Early life stress is associated with default system integrity and emotionality during infancy / Alice M. GRAHAM in Journal of Child Psychology and Psychiatry, 56-11 (November 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1212-1222 Titre : Early life stress is associated with default system integrity and emotionality during infancy Type de document : Texte imprimé et/ou numérique Auteurs : Alice M. GRAHAM, Auteur ; Jennifer H. PFEIFER, Auteur ; Philip A. FISHER, Auteur ; Samuel CARPENTER, Auteur ; Damien A. FAIR, Auteur Article en page(s) : p.1212-1222 Langues : Anglais (eng) Mots-clés : Functional MRI  infancy  stress  family functioning  brain development Index. décimale : PER Périodiques Résumé : Background Extensive animal research has demonstrated the vulnerability of the brain to early life stress (ELS) with consequences for emotional development and mental health. However, the influence of moderate and common forms of stress on early human brain development is less well-understood and precisely characterized. To date, most work has focused on severe forms of stress, and/or on brain functioning years after stress exposure. Methods In this report we focused on conflict between parents (interparental conflict), a common and relatively moderate form of ELS that is highly relevant for children's mental health outcomes. We used resting state functional connectivity MRI to examine the coordinated functioning of the infant brain (N = 23; 6–12-months-of-age) in the context of interparental conflict. We focused on the default mode network (DMN) due to its well-characterized developmental trajectory and implications for mental health. We further examined DMN strength as a mediator between conflict and infants’ negative emotionality. Results Higher interparental conflict since birth was associated with infants showing stronger connectivity between two core DMN regions, the posterior cingulate cortex (PCC) and the anterior medial prefrontal cortex (aMPFC). PCC to amygdala connectivity was also increased. Stronger PCC-aMPFC connectivity mediated between higher conflict and higher negative infant emotionality. Conclusions The developing DMN may be an important marker for effects of ELS with relevance for emotional development and subsequent mental health. Increasing understanding of the associations between common forms of family stress and emerging functional brain networks has potential to inform intervention efforts to improve mental health outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12409 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Early life stress is associated with default system integrity and emotionality during infancy [Texte imprimé et/ou numérique] / Alice M. GRAHAM, Auteur ; Jennifer H. PFEIFER, Auteur ; Philip A. FISHER, Auteur ; Samuel CARPENTER, Auteur ; Damien A. FAIR, Auteur . - p.1212-1222. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1212-1222 Mots-clés : Functional MRI  infancy  stress  family functioning  brain development Index. décimale : PER Périodiques Résumé : Background Extensive animal research has demonstrated the vulnerability of the brain to early life stress (ELS) with consequences for emotional development and mental health. However, the influence of moderate and common forms of stress on early human brain development is less well-understood and precisely characterized. To date, most work has focused on severe forms of stress, and/or on brain functioning years after stress exposure. Methods In this report we focused on conflict between parents (interparental conflict), a common and relatively moderate form of ELS that is highly relevant for children's mental health outcomes. We used resting state functional connectivity MRI to examine the coordinated functioning of the infant brain (N = 23; 6–12-months-of-age) in the context of interparental conflict. We focused on the default mode network (DMN) due to its well-characterized developmental trajectory and implications for mental health. We further examined DMN strength as a mediator between conflict and infants’ negative emotionality. Results Higher interparental conflict since birth was associated with infants showing stronger connectivity between two core DMN regions, the posterior cingulate cortex (PCC) and the anterior medial prefrontal cortex (aMPFC). PCC to amygdala connectivity was also increased. Stronger PCC-aMPFC connectivity mediated between higher conflict and higher negative infant emotionality. Conclusions The developing DMN may be an important marker for effects of ELS with relevance for emotional development and subsequent mental health. Increasing understanding of the associations between common forms of family stress and emerging functional brain networks has potential to inform intervention efforts to improve mental health outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12409 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism / Jennifer H. PFEIFER in Journal of Autism and Developmental Disorders, 43-2 (February 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-2 (February 2013) . - p.272-285 Titre : Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer H. PFEIFER, Auteur ; Junaid S. MERCHANT, Auteur ; Natalie L. COLICH, Auteur ; Leanna M. HERNANDEZ, Auteur ; Jeff D. RUDIE, Auteur ; Mirella DAPRETTO, Auteur Article en page(s) : p.272-285 Langues : (Eng) Mots-clés : Autism  Self  Ventral mPFC  Anterior insula  Middle cingulate cortex  Development Index. décimale : PER Périodiques Résumé : This fMRI study investigated neural responses while making appraisals of self and other, across the social and academic domains, in children and adolescents with and without autism spectrum disorders (ASD). Compared to neurotypical youth, those with ASD exhibited hypoactivation of ventromedial prefrontal cortex during self-appraisals. Responses in middle cingulate cortex (MCC) and anterior insula (AI) also distinguished between groups. Stronger activity in MCC and AI during self-appraisals was associated with better social functioning in the ASD group. Although self-appraisals were significantly more positive in the neurotypical group, positivity was unrelated to brain activity in these regions. Together, these results suggest that multiple brain regions support making self-appraisals in neurotypical development, and function atypically in youth with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1563-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 [article] Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism [Texte imprimé et/ou numérique] / Jennifer H. PFEIFER, Auteur ; Junaid S. MERCHANT, Auteur ; Natalie L. COLICH, Auteur ; Leanna M. HERNANDEZ, Auteur ; Jeff D. RUDIE, Auteur ; Mirella DAPRETTO, Auteur . - p.272-285. Langues : (Eng) in Journal of Autism and Developmental Disorders > 43-2 (February 2013) . - p.272-285 Mots-clés : Autism  Self  Ventral mPFC  Anterior insula  Middle cingulate cortex  Development Index. décimale : PER Périodiques Résumé : This fMRI study investigated neural responses while making appraisals of self and other, across the social and academic domains, in children and adolescents with and without autism spectrum disorders (ASD). Compared to neurotypical youth, those with ASD exhibited hypoactivation of ventromedial prefrontal cortex during self-appraisals. Responses in middle cingulate cortex (MCC) and anterior insula (AI) also distinguished between groups. Stronger activity in MCC and AI during self-appraisals was associated with better social functioning in the ASD group. Although self-appraisals were significantly more positive in the neurotypical group, positivity was unrelated to brain activity in these regions. Together, these results suggest that multiple brain regions support making self-appraisals in neurotypical development, and function atypically in youth with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1563-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188

Social determinants of mental health during a year of the COVID-19 pandemic / Amy ORBEN ; Annabel SONGCO ; Elaine FOX ; Cecile D. LADOUCEUR ; Louise MEWTON ; Michelle MOULDS ; Jennifer H. PFEIFER ; Anne-Laura VAN HARMELEN ; Susanne SCHWEIZER in Development and Psychopathology, 35-4 (October 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-4 (October 2023) . - p.1701-1713 Titre : Social determinants of mental health during a year of the COVID-19 pandemic Type de document : Texte imprimé et/ou numérique Auteurs : Amy ORBEN, Auteur ; Annabel SONGCO, Auteur ; Elaine FOX, Auteur ; Cecile D. LADOUCEUR, Auteur ; Louise MEWTON, Auteur ; Michelle MOULDS, Auteur ; Jennifer H. PFEIFER, Auteur ; Anne-Laura VAN HARMELEN, Auteur ; Susanne SCHWEIZER, Auteur Article en page(s) : p.1701-1713 Langues : Anglais (eng) Mots-clés : COVID-19  mental health  physical distancing  social connectedness  social rejection sensitivity Index. décimale : PER Périodiques Résumé : Belonging is a basic human need, with social isolation signaling a threat to biological fitness. Sensitivity to ostracism varies across individuals and the lifespan, peaking in adolescence. Government-imposed restrictions upon social interactions during COVID-19 may therefore be particularly detrimental to young people and those most sensitive to ostracism. Participants (N = 2367; 89.95% female, 11-100 years) from three countries with differing levels of government restrictions (Australia, UK, and USA) were surveyed thrice at three-month intervals (May 2020 - April 2021). Young people, and those living under the tightest government restrictions, reported the worst mental health, with these inequalities in mental health remaining constant throughout the study period. Further dissection of these results revealed that young people high on social rejection sensitivity reported the most mental health problems at the final assessment. These findings help account for the greater impact of enforced social isolation on young people?s mental health, and open novel avenues for intervention. En ligne : https://dx.doi.org/10.1017/S0954579422000396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 [article] Social determinants of mental health during a year of the COVID-19 pandemic [Texte imprimé et/ou numérique] / Amy ORBEN, Auteur ; Annabel SONGCO, Auteur ; Elaine FOX, Auteur ; Cecile D. LADOUCEUR, Auteur ; Louise MEWTON, Auteur ; Michelle MOULDS, Auteur ; Jennifer H. PFEIFER, Auteur ; Anne-Laura VAN HARMELEN, Auteur ; Susanne SCHWEIZER, Auteur . - p.1701-1713. Langues : Anglais (eng) in Development and Psychopathology > 35-4 (October 2023) . - p.1701-1713 Mots-clés : COVID-19  mental health  physical distancing  social connectedness  social rejection sensitivity Index. décimale : PER Périodiques Résumé : Belonging is a basic human need, with social isolation signaling a threat to biological fitness. Sensitivity to ostracism varies across individuals and the lifespan, peaking in adolescence. Government-imposed restrictions upon social interactions during COVID-19 may therefore be particularly detrimental to young people and those most sensitive to ostracism. Participants (N = 2367; 89.95% female, 11-100 years) from three countries with differing levels of government restrictions (Australia, UK, and USA) were surveyed thrice at three-month intervals (May 2020 - April 2021). Young people, and those living under the tightest government restrictions, reported the worst mental health, with these inequalities in mental health remaining constant throughout the study period. Further dissection of these results revealed that young people high on social rejection sensitivity reported the most mental health problems at the final assessment. These findings help account for the greater impact of enforced social isolation on young people?s mental health, and open novel avenues for intervention. En ligne : https://dx.doi.org/10.1017/S0954579422000396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515

Subgenual anterior cingulate responses to peer rejection: A marker of adolescents' risk for depression / Carrie L. MASTEN in Development and Psychopathology, 23-1 (January 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-1 (January 2011) . - p.283-292 Titre : Subgenual anterior cingulate responses to peer rejection: A marker of adolescents' risk for depression Type de document : Texte imprimé et/ou numérique Auteurs : Carrie L. MASTEN, Auteur ; Naomi I. EISENBERGER, Auteur ; Larissa A. BOROFSKY, Auteur ; Kristin MCNEALY, Auteur ; Jennifer H. PFEIFER, Auteur ; Mirella DAPRETTO, Auteur Année de publication : 2011 Article en page(s) : p.283-292 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Extensive developmental research has linked peer rejection during adolescence with a host of psychopathological outcomes, including depression. Moreover, recent neuroimaging research has suggested that increased activity in the subgenual region of the anterior cingulate cortex (subACC), which has been consistently linked with depression, is related to heightened sensitivity to peer rejection among adolescents. The goal of the current study was to directly test the hypothesis that adolescents' subACC responses are predictive of their risk for future depression, by examining the relationship between subACC activity during peer rejection and increases in depressive symptoms during the following year. During a functional magnetic resonance imaging scan, 20 13-year-olds were ostensibly excluded by peers during an online social interaction. Participants' depressive symptoms were assessed via parental reports at the time of the scan and 1 year later. Region of interest and whole-brain analyses indicated that greater subACC activity during exclusion was associated with increases in parent-reported depressive symptoms during the following year. These findings suggest that subACC responsivity to social exclusion may serve as a neural marker of adolescents' risk for future depression and have implications for understanding the relationship between sensitivity to peer rejection and the increased risk of depression that occurs during adolescence. En ligne : http://dx.doi.org/10.1017/S0954579410000799 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 [article] Subgenual anterior cingulate responses to peer rejection: A marker of adolescents' risk for depression [Texte imprimé et/ou numérique] / Carrie L. MASTEN, Auteur ; Naomi I. EISENBERGER, Auteur ; Larissa A. BOROFSKY, Auteur ; Kristin MCNEALY, Auteur ; Jennifer H. PFEIFER, Auteur ; Mirella DAPRETTO, Auteur . - 2011 . - p.283-292. Langues : Anglais (eng) in Development and Psychopathology > 23-1 (January 2011) . - p.283-292 Index. décimale : PER Périodiques Résumé : Extensive developmental research has linked peer rejection during adolescence with a host of psychopathological outcomes, including depression. Moreover, recent neuroimaging research has suggested that increased activity in the subgenual region of the anterior cingulate cortex (subACC), which has been consistently linked with depression, is related to heightened sensitivity to peer rejection among adolescents. The goal of the current study was to directly test the hypothesis that adolescents' subACC responses are predictive of their risk for future depression, by examining the relationship between subACC activity during peer rejection and increases in depressive symptoms during the following year. During a functional magnetic resonance imaging scan, 20 13-year-olds were ostensibly excluded by peers during an online social interaction. Participants' depressive symptoms were assessed via parental reports at the time of the scan and 1 year later. Region of interest and whole-brain analyses indicated that greater subACC activity during exclusion was associated with increases in parent-reported depressive symptoms during the following year. These findings suggest that subACC responsivity to social exclusion may serve as a neural marker of adolescents' risk for future depression and have implications for understanding the relationship between sensitivity to peer rejection and the increased risk of depression that occurs during adolescence. En ligne : http://dx.doi.org/10.1017/S0954579410000799 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117

The neurobiology of self-processing in abused depressed adolescents / Karina QUEVEDO in Development and Psychopathology, 29-3 (August 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-3 (August 2017) . - p.1057-1073 Titre : The neurobiology of self-processing in abused depressed adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Karina QUEVEDO, Auteur ; Rowena NG, Auteur ; Hannah SCOTT, Auteur ; Garry SMYDA, Auteur ; Jennifer H. PFEIFER, Auteur ; Sandra MALONE, Auteur Article en page(s) : p.1057-1073 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Maltreatment is associated with chronic depression, high negative self-attributions, and lifetime psychopathology. Adolescence is a sensitive period for the formation of self-concept. Identifying neurobiomarkers of self-processing in depressed adolescents with and without maltreatment may parse the effects of trauma and depression on self-development and chronic psychopathology. Depressed adolescents (n = 86) maltreated due to omission (DO, n = 13) or commission (DCM, n = 28) or without maltreatment (DC, n = 45), and HCs (HC, n = 37) appraised positive and negative self-descriptors in the scanner. DCM and DO showed hypoactivity in the dorsal anterior cingulate cortex (dACC) while processing positive versus negative self-descriptors compared to DC youth, who in turn showed reduced dACC recruitment versus HC. HC youth showed the highest activation in the dACC and striatum during positive self-descriptors; these regions showed a linear decline in activity across DC, DO, and DCM. Low dACC activity to positive versus negative self-descriptors was linked to inadequate coregulation of children's emotions by parents. Negative self-cognitions prevalent in DCM and DO adolescents may be perpetuated by activity in the dACC and striatum. Reduced activation of the dACC and striatum for positive self-descriptors, coupled with enhanced activity for negative self-descriptors, may heighten the risk for persistent depression. En ligne : http://dx.doi.org/10.1017/s0954579416001024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=312 [article] The neurobiology of self-processing in abused depressed adolescents [Texte imprimé et/ou numérique] / Karina QUEVEDO, Auteur ; Rowena NG, Auteur ; Hannah SCOTT, Auteur ; Garry SMYDA, Auteur ; Jennifer H. PFEIFER, Auteur ; Sandra MALONE, Auteur . - p.1057-1073. Langues : Anglais (eng) in Development and Psychopathology > 29-3 (August 2017) . - p.1057-1073 Index. décimale : PER Périodiques Résumé : Abstract Maltreatment is associated with chronic depression, high negative self-attributions, and lifetime psychopathology. Adolescence is a sensitive period for the formation of self-concept. Identifying neurobiomarkers of self-processing in depressed adolescents with and without maltreatment may parse the effects of trauma and depression on self-development and chronic psychopathology. Depressed adolescents (n = 86) maltreated due to omission (DO, n = 13) or commission (DCM, n = 28) or without maltreatment (DC, n = 45), and HCs (HC, n = 37) appraised positive and negative self-descriptors in the scanner. DCM and DO showed hypoactivity in the dorsal anterior cingulate cortex (dACC) while processing positive versus negative self-descriptors compared to DC youth, who in turn showed reduced dACC recruitment versus HC. HC youth showed the highest activation in the dACC and striatum during positive self-descriptors; these regions showed a linear decline in activity across DC, DO, and DCM. Low dACC activity to positive versus negative self-descriptors was linked to inadequate coregulation of children's emotions by parents. Negative self-cognitions prevalent in DCM and DO adolescents may be perpetuated by activity in the dACC and striatum. Reduced activation of the dACC and striatum for positive self-descriptors, coupled with enhanced activity for negative self-descriptors, may heighten the risk for persistent depression. En ligne : http://dx.doi.org/10.1017/s0954579416001024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=312

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