Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? / P. Cédric M. P. KOOLSCHIJN in Journal of Autism and Developmental Disorders, 45-9 (September 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.2779-2791 Titre : Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? Type de document : Texte imprimé et/ou numérique Auteurs : P. Cédric M. P. KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur ; Andries R. VAN DER LEIJ, Auteur ; H. Steven SCHOLTE, Auteur Article en page(s) : p.2779-2791 Langues : Anglais (eng) Mots-clés : Autistic traits  Gray matter volume  Cortical thickness  Surface area  Diffusion tensor imaging  Autism Index. décimale : PER Périodiques Résumé : There is accumulating evidence that autistic-related traits in the general population lie on a continuum, with autism spectrum disorders representing the extreme end of this distribution. Here, we tested the hypothesis of a possible relationship between autistic traits and brain morphometry in the general population. Participants completed the short autism-spectrum quotient-questionnaire (AQ); T1-anatomical and DWI-scans were acquired. Associations between autistic traits and gray matter, and white matter microstructural-integrity were performed on the exploration-group (N = 204; 105 males, M-age = 22.85), and validated in the validation-group (N = 304; 155 males, M-age = 22.82). No significant associations were found between AQ-scores and brain morphometry in the exploration-group, or after pooling the data. This questions the assumption that autistic traits and their morphological associations do lie on a continuum in the general population. En ligne : http://dx.doi.org/10.1007/s10803-015-2441-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? [Texte imprimé et/ou numérique] / P. Cédric M. P. KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur ; Andries R. VAN DER LEIJ, Auteur ; H. Steven SCHOLTE, Auteur . - p.2779-2791. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.2779-2791 Mots-clés : Autistic traits  Gray matter volume  Cortical thickness  Surface area  Diffusion tensor imaging  Autism Index. décimale : PER Périodiques Résumé : There is accumulating evidence that autistic-related traits in the general population lie on a continuum, with autism spectrum disorders representing the extreme end of this distribution. Here, we tested the hypothesis of a possible relationship between autistic traits and brain morphometry in the general population. Participants completed the short autism-spectrum quotient-questionnaire (AQ); T1-anatomical and DWI-scans were acquired. Associations between autistic traits and gray matter, and white matter microstructural-integrity were performed on the exploration-group (N = 204; 105 males, M-age = 22.85), and validated in the validation-group (N = 304; 155 males, M-age = 22.82). No significant associations were found between AQ-scores and brain morphometry in the exploration-group, or after pooling the data. This questions the assumption that autistic traits and their morphological associations do lie on a continuum in the general population. En ligne : http://dx.doi.org/10.1007/s10803-015-2441-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

The Relationship Between Grey-Matter and ASD and ADHD Traits in Typical Adults / Hilde M. GEURTS in Journal of Autism and Developmental Disorders, 43-7 (July 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-7 (July 2013) . - p.1630-1641 Titre : The Relationship Between Grey-Matter and ASD and ADHD Traits in Typical Adults Type de document : Texte imprimé et/ou numérique Auteurs : Hilde M. GEURTS, Auteur ; K. Richard RIDDERINKHOF, Auteur ; H. Steven SCHOLTE, Auteur Année de publication : 2013 Article en page(s) : p.1630-1641 Langues : Anglais (eng) Mots-clés : ADHD  Autism  ASD  VBM  Grey-matter  sMRI Index. décimale : PER Périodiques Résumé : We tested whether in 85 healthy adults (18–29 years) there is a relationship between grey-matter (GM) volume and autism and ADHD symptom severity. The structural MRI findings and autism and ADHD self-reports revealed that autism and ADHD symptom severity was correlated with GM volume in the left inferior frontal gyrus. Autism symptom-severity was correlated with the left posterior cingulate, ADHD with the right parietal lobe, right temporal frontal cortex, bilateral thalamus, and left hippocampus/amygdala complex. Symptom severity of both disorders form a continuum extending into the general population, but it seems to be an oversimplification to typify psychiatric disorders such as autism and ADHD solely as extremes of brain structure abnormalities. En ligne : http://dx.doi.org/10.1007/s10803-012-1708-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 [article] The Relationship Between Grey-Matter and ASD and ADHD Traits in Typical Adults [Texte imprimé et/ou numérique] / Hilde M. GEURTS, Auteur ; K. Richard RIDDERINKHOF, Auteur ; H. Steven SCHOLTE, Auteur . - 2013 . - p.1630-1641. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-7 (July 2013) . - p.1630-1641 Mots-clés : ADHD  Autism  ASD  VBM  Grey-matter  sMRI Index. décimale : PER Périodiques Résumé : We tested whether in 85 healthy adults (18–29 years) there is a relationship between grey-matter (GM) volume and autism and ADHD symptom severity. The structural MRI findings and autism and ADHD self-reports revealed that autism and ADHD symptom severity was correlated with GM volume in the left inferior frontal gyrus. Autism symptom-severity was correlated with the left posterior cingulate, ADHD with the right parietal lobe, right temporal frontal cortex, bilateral thalamus, and left hippocampus/amygdala complex. Symptom severity of both disorders form a continuum extending into the general population, but it seems to be an oversimplification to typify psychiatric disorders such as autism and ADHD solely as extremes of brain structure abnormalities. En ligne : http://dx.doi.org/10.1007/s10803-012-1708-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

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