Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders / Bradley P. ANDER in Molecular Autism, (June 2015)  

Public ISBD [article]  inMolecular Autism > (June 2015) . - p.1-13 Titre : Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders Type de document : texte imprimé Auteurs : Bradley P. ANDER, Auteur ; Nicole BARGER, Auteur ; Boryana STAMOVA, Auteur ; Frank R. SHARP, Auteur ; Cynthia M. SCHUMANN, Auteur Article en page(s) : p.1-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) likely involve dysregulation of multiple genes related to brain function and development. Abnormalities in individual regulatory small non-coding RNA (sncRNA), including microRNA (miRNA), could have profound effects upon multiple functional pathways. We assessed whether a brain region associated with core social impairments in ASD, the superior temporal sulcus (STS), would evidence greater transcriptional dysregulation of sncRNA than adjacent, yet functionally distinct, primary auditory cortex (PAC). En ligne : http://dx.doi.org/10.1186/s13229-015-0029-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders [texte imprimé] / Bradley P. ANDER, Auteur ; Nicole BARGER, Auteur ; Boryana STAMOVA, Auteur ; Frank R. SHARP, Auteur ; Cynthia M. SCHUMANN, Auteur . - p.1-13. Langues : Anglais (eng) in Molecular Autism > (June 2015) . - p.1-13 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) likely involve dysregulation of multiple genes related to brain function and development. Abnormalities in individual regulatory small non-coding RNA (sncRNA), including microRNA (miRNA), could have profound effects upon multiple functional pathways. We assessed whether a brain region associated with core social impairments in ASD, the superior temporal sulcus (STS), would evidence greater transcriptional dysregulation of sncRNA than adjacent, yet functionally distinct, primary auditory cortex (PAC). En ligne : http://dx.doi.org/10.1186/s13229-015-0029-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders / Boryana STAMOVA in Molecular Autism, (September 2013)  

Public ISBD [article]  inMolecular Autism > (September 2013) Titre : Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders Type de document : texte imprimé Auteurs : Boryana STAMOVA, Auteur ; Yingfang TIAN, Auteur ; Christine W. NORDAHL, Auteur ; Mark SHEN, Auteur ; Sally J. ROGERS, Auteur ; David G. AMARAL, Auteur ; Frank SHARP, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Since RNA expression differences have been reported in autism spectrum disorder (ASD) for blood and brain, and differential alternative splicing (DAS) has been reported in ASD brains, we determined if there was DAS in blood mRNA of ASD subjects compared to typically developing (TD) controls, as well as in ASD subgroups related to cerebral volume. RNA from blood was processed on whole genome exon arrays for 2-4-year-old ASD and TD boys. An ANCOVA with age and batch as covariates was used to predict DAS for ALL ASD (n=30), ASD with normal total cerebral volumes (NTCV), and ASD with large total cerebral volumes (LTCV) compared to TD controls (n=20). A total of 53 genes were predicted to have DAS for ALL ASD versus TD, 169 genes for ASD_NTCV versus TD, 1 gene for ASD_LTCV versus TD, and 27 genes for ASD_LTCV versus ASD_NTCV. These differences were significant at P 0.05 after false discovery rate corrections for multiple comparisons (FDR 5% false positives). A number of the genes predicted to have DAS in ASD are known to regulate DAS (SFPQ, SRPK1, SRSF11, SRSF2IP, FUS, LSM14A). In addition, a number of genes with predicted DAS are involved in pathways implicated in previous ASD studies, such as ROS monocyte/macrophage, Natural Killer Cell, mTOR, and NGF signaling. The only pathways significant after multiple comparison corrections (FDR 0.05) were the Nrf2-mediated reactive oxygen species (ROS) oxidative response (superoxide dismutase 2, catalase, peroxiredoxin 1, PIK3C3, DNAJC17, microsomal glutathione S-transferase 3) and superoxide radical degradation (SOD2, CAT). These data support differences in alternative splicing of mRNA in blood of ASD subjects compared to TD controls that differ related to head size. The findings are preliminary, need to be replicated in independent cohorts, and predicted alternative splicing differences need to be confirmed using direct analytical methods. En ligne : http://dx.doi.org/10.1186/2040-2392-4-30 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders [texte imprimé] / Boryana STAMOVA, Auteur ; Yingfang TIAN, Auteur ; Christine W. NORDAHL, Auteur ; Mark SHEN, Auteur ; Sally J. ROGERS, Auteur ; David G. AMARAL, Auteur ; Frank SHARP, Auteur. Langues : Anglais (eng) in Molecular Autism > (September 2013) Index. décimale : PER Périodiques Résumé : Since RNA expression differences have been reported in autism spectrum disorder (ASD) for blood and brain, and differential alternative splicing (DAS) has been reported in ASD brains, we determined if there was DAS in blood mRNA of ASD subjects compared to typically developing (TD) controls, as well as in ASD subgroups related to cerebral volume. RNA from blood was processed on whole genome exon arrays for 2-4-year-old ASD and TD boys. An ANCOVA with age and batch as covariates was used to predict DAS for ALL ASD (n=30), ASD with normal total cerebral volumes (NTCV), and ASD with large total cerebral volumes (LTCV) compared to TD controls (n=20). A total of 53 genes were predicted to have DAS for ALL ASD versus TD, 169 genes for ASD_NTCV versus TD, 1 gene for ASD_LTCV versus TD, and 27 genes for ASD_LTCV versus ASD_NTCV. These differences were significant at P 0.05 after false discovery rate corrections for multiple comparisons (FDR 5% false positives). A number of the genes predicted to have DAS in ASD are known to regulate DAS (SFPQ, SRPK1, SRSF11, SRSF2IP, FUS, LSM14A). In addition, a number of genes with predicted DAS are involved in pathways implicated in previous ASD studies, such as ROS monocyte/macrophage, Natural Killer Cell, mTOR, and NGF signaling. The only pathways significant after multiple comparison corrections (FDR 0.05) were the Nrf2-mediated reactive oxygen species (ROS) oxidative response (superoxide dismutase 2, catalase, peroxiredoxin 1, PIK3C3, DNAJC17, microsomal glutathione S-transferase 3) and superoxide radical degradation (SOD2, CAT). These data support differences in alternative splicing of mRNA in blood of ASD subjects compared to TD controls that differ related to head size. The findings are preliminary, need to be replicated in independent cohorts, and predicted alternative splicing differences need to be confirmed using direct analytical methods. En ligne : http://dx.doi.org/10.1186/2040-2392-4-30 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain / Cynthia M. SCHUMANN in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 4p. Titre : Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain Type de document : texte imprimé Auteurs : Cynthia M. SCHUMANN, Auteur ; Frank R. SHARP, Auteur ; Bradley P. ANDER, Auteur ; Boryana STAMOVA, Auteur Article en page(s) : 4p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/*genetics  Child  Child, Preschool  Female  Gene Expression Profiling/*methods  Gene Expression Regulation  Humans  Male  MicroRNAs/*genetics  Middle Aged  Oligonucleotide Array Sequence Analysis/*methods  RNA, Small Untranslated/*genetics  Sex Characteristics  Young Adult  *Auditory cortex  *Autism  *Myelin  *Oligodendrocytes  *Postmortem human brain  *Sex  *Sexual dimorphism  *Superior Temporal Sulcus  *miR-125  *miR-181  *miR-219  *miR-338  *miR-448  *microRNA  *small noncoding RNA Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is sexually dimorphic in brain structure, genetics, and behaviors. In studies of brain tissue, the age of the population is clearly a factor in interpreting study outcome, yet sex is rarely considered. To begin to address this issue, we extend our previously published microarray analyses to examine expression of small noncoding RNAs (sncRNAs), including microRNAs (miRNAs), in ASD and in the control temporal cortex in males and females. Predicted miRNA targets were identified as well as the pathways they overpopulate. FINDINGS: After considering age, sexual dimorphism in ASD sncRNA expression persists in the temporal cortex and in the patterning that distinguishes regions. Among the sexually dimorphic miRNAs are miR-219 and miR-338, which promote oligodendrocyte differentiation, miR-125, implicated in neuronal differentiation, and miR-488, implicated in anxiety. Putative miRNA targets are significantly over-represented in immune and nervous system pathways in both sexes, consistent with previous mRNA studies. Even for common pathways, the specific target mRNAs are often sexually dimorphic. For example, both male and female target genes significantly populate the Axonal Guidance Signaling pathway, yet less than a third of the targets are common to both sexes. CONCLUSIONS: Our findings of sexual dimorphism in sncRNA levels underscore the importance of considering sex, in addition to age, when interpreting molecular findings on ASD brain. En ligne : http://dx.doi.org/10.1186/s13229-017-0117-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 [article] Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain [texte imprimé] / Cynthia M. SCHUMANN, Auteur ; Frank R. SHARP, Auteur ; Bradley P. ANDER, Auteur ; Boryana STAMOVA, Auteur . - 4p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 4p. Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/*genetics  Child  Child, Preschool  Female  Gene Expression Profiling/*methods  Gene Expression Regulation  Humans  Male  MicroRNAs/*genetics  Middle Aged  Oligonucleotide Array Sequence Analysis/*methods  RNA, Small Untranslated/*genetics  Sex Characteristics  Young Adult  *Auditory cortex  *Autism  *Myelin  *Oligodendrocytes  *Postmortem human brain  *Sex  *Sexual dimorphism  *Superior Temporal Sulcus  *miR-125  *miR-181  *miR-219  *miR-338  *miR-448  *microRNA  *small noncoding RNA Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is sexually dimorphic in brain structure, genetics, and behaviors. In studies of brain tissue, the age of the population is clearly a factor in interpreting study outcome, yet sex is rarely considered. To begin to address this issue, we extend our previously published microarray analyses to examine expression of small noncoding RNAs (sncRNAs), including microRNAs (miRNAs), in ASD and in the control temporal cortex in males and females. Predicted miRNA targets were identified as well as the pathways they overpopulate. FINDINGS: After considering age, sexual dimorphism in ASD sncRNA expression persists in the temporal cortex and in the patterning that distinguishes regions. Among the sexually dimorphic miRNAs are miR-219 and miR-338, which promote oligodendrocyte differentiation, miR-125, implicated in neuronal differentiation, and miR-488, implicated in anxiety. Putative miRNA targets are significantly over-represented in immune and nervous system pathways in both sexes, consistent with previous mRNA studies. Even for common pathways, the specific target mRNAs are often sexually dimorphic. For example, both male and female target genes significantly populate the Axonal Guidance Signaling pathway, yet less than a third of the targets are common to both sexes. CONCLUSIONS: Our findings of sexual dimorphism in sncRNA levels underscore the importance of considering sex, in addition to age, when interpreting molecular findings on ASD brain. En ligne : http://dx.doi.org/10.1186/s13229-017-0117-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331

Tourette syndrome, tic disorders, and comorbidities / Joan R. GUNTHER

Public ISBD in Autism and Other Neurodevelopmental Disorders / Robin L. HANSEN Titre : Tourette syndrome, tic disorders, and comorbidities Type de document : texte imprimé Auteurs : Joan R. GUNTHER, Auteur ; Frank R. SHARP, Auteur Année de publication : 2013 Importance : p.103-125 Langues : Anglais (eng) Index. décimale : TRO-F TRO-F - Autres Troubles Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190 in Autism and Other Neurodevelopmental Disorders / Robin L. HANSEN Tourette syndrome, tic disorders, and comorbidities [texte imprimé] / Joan R. GUNTHER, Auteur ; Frank R. SHARP, Auteur . - 2013 . - p.103-125. Langues : Anglais (eng) Index. décimale : TRO-F TRO-F - Autres Troubles Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190

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