Dépouillements

Issue Information in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.509-512 Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.509-512 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Issue Information [Texte imprimé et/ou numérique] . - p.509-512. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.509-512 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies / Andre W. PHILLIPS ; Elena ARTIMOVICH ; Jonathan E. NESTOR ; John P. HUSSMAN ; Gene J. BLATT in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.513-535 Titre : Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies Type de document : Texte imprimé et/ou numérique Auteurs : Andre W. PHILLIPS, Auteur ; Elena ARTIMOVICH, Auteur ; Jonathan E. NESTOR, Auteur ; John P. HUSSMAN, Auteur ; Gene J. BLATT, Auteur Article en page(s) : p.513-535 Langues : Anglais (eng) Mots-clés : human stem cells  autism  drug-screening  high-throughput  inducible pluripotent stem cells  CRISPR  optogenetics  organoids Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental condition. Symptoms of ASD cover the spectrum from mild qualitative differences in social interaction to severe communication and social and behavioral challenges that require lifelong support. Attempts at understanding the pathophysiology of ASD have been hampered by a multifactorial etiology that stretches the limits of current behavioral and cell based models. Recent progress has implicated numerous autism-risk genes but efforts to gain a better understanding of the underlying biological mechanisms have seen slow progress. This is in part due to lack of appropriate models for complete molecular and pharmacological studies. The advent of induced pluripotent stem cells (iPSC) has reinvigorated efforts to establish more complete model systems that more reliably identify molecular pathways and predict effective drug targets and candidates in ASD. iPSCs are particularly appealing because they can be derived from human patients and controls for research purposes and provide a technology for the development of a personalized treatment regimen for ASD patients. The pluripotency of iPSCs allow them to be reprogrammed into a number of CNS cell types and phenotypically screened across many patients. This quality is already being exploited in protocols to generate 2-dimensional (2-D) and three-dimensional (3-D) models of neurons and developing brain structures. iPSC models make powerful platforms that can be interrogated using electrophysiology, gene expression studies, and other cell-based quantitative assays. iPSC technology has limitations but when combined with other model systems has great potential for helping define the underlying pathophysiology of ASD. En ligne : http://dx.doi.org/10.1002/aur.1570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies [Texte imprimé et/ou numérique] / Andre W. PHILLIPS, Auteur ; Elena ARTIMOVICH, Auteur ; Jonathan E. NESTOR, Auteur ; John P. HUSSMAN, Auteur ; Gene J. BLATT, Auteur . - p.513-535. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.513-535 Mots-clés : human stem cells  autism  drug-screening  high-throughput  inducible pluripotent stem cells  CRISPR  optogenetics  organoids Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental condition. Symptoms of ASD cover the spectrum from mild qualitative differences in social interaction to severe communication and social and behavioral challenges that require lifelong support. Attempts at understanding the pathophysiology of ASD have been hampered by a multifactorial etiology that stretches the limits of current behavioral and cell based models. Recent progress has implicated numerous autism-risk genes but efforts to gain a better understanding of the underlying biological mechanisms have seen slow progress. This is in part due to lack of appropriate models for complete molecular and pharmacological studies. The advent of induced pluripotent stem cells (iPSC) has reinvigorated efforts to establish more complete model systems that more reliably identify molecular pathways and predict effective drug targets and candidates in ASD. iPSCs are particularly appealing because they can be derived from human patients and controls for research purposes and provide a technology for the development of a personalized treatment regimen for ASD patients. The pluripotency of iPSCs allow them to be reprogrammed into a number of CNS cell types and phenotypically screened across many patients. This quality is already being exploited in protocols to generate 2-dimensional (2-D) and three-dimensional (3-D) models of neurons and developing brain structures. iPSC models make powerful platforms that can be interrogated using electrophysiology, gene expression studies, and other cell-based quantitative assays. iPSC technology has limitations but when combined with other model systems has great potential for helping define the underlying pathophysiology of ASD. En ligne : http://dx.doi.org/10.1002/aur.1570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Assessment of sleep problems and related risk factors observed in Turkish children with Autism spectrum disorders / Tuba MUTLUER in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.536-542 Titre : Assessment of sleep problems and related risk factors observed in Turkish children with Autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Tuba MUTLUER, Auteur ; Sevcan KARAKOC DEMIRKAYA, Auteur ; Osman ABALI, Auteur Article en page(s) : p.536-542 Langues : Anglais (eng) Mots-clés : autism  spectrum  sleep  disorder  neurodevelopmental  behavior Index. décimale : PER Périodiques Résumé : Sleep problems are common and difficult to manage in children with autism spectrum disorders (ASD). Another major adverse impact of sleep problems is that they exacerbate behavioral problems. To assess sleep problems and possible behavioral risk factors in detail, we aimed to compare sleep habits of children with ASD, with healthy children. The relationship between sleep difficulties and concomitant behavioral problems such as repetitive behaviors, hyperactivity, and social withdrawal were also examined. Hundred and seventeen children and adolescents including 64 with the diagnosis of ASD and 53 healthy subjects were enrolled in the study. Diagnostic Interview for ASD was performed according to DSM-IV-TR. Socio-demographical data form and childhood autism rating scale were filled by researchers. Aberrant behavior checklist (ABC), child behavior checklist and pediatric sleep questionnaire (PSQ) were completed by the parents of the children. Children with ASD had higher frequency of sleep problems, snoring, breathing problems, behavioral problems compared with healthy children (for all parameters; P? En ligne : http://dx.doi.org/10.1002/aur.1542 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Assessment of sleep problems and related risk factors observed in Turkish children with Autism spectrum disorders [Texte imprimé et/ou numérique] / Tuba MUTLUER, Auteur ; Sevcan KARAKOC DEMIRKAYA, Auteur ; Osman ABALI, Auteur . - p.536-542. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.536-542 Mots-clés : autism  spectrum  sleep  disorder  neurodevelopmental  behavior Index. décimale : PER Périodiques Résumé : Sleep problems are common and difficult to manage in children with autism spectrum disorders (ASD). Another major adverse impact of sleep problems is that they exacerbate behavioral problems. To assess sleep problems and possible behavioral risk factors in detail, we aimed to compare sleep habits of children with ASD, with healthy children. The relationship between sleep difficulties and concomitant behavioral problems such as repetitive behaviors, hyperactivity, and social withdrawal were also examined. Hundred and seventeen children and adolescents including 64 with the diagnosis of ASD and 53 healthy subjects were enrolled in the study. Diagnostic Interview for ASD was performed according to DSM-IV-TR. Socio-demographical data form and childhood autism rating scale were filled by researchers. Aberrant behavior checklist (ABC), child behavior checklist and pediatric sleep questionnaire (PSQ) were completed by the parents of the children. Children with ASD had higher frequency of sleep problems, snoring, breathing problems, behavioral problems compared with healthy children (for all parameters; P? En ligne : http://dx.doi.org/10.1002/aur.1542 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm / Alexandra M. URE in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.543-552 Titre : Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra M. URE, Auteur ; Karli TREYVAUD, Auteur ; Deanne K. THOMPSON, Auteur ; Leona PASCOE, Auteur ; Gehan ROBERTS, Auteur ; Katherine J. LEE, Auteur ; Marc L. SEAL, Auteur ; Elisabeth NORTHAM, Auteur ; Jeanie L. CHEONG, Auteur ; Rod W. HUNT, Auteur ; Terrie INDER, Auteur ; Lex W. DOYLE, Auteur ; Peter J. ANDERSON, Auteur Article en page(s) : p.543-552 Langues : Anglais (eng) Mots-clés : preterm birth  brain abnormality  autism spectrum disorder  magnetic resonance imaging  neonatal imaging Index. décimale : PER Périodiques Résumé : Very preterm (VP) survivors are at increased risk of autism spectrum disorder (ASD) compared with term-born children. This study explored whether neonatal magnetic resonance (MR) brain features differed in VP children with and without ASD at 7 years. One hundred and seventy-two VP children (<30 weeks' gestation or <1250 g birth weight) underwent structural brain MR scans at term equivalent age (TEA; 40 weeks' gestation ±2 weeks) and were assessed for ASD at 7 years of age. The presence and severity of white matter, cortical gray matter, deep nuclear gray matter, and cerebellar abnormalities were assessed, and total and regional brain volumes were measured. ASD was diagnosed using a standardized parent report diagnostic interview and confirmed via an independent assessment. Eight VP children (4.7%) were diagnosed with ASD. Children with ASD had more cystic lesions in the cortical white matter at TEA compared with those without ASD (odds ratio [OR] 8.7, 95% confidence interval [CI] 1.5, 51.3, P?=?0.02). There was also some evidence for smaller cerebellar volumes in children with ASD compared with those without ASD (OR?=?0.82, CI?=?0.66, 1.00, P?=?0.06). Overall, the results suggest that VP children with ASD have different brain structure in the neonatal period compared with those who do not have ASD. En ligne : http://dx.doi.org/10.1002/aur.1558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm [Texte imprimé et/ou numérique] / Alexandra M. URE, Auteur ; Karli TREYVAUD, Auteur ; Deanne K. THOMPSON, Auteur ; Leona PASCOE, Auteur ; Gehan ROBERTS, Auteur ; Katherine J. LEE, Auteur ; Marc L. SEAL, Auteur ; Elisabeth NORTHAM, Auteur ; Jeanie L. CHEONG, Auteur ; Rod W. HUNT, Auteur ; Terrie INDER, Auteur ; Lex W. DOYLE, Auteur ; Peter J. ANDERSON, Auteur . - p.543-552. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.543-552 Mots-clés : preterm birth  brain abnormality  autism spectrum disorder  magnetic resonance imaging  neonatal imaging Index. décimale : PER Périodiques Résumé : Very preterm (VP) survivors are at increased risk of autism spectrum disorder (ASD) compared with term-born children. This study explored whether neonatal magnetic resonance (MR) brain features differed in VP children with and without ASD at 7 years. One hundred and seventy-two VP children (<30 weeks' gestation or <1250 g birth weight) underwent structural brain MR scans at term equivalent age (TEA; 40 weeks' gestation ±2 weeks) and were assessed for ASD at 7 years of age. The presence and severity of white matter, cortical gray matter, deep nuclear gray matter, and cerebellar abnormalities were assessed, and total and regional brain volumes were measured. ASD was diagnosed using a standardized parent report diagnostic interview and confirmed via an independent assessment. Eight VP children (4.7%) were diagnosed with ASD. Children with ASD had more cystic lesions in the cortical white matter at TEA compared with those without ASD (odds ratio [OR] 8.7, 95% confidence interval [CI] 1.5, 51.3, P?=?0.02). There was also some evidence for smaller cerebellar volumes in children with ASD compared with those without ASD (OR?=?0.82, CI?=?0.66, 1.00, P?=?0.06). Overall, the results suggest that VP children with ASD have different brain structure in the neonatal period compared with those who do not have ASD. En ligne : http://dx.doi.org/10.1002/aur.1558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Identifying diagnostically-relevant resting state brain functional connectivity in the ventral posterior complex via genetic data mining in autism spectrum disorder / Philip R. BALDWIN in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.553-562 Titre : Identifying diagnostically-relevant resting state brain functional connectivity in the ventral posterior complex via genetic data mining in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Philip R. BALDWIN, Auteur ; Kaylah N. CURTIS, Auteur ; Michelle A. PATRIQUIN, Auteur ; Varina WOLF, Auteur ; Humsini VISWANATH, Auteur ; Chad SHAW, Auteur ; Yasunari SAKAI, Auteur ; Ramiro SALAS, Auteur Article en page(s) : p.553-562 Langues : Anglais (eng) Mots-clés : autism  brain  connectivity  genes  genetic data mining  neuroimaging  resting state  restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Exome sequencing and copy number variation analyses continue to provide novel insight to the biological bases of autism spectrum disorder (ASD). The growing speed at which massive genetic data are produced causes serious lags in analysis and interpretation of the data. Thus, there is a need to develop systematic genetic data mining processes that facilitate efficient analysis of large datasets. We report a new genetic data mining system, ProcessGeneLists and integrated a list of ASD-related genes with currently available resources in gene expression and functional connectivity of the human brain. Our data-mining program successfully identified three primary regions of interest (ROIs) in the mouse brain: inferior colliculus, ventral posterior complex of the thalamus (VPC), and parafascicular nucleus (PFn). To understand its pathogenic relevance in ASD, we examined the resting state functional connectivity (RSFC) of the homologous ROIs in human brain with other brain regions that were previously implicated in the neuro-psychiatric features of ASD. Among them, the RSFC of the VPC with the medial frontal gyrus (MFG) was significantly more anticorrelated, whereas the RSFC of the PN with the globus pallidus was significantly increased in children with ASD compared with healthy children. Moreover, greater values of RSFC between VPC and MFG were correlated with severity index and repetitive behaviors in children with ASD. No significant RSFC differences were detected in adults with ASD. Together, these data demonstrate the utility of our data-mining program through identifying the aberrant connectivity of thalamo-cortical circuits in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Identifying diagnostically-relevant resting state brain functional connectivity in the ventral posterior complex via genetic data mining in autism spectrum disorder [Texte imprimé et/ou numérique] / Philip R. BALDWIN, Auteur ; Kaylah N. CURTIS, Auteur ; Michelle A. PATRIQUIN, Auteur ; Varina WOLF, Auteur ; Humsini VISWANATH, Auteur ; Chad SHAW, Auteur ; Yasunari SAKAI, Auteur ; Ramiro SALAS, Auteur . - p.553-562. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.553-562 Mots-clés : autism  brain  connectivity  genes  genetic data mining  neuroimaging  resting state  restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Exome sequencing and copy number variation analyses continue to provide novel insight to the biological bases of autism spectrum disorder (ASD). The growing speed at which massive genetic data are produced causes serious lags in analysis and interpretation of the data. Thus, there is a need to develop systematic genetic data mining processes that facilitate efficient analysis of large datasets. We report a new genetic data mining system, ProcessGeneLists and integrated a list of ASD-related genes with currently available resources in gene expression and functional connectivity of the human brain. Our data-mining program successfully identified three primary regions of interest (ROIs) in the mouse brain: inferior colliculus, ventral posterior complex of the thalamus (VPC), and parafascicular nucleus (PFn). To understand its pathogenic relevance in ASD, we examined the resting state functional connectivity (RSFC) of the homologous ROIs in human brain with other brain regions that were previously implicated in the neuro-psychiatric features of ASD. Among them, the RSFC of the VPC with the medial frontal gyrus (MFG) was significantly more anticorrelated, whereas the RSFC of the PN with the globus pallidus was significantly increased in children with ASD compared with healthy children. Moreover, greater values of RSFC between VPC and MFG were correlated with severity index and repetitive behaviors in children with ASD. No significant RSFC differences were detected in adults with ASD. Together, these data demonstrate the utility of our data-mining program through identifying the aberrant connectivity of thalamo-cortical circuits in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Isolating Visual and Proprioceptive Components of Motor Sequence Learning in ASD / Elizabeth A. SHARER in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.563-569 Titre : Isolating Visual and Proprioceptive Components of Motor Sequence Learning in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth A. SHARER, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Alvaro PASCUAL-LEONE, Auteur ; Lindsay M. OBERMAN, Auteur Article en page(s) : p.563-569 Langues : Anglais (eng) Mots-clés : serial reaction time task  ASD  motor learning  proprioception Index. décimale : PER Périodiques Résumé : In addition to defining impairments in social communication skills, individuals with autism spectrum disorder (ASD) also show impairments in more basic sensory and motor skills. Development of new skills involves integrating information from multiple sensory modalities. This input is then used to form internal models of action that can be accessed when both performing skilled movements, as well as understanding those actions performed by others. Learning skilled gestures is particularly reliant on integration of visual and proprioceptive input. We used a modified serial reaction time task (SRTT) to decompose proprioceptive and visual components and examine whether patterns of implicit motor skill learning differ in ASD participants as compared with healthy controls. While both groups learned the implicit motor sequence during training, healthy controls showed robust generalization whereas ASD participants demonstrated little generalization when visual input was constant. In contrast, no group differences in generalization were observed when proprioceptive input was constant, with both groups showing limited degrees of generalization. The findings suggest, when learning a motor sequence, individuals with ASD tend to rely less on visual feedback than do healthy controls. Visuomotor representations are considered to underlie imitative learning and action understanding and are thereby crucial to social skill and cognitive development. Thus, anomalous patterns of implicit motor learning, with a tendency to discount visual feedback, may be an important contributor in core social communication deficits that characterize ASD. En ligne : http://dx.doi.org/10.1002/aur.1537 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Isolating Visual and Proprioceptive Components of Motor Sequence Learning in ASD [Texte imprimé et/ou numérique] / Elizabeth A. SHARER, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Alvaro PASCUAL-LEONE, Auteur ; Lindsay M. OBERMAN, Auteur . - p.563-569. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.563-569 Mots-clés : serial reaction time task  ASD  motor learning  proprioception Index. décimale : PER Périodiques Résumé : In addition to defining impairments in social communication skills, individuals with autism spectrum disorder (ASD) also show impairments in more basic sensory and motor skills. Development of new skills involves integrating information from multiple sensory modalities. This input is then used to form internal models of action that can be accessed when both performing skilled movements, as well as understanding those actions performed by others. Learning skilled gestures is particularly reliant on integration of visual and proprioceptive input. We used a modified serial reaction time task (SRTT) to decompose proprioceptive and visual components and examine whether patterns of implicit motor skill learning differ in ASD participants as compared with healthy controls. While both groups learned the implicit motor sequence during training, healthy controls showed robust generalization whereas ASD participants demonstrated little generalization when visual input was constant. In contrast, no group differences in generalization were observed when proprioceptive input was constant, with both groups showing limited degrees of generalization. The findings suggest, when learning a motor sequence, individuals with ASD tend to rely less on visual feedback than do healthy controls. Visuomotor representations are considered to underlie imitative learning and action understanding and are thereby crucial to social skill and cognitive development. Thus, anomalous patterns of implicit motor learning, with a tendency to discount visual feedback, may be an important contributor in core social communication deficits that characterize ASD. En ligne : http://dx.doi.org/10.1002/aur.1537 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Structural and functional correlates of a quantitative autistic trait measured using the social responsive scale in neurotypical male adolescents / Pei-Chi TU in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.570-578 Titre : Structural and functional correlates of a quantitative autistic trait measured using the social responsive scale in neurotypical male adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Pei-Chi TU, Auteur ; Ju-Wei HSU, Auteur ; Chen-Chia LAN, Auteur ; Chia-Chien LIU, Auteur ; Tung-Ping SU, Auteur ; Ying-Sheue CHEN, Auteur Article en page(s) : p.570-578 Langues : Anglais (eng) Mots-clés : social responsive scale scores  cortical thickness  functional connectivity  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Behaviors associated with autism spectrum disorder (ASD) have been suggested to be considered as quantitative traits. This study investigated the structural and functional correlates of autistic traits measured using the Social Responsiveness Scale (SRS) in neurotypical adolescents. Twenty-six neurotypical male adolescents (12–18 years old) were recruited for this study and underwent structural and resting functional magnetic resonance image scanning, and intelligence quotient and SRS evaluations. We used the automated surface-based method (FreeSurfer) to measure cortical thickness and seed-based functional connectivity (FC) analysis to derive the FC map of the dorsal anterior cingulate (dACC). Brain-wise regression analyses of cortical thickness and FC maps on SRS scores were performed using a general linear model. The results indicated that higher autistic trait ratings of total SRS scores were associated with a thinner cortex in the left insula, right insula, and right superior temporal gyrus. Furthermore, we observed that only higher scores of social awareness were correlated with increased FC between the dACC and right superior temporal gyrus and decreased FC between the dACC and right putamen and thalamus. These results indicated that a quantitative trait in social cognition is associated with structural and connectivity variations linked to ASD patients. En ligne : http://dx.doi.org/10.1002/aur.1535 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Structural and functional correlates of a quantitative autistic trait measured using the social responsive scale in neurotypical male adolescents [Texte imprimé et/ou numérique] / Pei-Chi TU, Auteur ; Ju-Wei HSU, Auteur ; Chen-Chia LAN, Auteur ; Chia-Chien LIU, Auteur ; Tung-Ping SU, Auteur ; Ying-Sheue CHEN, Auteur . - p.570-578. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.570-578 Mots-clés : social responsive scale scores  cortical thickness  functional connectivity  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Behaviors associated with autism spectrum disorder (ASD) have been suggested to be considered as quantitative traits. This study investigated the structural and functional correlates of autistic traits measured using the Social Responsiveness Scale (SRS) in neurotypical adolescents. Twenty-six neurotypical male adolescents (12–18 years old) were recruited for this study and underwent structural and resting functional magnetic resonance image scanning, and intelligence quotient and SRS evaluations. We used the automated surface-based method (FreeSurfer) to measure cortical thickness and seed-based functional connectivity (FC) analysis to derive the FC map of the dorsal anterior cingulate (dACC). Brain-wise regression analyses of cortical thickness and FC maps on SRS scores were performed using a general linear model. The results indicated that higher autistic trait ratings of total SRS scores were associated with a thinner cortex in the left insula, right insula, and right superior temporal gyrus. Furthermore, we observed that only higher scores of social awareness were correlated with increased FC between the dACC and right superior temporal gyrus and decreased FC between the dACC and right putamen and thalamus. These results indicated that a quantitative trait in social cognition is associated with structural and connectivity variations linked to ASD patients. En ligne : http://dx.doi.org/10.1002/aur.1535 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Children with Autism Show Altered Autonomic Adaptation to Novel and Familiar Social Partners / Emily NEUHAUS in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.579-591 Titre : Children with Autism Show Altered Autonomic Adaptation to Novel and Familiar Social Partners Type de document : Texte imprimé et/ou numérique Auteurs : Emily NEUHAUS, Auteur ; Raphael BERNIER, Auteur ; Theodore P. BEAUCHAINE, Auteur Article en page(s) : p.579-591 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  autonomic  parasympathetic  sympathetic  social interaction  heart rate  respiratory sinus arrhythmia  cardiac pre-ejection period Index. décimale : PER Périodiques Résumé : Social deficits are fundamental to autism spectrum disorder (ASD), and a growing body of research implicates altered functioning of the autonomic nervous system (ANS), including both sympathetic and parasympathetic branches. However, few studies have explored both branches concurrently in ASD, particularly within the context of social interaction. The current study investigates patterns of change in indices of sympathetic (pre-ejection period; PEP) and parasympathetic (respiratory sinus arrhythmia; RSA) cardiac influence as boys (ages 8–11 years) with (N?=?18) and without (N?=?18) ASD engage in dyadic social interaction with novel and familiar social partners. Groups showed similar patterns of autonomic change during interaction with the novel partner, but differed in heart rate, PEP, and RSA reactivity while interacting with a familiar partner. Boys without ASD evinced decreasing sympathetic and increasing parasympathetic influence, whereas boys with ASD increased in sympathetic influence. Boys without ASD also demonstrated more consistent ANS responses across partners than those with ASD, with parasympathetic responding differentiating familiar and novel interaction partners. Finally, PEP slopes with a familiar partner correlated with boys' social skills. Implications include the importance of considering autonomic state during clinical assessment and treatment, and the potential value of regulation strategies as a complement to intervention programs aiming to support social cognition and behavior. En ligne : http://dx.doi.org/10.1002/aur.1543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Children with Autism Show Altered Autonomic Adaptation to Novel and Familiar Social Partners [Texte imprimé et/ou numérique] / Emily NEUHAUS, Auteur ; Raphael BERNIER, Auteur ; Theodore P. BEAUCHAINE, Auteur . - p.579-591. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.579-591 Mots-clés : autism spectrum disorder  autonomic  parasympathetic  sympathetic  social interaction  heart rate  respiratory sinus arrhythmia  cardiac pre-ejection period Index. décimale : PER Périodiques Résumé : Social deficits are fundamental to autism spectrum disorder (ASD), and a growing body of research implicates altered functioning of the autonomic nervous system (ANS), including both sympathetic and parasympathetic branches. However, few studies have explored both branches concurrently in ASD, particularly within the context of social interaction. The current study investigates patterns of change in indices of sympathetic (pre-ejection period; PEP) and parasympathetic (respiratory sinus arrhythmia; RSA) cardiac influence as boys (ages 8–11 years) with (N?=?18) and without (N?=?18) ASD engage in dyadic social interaction with novel and familiar social partners. Groups showed similar patterns of autonomic change during interaction with the novel partner, but differed in heart rate, PEP, and RSA reactivity while interacting with a familiar partner. Boys without ASD evinced decreasing sympathetic and increasing parasympathetic influence, whereas boys with ASD increased in sympathetic influence. Boys without ASD also demonstrated more consistent ANS responses across partners than those with ASD, with parasympathetic responding differentiating familiar and novel interaction partners. Finally, PEP slopes with a familiar partner correlated with boys' social skills. Implications include the importance of considering autonomic state during clinical assessment and treatment, and the potential value of regulation strategies as a complement to intervention programs aiming to support social cognition and behavior. En ligne : http://dx.doi.org/10.1002/aur.1543 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Scientific Summaries for Families with ASD in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.592-594 Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.592-594 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1648 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.592-594. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.592-594 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1648 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Message from the President in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.595-596 Titre : Message from the President Type de document : Texte imprimé et/ou numérique Article en page(s) : p.595-596 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Message from the President [Texte imprimé et/ou numérique] . - p.595-596. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.595-596 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289