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Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder / Xiaonan GUO in Molecular Autism, 13 (2022)
[article]
Titre : Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Xiaonan GUO, Auteur ; Guangjin ZHAI, Auteur ; Junfeng LIU, Auteur ; Yabo CAO, Auteur ; Xia ZHANG, Auteur ; Dong CUI, Auteur ; Le GAO, Auteur Article en page(s) : 52 p. Langues : Anglais (eng) Mots-clés : Humans Male Child Autism Spectrum Disorder/diagnostic imaging Brain Mapping/methods Magnetic Resonance Imaging/methods Brain/diagnostic imaging Autistic Disorder Neural Pathways/diagnostic imaging Autism spectrum disorder Functional connectivity Functional magnetic resonance imaging Subtype k-means clustering Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical heterogeneity. This study aimed to explore the heterogeneity of ASD based on inter-individual heterogeneity of functional brain networks. METHODS: Resting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange database were used in this study for 105 children with ASD and 102 demographically matched typical controls (TC) children. Functional connectivity (FC) networks were first obtained for ASD and TC groups, and inter-individual deviation of functional connectivity (IDFC) from the TC group was then calculated for each individual with ASD. A k-means clustering algorithm was used to obtain ASD subtypes based on IDFC patterns. The FC patterns were further compared between ASD subtypes and the TC group from the brain region, network, and whole-brain levels. The relationship between IDFC and the severity of clinical symptoms of ASD for ASD subtypes was also analyzed using a support vector regression model. RESULTS: Two ASD subtypes were identified based on the IDFC patterns. Compared with the TC group, the ASD subtype 1 group exhibited a hypoconnectivity pattern and the ASD subtype 2 group exhibited a hyperconnectivity pattern. IDFC for ASD subtype 1 and subtype 2 was found to predict the severity of social communication impairments and the severity of restricted and repetitive behaviors in ASD, respectively. LIMITATIONS: Only male children were selected for this study, which limits the ability to study the effects of gender and development on ASD heterogeneity. CONCLUSIONS: These results suggest the existence of subtypes with different FC patterns in ASD and provide insight into the complex pathophysiological mechanism of clinical manifestations of ASD. En ligne : http://dx.doi.org/10.1186/s13229-022-00535-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Molecular Autism > 13 (2022) . - 52 p.[article] Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Xiaonan GUO, Auteur ; Guangjin ZHAI, Auteur ; Junfeng LIU, Auteur ; Yabo CAO, Auteur ; Xia ZHANG, Auteur ; Dong CUI, Auteur ; Le GAO, Auteur . - 52 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 52 p.
Mots-clés : Humans Male Child Autism Spectrum Disorder/diagnostic imaging Brain Mapping/methods Magnetic Resonance Imaging/methods Brain/diagnostic imaging Autistic Disorder Neural Pathways/diagnostic imaging Autism spectrum disorder Functional connectivity Functional magnetic resonance imaging Subtype k-means clustering Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical heterogeneity. This study aimed to explore the heterogeneity of ASD based on inter-individual heterogeneity of functional brain networks. METHODS: Resting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange database were used in this study for 105 children with ASD and 102 demographically matched typical controls (TC) children. Functional connectivity (FC) networks were first obtained for ASD and TC groups, and inter-individual deviation of functional connectivity (IDFC) from the TC group was then calculated for each individual with ASD. A k-means clustering algorithm was used to obtain ASD subtypes based on IDFC patterns. The FC patterns were further compared between ASD subtypes and the TC group from the brain region, network, and whole-brain levels. The relationship between IDFC and the severity of clinical symptoms of ASD for ASD subtypes was also analyzed using a support vector regression model. RESULTS: Two ASD subtypes were identified based on the IDFC patterns. Compared with the TC group, the ASD subtype 1 group exhibited a hypoconnectivity pattern and the ASD subtype 2 group exhibited a hyperconnectivity pattern. IDFC for ASD subtype 1 and subtype 2 was found to predict the severity of social communication impairments and the severity of restricted and repetitive behaviors in ASD, respectively. LIMITATIONS: Only male children were selected for this study, which limits the ability to study the effects of gender and development on ASD heterogeneity. CONCLUSIONS: These results suggest the existence of subtypes with different FC patterns in ASD and provide insight into the complex pathophysiological mechanism of clinical manifestations of ASD. En ligne : http://dx.doi.org/10.1186/s13229-022-00535-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Sex Differences in Functional Connectivity Between Resting State Brain Networks in Autism Spectrum Disorder / Vânia TAVARES in Journal of Autism and Developmental Disorders, 52-7 (July 2022)
[article]
Titre : Sex Differences in Functional Connectivity Between Resting State Brain Networks in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Vânia TAVARES, Auteur ; Luís Afonso FERNANDES, Auteur ; Marília ANTUNES, Auteur ; Hugo FERREIRA, Auteur ; Diana PRATA, Auteur Article en page(s) : p.3088-3101 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging Brain/diagnostic imaging Brain Mapping/methods Female Humans Magnetic Resonance Imaging/methods Male Neural Pathways Sex Characteristics Autism spectrum disorder Functional connectivity Functional magnetic resonance imaging Independent component analysis Resting-state networks Index. décimale : PER Périodiques Résumé : Functional brain connectivity (FBC) has previously been examined in autism spectrum disorder (ASD) between-resting-state networks (RSNs) using a highly sensitive and reproducible hypothesis-free approach. However, results have been inconsistent and sex differences have only recently been taken into consideration using this approach. We estimated main effects of diagnosis and sex and a diagnosis by sex interaction on between-RSNs FBC in 83 ASD (40 females/43 males) and 85 typically developing controls (TC; 43 females/42 males). We found increased connectivity between the default mode (DM) and (a) the executive control networks in ASD (vs. TC); (b) the cerebellum networks in males (vs. females); and (c) female-specific altered connectivity involving visual, language and basal ganglia (BG) networks in ASD-in suggestive compatibility with ASD cognitive and neuroscientific theories. En ligne : http://dx.doi.org/10.1007/s10803-021-05191-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3088-3101[article] Sex Differences in Functional Connectivity Between Resting State Brain Networks in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Vânia TAVARES, Auteur ; Luís Afonso FERNANDES, Auteur ; Marília ANTUNES, Auteur ; Hugo FERREIRA, Auteur ; Diana PRATA, Auteur . - p.3088-3101.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3088-3101
Mots-clés : Autism Spectrum Disorder/diagnostic imaging Brain/diagnostic imaging Brain Mapping/methods Female Humans Magnetic Resonance Imaging/methods Male Neural Pathways Sex Characteristics Autism spectrum disorder Functional connectivity Functional magnetic resonance imaging Independent component analysis Resting-state networks Index. décimale : PER Périodiques Résumé : Functional brain connectivity (FBC) has previously been examined in autism spectrum disorder (ASD) between-resting-state networks (RSNs) using a highly sensitive and reproducible hypothesis-free approach. However, results have been inconsistent and sex differences have only recently been taken into consideration using this approach. We estimated main effects of diagnosis and sex and a diagnosis by sex interaction on between-RSNs FBC in 83 ASD (40 females/43 males) and 85 typically developing controls (TC; 43 females/42 males). We found increased connectivity between the default mode (DM) and (a) the executive control networks in ASD (vs. TC); (b) the cerebellum networks in males (vs. females); and (c) female-specific altered connectivity involving visual, language and basal ganglia (BG) networks in ASD-in suggestive compatibility with ASD cognitive and neuroscientific theories. En ligne : http://dx.doi.org/10.1007/s10803-021-05191-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation / T. YAMADA in Molecular Autism, 7 (2016)
[article]
Titre : Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation Type de document : Texte imprimé et/ou numérique Auteurs : T. YAMADA, Auteur ; T. ITAHASHI, Auteur ; M. NAKAMURA, Auteur ; H. WATANABE, Auteur ; M. KURODA, Auteur ; H. OHTA, Auteur ; C. KANAI, Auteur ; N. KATO, Auteur ; R. I. HASHIMOTO, Auteur Article en page(s) : 41p. Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/diagnostic imaging/pathology/physiopathology Brain Mapping/methods Case-Control Studies Cerebral Cortex/diagnostic imaging/pathology/physiopathology Cluster Analysis Functional Laterality Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Nerve Net/diagnostic imaging/pathology/physiopathology Neural Pathways/diagnostic imaging/pathology/physiopathology Autism spectrum disorder Connectivity-based functional parcellation Insula Resting-state functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: The insular cortex comprises multiple functionally differentiated sub-regions, each of which has different patterns of connectivity with other brain regions. Such diverse connectivity patterns are thought to underlie a wide range of insular functions, including cognitive, affective, and sensorimotor processing, many of which are abnormal in autism spectrum disorder (ASD). Although past neuroimaging studies of ASD have shown structural and functional abnormalities in the insula, possible alterations in the sub-regional organization of the insula and the functional characteristics of each sub-region have not been examined in the ASD brain. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 36 adult males with ASD and 38 matched typically developed (TD) controls. A data-driven clustering analysis was applied to rs-fMRI data of voxels in the left and right insula to automatically group voxels with similar intrinsic connectivity pattern into a cluster. After determining the optimal number of clusters based on information theoretic measures of variation of information and mutual information, functional parcellation patterns in both the left and the right insula were compared between the TD and ASD groups. Furthermore, functional profiles of each sub-region were meta-analytically decoded using Neurosynth and were compared between the groups. RESULTS: We observed notable alterations in the anterior sector of the left insula and the middle ventral sub-region of the right insula in the ASD brain. Meta-analytic decoding revealed that whereas the anterior sector of the left insula contained two functionally differentiated sub-regions for cognitive, sensorimotor, and emotional/affective functions in TD brain, only a single functional cluster for cognitive and sensorimotor functions was identified in the anterior sector in the ASD brain. In the right insula, the middle ventral sub-region, which is primarily specialized for sensory- and auditory-related functions, showed a significant volumetric increase in the ASD brain compared with the TD brain. CONCLUSIONS: The results indicate an altered organization of sub-regions in specific parts of the left and right insula of the ASD brain. The alterations in the left and right insula may constitute neural substrates underlying abnormalities in emotional/affective and sensory functions in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0106-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 41p.[article] Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation [Texte imprimé et/ou numérique] / T. YAMADA, Auteur ; T. ITAHASHI, Auteur ; M. NAKAMURA, Auteur ; H. WATANABE, Auteur ; M. KURODA, Auteur ; H. OHTA, Auteur ; C. KANAI, Auteur ; N. KATO, Auteur ; R. I. HASHIMOTO, Auteur . - 41p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 41p.
Mots-clés : Adult Autism Spectrum Disorder/diagnostic imaging/pathology/physiopathology Brain Mapping/methods Case-Control Studies Cerebral Cortex/diagnostic imaging/pathology/physiopathology Cluster Analysis Functional Laterality Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Nerve Net/diagnostic imaging/pathology/physiopathology Neural Pathways/diagnostic imaging/pathology/physiopathology Autism spectrum disorder Connectivity-based functional parcellation Insula Resting-state functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: The insular cortex comprises multiple functionally differentiated sub-regions, each of which has different patterns of connectivity with other brain regions. Such diverse connectivity patterns are thought to underlie a wide range of insular functions, including cognitive, affective, and sensorimotor processing, many of which are abnormal in autism spectrum disorder (ASD). Although past neuroimaging studies of ASD have shown structural and functional abnormalities in the insula, possible alterations in the sub-regional organization of the insula and the functional characteristics of each sub-region have not been examined in the ASD brain. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 36 adult males with ASD and 38 matched typically developed (TD) controls. A data-driven clustering analysis was applied to rs-fMRI data of voxels in the left and right insula to automatically group voxels with similar intrinsic connectivity pattern into a cluster. After determining the optimal number of clusters based on information theoretic measures of variation of information and mutual information, functional parcellation patterns in both the left and the right insula were compared between the TD and ASD groups. Furthermore, functional profiles of each sub-region were meta-analytically decoded using Neurosynth and were compared between the groups. RESULTS: We observed notable alterations in the anterior sector of the left insula and the middle ventral sub-region of the right insula in the ASD brain. Meta-analytic decoding revealed that whereas the anterior sector of the left insula contained two functionally differentiated sub-regions for cognitive, sensorimotor, and emotional/affective functions in TD brain, only a single functional cluster for cognitive and sensorimotor functions was identified in the anterior sector in the ASD brain. In the right insula, the middle ventral sub-region, which is primarily specialized for sensory- and auditory-related functions, showed a significant volumetric increase in the ASD brain compared with the TD brain. CONCLUSIONS: The results indicate an altered organization of sub-regions in specific parts of the left and right insula of the ASD brain. The alterations in the left and right insula may constitute neural substrates underlying abnormalities in emotional/affective and sensory functions in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0106-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 Reward- and threat-related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil / Leehyun YOON in Journal of Child Psychology and Psychiatry, 63-5 (May 2022)
[article]
Titre : Reward- and threat-related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil Type de document : Texte imprimé et/ou numérique Auteurs : Leehyun YOON, Auteur ; Fernanda ROHRSETZER, Auteur ; Lucas BATTEL, Auteur ; Mauricio ANÉS, Auteur ; Pedro H. MANFRO, Auteur ; Luis A. ROHDE, Auteur ; Anna VIDUANI, Auteur ; Zuzanna ZAJKOWSKA, Auteur ; Valeria MONDELLI, Auteur ; Christian KIELING, Auteur ; Johnna R. SWARTZ, Auteur Article en page(s) : p.579-590 Langues : Anglais (eng) Mots-clés : Adolescent Brain/diagnostic imaging Brain Mapping/methods Brazil/epidemiology Depression/epidemiology Humans Magnetic Resonance Imaging/methods Reward Risk Factors Depression adolescence functional MRI (fMRI) Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimaging studies on adolescents at risk for depression have relied on a single risk factor and focused on adolescents in high-income countries. Using a composite risk score, this study aims to examine neural activity and connectivity associated with risk and presence of depression in adolescents in Brazil. METHODS: Depression risk was defined with the Identifying Depression Early in Adolescence Risk Score (IDEA-RS), calculated using a prognostic model that included 11 socio-demographic risk factors. Adolescents recruited from schools in Porto Alegre were classified into a low-risk (i.e., low IDEA-RS and no lifetime depression), high-risk (i.e., high IDEA-RS and no lifetime depression), or clinically depressed group (i.e., high IDEA-RS and depression diagnosis). One hundred fifty adolescents underwent a functional MRI scan while completing a reward-related gambling and a threat-related face-matching task. We compared group differences in activity and connectivity of the ventral striatum (VS) and amygdala during the gambling and face-matching tasks, respectively, and group differences in whole-brain neural activity. RESULTS: Although there was no group difference in reward-related VS or threat-related amygdala activity, the depressed group showed elevated VS activity to punishment relative to high-risk adolescents. The whole-brain analysis found reduced reward-related activity in the lateral prefrontal cortex of patients and high-risk adolescents compared with low-risk adolescents. Compared with low-risk adolescents, high-risk and depressed adolescents showed reduced threat-related left amygdala connectivity with thalamus, superior temporal gyrus, inferior parietal gyrus, precentral gyrus, and supplementary motor area. CONCLUSIONS: We identified neural correlates associated with risk and presence of depression in a well-characterized sample of adolescents. These findings enhance knowledge of the neurobiological underpinnings of risk and presence of depression in Brazil. Future longitudinal studies are needed to examine whether the observed neural patterns of high-risk adolescents predict the development of depression. En ligne : http://dx.doi.org/10.1111/jcpp.13496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.579-590[article] Reward- and threat-related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil [Texte imprimé et/ou numérique] / Leehyun YOON, Auteur ; Fernanda ROHRSETZER, Auteur ; Lucas BATTEL, Auteur ; Mauricio ANÉS, Auteur ; Pedro H. MANFRO, Auteur ; Luis A. ROHDE, Auteur ; Anna VIDUANI, Auteur ; Zuzanna ZAJKOWSKA, Auteur ; Valeria MONDELLI, Auteur ; Christian KIELING, Auteur ; Johnna R. SWARTZ, Auteur . - p.579-590.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.579-590
Mots-clés : Adolescent Brain/diagnostic imaging Brain Mapping/methods Brazil/epidemiology Depression/epidemiology Humans Magnetic Resonance Imaging/methods Reward Risk Factors Depression adolescence functional MRI (fMRI) Index. décimale : PER Périodiques Résumé : BACKGROUND: Neuroimaging studies on adolescents at risk for depression have relied on a single risk factor and focused on adolescents in high-income countries. Using a composite risk score, this study aims to examine neural activity and connectivity associated with risk and presence of depression in adolescents in Brazil. METHODS: Depression risk was defined with the Identifying Depression Early in Adolescence Risk Score (IDEA-RS), calculated using a prognostic model that included 11 socio-demographic risk factors. Adolescents recruited from schools in Porto Alegre were classified into a low-risk (i.e., low IDEA-RS and no lifetime depression), high-risk (i.e., high IDEA-RS and no lifetime depression), or clinically depressed group (i.e., high IDEA-RS and depression diagnosis). One hundred fifty adolescents underwent a functional MRI scan while completing a reward-related gambling and a threat-related face-matching task. We compared group differences in activity and connectivity of the ventral striatum (VS) and amygdala during the gambling and face-matching tasks, respectively, and group differences in whole-brain neural activity. RESULTS: Although there was no group difference in reward-related VS or threat-related amygdala activity, the depressed group showed elevated VS activity to punishment relative to high-risk adolescents. The whole-brain analysis found reduced reward-related activity in the lateral prefrontal cortex of patients and high-risk adolescents compared with low-risk adolescents. Compared with low-risk adolescents, high-risk and depressed adolescents showed reduced threat-related left amygdala connectivity with thalamus, superior temporal gyrus, inferior parietal gyrus, precentral gyrus, and supplementary motor area. CONCLUSIONS: We identified neural correlates associated with risk and presence of depression in a well-characterized sample of adolescents. These findings enhance knowledge of the neurobiological underpinnings of risk and presence of depression in Brazil. Future longitudinal studies are needed to examine whether the observed neural patterns of high-risk adolescents predict the development of depression. En ligne : http://dx.doi.org/10.1111/jcpp.13496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 Region-specific associations between gamma-aminobutyric acid A receptor binding and cortical thickness in high-functioning autistic adults / David JAMES in Autism Research, 15-6 (June 2022)
[article]
Titre : Region-specific associations between gamma-aminobutyric acid A receptor binding and cortical thickness in high-functioning autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : David JAMES, Auteur ; Vicky T. LAM, Auteur ; Booil JO, Auteur ; Lawrence K. FUNG, Auteur Article en page(s) : p.1068-1082 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder Autistic Disorder/diagnostic imaging/pathology Brain/pathology Brain Mapping/methods Female Humans Magnetic Resonance Imaging/methods Male gamma-Aminobutyric Acid GABAA receptor density autism cortical thickness postcentral gyrus Index. décimale : PER Périodiques Résumé : The neurobiology of autism has been shown to involve alterations in cortical morphology and gamma-aminobutyric acid A (GABA(A) ) receptor density. We hypothesized that GABA(A) receptor binding potential (GABA(A) R BP(ND) ) would correlate with cortical thickness, but their correlations would differ between autistic adults and typically developing (TD) controls. We studied 50 adults (23 autism, 27 TD, mean age of 27?years) using magnetic resonance imaging to measure cortical thickness, and [(18) F]flumazenil positron emission tomography imaging to measure GABA(A) R BP(ND) . We determined the correlations between cortical thickness and GABA(A) R BP(ND) by cortical lobe, region-of-interest, and diagnosis of autism spectrum disorder (ASD). We also explored potential sex differences in the relationship between cortical thickness and autism characteristics, as measured by autism spectrum quotient (AQ) scores. Comparing autism and TD groups, no significant differences were found in cortical thickness or GABA(A) R BP(ND) . In both autism and TD groups, a negative relationship between cortical thickness and GABA(A) R BP(ND) was observed in the frontal and occipital cortices, but no relationship was found in the temporal or limbic cortices. A positive correlation was seen in the parietal cortex that was only significant for the autism group. Interestingly, in an exploratory analysis, we found sex differences in the relationships between cortical thickness and GABA(A) R BP(ND) , and cortical thickness and AQ scores in the left postcentral gyrus. LAY SUMMARY: The thickness of the brain cortex and the density of the receptors associated with inhibitory neurotransmitter GABA have been hypothesized to underlie the neurobiology of autism. In this study, we found that these biomarkers correlate positively in the parietal cortex, but negatively in the frontal and occipital cortical regions of the brain. Furthermore, we collected preliminary evidence that the correlations between cortical thickness and GABA receptor density are sexdependent in a brain region where sensory inputs are registered. En ligne : http://dx.doi.org/10.1002/aur.2703 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Autism Research > 15-6 (June 2022) . - p.1068-1082[article] Region-specific associations between gamma-aminobutyric acid A receptor binding and cortical thickness in high-functioning autistic adults [Texte imprimé et/ou numérique] / David JAMES, Auteur ; Vicky T. LAM, Auteur ; Booil JO, Auteur ; Lawrence K. FUNG, Auteur . - p.1068-1082.
Langues : Anglais (eng)
in Autism Research > 15-6 (June 2022) . - p.1068-1082
Mots-clés : Adult Autism Spectrum Disorder Autistic Disorder/diagnostic imaging/pathology Brain/pathology Brain Mapping/methods Female Humans Magnetic Resonance Imaging/methods Male gamma-Aminobutyric Acid GABAA receptor density autism cortical thickness postcentral gyrus Index. décimale : PER Périodiques Résumé : The neurobiology of autism has been shown to involve alterations in cortical morphology and gamma-aminobutyric acid A (GABA(A) ) receptor density. We hypothesized that GABA(A) receptor binding potential (GABA(A) R BP(ND) ) would correlate with cortical thickness, but their correlations would differ between autistic adults and typically developing (TD) controls. We studied 50 adults (23 autism, 27 TD, mean age of 27?years) using magnetic resonance imaging to measure cortical thickness, and [(18) F]flumazenil positron emission tomography imaging to measure GABA(A) R BP(ND) . We determined the correlations between cortical thickness and GABA(A) R BP(ND) by cortical lobe, region-of-interest, and diagnosis of autism spectrum disorder (ASD). We also explored potential sex differences in the relationship between cortical thickness and autism characteristics, as measured by autism spectrum quotient (AQ) scores. Comparing autism and TD groups, no significant differences were found in cortical thickness or GABA(A) R BP(ND) . In both autism and TD groups, a negative relationship between cortical thickness and GABA(A) R BP(ND) was observed in the frontal and occipital cortices, but no relationship was found in the temporal or limbic cortices. A positive correlation was seen in the parietal cortex that was only significant for the autism group. Interestingly, in an exploratory analysis, we found sex differences in the relationships between cortical thickness and GABA(A) R BP(ND) , and cortical thickness and AQ scores in the left postcentral gyrus. LAY SUMMARY: The thickness of the brain cortex and the density of the receptors associated with inhibitory neurotransmitter GABA have been hypothesized to underlie the neurobiology of autism. In this study, we found that these biomarkers correlate positively in the parietal cortex, but negatively in the frontal and occipital cortical regions of the brain. Furthermore, we collected preliminary evidence that the correlations between cortical thickness and GABA receptor density are sexdependent in a brain region where sensory inputs are registered. En ligne : http://dx.doi.org/10.1002/aur.2703 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis / Pilar GARCES in Molecular Autism, 13 (2022)
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