Corpus callosum area in children and adults with autism / Molly B. D. PRIGGE in Research in Autism Spectrum Disorders, 7-2 (February 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-2 (February 2013) . - p.221-234 Titre : Corpus callosum area in children and adults with autism Type de document : Texte imprimé et/ou numérique Auteurs : Molly B. D. PRIGGE, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Tricia L. MERKLEY, Auteur ; E. Shannon NEELEY, Auteur ; Tracy J. ABILDSKOV, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Caitlin RAVICHANDRAN, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2013 Article en page(s) : p.221-234 Langues : Anglais (eng) Mots-clés : Autism  Corpus callosum area  Development  MRI Index. décimale : PER Périodiques Résumé : Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with autism compared to a typically developing sample. Midsagittal corpus callosum area and the 7 Witelson subregions were examined in 68 males with autism (mean age 14.1 years; range 3'36 years) and 47 males with typical development (mean age 15.3 years; range 4'29 years). Controlling for total brain volume, increased variability in total corpus callosum area was found in autism. In autism, increased midsagittal areas were associated with reduced severity of autism behaviors, higher intelligence, and faster speed of processing (p = 0.003, p = 0.011, p = 0.013, respectively). A trend toward group differences in isthmus development was found (p = 0.029, uncorrected). These results suggest that individuals with autism benefit functionally from increased corpus callosum area. Our cross-sectional examination also shows potential maturational abnormalities in autism, a finding that should be examined further with longitudinal datasets. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.09.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 [article] Corpus callosum area in children and adults with autism [Texte imprimé et/ou numérique] / Molly B. D. PRIGGE, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Tricia L. MERKLEY, Auteur ; E. Shannon NEELEY, Auteur ; Tracy J. ABILDSKOV, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; Caitlin RAVICHANDRAN, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - 2013 . - p.221-234. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-2 (February 2013) . - p.221-234 Mots-clés : Autism  Corpus callosum area  Development  MRI Index. décimale : PER Périodiques Résumé : Despite repeated findings of abnormal corpus callosum structure in autism, the developmental trajectories of corpus callosum growth in the disorder have not yet been reported. In this study, we examined corpus callosum size from a developmental perspective across a 30-year age range in a large cross-sectional sample of individuals with autism compared to a typically developing sample. Midsagittal corpus callosum area and the 7 Witelson subregions were examined in 68 males with autism (mean age 14.1 years; range 3'36 years) and 47 males with typical development (mean age 15.3 years; range 4'29 years). Controlling for total brain volume, increased variability in total corpus callosum area was found in autism. In autism, increased midsagittal areas were associated with reduced severity of autism behaviors, higher intelligence, and faster speed of processing (p = 0.003, p = 0.011, p = 0.013, respectively). A trend toward group differences in isthmus development was found (p = 0.029, uncorrected). These results suggest that individuals with autism benefit functionally from increased corpus callosum area. Our cross-sectional examination also shows potential maturational abnormalities in autism, a finding that should be examined further with longitudinal datasets. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.09.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186

Intact prototype formation but impaired generalization in autism / A.H. FROEHLICH in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.921-930 Titre : Intact prototype formation but impaired generalization in autism Type de document : Texte imprimé et/ou numérique Auteurs : A.H. FROEHLICH, Auteur ; Jeffrey S. ANDERSON, Auteur ; Erin D. BIGLER, Auteur ; J. S. MILLER, Auteur ; N. T. LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; J. A. NIELSEN, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2012 Article en page(s) : p.921-930 Langues : Anglais (eng) Mots-clés : Prototype  Autism  Categorization  Recognition  Generalization  fMRI Index. décimale : PER Périodiques Résumé : Cognitive processing in autism has been characterized by a difficulty with the abstraction of information across multiple stimuli or situations and subsequent generalization to new stimuli or situations. This apparent difficulty leads to the suggestion that prototype formation, a process of creating a mental summary representation of multiple experienced stimuli that go together in a category, may be impaired in autism. Adults with high functioning autism and a typically developing comparison group matched on age and IQ completed a random dot pattern categorization task. Participants with autism demonstrated intact prototype formation in all four ways it was operationally defined, and this performance was not significantly different from that of control participants. However, participants with autism categorized dot patterns that were more highly distorted from the category prototypes less accurately than did control participants. These findings suggest, at least within the constraints of the random dot pattern task, that although prototype formation may not be impaired in autism, difficulties may exist with the generalization of what has been learned about a category to novel stimuli, particularly as they become less similar to the category's prototype. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150 [article] Intact prototype formation but impaired generalization in autism [Texte imprimé et/ou numérique] / A.H. FROEHLICH, Auteur ; Jeffrey S. ANDERSON, Auteur ; Erin D. BIGLER, Auteur ; J. S. MILLER, Auteur ; N. T. LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jason R. COOPERRIDER, Auteur ; Annahir N. CARIELLO, Auteur ; J. A. NIELSEN, Auteur ; Janet E. LAINHART, Auteur . - 2012 . - p.921-930. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.921-930 Mots-clés : Prototype  Autism  Categorization  Recognition  Generalization  fMRI Index. décimale : PER Périodiques Résumé : Cognitive processing in autism has been characterized by a difficulty with the abstraction of information across multiple stimuli or situations and subsequent generalization to new stimuli or situations. This apparent difficulty leads to the suggestion that prototype formation, a process of creating a mental summary representation of multiple experienced stimuli that go together in a category, may be impaired in autism. Adults with high functioning autism and a typically developing comparison group matched on age and IQ completed a random dot pattern categorization task. Participants with autism demonstrated intact prototype formation in all four ways it was operationally defined, and this performance was not significantly different from that of control participants. However, participants with autism categorized dot patterns that were more highly distorted from the category prototypes less accurately than did control participants. These findings suggest, at least within the constraints of the random dot pattern task, that although prototype formation may not be impaired in autism, difficulties may exist with the generalization of what has been learned about a category to novel stimuli, particularly as they become less similar to the category's prototype. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150

Spectroscopic Brain Imaging in Autism / Janet E. LAINHART

Public ISBD in Imaging the Brain in Autism / Manuel F. CASANOVA Titre : Spectroscopic Brain Imaging in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Janet E. LAINHART, Auteur ; Jason R. COOPERRIDER, Auteur ; June TAYLOR, Auteur Année de publication : 2013 Importance : p.231-288 Langues : Anglais (eng) Mots-clés : Spectroscopie Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 in Imaging the Brain in Autism / Manuel F. CASANOVA Spectroscopic Brain Imaging in Autism [Texte imprimé et/ou numérique] / Janet E. LAINHART, Auteur ; Jason R. COOPERRIDER, Auteur ; June TAYLOR, Auteur . - 2013 . - p.231-288. Langues : Anglais (eng) Mots-clés : Spectroscopie Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

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