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Gray matter volume alteration is associated with insistence on sameness and cognitive flexibility in autistic youth / Guan-Jye SENG in Autism Research, 15-7 (July 2022)
[article]
Titre : Gray matter volume alteration is associated with insistence on sameness and cognitive flexibility in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Guan-Jye SENG, Auteur ; Meng-Chuan LAI, Auteur ; Joshua Oon Soo GOH, Auteur ; Wen-Yih Issac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.1209-1221 Langues : Anglais (eng) Mots-clés : autism spectrum disorder cognitive flexibility gray matter volume insistence on sameness voxel-based morphometry Index. décimale : PER Périodiques Résumé : Restricted and repetitive behaviors (RRBs) are hallmark characteristics of autism spectrum disorder (ASD). Previous studies suggest that insistence on sameness (IS) characterized as higher-order RRBs may be a promising subgrouping variable for ASD. Cognitive inflexibility may underpin IS behaviors. However, the neuroanatomical correlates of IS and associated cognitive functions remain unclear. We analyzed data from 140 autistic youth and 124 typically developing (TD) youth (mean age = 15.8?years). Autistic youth were stratified by median-split based on three current IS items in the autism diagnostic interview-revised into two groups (high, HIS, n = 70, and low, LIS, n = 70). Differences in cognitive flexibility were assessed by the Cambridge neuropsychological test automated battery (CANTAB). T1-weighted brain structural images were analyzed using voxel-based morphometry (VBM) to identify differences in gray matter (GM) volume among the three groups. GM volume of regions showing group differences was then correlated with cognitive flexibility. The HIS group showed decreased GM volumes in the left supramarginal gyrus compared to the LIS group and increased GM volumes in the vermis VIII and left cerebellar lobule VIII compared to TD individuals. We did not find significant correlations between regional GM volumes and extra-dimensional shift errors. IS may be a unique RRB component and a potentially valuable stratifier of ASD. However, the neurocognitive underpinnings require further clarification. LAY SUMMARY: The present study found parietal, temporal and cerebellar gray matter volume alterations in autistic youth with greater insistence on sameness. The findings suggest that insistence on sameness may be a useful feature to parse the heterogeneity of the autism spectrum yet further research investigating the underlying neurocognitive mechanism is warranted. En ligne : http://dx.doi.org/10.1002/aur.2732 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Autism Research > 15-7 (July 2022) . - p.1209-1221[article] Gray matter volume alteration is associated with insistence on sameness and cognitive flexibility in autistic youth [Texte imprimé et/ou numérique] / Guan-Jye SENG, Auteur ; Meng-Chuan LAI, Auteur ; Joshua Oon Soo GOH, Auteur ; Wen-Yih Issac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur . - p.1209-1221.
Langues : Anglais (eng)
in Autism Research > 15-7 (July 2022) . - p.1209-1221
Mots-clés : autism spectrum disorder cognitive flexibility gray matter volume insistence on sameness voxel-based morphometry Index. décimale : PER Périodiques Résumé : Restricted and repetitive behaviors (RRBs) are hallmark characteristics of autism spectrum disorder (ASD). Previous studies suggest that insistence on sameness (IS) characterized as higher-order RRBs may be a promising subgrouping variable for ASD. Cognitive inflexibility may underpin IS behaviors. However, the neuroanatomical correlates of IS and associated cognitive functions remain unclear. We analyzed data from 140 autistic youth and 124 typically developing (TD) youth (mean age = 15.8?years). Autistic youth were stratified by median-split based on three current IS items in the autism diagnostic interview-revised into two groups (high, HIS, n = 70, and low, LIS, n = 70). Differences in cognitive flexibility were assessed by the Cambridge neuropsychological test automated battery (CANTAB). T1-weighted brain structural images were analyzed using voxel-based morphometry (VBM) to identify differences in gray matter (GM) volume among the three groups. GM volume of regions showing group differences was then correlated with cognitive flexibility. The HIS group showed decreased GM volumes in the left supramarginal gyrus compared to the LIS group and increased GM volumes in the vermis VIII and left cerebellar lobule VIII compared to TD individuals. We did not find significant correlations between regional GM volumes and extra-dimensional shift errors. IS may be a unique RRB component and a potentially valuable stratifier of ASD. However, the neurocognitive underpinnings require further clarification. LAY SUMMARY: The present study found parietal, temporal and cerebellar gray matter volume alterations in autistic youth with greater insistence on sameness. The findings suggest that insistence on sameness may be a useful feature to parse the heterogeneity of the autism spectrum yet further research investigating the underlying neurocognitive mechanism is warranted. En ligne : http://dx.doi.org/10.1002/aur.2732 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 Abnormal gray matter volume and functional connectivity patterns in social cognition-related brain regions of young children with autism spectrum disorder / Chen BAI in Autism Research, 16-6 (June 2023)
[article]
Titre : Abnormal gray matter volume and functional connectivity patterns in social cognition-related brain regions of young children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chen BAI, Auteur ; Yunlei Wang, Auteur ; Yan ZHANG, Auteur ; Xianna Wang, Auteur ; Zhenbo Chen, Auteur ; Weiyong Yu, Auteur ; Haojie Zhang, Auteur ; Xingzhu Li, Auteur ; Kaixuan Zhu, Auteur ; Yuxiang Wang, Auteur ; Tong Zhang, Auteur Article en page(s) : p.1124-1137 Langues : Anglais (eng) Mots-clés : autism spectrum disorder functional connectivity gray matter volume support vector machine Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is associated with abnormal brain imaging findings, but descriptions thereof are inconsistent. The aim of the present study was to investigate brain abnormalities in young children with ASD using a combination of structural and functional brain magnetic resonance imaging (MRI). Structural and resting-state functional MRI was performed in 67 children with ASD (aged 2?7?years) and 39 age-matched typically developing (TD) controls. Voxel-based morphometry was used to evaluate differences in brain structure between groups. Topologic parameters of the functional brain network were compared by graph theoretic analysis and network connectomes were compared with network-based statistics. A support vector machine (SVM) was used to discriminate between ASD and TD groups. Results demonstrated young children with ASD had increased gray matter volumes (GMVs) in the right medial superior frontal gyrus and left fusiform gyrus compared with the TD group. The ASD group had altered subnetwork connectivity in frontal and temporal lobes and other social cognition-related brain regions. Functional connectivity in the left superior temporal gyrus and left temporal pole of the middle temporal gyrus was positively correlated with adaptability and language developmental quotient (DQ) in children with ASD. The combination of the brain structural and functional features had 86.2% accuracy in discriminating between ASD and TD. The present study shows that young children with ASD have altered GMVs and functional networks in social cognition-related brain regions, which are potential neuroimaging biomarkers for ASD. En ligne : https://doi.org/10.1002/aur.2936 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507
in Autism Research > 16-6 (June 2023) . - p.1124-1137[article] Abnormal gray matter volume and functional connectivity patterns in social cognition-related brain regions of young children with autism spectrum disorder [Texte imprimé et/ou numérique] / Chen BAI, Auteur ; Yunlei Wang, Auteur ; Yan ZHANG, Auteur ; Xianna Wang, Auteur ; Zhenbo Chen, Auteur ; Weiyong Yu, Auteur ; Haojie Zhang, Auteur ; Xingzhu Li, Auteur ; Kaixuan Zhu, Auteur ; Yuxiang Wang, Auteur ; Tong Zhang, Auteur . - p.1124-1137.
Langues : Anglais (eng)
in Autism Research > 16-6 (June 2023) . - p.1124-1137
Mots-clés : autism spectrum disorder functional connectivity gray matter volume support vector machine Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is associated with abnormal brain imaging findings, but descriptions thereof are inconsistent. The aim of the present study was to investigate brain abnormalities in young children with ASD using a combination of structural and functional brain magnetic resonance imaging (MRI). Structural and resting-state functional MRI was performed in 67 children with ASD (aged 2?7?years) and 39 age-matched typically developing (TD) controls. Voxel-based morphometry was used to evaluate differences in brain structure between groups. Topologic parameters of the functional brain network were compared by graph theoretic analysis and network connectomes were compared with network-based statistics. A support vector machine (SVM) was used to discriminate between ASD and TD groups. Results demonstrated young children with ASD had increased gray matter volumes (GMVs) in the right medial superior frontal gyrus and left fusiform gyrus compared with the TD group. The ASD group had altered subnetwork connectivity in frontal and temporal lobes and other social cognition-related brain regions. Functional connectivity in the left superior temporal gyrus and left temporal pole of the middle temporal gyrus was positively correlated with adaptability and language developmental quotient (DQ) in children with ASD. The combination of the brain structural and functional features had 86.2% accuracy in discriminating between ASD and TD. The present study shows that young children with ASD have altered GMVs and functional networks in social cognition-related brain regions, which are potential neuroimaging biomarkers for ASD. En ligne : https://doi.org/10.1002/aur.2936 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507 An Association Between Serotonin 1A Receptor, Gray Matter Volume, and Sociability in Healthy Subjects and in Autism Spectrum Disorder / Arthur LEFEVRE in Autism Research, 13-11 (November 2020)
[article]
Titre : An Association Between Serotonin 1A Receptor, Gray Matter Volume, and Sociability in Healthy Subjects and in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Arthur LEFEVRE, Auteur ; Nathalie RICHARD, Auteur ; Raphaelle MOTTOLESE, Auteur ; Marion LEBOYER, Auteur ; Angela SIRIGU, Auteur Article en page(s) : p.1843-1855 Langues : Anglais (eng) Mots-clés : Mri PET scan autism gray matter volume serotonin 1A receptor sociality Index. décimale : PER Périodiques Résumé : Central serotonin is an important molecular pathway, involved in the regulation of social behavior and gray matter volume (GMV). In men with autism spectrum disorders (ASD), the serotonergic system and the GMV have been found disrupted. Here, we investigated the relation between serotonin, GMV, and social personality in men with typical development (TD) and in men with ASD. We combined anatomical magnetic resonance imaging, Positron emission tomography scan with 2'-methoxyphenyl-(N-2'-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine radioligand and revised NEO personality inventory personality questionnaire to examine the association between serotonin 1A receptor (5-HT(1A) R) binding potential, GMV and social personality in 24 adult male TD subjects and 18 male men with ASD. In both groups, we found a positive correlation between 5-HT(1A) R binding potential and GMV in a region dependent manner. In the TD group, we observed a negative correlation between 5-HT(1A) R and GMV in the left and right posterior putamen. 5HT(1A) R binding and GMV in the putamen further correlated with social personality scores in the TD group. None of these associations were found in men with ASD, although no differences were observed for 5-HT(1A) R concentration among the two groups. Our findings point to a deregulation of 5-HT(1A) R density in the striatum of men with ASD, a failure that might contribute to their social disturbances. Serotonin is suspected to be involved in the pathophysiology of autism. We provide evidence for a role of serotonin 1A receptor in social behavior through a specific regulation of GMV in the putamen region in neurotypical subjects but not in men with autism. This suggests a potential impairment of the serotonergic system in men with autism which may contribute to patients' social disturbances. Our findings suggest further investigation on the role of serotonin 1A receptor and its activity in the striatum to regulate social behavior. Autism Res 2020, 13: 1843-1855. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: Serotonin is suspected to be involved in the pathophysiology of autism. We provide evidence for a role of serotonin 1A receptor in social behavior through a specific regulation of gray matter volume in the putamen region in neurotypical subjects but not in men with autism. This suggests a potential impairment of the serotonergic system in men with autism which may contribute to patients' social disturbances. Our findings suggest further investigation on the role of serotonin 1A receptor and its activity in the striatum to regulate social behavior. En ligne : http://dx.doi.org/10.1002/aur.2360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433
in Autism Research > 13-11 (November 2020) . - p.1843-1855[article] An Association Between Serotonin 1A Receptor, Gray Matter Volume, and Sociability in Healthy Subjects and in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Arthur LEFEVRE, Auteur ; Nathalie RICHARD, Auteur ; Raphaelle MOTTOLESE, Auteur ; Marion LEBOYER, Auteur ; Angela SIRIGU, Auteur . - p.1843-1855.
Langues : Anglais (eng)
in Autism Research > 13-11 (November 2020) . - p.1843-1855
Mots-clés : Mri PET scan autism gray matter volume serotonin 1A receptor sociality Index. décimale : PER Périodiques Résumé : Central serotonin is an important molecular pathway, involved in the regulation of social behavior and gray matter volume (GMV). In men with autism spectrum disorders (ASD), the serotonergic system and the GMV have been found disrupted. Here, we investigated the relation between serotonin, GMV, and social personality in men with typical development (TD) and in men with ASD. We combined anatomical magnetic resonance imaging, Positron emission tomography scan with 2'-methoxyphenyl-(N-2'-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine radioligand and revised NEO personality inventory personality questionnaire to examine the association between serotonin 1A receptor (5-HT(1A) R) binding potential, GMV and social personality in 24 adult male TD subjects and 18 male men with ASD. In both groups, we found a positive correlation between 5-HT(1A) R binding potential and GMV in a region dependent manner. In the TD group, we observed a negative correlation between 5-HT(1A) R and GMV in the left and right posterior putamen. 5HT(1A) R binding and GMV in the putamen further correlated with social personality scores in the TD group. None of these associations were found in men with ASD, although no differences were observed for 5-HT(1A) R concentration among the two groups. Our findings point to a deregulation of 5-HT(1A) R density in the striatum of men with ASD, a failure that might contribute to their social disturbances. Serotonin is suspected to be involved in the pathophysiology of autism. We provide evidence for a role of serotonin 1A receptor in social behavior through a specific regulation of GMV in the putamen region in neurotypical subjects but not in men with autism. This suggests a potential impairment of the serotonergic system in men with autism which may contribute to patients' social disturbances. Our findings suggest further investigation on the role of serotonin 1A receptor and its activity in the striatum to regulate social behavior. Autism Res 2020, 13: 1843-1855. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: Serotonin is suspected to be involved in the pathophysiology of autism. We provide evidence for a role of serotonin 1A receptor in social behavior through a specific regulation of gray matter volume in the putamen region in neurotypical subjects but not in men with autism. This suggests a potential impairment of the serotonergic system in men with autism which may contribute to patients' social disturbances. Our findings suggest further investigation on the role of serotonin 1A receptor and its activity in the striatum to regulate social behavior. En ligne : http://dx.doi.org/10.1002/aur.2360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 Gray Matter Characteristics in Mid and Old Aged Adults with ASD / P. Cédric M. P. KOOLSCHIJN in Journal of Autism and Developmental Disorders, 46-8 (August 2016)
[article]
Titre : Gray Matter Characteristics in Mid and Old Aged Adults with ASD Type de document : Texte imprimé et/ou numérique Auteurs : P. Cédric M. P. KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur Article en page(s) : p.2666-2678 Langues : Anglais (eng) Mots-clés : Autism Gray matter volume Cortical thickness Surface area Gyrification Adults Index. décimale : PER Périodiques Résumé : It is widely acknowledged that the brain anatomy of children and adolescents with autism spectrum disorder (ASD) shows a different developmental pattern then typical age-matched peers. There is however, a paucity of studies examining gray matter in mid and late adulthood in ASD. In this cross-sectional neuroimaging study, we, performed vertex-wise whole-brain and region-of-interest analyses of cortical volume, thickness, surface area, and gyrification index in 51 adults with and 49 without ASD, between 30 and 75 years. There was significant age-related volume loss and cortical thinning, but there were no group differences. The lack of significant anatomical differences between intellectual able individuals with and without ASD, suggests that ASD is not (strongly) related to gray matter morphology in mid and late adulthood. En ligne : http://dx.doi.org/10.1007/s10803-016-2810-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290
in Journal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2666-2678[article] Gray Matter Characteristics in Mid and Old Aged Adults with ASD [Texte imprimé et/ou numérique] / P. Cédric M. P. KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur . - p.2666-2678.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2666-2678
Mots-clés : Autism Gray matter volume Cortical thickness Surface area Gyrification Adults Index. décimale : PER Périodiques Résumé : It is widely acknowledged that the brain anatomy of children and adolescents with autism spectrum disorder (ASD) shows a different developmental pattern then typical age-matched peers. There is however, a paucity of studies examining gray matter in mid and late adulthood in ASD. In this cross-sectional neuroimaging study, we, performed vertex-wise whole-brain and region-of-interest analyses of cortical volume, thickness, surface area, and gyrification index in 51 adults with and 49 without ASD, between 30 and 75 years. There was significant age-related volume loss and cortical thinning, but there were no group differences. The lack of significant anatomical differences between intellectual able individuals with and without ASD, suggests that ASD is not (strongly) related to gray matter morphology in mid and late adulthood. En ligne : http://dx.doi.org/10.1007/s10803-016-2810-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? / P. Cédric M. P. KOOLSCHIJN in Journal of Autism and Developmental Disorders, 45-9 (September 2015)
[article]
Titre : Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? Type de document : Texte imprimé et/ou numérique Auteurs : P. Cédric M. P. KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur ; Andries R. VAN DER LEIJ, Auteur ; H. Steven SCHOLTE, Auteur Article en page(s) : p.2779-2791 Langues : Anglais (eng) Mots-clés : Autistic traits Gray matter volume Cortical thickness Surface area Diffusion tensor imaging Autism Index. décimale : PER Périodiques Résumé : There is accumulating evidence that autistic-related traits in the general population lie on a continuum, with autism spectrum disorders representing the extreme end of this distribution. Here, we tested the hypothesis of a possible relationship between autistic traits and brain morphometry in the general population. Participants completed the short autism-spectrum quotient-questionnaire (AQ); T1-anatomical and DWI-scans were acquired. Associations between autistic traits and gray matter, and white matter microstructural-integrity were performed on the exploration-group (N = 204; 105 males, M-age = 22.85), and validated in the validation-group (N = 304; 155 males, M-age = 22.82). No significant associations were found between AQ-scores and brain morphometry in the exploration-group, or after pooling the data. This questions the assumption that autistic traits and their morphological associations do lie on a continuum in the general population. En ligne : http://dx.doi.org/10.1007/s10803-015-2441-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267
in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.2779-2791[article] Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? [Texte imprimé et/ou numérique] / P. Cédric M. P. KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur ; Andries R. VAN DER LEIJ, Auteur ; H. Steven SCHOLTE, Auteur . - p.2779-2791.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.2779-2791
Mots-clés : Autistic traits Gray matter volume Cortical thickness Surface area Diffusion tensor imaging Autism Index. décimale : PER Périodiques Résumé : There is accumulating evidence that autistic-related traits in the general population lie on a continuum, with autism spectrum disorders representing the extreme end of this distribution. Here, we tested the hypothesis of a possible relationship between autistic traits and brain morphometry in the general population. Participants completed the short autism-spectrum quotient-questionnaire (AQ); T1-anatomical and DWI-scans were acquired. Associations between autistic traits and gray matter, and white matter microstructural-integrity were performed on the exploration-group (N = 204; 105 males, M-age = 22.85), and validated in the validation-group (N = 304; 155 males, M-age = 22.82). No significant associations were found between AQ-scores and brain morphometry in the exploration-group, or after pooling the data. This questions the assumption that autistic traits and their morphological associations do lie on a continuum in the general population. En ligne : http://dx.doi.org/10.1007/s10803-015-2441-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder / Haruhisa OHTA in Autism Research, 9-2 (February 2016)
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