Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder / Takashi ITAHASHI in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-14 Titre : Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder Type de document : texte imprimé Auteurs : Takashi ITAHASHI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Motoaki NAKAMURA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear. En ligne : http://dx.doi.org/10.1186/s13229-015-0026-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder [texte imprimé] / Takashi ITAHASHI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Motoaki NAKAMURA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear. En ligne : http://dx.doi.org/10.1186/s13229-015-0026-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation / Takashi YAMADA in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 41p. Titre : Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation Type de document : texte imprimé Auteurs : Takashi YAMADA, Auteur ; Takashi ITAHASHI, Auteur ; Motoaki NAKAMURA, Auteur ; Hiromi WATANABE, Auteur ; Miho KURODA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur Article en page(s) : 41p. Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/diagnostic imaging/pathology/physiopathology  Brain Mapping/methods  Case-Control Studies  Cerebral Cortex/diagnostic imaging/pathology/physiopathology  Cluster Analysis  Functional Laterality  Humans  Image Interpretation, Computer-Assisted  Magnetic Resonance Imaging  Male  Middle Aged  Nerve Net/diagnostic imaging/pathology/physiopathology  Neural Pathways/diagnostic imaging/pathology/physiopathology  Autism spectrum disorder  Connectivity-based functional parcellation  Insula  Resting-state functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: The insular cortex comprises multiple functionally differentiated sub-regions, each of which has different patterns of connectivity with other brain regions. Such diverse connectivity patterns are thought to underlie a wide range of insular functions, including cognitive, affective, and sensorimotor processing, many of which are abnormal in autism spectrum disorder (ASD). Although past neuroimaging studies of ASD have shown structural and functional abnormalities in the insula, possible alterations in the sub-regional organization of the insula and the functional characteristics of each sub-region have not been examined in the ASD brain. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 36 adult males with ASD and 38 matched typically developed (TD) controls. A data-driven clustering analysis was applied to rs-fMRI data of voxels in the left and right insula to automatically group voxels with similar intrinsic connectivity pattern into a cluster. After determining the optimal number of clusters based on information theoretic measures of variation of information and mutual information, functional parcellation patterns in both the left and the right insula were compared between the TD and ASD groups. Furthermore, functional profiles of each sub-region were meta-analytically decoded using Neurosynth and were compared between the groups. RESULTS: We observed notable alterations in the anterior sector of the left insula and the middle ventral sub-region of the right insula in the ASD brain. Meta-analytic decoding revealed that whereas the anterior sector of the left insula contained two functionally differentiated sub-regions for cognitive, sensorimotor, and emotional/affective functions in TD brain, only a single functional cluster for cognitive and sensorimotor functions was identified in the anterior sector in the ASD brain. In the right insula, the middle ventral sub-region, which is primarily specialized for sensory- and auditory-related functions, showed a significant volumetric increase in the ASD brain compared with the TD brain. CONCLUSIONS: The results indicate an altered organization of sub-regions in specific parts of the left and right insula of the ASD brain. The alterations in the left and right insula may constitute neural substrates underlying abnormalities in emotional/affective and sensory functions in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0106-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation [texte imprimé] / Takashi YAMADA, Auteur ; Takashi ITAHASHI, Auteur ; Motoaki NAKAMURA, Auteur ; Hiromi WATANABE, Auteur ; Miho KURODA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur . - 41p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 41p. Mots-clés : Adult  Autism Spectrum Disorder/diagnostic imaging/pathology/physiopathology  Brain Mapping/methods  Case-Control Studies  Cerebral Cortex/diagnostic imaging/pathology/physiopathology  Cluster Analysis  Functional Laterality  Humans  Image Interpretation, Computer-Assisted  Magnetic Resonance Imaging  Male  Middle Aged  Nerve Net/diagnostic imaging/pathology/physiopathology  Neural Pathways/diagnostic imaging/pathology/physiopathology  Autism spectrum disorder  Connectivity-based functional parcellation  Insula  Resting-state functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: The insular cortex comprises multiple functionally differentiated sub-regions, each of which has different patterns of connectivity with other brain regions. Such diverse connectivity patterns are thought to underlie a wide range of insular functions, including cognitive, affective, and sensorimotor processing, many of which are abnormal in autism spectrum disorder (ASD). Although past neuroimaging studies of ASD have shown structural and functional abnormalities in the insula, possible alterations in the sub-regional organization of the insula and the functional characteristics of each sub-region have not been examined in the ASD brain. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 36 adult males with ASD and 38 matched typically developed (TD) controls. A data-driven clustering analysis was applied to rs-fMRI data of voxels in the left and right insula to automatically group voxels with similar intrinsic connectivity pattern into a cluster. After determining the optimal number of clusters based on information theoretic measures of variation of information and mutual information, functional parcellation patterns in both the left and the right insula were compared between the TD and ASD groups. Furthermore, functional profiles of each sub-region were meta-analytically decoded using Neurosynth and were compared between the groups. RESULTS: We observed notable alterations in the anterior sector of the left insula and the middle ventral sub-region of the right insula in the ASD brain. Meta-analytic decoding revealed that whereas the anterior sector of the left insula contained two functionally differentiated sub-regions for cognitive, sensorimotor, and emotional/affective functions in TD brain, only a single functional cluster for cognitive and sensorimotor functions was identified in the anterior sector in the ASD brain. In the right insula, the middle ventral sub-region, which is primarily specialized for sensory- and auditory-related functions, showed a significant volumetric increase in the ASD brain compared with the TD brain. CONCLUSIONS: The results indicate an altered organization of sub-regions in specific parts of the left and right insula of the ASD brain. The alterations in the left and right insula may constitute neural substrates underlying abnormalities in emotional/affective and sensory functions in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0106-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Cognitive profiles of adults with Asperger's disorder, high-functioning autism, and pervasive developmental disorder not otherwise specified based on the WAIS-III / Chieko KANAI in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.58-64 Titre : Cognitive profiles of adults with Asperger's disorder, high-functioning autism, and pervasive developmental disorder not otherwise specified based on the WAIS-III Type de document : texte imprimé Auteurs : Chieko KANAI, Auteur ; Masayuki TANI, Auteur ; Ryuichiro HASHIMORO, Auteur ; Takashi YAMADA, Auteur ; Haruhisa OTA, Auteur ; Hiromi WATANABE, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur Année de publication : 2012 Article en page(s) : p.58-64 Langues : Anglais (eng) Mots-clés : Asperger's disorder (AS)  High-functioning autism (HFA)  Pervasive developmental disorder not otherwise specified (PDDNOS)  Wechsler Intelligence Scale III (WAIS-III) Index. décimale : PER Périodiques Résumé : Little is known about the cognitive profiles of high-functioning Pervasive Developmental Disorders (PDD) in adults based on the Wechsler Intelligence Scale III (WAIS-III). We examined cognitive profiles of adults with no intellectual disability (IQ > 70), and in adults with Asperger's disorder (AS; n = 47), high-functioning autism (HFA; n = 24), and pervasive developmental disorder not otherwise specified (PDDNOS; n = 51) using the WAIS-III. Verbal Intelligence (VIQ)–Performance Intelligence (PIQ) differences were detected between the three groups. Full Intelligence (FIQ) and VIQ scores were significantly higher in AS than in HFA and PDDNOS. Vocabulary, Information, and Comprehension subtest scores in the Verbal Comprehension index were significantly higher in AS than in the other subgroups, while Digit-Symbol Coding and Symbol Search subtest scores in the Processing Speed index were significantly lower in HFA. The findings demonstrated cognitive profiles characteristic of adults with high-functioning PDD. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.09.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Cognitive profiles of adults with Asperger's disorder, high-functioning autism, and pervasive developmental disorder not otherwise specified based on the WAIS-III [texte imprimé] / Chieko KANAI, Auteur ; Masayuki TANI, Auteur ; Ryuichiro HASHIMORO, Auteur ; Takashi YAMADA, Auteur ; Haruhisa OTA, Auteur ; Hiromi WATANABE, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur . - 2012 . - p.58-64. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.58-64 Mots-clés : Asperger's disorder (AS)  High-functioning autism (HFA)  Pervasive developmental disorder not otherwise specified (PDDNOS)  Wechsler Intelligence Scale III (WAIS-III) Index. décimale : PER Périodiques Résumé : Little is known about the cognitive profiles of high-functioning Pervasive Developmental Disorders (PDD) in adults based on the Wechsler Intelligence Scale III (WAIS-III). We examined cognitive profiles of adults with no intellectual disability (IQ > 70), and in adults with Asperger's disorder (AS; n = 47), high-functioning autism (HFA; n = 24), and pervasive developmental disorder not otherwise specified (PDDNOS; n = 51) using the WAIS-III. Verbal Intelligence (VIQ)–Performance Intelligence (PIQ) differences were detected between the three groups. Full Intelligence (FIQ) and VIQ scores were significantly higher in AS than in HFA and PDDNOS. Vocabulary, Information, and Comprehension subtest scores in the Verbal Comprehension index were significantly higher in AS than in the other subgroups, while Digit-Symbol Coding and Symbol Search subtest scores in the Processing Speed index were significantly lower in HFA. The findings demonstrated cognitive profiles characteristic of adults with high-functioning PDD. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.09.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

ental and behavioral symptoms of person's with Asperger's syndrome: Relationships with social isolation and handicaps / Masayuki TANI in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.907-912 Titre : ental and behavioral symptoms of person's with Asperger's syndrome: Relationships with social isolation and handicaps Type de document : texte imprimé Auteurs : Masayuki TANI, Auteur ; Chieko KANAI, Auteur ; Haruhisa OTA, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Hideki YOKOI, Auteur ; Yuko TAKAYAMA, Auteur ; Taisei ONO, Auteur ; Ryuichiro HASHIMORO, Auteur ; Nobumasa KATO, Auteur ; Akira IWANAMI, Auteur Année de publication : 2012 Article en page(s) : p.907-912 Langues : Anglais (eng) Mots-clés : Asperger's syndrome  Mental symptoms  Behavioral symptoms  Life history Index. décimale : PER Périodiques Résumé : People with Asperger's syndrome (AS) experience mental comorbidities, and behavioral symptoms that can deepen social isolation and handicaps. We compared the frequency of mental and behavioral symptoms, motor abnormality, and life history between adults with AS and those with no mental disorders but with disturbance of social functions and communication skills (ND) from our outpatient clinic. Participants with AS (n = 99) as compared with ND subjects (n = 63) showed significant higher rate of depressive mood, anxiety, unstable emotion, mood swings, oversensitivity to normal situation obsessive compulsive symptoms, persecutory idea, loss of energy, insomnia carelessness, restlessness, confusion in new environments, episodic agitation, inflexible adherence, egocentric behavior, self harm, circumscribed interest, poor lifestyle habits, non-athleticism, clumsiness, bulling at school, school non-attendance, social withdrawal, and lack of friendships. In AS, emotional instability and confusion in new environments might lead to social isolation. The findings demonstrated that individuals with AS experience greater social isolation and distress, as well as a wider range of mental and behavioral symptoms and disturbances of motor skills as compared to healthy subjects with disturbances of social functions and communication skills. These factors are interrelated and may be used as supplementary methods for differential diagnosis of AS from other conditions. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.12.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150 [article] ental and behavioral symptoms of person's with Asperger's syndrome: Relationships with social isolation and handicaps [texte imprimé] / Masayuki TANI, Auteur ; Chieko KANAI, Auteur ; Haruhisa OTA, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Hideki YOKOI, Auteur ; Yuko TAKAYAMA, Auteur ; Taisei ONO, Auteur ; Ryuichiro HASHIMORO, Auteur ; Nobumasa KATO, Auteur ; Akira IWANAMI, Auteur . - 2012 . - p.907-912. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.907-912 Mots-clés : Asperger's syndrome  Mental symptoms  Behavioral symptoms  Life history Index. décimale : PER Périodiques Résumé : People with Asperger's syndrome (AS) experience mental comorbidities, and behavioral symptoms that can deepen social isolation and handicaps. We compared the frequency of mental and behavioral symptoms, motor abnormality, and life history between adults with AS and those with no mental disorders but with disturbance of social functions and communication skills (ND) from our outpatient clinic. Participants with AS (n = 99) as compared with ND subjects (n = 63) showed significant higher rate of depressive mood, anxiety, unstable emotion, mood swings, oversensitivity to normal situation obsessive compulsive symptoms, persecutory idea, loss of energy, insomnia carelessness, restlessness, confusion in new environments, episodic agitation, inflexible adherence, egocentric behavior, self harm, circumscribed interest, poor lifestyle habits, non-athleticism, clumsiness, bulling at school, school non-attendance, social withdrawal, and lack of friendships. In AS, emotional instability and confusion in new environments might lead to social isolation. The findings demonstrated that individuals with AS experience greater social isolation and distress, as well as a wider range of mental and behavioral symptoms and disturbances of motor skills as compared to healthy subjects with disturbances of social functions and communication skills. These factors are interrelated and may be used as supplementary methods for differential diagnosis of AS from other conditions. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.12.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150

Standardization of the Japanese version of the Glasgow Sensory Questionnaire (GSQ) / Yuko TAKAYAMA in Research in Autism Spectrum Disorders, 8-4 (April 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-4 (April 2014) . - p.347-353 Titre : Standardization of the Japanese version of the Glasgow Sensory Questionnaire (GSQ) Type de document : texte imprimé Auteurs : Yuko TAKAYAMA, Auteur ; Ryu-ichiro HASHIMOTO, Auteur ; Masayuki TANI, Auteur ; Chieko KANAI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Taisei ONO, Auteur ; Nobumasa KATO, Auteur ; Akira IWANAMI, Auteur Article en page(s) : p.347-353 Mots-clés : Autism spectrum disorders  Sensory sensitivity  Glasgow Sensory Questionnaire  Autism spectrum quotient Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) often have sensory processing abnormalities. However, limited measures that assess these problems in adults with ASD have been developed till date, particularly in Japan. Robertson and Simmons (2012) developed a self-rating scale to investigate sensory sensitivity: the Glasgow Sensory Questionnaire (GSQ). In the present study, we developed a Japanese version of GSQ and investigated sensory abnormalities in adults with ASD. We compared results of the Japanese version of GSQ in adults between an ASD group (n = 64) and a control group (n = 70). In addition, we also administered these individuals with the autism spectrum quotient (AQ), which is a questionnaire for assessing autistic traits. The Japanese version of GSQ scores was significantly higher in the ASD group than that in the control group. The total GSQ score and each sensory subscale showed a positive correlation with AQ in the total study sample. These results indicate that individuals with pronounced autistic traits have more frequent and extreme sensory processing problems compared with that in individuals with less pronounced autistic traits. We also assessed validity of the new test. Cronbach's α of the questionnaire was calculated, and its high value indicates that the Japanese version of GSQ has high reliability. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226 [article] Standardization of the Japanese version of the Glasgow Sensory Questionnaire (GSQ) [texte imprimé] / Yuko TAKAYAMA, Auteur ; Ryu-ichiro HASHIMOTO, Auteur ; Masayuki TANI, Auteur ; Chieko KANAI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Taisei ONO, Auteur ; Nobumasa KATO, Auteur ; Akira IWANAMI, Auteur . - p.347-353. in Research in Autism Spectrum Disorders > 8-4 (April 2014) . - p.347-353 Mots-clés : Autism spectrum disorders  Sensory sensitivity  Glasgow Sensory Questionnaire  Autism spectrum quotient Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) often have sensory processing abnormalities. However, limited measures that assess these problems in adults with ASD have been developed till date, particularly in Japan. Robertson and Simmons (2012) developed a self-rating scale to investigate sensory sensitivity: the Glasgow Sensory Questionnaire (GSQ). In the present study, we developed a Japanese version of GSQ and investigated sensory abnormalities in adults with ASD. We compared results of the Japanese version of GSQ in adults between an ASD group (n = 64) and a control group (n = 70). In addition, we also administered these individuals with the autism spectrum quotient (AQ), which is a questionnaire for assessing autistic traits. The Japanese version of GSQ scores was significantly higher in the ASD group than that in the control group. The total GSQ score and each sensory subscale showed a positive correlation with AQ in the total study sample. These results indicate that individuals with pronounced autistic traits have more frequent and extreme sensory processing problems compared with that in individuals with less pronounced autistic traits. We also assessed validity of the new test. Cronbach's α of the questionnaire was calculated, and its high value indicates that the Japanese version of GSQ has high reliability. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226

Task dependent prefrontal dysfunction in persons with Asperger's disorder investigated with multi-channel near-infrared spectroscopy / Akira IWANAMI in Research in Autism Spectrum Disorders, 5-3 (July-September 2011)  

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The effect of intranasal oxytocin versus placebo treatment on the autonomic responses to human sounds in autism: a single-blind, randomized, placebo-controlled, crossover design study / I. Fan LIN in Molecular Autism, (February 2014)  

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