Autism and lack of D3 vitamin: A systematic review / G. PIOGGIA in Research in Autism Spectrum Disorders, 8-12 (December 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1685-1698 Titre : Autism and lack of D3 vitamin: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : G. PIOGGIA, Auteur ; A. TONACCI, Auteur ; G. TARTARISCO, Auteur ; Lucia BILLECI, Auteur ; F. MURATORI, Auteur ; L. RUTA, Auteur ; S. GANGEMI, Auteur Article en page(s) : p.1685-1698 Langues : Anglais (eng) Mots-clés : Autism  Autoimmune disease  Brain function  Cholecalciferol  Neurodevelopmental disorders  Vitamin D3 Index. décimale : PER Périodiques Résumé : Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication deficits and restricted, repetitive patterns of behavior. Several medical conditions including gastrointestinal (GI) problems, asthma and allergies have been associated with ASD, and multiple risk factors, both genetic and environmental, have been proposed. Among them, vitamin D (VD) deficiency is probably associated with ASD, and may play a role in the condition. We conducted a systematic review of the literature for the period January 1, 2010 through June 15, 2014, according to PRISMA guidelines, aiming to investigate the complex biological interplay between VD, metabolism, immune system and nervous system in ASD. Different trends in the association between ASD and VD deficiency have been observed, and factors such as gender, ethnicity, sampling, and methodology play a role in the results and outcomes. At present, for at least a subgroup of ASD individuals, an imbalance in VD metabolism probably exists and may be associated with the condition. In this cohort, VD replacement in these individuals might contribute to improving ASD symptoms and/or associated conditions. This topic is an important challenge for future research, and could lead to a new tailored therapeutic approach for VD in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Autism and lack of D3 vitamin: A systematic review [Texte imprimé et/ou numérique] / G. PIOGGIA, Auteur ; A. TONACCI, Auteur ; G. TARTARISCO, Auteur ; Lucia BILLECI, Auteur ; F. MURATORI, Auteur ; L. RUTA, Auteur ; S. GANGEMI, Auteur . - p.1685-1698. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1685-1698 Mots-clés : Autism  Autoimmune disease  Brain function  Cholecalciferol  Neurodevelopmental disorders  Vitamin D3 Index. décimale : PER Périodiques Résumé : Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication deficits and restricted, repetitive patterns of behavior. Several medical conditions including gastrointestinal (GI) problems, asthma and allergies have been associated with ASD, and multiple risk factors, both genetic and environmental, have been proposed. Among them, vitamin D (VD) deficiency is probably associated with ASD, and may play a role in the condition. We conducted a systematic review of the literature for the period January 1, 2010 through June 15, 2014, according to PRISMA guidelines, aiming to investigate the complex biological interplay between VD, metabolism, immune system and nervous system in ASD. Different trends in the association between ASD and VD deficiency have been observed, and factors such as gender, ethnicity, sampling, and methodology play a role in the results and outcomes. At present, for at least a subgroup of ASD individuals, an imbalance in VD metabolism probably exists and may be associated with the condition. In this cohort, VD replacement in these individuals might contribute to improving ASD symptoms and/or associated conditions. This topic is an important challenge for future research, and could lead to a new tailored therapeutic approach for VD in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Autism and social robotics: A systematic review / Paola PENNISI in Autism Research, 9-2 (February 2016)  

Public ISBD [article]  inAutism Research > 9-2 (February 2016) . - p.165-183 Titre : Autism and social robotics: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Paola PENNISI, Auteur ; Alessandro TONACCI, Auteur ; Gennaro TARTARISCO, Auteur ; Lucia BILLECI, Auteur ; Liliana RUTA, Auteur ; Sebastiano GANGEMI, Auteur ; Giovanni PIOGGIA, Auteur Article en page(s) : p.165-183 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  social robotics  autism therapy  humanoid robots  autism diagnosis Index. décimale : PER Périodiques Résumé : Social robotics could be a promising method for Autism Spectrum Disorders (ASD) treatment. The aim of this article is to carry out a systematic literature review of the studies on this topic that were published in the last 10 years. We tried to address the following questions: can social robots be a useful tool in autism therapy? We followed the PRISMA guidelines, and the protocol was registered within PROSPERO database (CRD42015016158). We found many positive implications in the use of social robots in therapy as for example: ASD subjects often performed better with a robot partner rather than a human partner; sometimes, ASD patients had, toward robots, behaviors that TD patients had toward human agents; ASDs had a lot of social behaviors toward robots; during robotic sessions, ASDs showed reduced repetitive and stereotyped behaviors and, social robots manage to improve spontaneous language during therapy sessions. Therefore, robots provide therapists and researchers a means to connect with autistic subjects in an easier way, but studies in this area are still insufficient. It is necessary to clarify whether sex, intelligence quotient, and age of participants affect the outcome of therapy and whether any beneficial effects only occur during the robotic session or if they are still observable outside the clinical/experimental context. En ligne : http://dx.doi.org/10.1002/aur.1527 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Autism and social robotics: A systematic review [Texte imprimé et/ou numérique] / Paola PENNISI, Auteur ; Alessandro TONACCI, Auteur ; Gennaro TARTARISCO, Auteur ; Lucia BILLECI, Auteur ; Liliana RUTA, Auteur ; Sebastiano GANGEMI, Auteur ; Giovanni PIOGGIA, Auteur . - p.165-183. Langues : Anglais (eng) in Autism Research > 9-2 (February 2016) . - p.165-183 Mots-clés : autism spectrum disorder  social robotics  autism therapy  humanoid robots  autism diagnosis Index. décimale : PER Périodiques Résumé : Social robotics could be a promising method for Autism Spectrum Disorders (ASD) treatment. The aim of this article is to carry out a systematic literature review of the studies on this topic that were published in the last 10 years. We tried to address the following questions: can social robots be a useful tool in autism therapy? We followed the PRISMA guidelines, and the protocol was registered within PROSPERO database (CRD42015016158). We found many positive implications in the use of social robots in therapy as for example: ASD subjects often performed better with a robot partner rather than a human partner; sometimes, ASD patients had, toward robots, behaviors that TD patients had toward human agents; ASDs had a lot of social behaviors toward robots; during robotic sessions, ASDs showed reduced repetitive and stereotyped behaviors and, social robots manage to improve spontaneous language during therapy sessions. Therefore, robots provide therapists and researchers a means to connect with autistic subjects in an easier way, but studies in this area are still insufficient. It is necessary to clarify whether sex, intelligence quotient, and age of participants affect the outcome of therapy and whether any beneficial effects only occur during the robotic session or if they are still observable outside the clinical/experimental context. En ligne : http://dx.doi.org/10.1002/aur.1527 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Erratum to: Olfactory Processing in Male Children with Autism: Atypical Odor Threshold and Identification / Filippo MURATORI in Journal of Autism and Developmental Disorders, 47-10 (October 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-10 (October 2017) . - p.3252-3252 Titre : Erratum to: Olfactory Processing in Male Children with Autism: Atypical Odor Threshold and Identification Type de document : Texte imprimé et/ou numérique Auteurs : Filippo MURATORI, Auteur ; Alessandro TONACCI, Auteur ; Lucia BILLECI, Auteur ; Tiziana CATALUCCI, Auteur ; Roberta IGLIOZZI, Auteur ; Sara CALDERONI, Auteur ; Antonio NARZISI, Auteur Article en page(s) : p.3252-3252 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-017-3291-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319 [article] Erratum to: Olfactory Processing in Male Children with Autism: Atypical Odor Threshold and Identification [Texte imprimé et/ou numérique] / Filippo MURATORI, Auteur ; Alessandro TONACCI, Auteur ; Lucia BILLECI, Auteur ; Tiziana CATALUCCI, Auteur ; Roberta IGLIOZZI, Auteur ; Sara CALDERONI, Auteur ; Antonio NARZISI, Auteur . - p.3252-3252. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-10 (October 2017) . - p.3252-3252 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-017-3291-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319

Olfactory Processing in Male Children with Autism: Atypical Odor Threshold and Identification / Filippo MURATORI in Journal of Autism and Developmental Disorders, 47-10 (October 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-10 (October 2017) . - p.3243-3251 Titre : Olfactory Processing in Male Children with Autism: Atypical Odor Threshold and Identification Type de document : Texte imprimé et/ou numérique Auteurs : Filippo MURATORI, Auteur ; Alessandro TONACCI, Auteur ; Lucia BILLECI, Auteur ; Tiziana CATALUCCI, Auteur ; Roberta IGLIOZZI, Auteur ; Sara CALDERONI, Auteur ; Antonio NARZISI, Auteur Article en page(s) : p.3243-3251 Langues : Anglais (eng) Mots-clés : Autism  Sensory processing  Olfactory functioning  Hypo-priors hypothesis Index. décimale : PER Périodiques Résumé : Sensory issues are of great interest in ASD diagnosis. However, their investigation is mainly based on external observation (parent reports), with methodological limitations. Unobtrusive olfactory assessment allows studying autism neurosensoriality. Here, 20 male children with high-functioning ASD and 20 matched controls were administered a complete olfactory test battery, assessing olfactory threshold, identification and discrimination. ASD children show lower sensitivity (p?=?0.041), lower identification (p?=?0.014), and intact odor discrimination (p?=?0.199) than controls. Comparing olfactory and clinical scores, a significant correlation was found in ASD between olfactory threshold and the CBCL social problems (p?=?0.011) and aggressive behavior (p?=?0.012) sub-scales. The pattern featuring peripheral hyposensitivity, high-order difficulties in odor identification and regular subcortical odor discrimination is discussed in light of hypo-priors hypothesis for autism. En ligne : https://doi.org/10.1007/s10803-017-3250-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319 [article] Olfactory Processing in Male Children with Autism: Atypical Odor Threshold and Identification [Texte imprimé et/ou numérique] / Filippo MURATORI, Auteur ; Alessandro TONACCI, Auteur ; Lucia BILLECI, Auteur ; Tiziana CATALUCCI, Auteur ; Roberta IGLIOZZI, Auteur ; Sara CALDERONI, Auteur ; Antonio NARZISI, Auteur . - p.3243-3251. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-10 (October 2017) . - p.3243-3251 Mots-clés : Autism  Sensory processing  Olfactory functioning  Hypo-priors hypothesis Index. décimale : PER Périodiques Résumé : Sensory issues are of great interest in ASD diagnosis. However, their investigation is mainly based on external observation (parent reports), with methodological limitations. Unobtrusive olfactory assessment allows studying autism neurosensoriality. Here, 20 male children with high-functioning ASD and 20 matched controls were administered a complete olfactory test battery, assessing olfactory threshold, identification and discrimination. ASD children show lower sensitivity (p?=?0.041), lower identification (p?=?0.014), and intact odor discrimination (p?=?0.199) than controls. Comparing olfactory and clinical scores, a significant correlation was found in ASD between olfactory threshold and the CBCL social problems (p?=?0.011) and aggressive behavior (p?=?0.012) sub-scales. The pattern featuring peripheral hyposensitivity, high-order difficulties in odor identification and regular subcortical odor discrimination is discussed in light of hypo-priors hypothesis for autism. En ligne : https://doi.org/10.1007/s10803-017-3250-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319

A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism / Lucia BILLECI in Autism, 27-1 (January 2023)  

Public ISBD [article]  inAutism > 27-1 (January 2023) . - p.117-132 Titre : A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism Type de document : Texte imprimé et/ou numérique Auteurs : Lucia BILLECI, Auteur ; Alejandro Luis CALLARA, Auteur ; Letizia GUIDUCCI, Auteur ; Margherita PROSPERI, Auteur ; Maria Aurora MORALES, Auteur ; Sara CALDERONI, Auteur ; Filippo MURATORI, Auteur ; Elisa SANTOCCHI, Auteur Article en page(s) : p.117-132 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  clinical trial  EEG  preschoolers  probiotics Index. décimale : PER Périodiques Résumé : Previous studies suggest that autism spectrum disorders are characterized by alterations in the microbiota-gut-brain axis. Probiotics may modify the composition and the functionality of the gut microbiota of autism spectrum disorder individuals, with possible cascading effects on brain function. In this study, we analyzed possible brain modifications induced by the administration of probiotics in 46 children with autism spectrum disorder using electroencephalography. A randomized 6-month controlled trial was performed. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. Lay abstract This study investigates the effects of a probiotic on preschoolers’ brain electrical activity with autism spectrum disorder. Autism is a disorder with an increasing prevalence characterized by an enormous individual, family, and social cost. Although the etiology of autism spectrum disorder is unknown, an interaction between genetic and environmental factors is implicated, converging in altered brain synaptogenesis and, therefore, connectivity. Besides deepening the knowledge on the resting brain electrical activity that characterizes this disorder, this study allows analyzing the positive central effects of a 6-month therapy with a probiotic through a randomized, double-blind placebo-controlled study and the correlations between electroencephalography activity and biochemical and clinical parameters. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. En ligne : http://dx.doi.org/10.1177/13623613221082710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism [Texte imprimé et/ou numérique] / Lucia BILLECI, Auteur ; Alejandro Luis CALLARA, Auteur ; Letizia GUIDUCCI, Auteur ; Margherita PROSPERI, Auteur ; Maria Aurora MORALES, Auteur ; Sara CALDERONI, Auteur ; Filippo MURATORI, Auteur ; Elisa SANTOCCHI, Auteur . - p.117-132. Langues : Anglais (eng) in Autism > 27-1 (January 2023) . - p.117-132 Mots-clés : autism spectrum disorder  clinical trial  EEG  preschoolers  probiotics Index. décimale : PER Périodiques Résumé : Previous studies suggest that autism spectrum disorders are characterized by alterations in the microbiota-gut-brain axis. Probiotics may modify the composition and the functionality of the gut microbiota of autism spectrum disorder individuals, with possible cascading effects on brain function. In this study, we analyzed possible brain modifications induced by the administration of probiotics in 46 children with autism spectrum disorder using electroencephalography. A randomized 6-month controlled trial was performed. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. Lay abstract This study investigates the effects of a probiotic on preschoolers’ brain electrical activity with autism spectrum disorder. Autism is a disorder with an increasing prevalence characterized by an enormous individual, family, and social cost. Although the etiology of autism spectrum disorder is unknown, an interaction between genetic and environmental factors is implicated, converging in altered brain synaptogenesis and, therefore, connectivity. Besides deepening the knowledge on the resting brain electrical activity that characterizes this disorder, this study allows analyzing the positive central effects of a 6-month therapy with a probiotic through a randomized, double-blind placebo-controlled study and the correlations between electroencephalography activity and biochemical and clinical parameters. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. En ligne : http://dx.doi.org/10.1177/13623613221082710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Reciprocity in Interaction: A Window on the First Year of Life in Autism / Fabio APICELLA in Autism Research and Treatment, (April 2013)  

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