anterior insula (AI) also distinguished between groups. Stronger activity in MCC and AI during self-appraisals was associated with better social functioning in the ASD group. Although self-appraisals were significantly more positive in the neurotypical group, positivity was unrelated to brain activity in these regions. Together, these results suggest that multiple brain regions support making self-appraisals in neurotypical development, and function atypically in youth with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1563-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 [article] Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism [texte imprimé] / Jennifer H. PFEIFER, Auteur ; Junaid S. MERCHANT, Auteur ; Natalie L. COLICH, Auteur ; Leanna M. HERNANDEZ, Auteur ; Jeff D. RUDIE, Auteur ; Mirella DAPRETTO, Auteur . - p.272-285. Langues : (Eng) in Journal of Autism and Developmental Disorders > 43-2 (February 2013) . - p.272-285 Mots-clés : Autism  Self  Ventral mPFC  Anterior insula  Middle cingulate cortex  Development Index. décimale : PER Périodiques Résumé : This fMRI study investigated neural responses while making appraisals of self and other, across the social and academic domains, in children and adolescents with and without autism spectrum disorders (ASD). Compared to neurotypical youth, those with ASD exhibited hypoactivation of ventromedial prefrontal cortex during self-appraisals. Responses in middle cingulate cortex (MCC) and anterior insula (AI) also distinguished between groups. Stronger activity in MCC and AI during self-appraisals was associated with better social functioning in the ASD group. Although self-appraisals were significantly more positive in the neurotypical group, positivity was unrelated to brain activity in these regions. Together, these results suggest that multiple brain regions support making self-appraisals in neurotypical development, and function atypically in youth with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1563-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188

Psychobiological markers of allostatic load in depressed and nondepressed mothers and their adolescent offspring / Benjamin W. NELSON in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.199-211 Titre : Psychobiological markers of allostatic load in depressed and nondepressed mothers and their adolescent offspring Type de document : texte imprimé Auteurs : Benjamin W. NELSON, Auteur ; Lisa SHEEBER, Auteur ; Jennifer H. PFEIFER, Auteur ; Nicholas B. ALLEN, Auteur Année de publication : 2021 Article en page(s) : p.199-211 Langues : Anglais (eng) Mots-clés : Adolescence  biomarkers  health psychology  maternal depression  parent-child relationships Index. décimale : PER Périodiques Résumé : BACKGROUND: A substantial body of research has emerged suggesting that depression is strongly linked to poor physical health outcomes, which may be partly due to increased allostatic load across stress response systems. Interestingly, health risks associated with depression are also borne by the offspring of depressed persons. Our aim was to simultaneously investigate whether maternal depression is associated not only with increased allostatic load across cardiac control, inflammation, cellular aging, but also if this is transmitted to adolescent children, possibly increasing the risk for early onset of psychiatric conditions and disease in these offspring. METHODS: A preregistered, case-control study of 180 low-income mothers (50% mothers depressed, 50% mothers nondepressed) and their adolescent offspring was conducted to determine how depressed mothers and their adolescent offspring systematically differ in terms of autonomic, sympathetic, and parasympathetic cardiac control; inflammation; cellular aging; and behavioral health in offspring, which are indicators suggestive of higher allostatic load. RESULTS: Findings indicate that depressed mothers and their adolescent offspring differ in terms of comorbid mental and physical health risk profiles that are suggestive of higher allostatic load. Findings indicate that depressed mothers exhibit elevated resting heart rate and decreased heart rate variability, and adolescent offspring of depressed mothers exhibit greater mental health symptoms, elevated heart rate, and accelerated biological aging (shorter telomeres). These effects persisted after controlling for a range of potential covariates, including medication use, sex, age, and adolescents' own mental health symptoms. CONCLUSIONS: Findings indicate that maternal depression is associated with increased allostatic load in depressed women and their adolescent children, possibly increasing risk for early onset of psychiatric conditions and disease in these offspring. Future research is needed to delineate why some biological systems are more impacted than others and to explore how findings might inform preventative programs targeted at adolescent offspring of depressed mothers. En ligne : http://dx.doi.org/10.1111/jcpp.13264 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] Psychobiological markers of allostatic load in depressed and nondepressed mothers and their adolescent offspring [texte imprimé] / Benjamin W. NELSON, Auteur ; Lisa SHEEBER, Auteur ; Jennifer H. PFEIFER, Auteur ; Nicholas B. ALLEN, Auteur . - 2021 . - p.199-211. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.199-211 Mots-clés : Adolescence  biomarkers  health psychology  maternal depression  parent-child relationships Index. décimale : PER Périodiques Résumé : BACKGROUND: A substantial body of research has emerged suggesting that depression is strongly linked to poor physical health outcomes, which may be partly due to increased allostatic load across stress response systems. Interestingly, health risks associated with depression are also borne by the offspring of depressed persons. Our aim was to simultaneously investigate whether maternal depression is associated not only with increased allostatic load across cardiac control, inflammation, cellular aging, but also if this is transmitted to adolescent children, possibly increasing the risk for early onset of psychiatric conditions and disease in these offspring. METHODS: A preregistered, case-control study of 180 low-income mothers (50% mothers depressed, 50% mothers nondepressed) and their adolescent offspring was conducted to determine how depressed mothers and their adolescent offspring systematically differ in terms of autonomic, sympathetic, and parasympathetic cardiac control; inflammation; cellular aging; and behavioral health in offspring, which are indicators suggestive of higher allostatic load. RESULTS: Findings indicate that depressed mothers and their adolescent offspring differ in terms of comorbid mental and physical health risk profiles that are suggestive of higher allostatic load. Findings indicate that depressed mothers exhibit elevated resting heart rate and decreased heart rate variability, and adolescent offspring of depressed mothers exhibit greater mental health symptoms, elevated heart rate, and accelerated biological aging (shorter telomeres). These effects persisted after controlling for a range of potential covariates, including medication use, sex, age, and adolescents' own mental health symptoms. CONCLUSIONS: Findings indicate that maternal depression is associated with increased allostatic load in depressed women and their adolescent children, possibly increasing risk for early onset of psychiatric conditions and disease in these offspring. Future research is needed to delineate why some biological systems are more impacted than others and to explore how findings might inform preventative programs targeted at adolescent offspring of depressed mothers. En ligne : http://dx.doi.org/10.1111/jcpp.13264 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

Self-Conscious Emotion Processing in Autistic Adolescents: Over-Reliance on Learned Social Rules During Tasks with Heightened Perspective-Taking Demands May Serve as Compensatory Strategy for Less Reflexive Mentalizing / Kathryn F. JANKOWSKI in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3514-3532 Titre : Self-Conscious Emotion Processing in Autistic Adolescents: Over-Reliance on Learned Social Rules During Tasks with Heightened Perspective-Taking Demands May Serve as Compensatory Strategy for Less Reflexive Mentalizing Type de document : texte imprimé Auteurs : Kathryn F. JANKOWSKI, Auteur ; Jennifer H. PFEIFER, Auteur Article en page(s) : p.3514-3532 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Emotions  Empathy  Humans  Mentalization  Autism  Perspective-taking  Self-conscious emotions  Social context  Social emotions Index. décimale : PER Périodiques Résumé : Autistic adolescents experience a secondary wave of social cognitive challenges which impact interpersonal success. We investigated self-conscious emotion (SCE) processing in autistic and neurotypical adolescents. Participants watched videos of peers acting embarrassed and proud and rated inferred and empathic SCEs. We compared intensity ratings across groups and conducted correlations with social cognitive abilities and autistic features. Autistic adolescents recognized SCEs and felt empathic SCEs; however, they made atypical emotion attributions when perspective-taking demands were high, which more strongly reflected the situational context. Atypical attributions were associated with perspective-taking difficulties and autistic feature intensity. An over-reliance on contextual cues may reflect a strict adherence to learned social rules, possibly compensating for less reflexive mentalizing, which may underlie interpersonal challenges in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04808-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Self-Conscious Emotion Processing in Autistic Adolescents: Over-Reliance on Learned Social Rules During Tasks with Heightened Perspective-Taking Demands May Serve as Compensatory Strategy for Less Reflexive Mentalizing [texte imprimé] / Kathryn F. JANKOWSKI, Auteur ; Jennifer H. PFEIFER, Auteur . - p.3514-3532. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3514-3532 Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Emotions  Empathy  Humans  Mentalization  Autism  Perspective-taking  Self-conscious emotions  Social context  Social emotions Index. décimale : PER Périodiques Résumé : Autistic adolescents experience a secondary wave of social cognitive challenges which impact interpersonal success. We investigated self-conscious emotion (SCE) processing in autistic and neurotypical adolescents. Participants watched videos of peers acting embarrassed and proud and rated inferred and empathic SCEs. We compared intensity ratings across groups and conducted correlations with social cognitive abilities and autistic features. Autistic adolescents recognized SCEs and felt empathic SCEs; however, they made atypical emotion attributions when perspective-taking demands were high, which more strongly reflected the situational context. Atypical attributions were associated with perspective-taking difficulties and autistic feature intensity. An over-reliance on contextual cues may reflect a strict adherence to learned social rules, possibly compensating for less reflexive mentalizing, which may underlie interpersonal challenges in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04808-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Social determinants of mental health during a year of the COVID-19 pandemic / Amy ORBEN ; Annabel SONGCO ; Elaine FOX ; Cecile D. LADOUCEUR ; Louise MEWTON ; Michelle MOULDS ; Jennifer H. PFEIFER ; Anne-Laura VAN HARMELEN ; Susanne SCHWEIZER in Development and Psychopathology, 35-4 (October 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-4 (October 2023) . - p.1701-1713 Titre : Social determinants of mental health during a year of the COVID-19 pandemic Type de document : texte imprimé Auteurs : Amy ORBEN, Auteur ; Annabel SONGCO, Auteur ; Elaine FOX, Auteur ; Cecile D. LADOUCEUR, Auteur ; Louise MEWTON, Auteur ; Michelle MOULDS, Auteur ; Jennifer H. PFEIFER, Auteur ; Anne-Laura VAN HARMELEN, Auteur ; Susanne SCHWEIZER, Auteur Article en page(s) : p.1701-1713 Langues : Anglais (eng) Mots-clés : COVID-19  mental health  physical distancing  social connectedness  social rejection sensitivity Index. décimale : PER Périodiques Résumé : Belonging is a basic human need, with social isolation signaling a threat to biological fitness. Sensitivity to ostracism varies across individuals and the lifespan, peaking in adolescence. Government-imposed restrictions upon social interactions during COVID-19 may therefore be particularly detrimental to young people and those most sensitive to ostracism. Participants (N = 2367; 89.95% female, 11-100 years) from three countries with differing levels of government restrictions (Australia, UK, and USA) were surveyed thrice at three-month intervals (May 2020 - April 2021). Young people, and those living under the tightest government restrictions, reported the worst mental health, with these inequalities in mental health remaining constant throughout the study period. Further dissection of these results revealed that young people high on social rejection sensitivity reported the most mental health problems at the final assessment. These findings help account for the greater impact of enforced social isolation on young people?s mental health, and open novel avenues for intervention. En ligne : https://dx.doi.org/10.1017/S0954579422000396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 [article] Social determinants of mental health during a year of the COVID-19 pandemic [texte imprimé] / Amy ORBEN, Auteur ; Annabel SONGCO, Auteur ; Elaine FOX, Auteur ; Cecile D. LADOUCEUR, Auteur ; Louise MEWTON, Auteur ; Michelle MOULDS, Auteur ; Jennifer H. PFEIFER, Auteur ; Anne-Laura VAN HARMELEN, Auteur ; Susanne SCHWEIZER, Auteur . - p.1701-1713. Langues : Anglais (eng) in Development and Psychopathology > 35-4 (October 2023) . - p.1701-1713 Mots-clés : COVID-19  mental health  physical distancing  social connectedness  social rejection sensitivity Index. décimale : PER Périodiques Résumé : Belonging is a basic human need, with social isolation signaling a threat to biological fitness. Sensitivity to ostracism varies across individuals and the lifespan, peaking in adolescence. Government-imposed restrictions upon social interactions during COVID-19 may therefore be particularly detrimental to young people and those most sensitive to ostracism. Participants (N = 2367; 89.95% female, 11-100 years) from three countries with differing levels of government restrictions (Australia, UK, and USA) were surveyed thrice at three-month intervals (May 2020 - April 2021). Young people, and those living under the tightest government restrictions, reported the worst mental health, with these inequalities in mental health remaining constant throughout the study period. Further dissection of these results revealed that young people high on social rejection sensitivity reported the most mental health problems at the final assessment. These findings help account for the greater impact of enforced social isolation on young people?s mental health, and open novel avenues for intervention. En ligne : https://dx.doi.org/10.1017/S0954579422000396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515

Subgenual anterior cingulate responses to peer rejection: A marker of adolescents' risk for depression / Carrie L. MASTEN in Development and Psychopathology, 23-1 (January 2011)  

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The neurobiology of self-processing in abused depressed adolescents / Karina QUEVEDO in Development and Psychopathology, 29-3 (August 2017)  

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