Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development / Lisa A. CROEN in Autism Research, 12-1 (January 2019)  

Public ISBD [article]  inAutism Research > 12-1 (January 2019) . - p.123-135 Titre : Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development Type de document : texte imprimé Auteurs : Lisa A. CROEN, Auteur ; Yinge QIAN, Auteur ; Paul ASHWOOD, Auteur ; Julie L. DANIELS, Auteur ; M. Daniele FALLIN, Auteur ; Diana SCHENDEL, Auteur ; Laura A. SCHIEVE, Auteur ; Alison B. SINGER, Auteur ; Ousseny ZERBO, Auteur Article en page(s) : p.123-135 Langues : Anglais (eng) Mots-clés : allergy  asthma  autism  autoimmune  pregnancy  prenatal Index. décimale : PER Périodiques Résumé : Numerous studies have reported immune system disturbances in individuals with autism and their family members; however, there is considerable variability in findings with respect to the specific immune conditions involved, their timing, and the family members affected and little understanding of variation by autism subphenotype. Using data from the Study to Explore Early Development (SEED), a multi-site case-control study of children born 2003-2006 in the United States, we examined the role of family history of autoimmune diseases, asthma, and allergies in autism spectrum disorder (ASD) as well as other developmental disorders (DD). We investigated maternal immune conditions during the pregnancy period, as well as lifetime history of these conditions in several family members (mother, father, siblings, and study child). Logistic regression analyses included 663 children with ASD, 984 children with DD, and 915 controls ascertained from the general population (POP). Maternal history of eczema/psoriasis and asthma was associated with a 20%-40% increased odds of both ASD and DD. Risk estimates varied by specific ASD subphenotypes in association with these exposures. In addition, children with ASD were more likely to have a history of psoriasis/eczema or allergies than POP controls. No association was observed for paternal history or family history of these immune conditions for either ASD or DD. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes, and further suggest that associations may differ by ASD phenotype of the child. Autism Research 2019, 12: 123-135. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multi-site study in the US-the Study to Explore Early Development-we found that women with a history of eczema/psoriasis and asthma are more likely to have children with ASD or DD. In addition, children with ASD are more likely to have a history of psoriasis/eczema or allergies than typically developing children. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes. En ligne : http://dx.doi.org/10.1002/aur.1979 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development [texte imprimé] / Lisa A. CROEN, Auteur ; Yinge QIAN, Auteur ; Paul ASHWOOD, Auteur ; Julie L. DANIELS, Auteur ; M. Daniele FALLIN, Auteur ; Diana SCHENDEL, Auteur ; Laura A. SCHIEVE, Auteur ; Alison B. SINGER, Auteur ; Ousseny ZERBO, Auteur . - p.123-135. Langues : Anglais (eng) in Autism Research > 12-1 (January 2019) . - p.123-135 Mots-clés : allergy  asthma  autism  autoimmune  pregnancy  prenatal Index. décimale : PER Périodiques Résumé : Numerous studies have reported immune system disturbances in individuals with autism and their family members; however, there is considerable variability in findings with respect to the specific immune conditions involved, their timing, and the family members affected and little understanding of variation by autism subphenotype. Using data from the Study to Explore Early Development (SEED), a multi-site case-control study of children born 2003-2006 in the United States, we examined the role of family history of autoimmune diseases, asthma, and allergies in autism spectrum disorder (ASD) as well as other developmental disorders (DD). We investigated maternal immune conditions during the pregnancy period, as well as lifetime history of these conditions in several family members (mother, father, siblings, and study child). Logistic regression analyses included 663 children with ASD, 984 children with DD, and 915 controls ascertained from the general population (POP). Maternal history of eczema/psoriasis and asthma was associated with a 20%-40% increased odds of both ASD and DD. Risk estimates varied by specific ASD subphenotypes in association with these exposures. In addition, children with ASD were more likely to have a history of psoriasis/eczema or allergies than POP controls. No association was observed for paternal history or family history of these immune conditions for either ASD or DD. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes, and further suggest that associations may differ by ASD phenotype of the child. Autism Research 2019, 12: 123-135. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multi-site study in the US-the Study to Explore Early Development-we found that women with a history of eczema/psoriasis and asthma are more likely to have children with ASD or DD. In addition, children with ASD are more likely to have a history of psoriasis/eczema or allergies than typically developing children. These data support a link between maternal and child immune conditions and adverse neurodevelopmental outcomes. En ligne : http://dx.doi.org/10.1002/aur.1979 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development / Lisa A. CROEN in Autism Research, 12-10 (October 2019)  

Public ISBD [article]  inAutism Research > 12-10 (October 2019) . - p.1551-1561 Titre : Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development Type de document : texte imprimé Auteurs : Lisa A. CROEN, Auteur ; Yinge QIAN, Auteur ; Paul ASHWOOD, Auteur ; Ousseny ZERBO, Auteur ; Diana SCHENDEL, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; M. Daniele FALLIN, Auteur ; Sebastien LEVY, Auteur ; Laura A. SCHIEVE, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Katherine R. SABOURIN, Auteur ; Jennifer L. AMES, Auteur Article en page(s) : p.1551-1561 Langues : Anglais (eng) Mots-clés : autism  developmental disorder  immune function  infection  neurodevelopment  prenatal Index. décimale : PER Périodiques Résumé : Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case-control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3-5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14-4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551-1561. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multisite study in the United States-the Study to Explore Early Development-we found that women who had an infection during the second trimester of pregnancy accompanied by a fever are more likely to have children with ASD. These findings suggest the possibility that only more severe infections accompanied by a robust inflammatory response increase the risk of ASD. En ligne : http://dx.doi.org/10.1002/aur.2175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development [texte imprimé] / Lisa A. CROEN, Auteur ; Yinge QIAN, Auteur ; Paul ASHWOOD, Auteur ; Ousseny ZERBO, Auteur ; Diana SCHENDEL, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; M. Daniele FALLIN, Auteur ; Sebastien LEVY, Auteur ; Laura A. SCHIEVE, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Katherine R. SABOURIN, Auteur ; Jennifer L. AMES, Auteur . - p.1551-1561. Langues : Anglais (eng) in Autism Research > 12-10 (October 2019) . - p.1551-1561 Mots-clés : autism  developmental disorder  immune function  infection  neurodevelopment  prenatal Index. décimale : PER Périodiques Résumé : Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case-control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3-5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14-4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551-1561. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Using data from a large multisite study in the United States-the Study to Explore Early Development-we found that women who had an infection during the second trimester of pregnancy accompanied by a fever are more likely to have children with ASD. These findings suggest the possibility that only more severe infections accompanied by a robust inflammatory response increase the risk of ASD. En ligne : http://dx.doi.org/10.1002/aur.2175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study / Ousseny ZERBO in Journal of Autism and Developmental Disorders, 43-1 (January 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.25-33 Titre : Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study Type de document : texte imprimé Auteurs : Ousseny ZERBO, Auteur ; Ana-Maria IOSIF, Auteur ; Cheryl K. WALKER, Auteur ; Sally OZONOFF, Auteur ; Robin L. HANSEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur Année de publication : 2013 Article en page(s) : p.25-33 Langues : Anglais (eng) Mots-clés : Maternal influenza  Fever  Autism  Anti-fever medication Index. décimale : PER Périodiques Résumé : We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99). En ligne : http://dx.doi.org/10.1007/s10803-012-1540-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 [article] Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study [texte imprimé] / Ousseny ZERBO, Auteur ; Ana-Maria IOSIF, Auteur ; Cheryl K. WALKER, Auteur ; Sally OZONOFF, Auteur ; Robin L. HANSEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - 2013 . - p.25-33. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.25-33 Mots-clés : Maternal influenza  Fever  Autism  Anti-fever medication Index. décimale : PER Périodiques Résumé : We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99). En ligne : http://dx.doi.org/10.1007/s10803-012-1540-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187

Maternal Infection During Pregnancy and Autism Spectrum Disorders / Ousseny ZERBO in Journal of Autism and Developmental Disorders, 45-12 (December 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4015-4025 Titre : Maternal Infection During Pregnancy and Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Ousseny ZERBO, Auteur ; Yinge QIAN, Auteur ; Cathleen YOSHIDA, Auteur ; Judith K. GRETHER, Auteur ; Judy VAN DE WATER, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.4015-4025 Langues : Anglais (eng) Mots-clés : Maternal infection  Pregnancy  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : We conducted a nested case–control study including 407 cases and 2,075 frequency matched controls to investigate the association between maternal infections during pregnancy and risk of autism spectrum disorders (ASD). Cases, controls, and maternal infections were ascertained from Kaiser Permanente Northern California clinical databases. No overall association between diagnoses of any maternal infection during pregnancy and ASD was observed [adjusted odds ratio (ORadj) = 1.15, 95 % confidence interval (CI) 0.92–1.43]. However, women with infections diagnosed during a hospital admission (ORadj = 1.48, 95 % CI 1.07–2.04), particularly bacterial infections (ORadj = 1.58, 95 % CI 1.06–2.37), were at increased risk of delivering a child with ASD. Multiple infections during pregnancy were associated with ASD (ORadj = 1.36, 95 % CI 1.05–1.78). En ligne : http://dx.doi.org/10.1007/s10803-013-2016-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274 [article] Maternal Infection During Pregnancy and Autism Spectrum Disorders [texte imprimé] / Ousseny ZERBO, Auteur ; Yinge QIAN, Auteur ; Cathleen YOSHIDA, Auteur ; Judith K. GRETHER, Auteur ; Judy VAN DE WATER, Auteur ; Lisa A. CROEN, Auteur . - p.4015-4025. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4015-4025 Mots-clés : Maternal infection  Pregnancy  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : We conducted a nested case–control study including 407 cases and 2,075 frequency matched controls to investigate the association between maternal infections during pregnancy and risk of autism spectrum disorders (ASD). Cases, controls, and maternal infections were ascertained from Kaiser Permanente Northern California clinical databases. No overall association between diagnoses of any maternal infection during pregnancy and ASD was observed [adjusted odds ratio (ORadj) = 1.15, 95 % confidence interval (CI) 0.92–1.43]. However, women with infections diagnosed during a hospital admission (ORadj = 1.48, 95 % CI 1.07–2.04), particularly bacterial infections (ORadj = 1.58, 95 % CI 1.06–2.37), were at increased risk of delivering a child with ASD. Multiple infections during pregnancy were associated with ASD (ORadj = 1.36, 95 % CI 1.05–1.78). En ligne : http://dx.doi.org/10.1007/s10803-013-2016-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274

A Study of Physician Knowledge and Experience with Autism in Adults in a Large Integrated Healthcare System / Ousseny ZERBO in Journal of Autism and Developmental Disorders, 45-12 (December 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4002-4014 Titre : A Study of Physician Knowledge and Experience with Autism in Adults in a Large Integrated Healthcare System Type de document : texte imprimé Auteurs : Ousseny ZERBO, Auteur ; Maria L. MASSOLO, Auteur ; Yinge QIAN, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2015 Article en page(s) : p.4002-4014 Langues : Anglais (eng) Mots-clés : Adults  Survey  Autism spectrum disorder  Healthcare providers  Knowledge Index. décimale : PER Périodiques Résumé : We conducted an online survey of adult health care providers at Kaiser Permanente Northern California and semi-structured interviews with a subset of physicians. The survey assessed providers’ ability to recognize autism spectrum disorder (ASD), asked them to rate their autism knowledge, comfort level in treating affected patients, and evaluated training and resource needs. 922 providers completed the survey (response rate 25.3 %), and 9 were interviewed by telephone regarding their autism training and experiences caring for patients with autism. Most providers reported lacking skills and tools to care for this adult patient population. A high proportion of adult providers were not aware that they had patients with ASD. These findings underscore the need to educate physicians caring for adults with ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2579-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] A Study of Physician Knowledge and Experience with Autism in Adults in a Large Integrated Healthcare System [texte imprimé] / Ousseny ZERBO, Auteur ; Maria L. MASSOLO, Auteur ; Yinge QIAN, Auteur ; Lisa A. CROEN, Auteur . - 2015 . - p.4002-4014. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4002-4014 Mots-clés : Adults  Survey  Autism spectrum disorder  Healthcare providers  Knowledge Index. décimale : PER Périodiques Résumé : We conducted an online survey of adult health care providers at Kaiser Permanente Northern California and semi-structured interviews with a subset of physicians. The survey assessed providers’ ability to recognize autism spectrum disorder (ASD), asked them to rate their autism knowledge, comfort level in treating affected patients, and evaluated training and resource needs. 922 providers completed the survey (response rate 25.3 %), and 9 were interviewed by telephone regarding their autism training and experiences caring for patients with autism. Most providers reported lacking skills and tools to care for this adult patient population. A high proportion of adult providers were not aware that they had patients with ASD. These findings underscore the need to educate physicians caring for adults with ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2579-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

The health status of adults on the autism spectrum / Lisa A. CROEN in Autism, 19-7 (October 2015)  

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