Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD / Yuanxin ZHONG in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD Type de document : texte imprimé Auteurs : Yuanxin ZHONG, Auteur ; Larry W. BAUM, Auteur ; Justin D. TUBBS, Auteur ; Rui YE, Auteur ; Lu Hua CHEN, Auteur ; Tian WU, Auteur ; Se-fong HUNG, Auteur ; Chun-pan TANG, Auteur ; Ting-pong HO, Auteur ; Robert MOYZIS, Auteur ; James SWANSON, Auteur ; Chi-chiu LEE, Auteur ; Pak C. SHAM, Auteur ; Patrick W.L. LEUNG, Auteur Langues : Anglais (eng) Mots-clés : Humans  Attention Deficit Disorder with  Hyperactivity/genetics/immunology/physiopathology  Cerebellum/growth & development/diagnostic imaging/physiopathology  Male  Female  Genome-Wide Association Study  Genetic Predisposition to Disease  Child  Magnetic Resonance Imaging  Hong Kong  Polymorphism, Single Nucleotide  Infant  Adhd  Cerebellum  Common variant  Immune response  Late-infancy  Low-frequency / rare variant  University of Hong Kong-New Territories East Cluster, the Hospital Authority  Kowloon Central and Kowloon West Cluster Clinical Research Ethics Committee  provided ethical approval for this study, which complies with the most recent  Declaration of Helsinki. All participants provided informed consent for the  current study. Consent for publication: Not applicable. Competing interests: The  authors declare no competing interests. Index. décimale : PER Périodiques Résumé : OBJECTIVE: Attention-deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder with a significant genetic component. The latest genome-wide association study (GWAS) meta-analysis of ADHD identified 27 whole-genome significant risk loci in the European population. However, genetic risk factors for ADHD are less well-characterized in the Asian population, especially for low-frequency / rare variants. METHODS: In this study, we aimed to investigate the contributions of both common and low-frequency / rare variants to ADHD in a Hong Kong sample. Our sample comprised 279 cases and 432 controls who underwent genotyping using the Illumina Infinium Global Screening Array. We employed various analytical methods at different levels, while also leveraging multi-omics data and large-scale summary statistics to comprehensively analyze the genetic basis of ADHD. RESULTS: We identified 41 potential genomic risk loci with a suggestive association (p < 1e(-4)), pointing to 111 candidate risk genes, which were enriched for genes differentially expressed during late infancy brain development. Furthermore, tissue enrichment analysis implicated the involvement of the cerebellum. At the polygenic level, we also discovered a strong genetic correlation with resting-state functional MRI connectivity of the cerebellum involved in the attention/central executive and subcortical-cerebellum networks. In addition, an accumulation of ADHD common-variant risks found in European ancestry samples was found to be significantly associated with ADHD in the current study. In low-frequency / rare variant analyses, we discovered the correlations between ADHD and collapsing effects of rare damaging variants in TEP1, MTMR10, DBH, TBCC, and ANO1. Based on biological and functional profiles of the potential risk genes and gene sets, both common and low-frequency / rare variant analyses demonstrated that ADHD genetic risk was associated with immune processes. CONCLUSIONS: These findings re-validate the abnormal development of the neural system in ADHD and extend the existing neuro-dysfunction hypothesis to a multi-system perspective. The current study identified convergent risk factors from common and low-frequency / rare variants, which implicates vulnerability in late-infancy brain development, affecting especially the cerebellum, and the involvement of immune processes. En ligne : https://dx.doi.org/10.1186/s11689-025-09626-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD [texte imprimé] / Yuanxin ZHONG, Auteur ; Larry W. BAUM, Auteur ; Justin D. TUBBS, Auteur ; Rui YE, Auteur ; Lu Hua CHEN, Auteur ; Tian WU, Auteur ; Se-fong HUNG, Auteur ; Chun-pan TANG, Auteur ; Ting-pong HO, Auteur ; Robert MOYZIS, Auteur ; James SWANSON, Auteur ; Chi-chiu LEE, Auteur ; Pak C. SHAM, Auteur ; Patrick W.L. LEUNG, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Attention Deficit Disorder with  Hyperactivity/genetics/immunology/physiopathology  Cerebellum/growth & development/diagnostic imaging/physiopathology  Male  Female  Genome-Wide Association Study  Genetic Predisposition to Disease  Child  Magnetic Resonance Imaging  Hong Kong  Polymorphism, Single Nucleotide  Infant  Adhd  Cerebellum  Common variant  Immune response  Late-infancy  Low-frequency / rare variant  University of Hong Kong-New Territories East Cluster, the Hospital Authority  Kowloon Central and Kowloon West Cluster Clinical Research Ethics Committee  provided ethical approval for this study, which complies with the most recent  Declaration of Helsinki. All participants provided informed consent for the  current study. Consent for publication: Not applicable. Competing interests: The  authors declare no competing interests. Index. décimale : PER Périodiques Résumé : OBJECTIVE: Attention-deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder with a significant genetic component. The latest genome-wide association study (GWAS) meta-analysis of ADHD identified 27 whole-genome significant risk loci in the European population. However, genetic risk factors for ADHD are less well-characterized in the Asian population, especially for low-frequency / rare variants. METHODS: In this study, we aimed to investigate the contributions of both common and low-frequency / rare variants to ADHD in a Hong Kong sample. Our sample comprised 279 cases and 432 controls who underwent genotyping using the Illumina Infinium Global Screening Array. We employed various analytical methods at different levels, while also leveraging multi-omics data and large-scale summary statistics to comprehensively analyze the genetic basis of ADHD. RESULTS: We identified 41 potential genomic risk loci with a suggestive association (p < 1e(-4)), pointing to 111 candidate risk genes, which were enriched for genes differentially expressed during late infancy brain development. Furthermore, tissue enrichment analysis implicated the involvement of the cerebellum. At the polygenic level, we also discovered a strong genetic correlation with resting-state functional MRI connectivity of the cerebellum involved in the attention/central executive and subcortical-cerebellum networks. In addition, an accumulation of ADHD common-variant risks found in European ancestry samples was found to be significantly associated with ADHD in the current study. In low-frequency / rare variant analyses, we discovered the correlations between ADHD and collapsing effects of rare damaging variants in TEP1, MTMR10, DBH, TBCC, and ANO1. Based on biological and functional profiles of the potential risk genes and gene sets, both common and low-frequency / rare variant analyses demonstrated that ADHD genetic risk was associated with immune processes. CONCLUSIONS: These findings re-validate the abnormal development of the neural system in ADHD and extend the existing neuro-dysfunction hypothesis to a multi-system perspective. The current study identified convergent risk factors from common and low-frequency / rare variants, which implicates vulnerability in late-infancy brain development, affecting especially the cerebellum, and the involvement of immune processes. En ligne : https://dx.doi.org/10.1186/s11689-025-09626-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Test–retest reliability and criterion validity of the Chinese version of CBCL, TRF, and YSR / Patrick W.L. LEUNG in Journal of Child Psychology and Psychiatry, 47-9 (September 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-9 (September 2006) . - p.970–973 Titre : Test–retest reliability and criterion validity of the Chinese version of CBCL, TRF, and YSR Type de document : texte imprimé Auteurs : Patrick W.L. LEUNG, Auteur ; S.L. KWONG, Auteur ; T.P. HO, Auteur ; Cheuk-Chi LEE, Auteur ; S.L. HONG, Auteur ; C.M. CHIU, Auteur ; W.S. LIU, Auteur ; Se-fong HUNG, Auteur ; Chun-pan TANG, Auteur Année de publication : 2006 Article en page(s) : p.970–973 Langues : Anglais (eng) Mots-clés : CBCL TRF YSR reliability validity Chinese Index. décimale : PER Périodiques Résumé : Background: Psychometric properties of the Chinese version of CBCL, TRF, and YSR were understudied. This study aimed at examining their test–retest reliability and criterion validity. Methods: Three Chinese community and clinic samples were recruited in Hong Kong. The parents, teachers, and youths respectively completed the CBCL, TRF, and YSR. Results: The Chinese CBCL, TRF, and YSR were test–retest reliable and valid. However, there was score/case attenuation at retest. CBCL and TRF appeared to screen externalizing and ADHD problems better, while YSR screened internalizing problems better. Conclusions: Clinicians should be cautious about score/case attenuation at retest while using CBCL, TRF, and YSR to chart patients' progress. They should also recognize their different strengths in screening various disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01570.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=784 [article] Test–retest reliability and criterion validity of the Chinese version of CBCL, TRF, and YSR [texte imprimé] / Patrick W.L. LEUNG, Auteur ; S.L. KWONG, Auteur ; T.P. HO, Auteur ; Cheuk-Chi LEE, Auteur ; S.L. HONG, Auteur ; C.M. CHIU, Auteur ; W.S. LIU, Auteur ; Se-fong HUNG, Auteur ; Chun-pan TANG, Auteur . - 2006 . - p.970–973. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-9 (September 2006) . - p.970–973 Mots-clés : CBCL TRF YSR reliability validity Chinese Index. décimale : PER Périodiques Résumé : Background: Psychometric properties of the Chinese version of CBCL, TRF, and YSR were understudied. This study aimed at examining their test–retest reliability and criterion validity. Methods: Three Chinese community and clinic samples were recruited in Hong Kong. The parents, teachers, and youths respectively completed the CBCL, TRF, and YSR. Results: The Chinese CBCL, TRF, and YSR were test–retest reliable and valid. However, there was score/case attenuation at retest. CBCL and TRF appeared to screen externalizing and ADHD problems better, while YSR screened internalizing problems better. Conclusions: Clinicians should be cautious about score/case attenuation at retest while using CBCL, TRF, and YSR to chart patients' progress. They should also recognize their different strengths in screening various disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01570.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=784

The Mental Health of the Peers of Suicide Completers and Attempters / Ting-pong HO in Journal of Child Psychology and Psychiatry, 41-3 (March 2000)

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 41-3 (March 2000) . - p.301-308 Titre : The Mental Health of the Peers of Suicide Completers and Attempters Type de document : texte imprimé Auteurs : Ting-pong HO, Auteur ; Patrick W.L. LEUNG, Auteur ; Se-fong HUNG, Auteur ; Chi-chiu LEE, Auteur ; Chun-pan TANG, Auteur Année de publication : 2000 Article en page(s) : p.301-308 Langues : Anglais (eng) Mots-clés : Adolescence  mental health  peer relationships  psychiatric disturbances  suicidal behaviour Index. décimale : PER Périodiques Résumé : This study examined the prevalence and risk of psychiatric disturbances and suicidal behaviours among the peers of suicide attempters and completers. The subjects were selected from high schools with and without history of student suicides in the past 3 years. The psychiatric disturbances (as measured by the YSR and CBCL), suicidal behaviours, drug use, and a wide range of potential risk factors were measured. About a quarter of the peers of suicide completers and attempters were probable psychiatric cases and 15–21% of them reported suicidal acts. The increased risk of psychiatric disturbances and suicidal behaviours were still evident after controlling for age, sex, and potential risk factors. The presence of psychiatric disturbances could not wholly account for the increased odds of suicidal behaviours. Peers of suicide attempters carried a higher risk than peers of suicide completers. The close friends of suicide completers were particularly at risk of internalising problems, whereas the close friends of suicide attempters were at high risk of externalising problems. The peers of suicide completers and attempters represent a high-risk group for psychiatric disturbances and suicidal behaviours. The specific association of different types of psychiatric disturbances in the peers of suicide completers and attempters suggested that different risk mechanisms might be in operation within these peer groups. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125 [article] The Mental Health of the Peers of Suicide Completers and Attempters [texte imprimé] / Ting-pong HO, Auteur ; Patrick W.L. LEUNG, Auteur ; Se-fong HUNG, Auteur ; Chi-chiu LEE, Auteur ; Chun-pan TANG, Auteur . - 2000 . - p.301-308. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 41-3 (March 2000) . - p.301-308 Mots-clés : Adolescence  mental health  peer relationships  psychiatric disturbances  suicidal behaviour Index. décimale : PER Périodiques Résumé : This study examined the prevalence and risk of psychiatric disturbances and suicidal behaviours among the peers of suicide attempters and completers. The subjects were selected from high schools with and without history of student suicides in the past 3 years. The psychiatric disturbances (as measured by the YSR and CBCL), suicidal behaviours, drug use, and a wide range of potential risk factors were measured. About a quarter of the peers of suicide completers and attempters were probable psychiatric cases and 15–21% of them reported suicidal acts. The increased risk of psychiatric disturbances and suicidal behaviours were still evident after controlling for age, sex, and potential risk factors. The presence of psychiatric disturbances could not wholly account for the increased odds of suicidal behaviours. Peers of suicide attempters carried a higher risk than peers of suicide completers. The close friends of suicide completers were particularly at risk of internalising problems, whereas the close friends of suicide attempters were at high risk of externalising problems. The peers of suicide completers and attempters represent a high-risk group for psychiatric disturbances and suicidal behaviours. The specific association of different types of psychiatric disturbances in the peers of suicide completers and attempters suggested that different risk mechanisms might be in operation within these peer groups. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125

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