Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica / Mohammad Hossein RAHBAR in Journal of Autism and Developmental Disorders, 42-9 (September 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1928-1938 Titre : Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad Hossein RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Katherine A. LOVELAND, Auteur ; Deborah A. PEARSON, Auteur ; Jan BRESSLER, Auteur ; Zhongxue CHEN, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Compton BEECHER, Auteur ; Kari BLOOM, Auteur ; Eric BOERWINKLE, Auteur Année de publication : 2012 Article en page(s) : p.1928-1938 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Maternal age  Paternal age  Multivariate General Linear Models  Multicollinearity Index. décimale : PER Périodiques Résumé : Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM. En ligne : http://dx.doi.org/10.1007/s10803-011-1438-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 [article] Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica [Texte imprimé et/ou numérique] / Mohammad Hossein RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Katherine A. LOVELAND, Auteur ; Deborah A. PEARSON, Auteur ; Jan BRESSLER, Auteur ; Zhongxue CHEN, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Compton BEECHER, Auteur ; Kari BLOOM, Auteur ; Eric BOERWINKLE, Auteur . - 2012 . - p.1928-1938. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1928-1938 Mots-clés : Autism spectrum disorders  Maternal age  Paternal age  Multivariate General Linear Models  Multicollinearity Index. décimale : PER Périodiques Résumé : Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM. En ligne : http://dx.doi.org/10.1007/s10803-011-1438-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180

Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 8-9 (September 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-9 (September 2014) . - p.1134-1145 Titre : Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Aisha S. DICKERSON, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Deborah A. PEARSON, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.1134-1145 Langues : Anglais (eng) Mots-clés : Cadmium  Autism Spectrum Disorder  Grains  Fruits  Seafood  Jamaica Index. décimale : PER Périodiques Résumé : Abstract Human exposure to cadmium has adverse effects on the nervous system. Utilizing data from 110 age- and sex-matched case–control pairs (220 children) ages 2–8 years in Kingston, Jamaica, we compared the 75th percentile of blood cadmium concentrations in children with and without Autism Spectrum Disorder (ASD). In both univariable and multivariable Quantile Regression Models that controlled for potential confounding factors, we did not find any significant differences between ASD cases and typically developing (TD) controls with respect to the 75th percentile of blood cadmium concentrations (P gt; 0.22). However, we found a significantly higher 75th percentile of blood cadmium concentrations in TD Jamaican children who consumed shellfish (lobsters, crabs) (P lt; 0.05), fried plantain (P lt; 0.01), and boiled dumpling (P lt; 0.01). We also observed that children living in Jamaica have an arithmetic mean blood cadmium concentration of 0.16 ?g/L which is similar to that of the children in developed countries and much lower than that of children in developing countries. Although our results do not support an association between blood cadmium concentrations and ASD, to our knowledge, this study is the first to report levels of blood cadmium in TD children as well as those with ASD in Jamaica. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.06.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Aisha S. DICKERSON, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Deborah A. PEARSON, Auteur ; Eric BOERWINKLE, Auteur . - p.1134-1145. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-9 (September 2014) . - p.1134-1145 Mots-clés : Cadmium  Autism Spectrum Disorder  Grains  Fruits  Seafood  Jamaica Index. décimale : PER Périodiques Résumé : Abstract Human exposure to cadmium has adverse effects on the nervous system. Utilizing data from 110 age- and sex-matched case–control pairs (220 children) ages 2–8 years in Kingston, Jamaica, we compared the 75th percentile of blood cadmium concentrations in children with and without Autism Spectrum Disorder (ASD). In both univariable and multivariable Quantile Regression Models that controlled for potential confounding factors, we did not find any significant differences between ASD cases and typically developing (TD) controls with respect to the 75th percentile of blood cadmium concentrations (P gt; 0.22). However, we found a significantly higher 75th percentile of blood cadmium concentrations in TD Jamaican children who consumed shellfish (lobsters, crabs) (P lt; 0.05), fried plantain (P lt; 0.01), and boiled dumpling (P lt; 0.01). We also observed that children living in Jamaica have an arithmetic mean blood cadmium concentration of 0.16 ?g/L which is similar to that of the children in developed countries and much lower than that of children in developing countries. Although our results do not support an association between blood cadmium concentrations and ASD, to our knowledge, this study is the first to report levels of blood cadmium in TD children as well as those with ASD in Jamaica. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.06.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

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