Associations between physiological and neural measures of sensory reactivity in youth with autism / Jiwon JUNG in Journal of Child Psychology and Psychiatry, 62-10 (October 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-10 (October 2021) . - p.1183-1194 Titre : Associations between physiological and neural measures of sensory reactivity in youth with autism Type de document : texte imprimé Auteurs : Jiwon JUNG, Auteur ; Tomislav D. ZBOZINEK, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Frank H. WILHELM, Auteur ; Mirella DAPRETTO, Auteur ; Michelle G. CRASKE, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Shulamite A. GREEN, Auteur Article en page(s) : p.1183-1194 Langues : Anglais (eng) Mots-clés : Adolescent  Attention  Autism Spectrum Disorder  Autistic Disorder  Brain/diagnostic imaging  Child  Humans  Magnetic Resonance Imaging  Autism spectrum disorders  fMRI  physiology  sensory over-responsivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with Autism Spectrum Disorder (ASD) commonly show sensory over-responsivity (SOR), an impairing condition related to over-reactive brain and behavioral responses to aversive stimuli. While individuals with ASD often show atypically high physiological arousal, it is unclear how this relates to sensory reactivity. We therefore investigated how physiological arousal relates to brain and behavioral indices of SOR, to inform understanding of the biological mechanisms underlying SOR and to determine whether physiological measures are associated with SOR-related brain responses. METHODS: Youth aged 8-18 (49 ASD; 30 age- and performance-IQ-matched typically developing (TD)) experienced mildly aversive tactile and auditory stimuli first during functional magnetic resonance imaging (N = 41 ASD, 26 TD) and then during skin conductance (SCR) (N = 48 ASD, 28 TD) and heart rate (HR) measurements (N = 48 ASD, 30 TD). Parents reported on their children's SOR severity. RESULTS: Autism Spectrum Disorder youth overall displayed greater SCR to aversive sensory stimulation than TD youth and greater baseline HR. Within ASD, higher SOR was associated with higher mean HR across all stimuli after controlling for baseline HR. Furthermore, the ASD group overall, and the ASD-high-SOR group in particular, showed reduced HR deceleration/greater acceleration to sensory stimulation compared to the TD group. Both SCR and HR were associated with brain responses to sensory stimulation in regions previously associated with SOR and sensory regulation. CONCLUSIONS: Autism Spectrum Disorder youth displayed heightened physiological arousal to mildly aversive sensory stimulation, with HR responses in particular showing associations with brain and behavioral measures of SOR. These results have implications for using psychophysiological measures to assess SOR, particularly in individuals with ASD who cannot undergo MRI. En ligne : http://dx.doi.org/10.1111/jcpp.13387 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Associations between physiological and neural measures of sensory reactivity in youth with autism [texte imprimé] / Jiwon JUNG, Auteur ; Tomislav D. ZBOZINEK, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Frank H. WILHELM, Auteur ; Mirella DAPRETTO, Auteur ; Michelle G. CRASKE, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Shulamite A. GREEN, Auteur . - p.1183-1194. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-10 (October 2021) . - p.1183-1194 Mots-clés : Adolescent  Attention  Autism Spectrum Disorder  Autistic Disorder  Brain/diagnostic imaging  Child  Humans  Magnetic Resonance Imaging  Autism spectrum disorders  fMRI  physiology  sensory over-responsivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with Autism Spectrum Disorder (ASD) commonly show sensory over-responsivity (SOR), an impairing condition related to over-reactive brain and behavioral responses to aversive stimuli. While individuals with ASD often show atypically high physiological arousal, it is unclear how this relates to sensory reactivity. We therefore investigated how physiological arousal relates to brain and behavioral indices of SOR, to inform understanding of the biological mechanisms underlying SOR and to determine whether physiological measures are associated with SOR-related brain responses. METHODS: Youth aged 8-18 (49 ASD; 30 age- and performance-IQ-matched typically developing (TD)) experienced mildly aversive tactile and auditory stimuli first during functional magnetic resonance imaging (N = 41 ASD, 26 TD) and then during skin conductance (SCR) (N = 48 ASD, 28 TD) and heart rate (HR) measurements (N = 48 ASD, 30 TD). Parents reported on their children's SOR severity. RESULTS: Autism Spectrum Disorder youth overall displayed greater SCR to aversive sensory stimulation than TD youth and greater baseline HR. Within ASD, higher SOR was associated with higher mean HR across all stimuli after controlling for baseline HR. Furthermore, the ASD group overall, and the ASD-high-SOR group in particular, showed reduced HR deceleration/greater acceleration to sensory stimulation compared to the TD group. Both SCR and HR were associated with brain responses to sensory stimulation in regions previously associated with SOR and sensory regulation. CONCLUSIONS: Autism Spectrum Disorder youth displayed heightened physiological arousal to mildly aversive sensory stimulation, with HR responses in particular showing associations with brain and behavioral measures of SOR. These results have implications for using psychophysiological measures to assess SOR, particularly in individuals with ASD who cannot undergo MRI. En ligne : http://dx.doi.org/10.1111/jcpp.13387 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Children's vagal regulatory capacity predicts attenuated sympathetic stress reactivity in a socially supportive context: Evidence for a protective effect of the vagal system / Brian C. WOLFF in Development and Psychopathology, 24-2 (May 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-2 (May 2012) . - p.677-689 Titre : Children's vagal regulatory capacity predicts attenuated sympathetic stress reactivity in a socially supportive context: Evidence for a protective effect of the vagal system Type de document : texte imprimé Auteurs : Brian C. WOLFF, Auteur ; Martha E. WADSWORTH, Auteur ; Frank H. WILHELM, Auteur ; Iris B. MAUSS, Auteur Année de publication : 2012 Article en page(s) : p.677-689 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Social support and vagal regulatory capacity (VRC), an index of flexible vagal responses during various types of stress, are linked to attenuated stress responding and positive health outcomes. Guided by the polyvagal perspective, we tested whether children's VRC is associated with attenuated sympathetic nervous system (SNS) stress reactivity in socially supportive conditions. Sixty-one 4- to 5-year-old children living in poverty underwent two standardized laboratory stress induction procedures. Cardiac vagal reactivity (respiratory sinus arrhythmia) to a first set of stressors (social, cognitive, physical, and emotional) indexed VRC. During a second set of stressors, participants were randomly assigned to a supportive or nonsupportive social context, and cardiac sympathetic reactivity (preejection period) was assessed. We hypothesized VRC would predict lower SNS stress reactivity, but only in the socially supportive context. Children with high VRC showed attenuated SNS stress reactivity in the socially supportive context compared to children with high VRC in the nonsupportive context and children with low VRC in either context. Individual differences in VRC predict attenuated SNS stress reactivity in socially supportive conditions. Understanding how social support and VRC jointly mitigate SNS stress reactivity may further efforts to prevent negative health outcomes. Implications for biological sensitivity to context and differential susceptibility theories are discussed. En ligne : http://dx.doi.org/10.1017/S0954579412000247 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 [article] Children's vagal regulatory capacity predicts attenuated sympathetic stress reactivity in a socially supportive context: Evidence for a protective effect of the vagal system [texte imprimé] / Brian C. WOLFF, Auteur ; Martha E. WADSWORTH, Auteur ; Frank H. WILHELM, Auteur ; Iris B. MAUSS, Auteur . - 2012 . - p.677-689. Langues : Anglais (eng) in Development and Psychopathology > 24-2 (May 2012) . - p.677-689 Index. décimale : PER Périodiques Résumé : Social support and vagal regulatory capacity (VRC), an index of flexible vagal responses during various types of stress, are linked to attenuated stress responding and positive health outcomes. Guided by the polyvagal perspective, we tested whether children's VRC is associated with attenuated sympathetic nervous system (SNS) stress reactivity in socially supportive conditions. Sixty-one 4- to 5-year-old children living in poverty underwent two standardized laboratory stress induction procedures. Cardiac vagal reactivity (respiratory sinus arrhythmia) to a first set of stressors (social, cognitive, physical, and emotional) indexed VRC. During a second set of stressors, participants were randomly assigned to a supportive or nonsupportive social context, and cardiac sympathetic reactivity (preejection period) was assessed. We hypothesized VRC would predict lower SNS stress reactivity, but only in the socially supportive context. Children with high VRC showed attenuated SNS stress reactivity in the socially supportive context compared to children with high VRC in the nonsupportive context and children with low VRC in either context. Individual differences in VRC predict attenuated SNS stress reactivity in socially supportive conditions. Understanding how social support and VRC jointly mitigate SNS stress reactivity may further efforts to prevent negative health outcomes. Implications for biological sensitivity to context and differential susceptibility theories are discussed. En ligne : http://dx.doi.org/10.1017/S0954579412000247 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155

Separation anxiety disorder in children: disorder-specific responses to experimental separation from the mother / Joe KOSSOWSKY in Journal of Child Psychology and Psychiatry, 53-2 (February 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-2 (February 2012) . - p.178-187 Titre : Separation anxiety disorder in children: disorder-specific responses to experimental separation from the mother Type de document : texte imprimé Auteurs : Joe KOSSOWSKY, Auteur ; Frank H. WILHELM, Auteur ; Walton T. ROTH, Auteur ; Silvia SCHNEIDER, Auteur Année de publication : 2012 Article en page(s) : p.178-187 Langues : Anglais (eng) Mots-clés : Childhood anxiety  separation anxiety disorder  autonomic nervous system  respiration Index. décimale : PER Périodiques Résumé : Background:  Separation anxiety disorder (SAD) is one of the most common anxiety disorders in childhood and is predictive of adult anxiety disorders, especially panic disorder. However, the disorder has seldom been studied and the attempt to distinguish SAD from other anxiety disorders with regard to psychophysiology has not been made. We expected exaggerated anxiety as well as sympathetic and respiratory reactivity in SAD during separation from the mother. Method:  Participants were 49 children with a principal diagnosis of SAD, 21 clinical controls (CC) with a principal diagnosis of anxiety disorder other than SAD, and 39 healthy controls (HC) not meeting criteria for any current diagnosis. Analyses of covariance controlling for age were used to assess sympathetic and parasympathetic activation (preejection period and respiratory sinus arrhythmia) as well as cardiovascular (heart rate, mean arterial pressure, total peripheral resistance), respiratory (total breath time, minute ventilation, tidal volume, end-tidal CO2, respiratory variability), electrodermal, and self-report (anxiety, cognitions, symptoms) variables during baseline, 4-min separation from, and reunion with the mother. Results:  Children with a diagnosis of SAD were characterized by elevated self-reported anxiety responses to separation and increased sympathetic reactivity compared with CC and HC groups. The SAD group also displayed greater vagal withdrawal and higher reactivity in multiple cardiovascular, respiratory, and electrodermal measures compared with the HC group, while corresponding responses were less in the CC group and not significantly different from the other groups. Conclusions:  Separation from the mother elicits greater autonomic, respiratory, and experiential responses in children with SAD. Our findings based on brief experimental separation demonstrate differential subjective and physiological manifestations of specific anxiety diagnoses, thus supporting the validity of the diagnostic category of SAD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02465.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150 [article] Separation anxiety disorder in children: disorder-specific responses to experimental separation from the mother [texte imprimé] / Joe KOSSOWSKY, Auteur ; Frank H. WILHELM, Auteur ; Walton T. ROTH, Auteur ; Silvia SCHNEIDER, Auteur . - 2012 . - p.178-187. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-2 (February 2012) . - p.178-187 Mots-clés : Childhood anxiety  separation anxiety disorder  autonomic nervous system  respiration Index. décimale : PER Périodiques Résumé : Background:  Separation anxiety disorder (SAD) is one of the most common anxiety disorders in childhood and is predictive of adult anxiety disorders, especially panic disorder. However, the disorder has seldom been studied and the attempt to distinguish SAD from other anxiety disorders with regard to psychophysiology has not been made. We expected exaggerated anxiety as well as sympathetic and respiratory reactivity in SAD during separation from the mother. Method:  Participants were 49 children with a principal diagnosis of SAD, 21 clinical controls (CC) with a principal diagnosis of anxiety disorder other than SAD, and 39 healthy controls (HC) not meeting criteria for any current diagnosis. Analyses of covariance controlling for age were used to assess sympathetic and parasympathetic activation (preejection period and respiratory sinus arrhythmia) as well as cardiovascular (heart rate, mean arterial pressure, total peripheral resistance), respiratory (total breath time, minute ventilation, tidal volume, end-tidal CO2, respiratory variability), electrodermal, and self-report (anxiety, cognitions, symptoms) variables during baseline, 4-min separation from, and reunion with the mother. Results:  Children with a diagnosis of SAD were characterized by elevated self-reported anxiety responses to separation and increased sympathetic reactivity compared with CC and HC groups. The SAD group also displayed greater vagal withdrawal and higher reactivity in multiple cardiovascular, respiratory, and electrodermal measures compared with the HC group, while corresponding responses were less in the CC group and not significantly different from the other groups. Conclusions:  Separation from the mother elicits greater autonomic, respiratory, and experiential responses in children with SAD. Our findings based on brief experimental separation demonstrate differential subjective and physiological manifestations of specific anxiety diagnoses, thus supporting the validity of the diagnostic category of SAD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02465.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150

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