Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study / Ousseny ZERBO in Journal of Autism and Developmental Disorders, 43-1 (January 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.25-33 Titre : Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study Type de document : Texte imprimé et/ou numérique Auteurs : Ousseny ZERBO, Auteur ; Ana-Maria IOSIF, Auteur ; Cheryl K. WALKER, Auteur ; Sally OZONOFF, Auteur ; Robin L. HANSEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur Année de publication : 2013 Article en page(s) : p.25-33 Langues : Anglais (eng) Mots-clés : Maternal influenza  Fever  Autism  Anti-fever medication Index. décimale : PER Périodiques Résumé : We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99). En ligne : http://dx.doi.org/10.1007/s10803-012-1540-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 [article] Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study [Texte imprimé et/ou numérique] / Ousseny ZERBO, Auteur ; Ana-Maria IOSIF, Auteur ; Cheryl K. WALKER, Auteur ; Sally OZONOFF, Auteur ; Robin L. HANSEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - 2013 . - p.25-33. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.25-33 Mots-clés : Maternal influenza  Fever  Autism  Anti-fever medication Index. décimale : PER Périodiques Résumé : We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99). En ligne : http://dx.doi.org/10.1007/s10803-012-1540-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187

Maternal Infection During Pregnancy and Autism Spectrum Disorders / Ousseny ZERBO in Journal of Autism and Developmental Disorders, 45-12 (December 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4015-4025 Titre : Maternal Infection During Pregnancy and Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ousseny ZERBO, Auteur ; Yinge QIAN, Auteur ; Cathleen YOSHIDA, Auteur ; Judith K. GRETHER, Auteur ; Judy VAN DE WATER, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.4015-4025 Langues : Anglais (eng) Mots-clés : Maternal infection  Pregnancy  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : We conducted a nested case–control study including 407 cases and 2,075 frequency matched controls to investigate the association between maternal infections during pregnancy and risk of autism spectrum disorders (ASD). Cases, controls, and maternal infections were ascertained from Kaiser Permanente Northern California clinical databases. No overall association between diagnoses of any maternal infection during pregnancy and ASD was observed [adjusted odds ratio (ORadj) = 1.15, 95 % confidence interval (CI) 0.92–1.43]. However, women with infections diagnosed during a hospital admission (ORadj = 1.48, 95 % CI 1.07–2.04), particularly bacterial infections (ORadj = 1.58, 95 % CI 1.06–2.37), were at increased risk of delivering a child with ASD. Multiple infections during pregnancy were associated with ASD (ORadj = 1.36, 95 % CI 1.05–1.78). En ligne : http://dx.doi.org/10.1007/s10803-013-2016-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274 [article] Maternal Infection During Pregnancy and Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Ousseny ZERBO, Auteur ; Yinge QIAN, Auteur ; Cathleen YOSHIDA, Auteur ; Judith K. GRETHER, Auteur ; Judy VAN DE WATER, Auteur ; Lisa A. CROEN, Auteur . - p.4015-4025. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4015-4025 Mots-clés : Maternal infection  Pregnancy  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : We conducted a nested case–control study including 407 cases and 2,075 frequency matched controls to investigate the association between maternal infections during pregnancy and risk of autism spectrum disorders (ASD). Cases, controls, and maternal infections were ascertained from Kaiser Permanente Northern California clinical databases. No overall association between diagnoses of any maternal infection during pregnancy and ASD was observed [adjusted odds ratio (ORadj) = 1.15, 95 % confidence interval (CI) 0.92–1.43]. However, women with infections diagnosed during a hospital admission (ORadj = 1.48, 95 % CI 1.07–2.04), particularly bacterial infections (ORadj = 1.58, 95 % CI 1.06–2.37), were at increased risk of delivering a child with ASD. Multiple infections during pregnancy were associated with ASD (ORadj = 1.36, 95 % CI 1.05–1.78). En ligne : http://dx.doi.org/10.1007/s10803-013-2016-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=274

A Study of Physician Knowledge and Experience with Autism in Adults in a Large Integrated Healthcare System / Ousseny ZERBO in Journal of Autism and Developmental Disorders, 45-12 (December 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4002-4014 Titre : A Study of Physician Knowledge and Experience with Autism in Adults in a Large Integrated Healthcare System Type de document : Texte imprimé et/ou numérique Auteurs : Ousseny ZERBO, Auteur ; Maria L. MASSOLO, Auteur ; Yinge QIAN, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2015 Article en page(s) : p.4002-4014 Langues : Anglais (eng) Mots-clés : Adults  Survey  Autism spectrum disorder  Healthcare providers  Knowledge Index. décimale : PER Périodiques Résumé : We conducted an online survey of adult health care providers at Kaiser Permanente Northern California and semi-structured interviews with a subset of physicians. The survey assessed providers’ ability to recognize autism spectrum disorder (ASD), asked them to rate their autism knowledge, comfort level in treating affected patients, and evaluated training and resource needs. 922 providers completed the survey (response rate 25.3 %), and 9 were interviewed by telephone regarding their autism training and experiences caring for patients with autism. Most providers reported lacking skills and tools to care for this adult patient population. A high proportion of adult providers were not aware that they had patients with ASD. These findings underscore the need to educate physicians caring for adults with ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2579-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] A Study of Physician Knowledge and Experience with Autism in Adults in a Large Integrated Healthcare System [Texte imprimé et/ou numérique] / Ousseny ZERBO, Auteur ; Maria L. MASSOLO, Auteur ; Yinge QIAN, Auteur ; Lisa A. CROEN, Auteur . - 2015 . - p.4002-4014. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-12 (December 2015) . - p.4002-4014 Mots-clés : Adults  Survey  Autism spectrum disorder  Healthcare providers  Knowledge Index. décimale : PER Périodiques Résumé : We conducted an online survey of adult health care providers at Kaiser Permanente Northern California and semi-structured interviews with a subset of physicians. The survey assessed providers’ ability to recognize autism spectrum disorder (ASD), asked them to rate their autism knowledge, comfort level in treating affected patients, and evaluated training and resource needs. 922 providers completed the survey (response rate 25.3 %), and 9 were interviewed by telephone regarding their autism training and experiences caring for patients with autism. Most providers reported lacking skills and tools to care for this adult patient population. A high proportion of adult providers were not aware that they had patients with ASD. These findings underscore the need to educate physicians caring for adults with ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2579-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

The health status of adults on the autism spectrum / Lisa A. CROEN in Autism, 19-7 (October 2015)  

Public ISBD [article]  inAutism > 19-7 (October 2015) . - p.814-823 Titre : The health status of adults on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Lisa A. CROEN, Auteur ; Ousseny ZERBO, Auteur ; Yinge QIAN, Auteur ; Maria L. MASSOLO, Auteur ; Steve RICH, Auteur ; Stephen SIDNEY, Auteur ; Clarissa KRIPKE, Auteur Année de publication : 2015 Article en page(s) : p.814-823 Langues : Anglais (eng) Mots-clés : adults  autism spectrum disorders  medical comorbidity  psychiatric comorbidity Index. décimale : PER Périodiques Résumé : Compared to the general pediatric population, children with autism have higher rates of co-occurring medical and psychiatric illnesses, yet very little is known about the general health status of adults with autism. The objective of this study was to describe the frequency of psychiatric and medical conditions among a large, diverse, insured population of adults with autism in the United States. Participants were adult members of Kaiser Permanente Northern California enrolled from 2008 to 2012. Autism spectrum disorder cases (N?=?1507) were adults with autism spectrum disorder diagnoses (International Classification of Diseases-9-Clinical Modification codes 299.0, 299.8, 299.9) recorded in medical records on at least two separate occasions. Controls (N?=?15,070) were adults without any autism spectrum disorder diagnoses sampled at a 10:1 ratio and frequency matched to cases on sex and age. Adults with autism had significantly increased rates of all major psychiatric disorders including depression, anxiety, bipolar disorder, obsessive–compulsive disorder, schizophrenia, and suicide attempts. Nearly all medical conditions were significantly more common in adults with autism, including immune conditions, gastrointestinal and sleep disorders, seizure, obesity, dyslipidemia, hypertension, and diabetes. Rarer conditions, such as stroke and Parkinson’s disease, were also significantly more common among adults with autism. Future research is needed to understand the social, healthcare access, and biological factors underlying these observations. En ligne : http://dx.doi.org/10.1177/1362361315577517 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269 [article] The health status of adults on the autism spectrum [Texte imprimé et/ou numérique] / Lisa A. CROEN, Auteur ; Ousseny ZERBO, Auteur ; Yinge QIAN, Auteur ; Maria L. MASSOLO, Auteur ; Steve RICH, Auteur ; Stephen SIDNEY, Auteur ; Clarissa KRIPKE, Auteur . - 2015 . - p.814-823. Langues : Anglais (eng) in Autism > 19-7 (October 2015) . - p.814-823 Mots-clés : adults  autism spectrum disorders  medical comorbidity  psychiatric comorbidity Index. décimale : PER Périodiques Résumé : Compared to the general pediatric population, children with autism have higher rates of co-occurring medical and psychiatric illnesses, yet very little is known about the general health status of adults with autism. The objective of this study was to describe the frequency of psychiatric and medical conditions among a large, diverse, insured population of adults with autism in the United States. Participants were adult members of Kaiser Permanente Northern California enrolled from 2008 to 2012. Autism spectrum disorder cases (N?=?1507) were adults with autism spectrum disorder diagnoses (International Classification of Diseases-9-Clinical Modification codes 299.0, 299.8, 299.9) recorded in medical records on at least two separate occasions. Controls (N?=?15,070) were adults without any autism spectrum disorder diagnoses sampled at a 10:1 ratio and frequency matched to cases on sex and age. Adults with autism had significantly increased rates of all major psychiatric disorders including depression, anxiety, bipolar disorder, obsessive–compulsive disorder, schizophrenia, and suicide attempts. Nearly all medical conditions were significantly more common in adults with autism, including immune conditions, gastrointestinal and sleep disorders, seizure, obesity, dyslipidemia, hypertension, and diabetes. Rarer conditions, such as stroke and Parkinson’s disease, were also significantly more common among adults with autism. Future research is needed to understand the social, healthcare access, and biological factors underlying these observations. En ligne : http://dx.doi.org/10.1177/1362361315577517 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269

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