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Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder / Haruhisa OHTA in Autism Research, 9-2 (February 2016)
[article]
Titre : Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Haruhisa OHTA, Auteur ; Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Aaron LEE, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.232-248 Langues : Anglais (eng) Mots-clés : cortical thickness surface area gray matter volume megalencephaly autism spectrum disorder FreeSurfer Index. décimale : PER Périodiques Résumé : The Autism Phenome Project is the largest, single site, longitudinal magnetic resonance imaging (MRI) study of young children with autism spectrum disorder (ASD). Previous analyses from this cohort have shown that the children with autism have a total brain volume at time 1 (?3 years of age) that is 6% larger than typically developing (TD) children. This finding is driven primarily by 15% of the boys with ASD that have disproportionate megalencephaly (ASD-DM) or brain size that is 1.5 standard deviations above what would be expected for the child's height. In the current study, cerebral cortical grey matter volume, thickness, and surface area were assayed from MRI scans of 112, 3-year-old boys with ASD and 50 age-matched TD boys. The boys with ASD-DM (n?=?17) were analyzed separately from the boys with normal brain size (ASD-N, n?=?95). Previous studies of cortical thickness and surface area for ASD children in this age range have come to diametrically different conclusions concerning the significance of cortical thickness vs. surface area. Current analyses indicate that cortical thickness was comparable across the ASD and TD groups. However, surface area was significantly greater in the ASD group compared to the TD group. This result was driven largely by the children with ASD-DM. Even in the ASD-DM group, not all cortical regions demonstrated increased surface area. These results provide strong evidence that the early cortical overgrowth associated with ASD is due primarily to increased surface area and not to increased cortical thickness. En ligne : http://dx.doi.org/10.1002/aur.1520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-2 (February 2016) . - p.232-248[article] Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Haruhisa OHTA, Auteur ; Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Aaron LEE, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur . - p.232-248.
Langues : Anglais (eng)
in Autism Research > 9-2 (February 2016) . - p.232-248
Mots-clés : cortical thickness surface area gray matter volume megalencephaly autism spectrum disorder FreeSurfer Index. décimale : PER Périodiques Résumé : The Autism Phenome Project is the largest, single site, longitudinal magnetic resonance imaging (MRI) study of young children with autism spectrum disorder (ASD). Previous analyses from this cohort have shown that the children with autism have a total brain volume at time 1 (?3 years of age) that is 6% larger than typically developing (TD) children. This finding is driven primarily by 15% of the boys with ASD that have disproportionate megalencephaly (ASD-DM) or brain size that is 1.5 standard deviations above what would be expected for the child's height. In the current study, cerebral cortical grey matter volume, thickness, and surface area were assayed from MRI scans of 112, 3-year-old boys with ASD and 50 age-matched TD boys. The boys with ASD-DM (n?=?17) were analyzed separately from the boys with normal brain size (ASD-N, n?=?95). Previous studies of cortical thickness and surface area for ASD children in this age range have come to diametrically different conclusions concerning the significance of cortical thickness vs. surface area. Current analyses indicate that cortical thickness was comparable across the ASD and TD groups. However, surface area was significantly greater in the ASD group compared to the TD group. This result was driven largely by the children with ASD-DM. Even in the ASD-DM group, not all cortical regions demonstrated increased surface area. These results provide strong evidence that the early cortical overgrowth associated with ASD is due primarily to increased surface area and not to increased cortical thickness. En ligne : http://dx.doi.org/10.1002/aur.1520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Brain morphology, autistic traits, and polygenic risk for autism: A population-based neuroimaging study / Silvia ALEMANY in Autism Research, 14-10 (October 2021)
[article]
Titre : Brain morphology, autistic traits, and polygenic risk for autism: A population-based neuroimaging study Type de document : Texte imprimé et/ou numérique Auteurs : Silvia ALEMANY, Auteur ; E. BLOK, Auteur ; P. R. JANSEN, Auteur ; R. L. MUETZEL, Auteur ; T. WHITE, Auteur Article en page(s) : p.2085-2099 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/genetics Autistic Disorder/diagnostic imaging/genetics Brain/diagnostic imaging Child Humans Magnetic Resonance Imaging Neuroimaging autism cortical thickness genetics gyrification surface area Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with widespread brain alterations. Previous research in our group linked autistic traits with altered gyrification, but without pronounced differences in cortical thickness. Herein, we aim to replicate and extend these findings using a larger and older sample. Additionally, we examined whether (a) brain correlates of autistic traits were associated with polygenic risk scores (PRS) for ASD, and (b) autistic traits are related with brain morphological changes over time in a subset of children with longitudinal data available. The sample included 2400 children from the Generation R cohort. Autistic traits were measured using the Social Responsiveness Scale (SRS) at age 6?years. Gyrification, cortical thickness, surface area, and global morphological measures were obtained from high-resolution structural MRI scans at ages 9-to-12?years. We performed multiple linear regression analyses on a vertex-wise level. Corresponding regions of interest were tested for association with PRS. Results showed that autistic traits were related to (a) lower gyrification in the lateral occipital and the superior and inferior parietal lobes, (b) lower cortical thickness in the superior frontal region, and (c) lower surface area in inferior temporal and rostral middle frontal regions. PRS for ASD and longitudinal analyses showed significant associations that did not survive correction for multiple testing. Our findings support stability in the relationship between higher autistic symptoms and lower gyrification and smaller surface areas in school-aged children. These relationships remained when excluding ASD cases, providing neurobiological evidence for the extension of autistic traits into the general population. LAY SUMMARY: We found that school-aged children with higher levels of autistic traits had smaller total brain volume, cerebellum, cortical thickness, and surface area. Further, we also found differences in the folding patterns of the brain (gyrification). Overall, genetic susceptibility for autism spectrum disorders was not related to these brain regions suggesting that other factors could be involved in their origin. These results remained significant when excluding children with a diagnosis of ASD, providing support for the extension of the relationship between autistic traits and brain findings into the general population. En ligne : http://dx.doi.org/10.1002/aur.2576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-10 (October 2021) . - p.2085-2099[article] Brain morphology, autistic traits, and polygenic risk for autism: A population-based neuroimaging study [Texte imprimé et/ou numérique] / Silvia ALEMANY, Auteur ; E. BLOK, Auteur ; P. R. JANSEN, Auteur ; R. L. MUETZEL, Auteur ; T. WHITE, Auteur . - p.2085-2099.
Langues : Anglais (eng)
in Autism Research > 14-10 (October 2021) . - p.2085-2099
Mots-clés : Autism Spectrum Disorder/diagnostic imaging/genetics Autistic Disorder/diagnostic imaging/genetics Brain/diagnostic imaging Child Humans Magnetic Resonance Imaging Neuroimaging autism cortical thickness genetics gyrification surface area Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with widespread brain alterations. Previous research in our group linked autistic traits with altered gyrification, but without pronounced differences in cortical thickness. Herein, we aim to replicate and extend these findings using a larger and older sample. Additionally, we examined whether (a) brain correlates of autistic traits were associated with polygenic risk scores (PRS) for ASD, and (b) autistic traits are related with brain morphological changes over time in a subset of children with longitudinal data available. The sample included 2400 children from the Generation R cohort. Autistic traits were measured using the Social Responsiveness Scale (SRS) at age 6?years. Gyrification, cortical thickness, surface area, and global morphological measures were obtained from high-resolution structural MRI scans at ages 9-to-12?years. We performed multiple linear regression analyses on a vertex-wise level. Corresponding regions of interest were tested for association with PRS. Results showed that autistic traits were related to (a) lower gyrification in the lateral occipital and the superior and inferior parietal lobes, (b) lower cortical thickness in the superior frontal region, and (c) lower surface area in inferior temporal and rostral middle frontal regions. PRS for ASD and longitudinal analyses showed significant associations that did not survive correction for multiple testing. Our findings support stability in the relationship between higher autistic symptoms and lower gyrification and smaller surface areas in school-aged children. These relationships remained when excluding ASD cases, providing neurobiological evidence for the extension of autistic traits into the general population. LAY SUMMARY: We found that school-aged children with higher levels of autistic traits had smaller total brain volume, cerebellum, cortical thickness, and surface area. Further, we also found differences in the folding patterns of the brain (gyrification). Overall, genetic susceptibility for autism spectrum disorders was not related to these brain regions suggesting that other factors could be involved in their origin. These results remained significant when excluding children with a diagnosis of ASD, providing support for the extension of the relationship between autistic traits and brain findings into the general population. En ligne : http://dx.doi.org/10.1002/aur.2576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Gray Matter Characteristics in Mid and Old Aged Adults with ASD / P. Cédric M. P. KOOLSCHIJN in Journal of Autism and Developmental Disorders, 46-8 (August 2016)
[article]
Titre : Gray Matter Characteristics in Mid and Old Aged Adults with ASD Type de document : Texte imprimé et/ou numérique Auteurs : P. Cédric M. P. KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur Article en page(s) : p.2666-2678 Langues : Anglais (eng) Mots-clés : Autism Gray matter volume Cortical thickness Surface area Gyrification Adults Index. décimale : PER Périodiques Résumé : It is widely acknowledged that the brain anatomy of children and adolescents with autism spectrum disorder (ASD) shows a different developmental pattern then typical age-matched peers. There is however, a paucity of studies examining gray matter in mid and late adulthood in ASD. In this cross-sectional neuroimaging study, we, performed vertex-wise whole-brain and region-of-interest analyses of cortical volume, thickness, surface area, and gyrification index in 51 adults with and 49 without ASD, between 30 and 75 years. There was significant age-related volume loss and cortical thinning, but there were no group differences. The lack of significant anatomical differences between intellectual able individuals with and without ASD, suggests that ASD is not (strongly) related to gray matter morphology in mid and late adulthood. En ligne : http://dx.doi.org/10.1007/s10803-016-2810-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290
in Journal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2666-2678[article] Gray Matter Characteristics in Mid and Old Aged Adults with ASD [Texte imprimé et/ou numérique] / P. Cédric M. P. KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur . - p.2666-2678.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2666-2678
Mots-clés : Autism Gray matter volume Cortical thickness Surface area Gyrification Adults Index. décimale : PER Périodiques Résumé : It is widely acknowledged that the brain anatomy of children and adolescents with autism spectrum disorder (ASD) shows a different developmental pattern then typical age-matched peers. There is however, a paucity of studies examining gray matter in mid and late adulthood in ASD. In this cross-sectional neuroimaging study, we, performed vertex-wise whole-brain and region-of-interest analyses of cortical volume, thickness, surface area, and gyrification index in 51 adults with and 49 without ASD, between 30 and 75 years. There was significant age-related volume loss and cortical thinning, but there were no group differences. The lack of significant anatomical differences between intellectual able individuals with and without ASD, suggests that ASD is not (strongly) related to gray matter morphology in mid and late adulthood. En ligne : http://dx.doi.org/10.1007/s10803-016-2810-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 Measures of Cortical Grey Matter Structure and Development in Children with Autism Spectrum Disorder / Kathleen M. MAK-FAN in Journal of Autism and Developmental Disorders, 42-3 (March 2012)
[article]
Titre : Measures of Cortical Grey Matter Structure and Development in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kathleen M. MAK-FAN, Auteur ; Margot J. TAYLOR, Auteur ; Wendy ROBERTS, Auteur ; Jason LERCH, Auteur Année de publication : 2012 Article en page(s) : p.419-427 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Brain structure Volume Surface area Cortical thickness Development Index. décimale : PER Périodiques Résumé : The current study examined group differences in cortical volume, surface area, and thickness with age, in a group of typically developing children and a group of children with ASD aged 6–15 years. Results showed evidence of age by group interactions, suggesting atypicalities in the relation between these measures and age in the ASD group. Additional vertex-based analyses of cortical thickness revealed that specific regions in the left inferior frontal gyrus (BA 44) and left precuneus showed thicker cortex for the ASD group at younger ages only. These data support the hypothesis of an abnormal developmental trajectory of the cortex in ASD, which could have profound effects on other aspects of neural development in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1261-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152
in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.419-427[article] Measures of Cortical Grey Matter Structure and Development in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Kathleen M. MAK-FAN, Auteur ; Margot J. TAYLOR, Auteur ; Wendy ROBERTS, Auteur ; Jason LERCH, Auteur . - 2012 . - p.419-427.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.419-427
Mots-clés : Autism spectrum disorder Brain structure Volume Surface area Cortical thickness Development Index. décimale : PER Périodiques Résumé : The current study examined group differences in cortical volume, surface area, and thickness with age, in a group of typically developing children and a group of children with ASD aged 6–15 years. Results showed evidence of age by group interactions, suggesting atypicalities in the relation between these measures and age in the ASD group. Additional vertex-based analyses of cortical thickness revealed that specific regions in the left inferior frontal gyrus (BA 44) and left precuneus showed thicker cortex for the ASD group at younger ages only. These data support the hypothesis of an abnormal developmental trajectory of the cortex in ASD, which could have profound effects on other aspects of neural development in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1261-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? / P. Cédric M. P. KOOLSCHIJN in Journal of Autism and Developmental Disorders, 45-9 (September 2015)
[article]
Titre : Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? Type de document : Texte imprimé et/ou numérique Auteurs : P. Cédric M. P. KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur ; Andries R. VAN DER LEIJ, Auteur ; H. Steven SCHOLTE, Auteur Article en page(s) : p.2779-2791 Langues : Anglais (eng) Mots-clés : Autistic traits Gray matter volume Cortical thickness Surface area Diffusion tensor imaging Autism Index. décimale : PER Périodiques Résumé : There is accumulating evidence that autistic-related traits in the general population lie on a continuum, with autism spectrum disorders representing the extreme end of this distribution. Here, we tested the hypothesis of a possible relationship between autistic traits and brain morphometry in the general population. Participants completed the short autism-spectrum quotient-questionnaire (AQ); T1-anatomical and DWI-scans were acquired. Associations between autistic traits and gray matter, and white matter microstructural-integrity were performed on the exploration-group (N = 204; 105 males, M-age = 22.85), and validated in the validation-group (N = 304; 155 males, M-age = 22.82). No significant associations were found between AQ-scores and brain morphometry in the exploration-group, or after pooling the data. This questions the assumption that autistic traits and their morphological associations do lie on a continuum in the general population. En ligne : http://dx.doi.org/10.1007/s10803-015-2441-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267
in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.2779-2791[article] Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? [Texte imprimé et/ou numérique] / P. Cédric M. P. KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur ; Andries R. VAN DER LEIJ, Auteur ; H. Steven SCHOLTE, Auteur . - p.2779-2791.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.2779-2791
Mots-clés : Autistic traits Gray matter volume Cortical thickness Surface area Diffusion tensor imaging Autism Index. décimale : PER Périodiques Résumé : There is accumulating evidence that autistic-related traits in the general population lie on a continuum, with autism spectrum disorders representing the extreme end of this distribution. Here, we tested the hypothesis of a possible relationship between autistic traits and brain morphometry in the general population. Participants completed the short autism-spectrum quotient-questionnaire (AQ); T1-anatomical and DWI-scans were acquired. Associations between autistic traits and gray matter, and white matter microstructural-integrity were performed on the exploration-group (N = 204; 105 males, M-age = 22.85), and validated in the validation-group (N = 304; 155 males, M-age = 22.82). No significant associations were found between AQ-scores and brain morphometry in the exploration-group, or after pooling the data. This questions the assumption that autistic traits and their morphological associations do lie on a continuum in the general population. En ligne : http://dx.doi.org/10.1007/s10803-015-2441-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267