Atypical object exploration at 12 months of age is associated with autism in a prospective sample / Sally OZONOFF in Autism, 12-5 (September 2008)  

Public ISBD [article]  inAutism > 12-5 (September 2008) . - p.457-472 Titre : Atypical object exploration at 12 months of age is associated with autism in a prospective sample Type de document : Texte imprimé et/ou numérique Auteurs : Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Stacy GOLDRING, Auteur ; Meagan THOMPSON, Auteur ; Suzanne L. MACARI, Auteur ; Sally J ROGERS, Auteur Année de publication : 2008 Article en page(s) : p.457-472 Langues : Anglais (eng) Mots-clés : autism diagnosis early-identification repetitive-behavior Index. décimale : PER Périodiques Résumé : This prospective study examined object exploration behavior in 66 12-month-old infants, of whom nine were subsequently diagnosed with an autism spectrum disorder. Previous investigations differ on when the repetitive behaviors characteristic of autism are first present in early development. A task was developed that afforded specific opportunities for a range of repetitive uses of objects and was coded blind to outcome status. The autism/ASD outcome group displayed significantly more spinning, rotating, and unusual visual exploration of objects than two comparison groups. The average unusual visual exploration score of the autism/ASD group was over four standard deviations above the mean of the group with no concerns at outcome. Repetitive behaviors at 12 months were significantly related to cognitive and symptomatic status at 36 month outcome. These results suggest that repetitive or stereotyped behaviors may be present earlier than initially thought in very young children developing the autism phenotype. En ligne : http://dx.doi.org/10.1177/1362361308096402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=601 [article] Atypical object exploration at 12 months of age is associated with autism in a prospective sample [Texte imprimé et/ou numérique] / Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Stacy GOLDRING, Auteur ; Meagan THOMPSON, Auteur ; Suzanne L. MACARI, Auteur ; Sally J ROGERS, Auteur . - 2008 . - p.457-472. Langues : Anglais (eng) in Autism > 12-5 (September 2008) . - p.457-472 Mots-clés : autism diagnosis early-identification repetitive-behavior Index. décimale : PER Périodiques Résumé : This prospective study examined object exploration behavior in 66 12-month-old infants, of whom nine were subsequently diagnosed with an autism spectrum disorder. Previous investigations differ on when the repetitive behaviors characteristic of autism are first present in early development. A task was developed that afforded specific opportunities for a range of repetitive uses of objects and was coded blind to outcome status. The autism/ASD outcome group displayed significantly more spinning, rotating, and unusual visual exploration of objects than two comparison groups. The average unusual visual exploration score of the autism/ASD group was over four standard deviations above the mean of the group with no concerns at outcome. Repetitive behaviors at 12 months were significantly related to cognitive and symptomatic status at 36 month outcome. These results suggest that repetitive or stereotyped behaviors may be present earlier than initially thought in very young children developing the autism phenotype. En ligne : http://dx.doi.org/10.1177/1362361308096402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=601

Context modulates attention to social scenes in toddlers with autism / Katarzyna CHAWARSKA in Journal of Child Psychology and Psychiatry, 53-8 (August 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-8 (August 2012) . - p.903-913 Titre : Context modulates attention to social scenes in toddlers with autism Type de document : Texte imprimé et/ou numérique Auteurs : Katarzyna CHAWARSKA, Auteur ; Suzanne L. MACARI, Auteur ; Frederick SHIC, Auteur Année de publication : 2012 Article en page(s) : p.903-913 Langues : Anglais (eng) Mots-clés : Autism  infants  toddlers  eye-tracking  visual attention  dyadic attention  scanning  naturalistic  dynamic stimuli Index. décimale : PER Périodiques Résumé : Background:  In typical development, the unfolding of social and communicative skills hinges upon the ability to allocate and sustain attention toward people, a skill present moments after birth. Deficits in social attention have been well documented in autism, though the underlying mechanisms are poorly understood. Methods:  In order to parse the factors that are responsible for limited social attention in toddlers with autism, we manipulated the context in which a person appeared in their visual field with regard to the presence of salient social (child-directed speech and eye contact) and nonsocial (distractor toys) cues for attention. Participants included 13- to 25-month-old toddlers with autism (autism; n = 54), developmental delay (DD; n = 22), and typical development (TD; n = 48). Their visual responses were recorded with an eye-tracker. Results:  In conditions devoid of eye contact and speech, the distribution of attention between key features of the social scene in toddlers with autism was comparable to that in DD and TD controls. However, when explicit dyadic cues were introduced, toddlers with autism showed decreased attention to the entire scene and, when they looked at the scene, they spent less time looking at the speaker’s face and monitoring her lip movements than the control groups. In toddlers with autism, decreased time spent exploring the entire scene was associated with increased symptom severity and lower nonverbal functioning; atypical language profiles were associated with decreased monitoring of the speaker’s face and her mouth. Conclusions:  While in certain contexts toddlers with autism attend to people and objects in a typical manner, they show decreased attentional response to dyadic cues for attention. Given that mechanisms supporting responsivity to dyadic cues are present shortly after birth and are highly consequential for development of social cognition and communication, these findings have important implications for the understanding of the underlying mechanisms of limited social monitoring and identifying pivotal targets for treatment. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02538.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177 [article] Context modulates attention to social scenes in toddlers with autism [Texte imprimé et/ou numérique] / Katarzyna CHAWARSKA, Auteur ; Suzanne L. MACARI, Auteur ; Frederick SHIC, Auteur . - 2012 . - p.903-913. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-8 (August 2012) . - p.903-913 Mots-clés : Autism  infants  toddlers  eye-tracking  visual attention  dyadic attention  scanning  naturalistic  dynamic stimuli Index. décimale : PER Périodiques Résumé : Background:  In typical development, the unfolding of social and communicative skills hinges upon the ability to allocate and sustain attention toward people, a skill present moments after birth. Deficits in social attention have been well documented in autism, though the underlying mechanisms are poorly understood. Methods:  In order to parse the factors that are responsible for limited social attention in toddlers with autism, we manipulated the context in which a person appeared in their visual field with regard to the presence of salient social (child-directed speech and eye contact) and nonsocial (distractor toys) cues for attention. Participants included 13- to 25-month-old toddlers with autism (autism; n = 54), developmental delay (DD; n = 22), and typical development (TD; n = 48). Their visual responses were recorded with an eye-tracker. Results:  In conditions devoid of eye contact and speech, the distribution of attention between key features of the social scene in toddlers with autism was comparable to that in DD and TD controls. However, when explicit dyadic cues were introduced, toddlers with autism showed decreased attention to the entire scene and, when they looked at the scene, they spent less time looking at the speaker’s face and monitoring her lip movements than the control groups. In toddlers with autism, decreased time spent exploring the entire scene was associated with increased symptom severity and lower nonverbal functioning; atypical language profiles were associated with decreased monitoring of the speaker’s face and her mouth. Conclusions:  While in certain contexts toddlers with autism attend to people and objects in a typical manner, they show decreased attentional response to dyadic cues for attention. Given that mechanisms supporting responsivity to dyadic cues are present shortly after birth and are highly consequential for development of social cognition and communication, these findings have important implications for the understanding of the underlying mechanisms of limited social monitoring and identifying pivotal targets for treatment. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02538.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177

Diagnostic Issues and Complexities in Autism and Related Conditions / Marc WOODBURY-SMITH ; Suzanne L. MACARI ; Roald A. ØIEN

Public ISBD in Differential diagnosis of autism spectrum disorder / Katherine K. M. STAVROPOULOS Titre : Diagnostic Issues and Complexities in Autism and Related Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Marc WOODBURY-SMITH, Auteur ; Suzanne L. MACARI, Auteur ; Roald A. ØIEN, Auteur Année de publication : 2022 Importance : p.1-21 Langues : Anglais (eng) Index. décimale : AUT-D AUT-D - L'Autisme - Dépistage et Diagnostic Résumé : Since the first recognition of autism and Asperger?s disorder, there have been important debates about the boundaries of these conditions and the degree to which they ?shade off? into normalcy. These debates have centered on the relevance of a narrow versus broad view of the clinical disorder(s) as well as on the implications of its complex genetic underpinnings and increased knowledge of the social neuroscience of autism and related conditions. With the recognition of the complexity of the genetics of autism there has been much debate regarding the broader autism phenotype and the potential adaptive function of some aspects of the condition. In addition, concerns with boundary issues in relation to cognitive and communicative ability, and the relevance of gender, diverse backgrounds, and cultural issues have all arisen. The current DSM-5 definition was developed using research instruments and has proven overly stringent in important respects. Clarification of these issues will enhance both clinical work and research. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 in Differential diagnosis of autism spectrum disorder / Katherine K. M. STAVROPOULOS Diagnostic Issues and Complexities in Autism and Related Conditions [Texte imprimé et/ou numérique] / Marc WOODBURY-SMITH, Auteur ; Suzanne L. MACARI, Auteur ; Roald A. ØIEN, Auteur . - 2022 . - p.1-21. Langues : Anglais (eng) Index. décimale : AUT-D AUT-D - L'Autisme - Dépistage et Diagnostic Résumé : Since the first recognition of autism and Asperger?s disorder, there have been important debates about the boundaries of these conditions and the degree to which they ?shade off? into normalcy. These debates have centered on the relevance of a narrow versus broad view of the clinical disorder(s) as well as on the implications of its complex genetic underpinnings and increased knowledge of the social neuroscience of autism and related conditions. With the recognition of the complexity of the genetics of autism there has been much debate regarding the broader autism phenotype and the potential adaptive function of some aspects of the condition. In addition, concerns with boundary issues in relation to cognitive and communicative ability, and the relevance of gender, diverse backgrounds, and cultural issues have all arisen. The current DSM-5 definition was developed using research instruments and has proven overly stringent in important respects. Clarification of these issues will enhance both clinical work and research. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528

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Diagnostic stability in young children at risk for autism spectrum disorder: a baby siblings research consortium study / Sally OZONOFF in Journal of Child Psychology and Psychiatry, 56-9 (September 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-9 (September 2015) . - p.988-998 Titre : Diagnostic stability in young children at risk for autism spectrum disorder: a baby siblings research consortium study Type de document : Texte imprimé et/ou numérique Auteurs : Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Rebecca J. LANDA, Auteur ; Jessica BRIAN, Auteur ; Susan E. BRYSON, Auteur ; Tony CHARMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne L. MACARI, Auteur ; Daniel MESSINGER, Auteur ; Wendy L. STONE, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Ana-Maria IOSIF, Auteur Article en page(s) : p.988-998 Langues : Anglais (eng) Mots-clés : Preschool children  autism spectrum disorders  diagnosis Index. décimale : PER Périodiques Résumé : Background The diagnosis of autism spectrum disorder (ASD) made before age 3 has been found to be remarkably stable in clinic- and community-ascertained samples. The stability of an ASD diagnosis in prospectively ascertained samples of infants at risk for ASD due to familial factors has not yet been studied, however. The American Academy of Pediatrics recommends intensive surveillance and screening for this high-risk group, which may afford earlier identification. Therefore, it is critical to understand the stability of an ASD diagnosis made before age 3 in young children at familial risk. Methods Data were pooled across seven sites of the Baby Siblings Research Consortium. Evaluations of 418 later-born siblings of children with ASD were conducted at 18, 24, and 36 months of age and a clinical diagnosis of ASD or Not ASD was made at each age. Results The stability of an ASD diagnosis at 18 months was 93% and at 24 months was 82%. There were relatively few children diagnosed with ASD at 18 or 24 months whose diagnosis was not confirmed at 36 months. There were, however, many children with ASD outcomes at 36 months who had not yet been diagnosed at 18 months (63%) or 24 months (41%). Conclusions The stability of an ASD diagnosis in this familial-risk sample was high at both 18 and 24 months of age and comparable with previous data from clinic- and community-ascertained samples. However, almost half of the children with ASD outcomes were not identified as being on the spectrum at 24 months and did not receive an ASD diagnosis until 36 months. Thus, longitudinal follow-up is critical for children with early signs of social-communication difficulties, even if they do not meet diagnostic criteria at initial assessment. A public health implication of these data is that screening for ASD may need to be repeated multiple times in the first years of life. These data also suggest that there is a period of early development in which ASD features unfold and emerge but have not yet reached levels supportive of a diagnosis. En ligne : http://dx.doi.org/10.1111/jcpp.12421 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Diagnostic stability in young children at risk for autism spectrum disorder: a baby siblings research consortium study [Texte imprimé et/ou numérique] / Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Rebecca J. LANDA, Auteur ; Jessica BRIAN, Auteur ; Susan E. BRYSON, Auteur ; Tony CHARMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne L. MACARI, Auteur ; Daniel MESSINGER, Auteur ; Wendy L. STONE, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Ana-Maria IOSIF, Auteur . - p.988-998. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-9 (September 2015) . - p.988-998 Mots-clés : Preschool children  autism spectrum disorders  diagnosis Index. décimale : PER Périodiques Résumé : Background The diagnosis of autism spectrum disorder (ASD) made before age 3 has been found to be remarkably stable in clinic- and community-ascertained samples. The stability of an ASD diagnosis in prospectively ascertained samples of infants at risk for ASD due to familial factors has not yet been studied, however. The American Academy of Pediatrics recommends intensive surveillance and screening for this high-risk group, which may afford earlier identification. Therefore, it is critical to understand the stability of an ASD diagnosis made before age 3 in young children at familial risk. Methods Data were pooled across seven sites of the Baby Siblings Research Consortium. Evaluations of 418 later-born siblings of children with ASD were conducted at 18, 24, and 36 months of age and a clinical diagnosis of ASD or Not ASD was made at each age. Results The stability of an ASD diagnosis at 18 months was 93% and at 24 months was 82%. There were relatively few children diagnosed with ASD at 18 or 24 months whose diagnosis was not confirmed at 36 months. There were, however, many children with ASD outcomes at 36 months who had not yet been diagnosed at 18 months (63%) or 24 months (41%). Conclusions The stability of an ASD diagnosis in this familial-risk sample was high at both 18 and 24 months of age and comparable with previous data from clinic- and community-ascertained samples. However, almost half of the children with ASD outcomes were not identified as being on the spectrum at 24 months and did not receive an ASD diagnosis until 36 months. Thus, longitudinal follow-up is critical for children with early signs of social-communication difficulties, even if they do not meet diagnostic criteria at initial assessment. A public health implication of these data is that screening for ASD may need to be repeated multiple times in the first years of life. These data also suggest that there is a period of early development in which ASD features unfold and emerge but have not yet reached levels supportive of a diagnosis. En ligne : http://dx.doi.org/10.1111/jcpp.12421 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

Electrodermal and Behavioral Responses of Children With Autism Spectrum Disorders to Sensory and Repetitive Stimuli / Carolyn MCCORMICK in Autism Research, 7-4 (August 2014)  

Public ISBD [article]  inAutism Research > 7-4 (August 2014) . - p.468-480 Titre : Electrodermal and Behavioral Responses of Children With Autism Spectrum Disorders to Sensory and Repetitive Stimuli Type de document : Texte imprimé et/ou numérique Auteurs : Carolyn MCCORMICK, Auteur ; David HESSL, Auteur ; Suzanne L. MACARI, Auteur ; Sally OZONOFF, Auteur ; Cherie C. GREEN, Auteur ; Sally J ROGERS, Auteur Année de publication : 2014 Article en page(s) : p.468-480 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  psychophysiology  sensory  repetitive behaviors Index. décimale : PER Périodiques Résumé : Parents frequently report that their children with autism spectrum disorders (ASD) respond atypically to sensory stimuli. Repetitive behaviors are also part of the ASD behavioral profile. Abnormal physiological arousal may underlie both of these symptoms. Electrodermal activity (EDA) is an index of sympathetic nervous system arousal. The goals of this study were twofold: (1) to pilot methods for collecting EDA data in young children and (2) to examine hypothesized relationships among EDA, and sensory symptoms and repetitive behaviors in children with ASD as compared with children with typical development. EDA was recorded on 54 young children with ASD and on 33 children with typical development (TD) during a protocol that included baseline, exposure to sensory and repetitive stimuli, and play. Parents completed standardized questionnaires regarding their child's sensory symptoms and repetitive behaviors. Frequency and type of repetitive behavior during play was coded offline. Comparisons between EDA data for ASD and TD groups indicated no significant between-group differences in any measures. Parents of children with ASD reported more abnormal responses to sensory stimuli and more repetitive behaviors, but scores on these measures were not significantly correlated with EDA or with frequency of observed repetitive behaviors. Parent report of frequency and severity of sensory symptoms was significantly correlated with reports of repetitive behaviors in both groups. Although parents of children with ASD report high levels of sensory symptoms and repetitive behaviors, these differences are not related to measured EDA arousal or reactivity. En ligne : http://dx.doi.org/10.1002/aur.1382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Electrodermal and Behavioral Responses of Children With Autism Spectrum Disorders to Sensory and Repetitive Stimuli [Texte imprimé et/ou numérique] / Carolyn MCCORMICK, Auteur ; David HESSL, Auteur ; Suzanne L. MACARI, Auteur ; Sally OZONOFF, Auteur ; Cherie C. GREEN, Auteur ; Sally J ROGERS, Auteur . - 2014 . - p.468-480. Langues : Anglais (eng) in Autism Research > 7-4 (August 2014) . - p.468-480 Mots-clés : autism spectrum disorder  psychophysiology  sensory  repetitive behaviors Index. décimale : PER Périodiques Résumé : Parents frequently report that their children with autism spectrum disorders (ASD) respond atypically to sensory stimuli. Repetitive behaviors are also part of the ASD behavioral profile. Abnormal physiological arousal may underlie both of these symptoms. Electrodermal activity (EDA) is an index of sympathetic nervous system arousal. The goals of this study were twofold: (1) to pilot methods for collecting EDA data in young children and (2) to examine hypothesized relationships among EDA, and sensory symptoms and repetitive behaviors in children with ASD as compared with children with typical development. EDA was recorded on 54 young children with ASD and on 33 children with typical development (TD) during a protocol that included baseline, exposure to sensory and repetitive stimuli, and play. Parents completed standardized questionnaires regarding their child's sensory symptoms and repetitive behaviors. Frequency and type of repetitive behavior during play was coded offline. Comparisons between EDA data for ASD and TD groups indicated no significant between-group differences in any measures. Parents of children with ASD reported more abnormal responses to sensory stimuli and more repetitive behaviors, but scores on these measures were not significantly correlated with EDA or with frequency of observed repetitive behaviors. Parent report of frequency and severity of sensory symptoms was significantly correlated with reports of repetitive behaviors in both groups. Although parents of children with ASD report high levels of sensory symptoms and repetitive behaviors, these differences are not related to measured EDA arousal or reactivity. En ligne : http://dx.doi.org/10.1002/aur.1382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

Gaze Response to Dyadic Bids at 2 Years Related to Outcomes at 3 Years in Autism Spectrum Disorders: A Subtyping Analysis / Daniel J. CAMPBELL in Journal of Autism and Developmental Disorders, 44-2 (February 2014)  

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Gross Motor Development, Movement Abnormalities, and Early Identification of Autism / Sally OZONOFF in Journal of Autism and Developmental Disorders, 38-4 (April 2008)  

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Predicting Developmental Status from 12 to 24 Months in Infants at Risk for Autism Spectrum Disorder: A Preliminary Report / Suzanne L. MACARI in Journal of Autism and Developmental Disorders, 42-12 (December 2012)  

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A prospective study of toddlers with ASD: short-term diagnostic and cognitive outcomes / Katarzyna CHAWARSKA in Journal of Child Psychology and Psychiatry, 50-10 (October 2009)  

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Temperamental markers in toddlers with autism spectrum disorder / Suzanne L. MACARI in Journal of Child Psychology and Psychiatry, 58-7 (July 2017)  

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