Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: Initial studies and future directions / Michelle D. CARTER in Autism Research, 4-1 (February 2011)  

Public ISBD [article]  inAutism Research > 4-1 (February 2011) . - p.57-67 Titre : Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: Initial studies and future directions Type de document : Texte imprimé et/ou numérique Auteurs : Michelle D. CARTER, Auteur ; Charisma R. SHAH, Auteur ; Christopher L. MULLER, Auteur ; Jacqueline N. CRAWLEY, Auteur ; Ana M.D. CARNEIRO, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Année de publication : 2011 Article en page(s) : p.57-67 Langues : Anglais (eng) Mots-clés : autism  genetic  integrin  cell adhesion  serotonin  social memory  grooming  obsessive–compulsive disorder Index. décimale : PER Périodiques Résumé : Elevated whole blood serotonin 5-HT, or hyperserotonemia, is a common biomarker in autism spectrum disorder (ASD). The integrin β3 receptor subunit gene (ITGB3) is a quantitative trait locus for whole blood 5-HT levels. Recent work shows that integrin β3 interacts with the serotonin transporter (SERT) in both platelets and in the midbrain. Furthermore, multiple studies have now reported gene–gene interaction between the integrin β3 and SERT genes in association with ASD. Given the lack of previous data on the impact of integrin β3 on brain or behavioral phenotypes, we sought to compare mice with decreased or absent expression of the integrin β3 receptor subunit (Itgb3 + / − and −/ −) with wildtype littermate controls in behavioral tasks relevant to ASD. These mice did not show deficits in activity level in the open field or anxiety-like behavior on the elevated plus maze, two potential confounds in the evaluation of mouse social behavior. In the three-chamber social test, mice lacking integrin β3 were shown to have normal sociability but did not show a preference for social novelty. Importantly, the absence of integrin β3 did not impair olfaction or the ability to recall familiar social odors. Additionally, mice lacking integrin β3 showed increased grooming behavior in novel environments. These preliminary studies reveal altered social and repetitive behavior in these mice, which suggests that the integrin β3 subunit may be involved in brain systems relevant to ASD. Further work is needed to fully characterize these behavioral changes and the underlying brain mechanisms. En ligne : http://dx.doi.org/10.1002/aur.180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: Initial studies and future directions [Texte imprimé et/ou numérique] / Michelle D. CARTER, Auteur ; Charisma R. SHAH, Auteur ; Christopher L. MULLER, Auteur ; Jacqueline N. CRAWLEY, Auteur ; Ana M.D. CARNEIRO, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - 2011 . - p.57-67. Langues : Anglais (eng) in Autism Research > 4-1 (February 2011) . - p.57-67 Mots-clés : autism  genetic  integrin  cell adhesion  serotonin  social memory  grooming  obsessive–compulsive disorder Index. décimale : PER Périodiques Résumé : Elevated whole blood serotonin 5-HT, or hyperserotonemia, is a common biomarker in autism spectrum disorder (ASD). The integrin β3 receptor subunit gene (ITGB3) is a quantitative trait locus for whole blood 5-HT levels. Recent work shows that integrin β3 interacts with the serotonin transporter (SERT) in both platelets and in the midbrain. Furthermore, multiple studies have now reported gene–gene interaction between the integrin β3 and SERT genes in association with ASD. Given the lack of previous data on the impact of integrin β3 on brain or behavioral phenotypes, we sought to compare mice with decreased or absent expression of the integrin β3 receptor subunit (Itgb3 + / − and −/ −) with wildtype littermate controls in behavioral tasks relevant to ASD. These mice did not show deficits in activity level in the open field or anxiety-like behavior on the elevated plus maze, two potential confounds in the evaluation of mouse social behavior. In the three-chamber social test, mice lacking integrin β3 were shown to have normal sociability but did not show a preference for social novelty. Importantly, the absence of integrin β3 did not impair olfaction or the ability to recall familiar social odors. Additionally, mice lacking integrin β3 showed increased grooming behavior in novel environments. These preliminary studies reveal altered social and repetitive behavior in these mice, which suggests that the integrin β3 subunit may be involved in brain systems relevant to ASD. Further work is needed to fully characterize these behavioral changes and the underlying brain mechanisms. En ligne : http://dx.doi.org/10.1002/aur.180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical / Charisma R. SHAH in Autism Research, 6-3 (June 2013)  

Public ISBD [article]  inAutism Research > 6-3 (June 2013) . - p.212-220 Titre : Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical Type de document : Texte imprimé et/ou numérique Auteurs : Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Année de publication : 2013 Article en page(s) : p.212-220 Langues : Anglais (eng) Mots-clés : animal models  behavioral analysis of animal models??animal models  genetics  gamma-aminobutyric acid neurochemistry Index. décimale : PER Périodiques Résumé : Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a “typical” way. We hypothesized that mice could be used to make a similar judgment if they prefer “typical” over “atypical” social interactions with mouse models relevant to ASD. We used wild-type C57BL/6 (B6) mice as “judges” and evaluated their preference for a chamber containing a “typical” (B6 or 129S6) or an “atypical” mouse. For our atypical mouse stimuli, we chose two inbred strains with well-documented social phenotypes (BTBR and BALB/c), as well a mutant line with abnormal social behavior and seizures (Gabrb3 +/?). Overall, we observed a stimulus by time interaction (P??0.0001), with B6 mice preferring the typical mouse chamber during the last 10?min of the 30-min test. For two of the individual stimulus pairings, we observed a similar chamber by time interaction (BALB/c vs. 129S6, P?=?0.0007; Gabrb3 +/? vs. 129S6, P?=?0.033). For the third stimulus pairing, we found a trend for preference of the typical mouse across time (BTBR vs. B6, P?=?0.051). We repeated the experiments using 129S6 mice as judges and found a significant overall interaction (P?=?0.034), but only one stimulus pairing reached significance on its own (BALB/c vs. 129S6, P?=?0.0021). These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls. En ligne : http://dx.doi.org/10.1002/aur.1280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 [article] Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical [Texte imprimé et/ou numérique] / Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - 2013 . - p.212-220. Langues : Anglais (eng) in Autism Research > 6-3 (June 2013) . - p.212-220 Mots-clés : animal models  behavioral analysis of animal models??animal models  genetics  gamma-aminobutyric acid neurochemistry Index. décimale : PER Périodiques Résumé : Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a “typical” way. We hypothesized that mice could be used to make a similar judgment if they prefer “typical” over “atypical” social interactions with mouse models relevant to ASD. We used wild-type C57BL/6 (B6) mice as “judges” and evaluated their preference for a chamber containing a “typical” (B6 or 129S6) or an “atypical” mouse. For our atypical mouse stimuli, we chose two inbred strains with well-documented social phenotypes (BTBR and BALB/c), as well a mutant line with abnormal social behavior and seizures (Gabrb3 +/?). Overall, we observed a stimulus by time interaction (P??0.0001), with B6 mice preferring the typical mouse chamber during the last 10?min of the 30-min test. For two of the individual stimulus pairings, we observed a similar chamber by time interaction (BALB/c vs. 129S6, P?=?0.0007; Gabrb3 +/? vs. 129S6, P?=?0.033). For the third stimulus pairing, we found a trend for preference of the typical mouse across time (BTBR vs. B6, P?=?0.051). We repeated the experiments using 129S6 mice as judges and found a significant overall interaction (P?=?0.034), but only one stimulus pairing reached significance on its own (BALB/c vs. 129S6, P?=?0.0021). These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls. En ligne : http://dx.doi.org/10.1002/aur.1280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical / Charisma R. SHAH in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.120-120 Titre : Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical Type de document : Texte imprimé et/ou numérique Auteurs : Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.120-120 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical [Texte imprimé et/ou numérique] / Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.120-120. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.120-120 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

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