Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder / Lawrence K. FUNG in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2971-2977 Titre : Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence K. FUNG, Auteur ; Robin A. LIBOVE, Auteur ; Jennifer PHILLIPS, Auteur ; Francois HADDAD, Auteur ; Antonio Y. HARDAN, Auteur Article en page(s) : p.2971-2977 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Pregnenolone  Neurosteroids  Irritability  Open-label trial Index. décimale : PER Périodiques Résumé : The objective of this study was to assess the tolerability and efficacy of pregnenolone in reducing irritability in adults with autism spectrum disorder (ASD). This was a pilot, open-label, 12-week trial that included twelve subjects with a mean age of 22.5 ± 5.8 years. Two participants dropped out of the study due to reasons unrelated to adverse effects. Pregnenolone yielded a statistically significant improvement in the primary measure, Aberrant Behavior Checklist (ABC)-Irritability [from 17.4 ± 7.4 at baseline to 11.2 ± 7.0 at 12 weeks (p = 0.028)]. Secondary measures were not statistically significant with the exception of ABC-lethargy (p = 0.046) and total Short Sensory Profile score (p = 0.009). No significant vital sign changes occurred during this study. Pregnenolone was not associated with any severe side effects. Single episodes of tiredness, diarrhea and depressive affect that could be related to pregnenolone were reported. Overall, pregnenolone was modestly effective and well-tolerated in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2144-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lawrence K. FUNG, Auteur ; Robin A. LIBOVE, Auteur ; Jennifer PHILLIPS, Auteur ; Francois HADDAD, Auteur ; Antonio Y. HARDAN, Auteur . - p.2971-2977. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2971-2977 Mots-clés : Autism spectrum disorder  Pregnenolone  Neurosteroids  Irritability  Open-label trial Index. décimale : PER Périodiques Résumé : The objective of this study was to assess the tolerability and efficacy of pregnenolone in reducing irritability in adults with autism spectrum disorder (ASD). This was a pilot, open-label, 12-week trial that included twelve subjects with a mean age of 22.5 ± 5.8 years. Two participants dropped out of the study due to reasons unrelated to adverse effects. Pregnenolone yielded a statistically significant improvement in the primary measure, Aberrant Behavior Checklist (ABC)-Irritability [from 17.4 ± 7.4 at baseline to 11.2 ± 7.0 at 12 weeks (p = 0.028)]. Secondary measures were not statistically significant with the exception of ABC-lethargy (p = 0.046) and total Short Sensory Profile score (p = 0.009). No significant vital sign changes occurred during this study. Pregnenolone was not associated with any severe side effects. Single episodes of tiredness, diarrhea and depressive affect that could be related to pregnenolone were reported. Overall, pregnenolone was modestly effective and well-tolerated in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2144-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Head Circumferences in Twins With and Without Autism Spectrum Disorders / Wendy FROEHLICH in Journal of Autism and Developmental Disorders, 43-9 (September 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2026-2037 Titre : Head Circumferences in Twins With and Without Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Wendy FROEHLICH, Auteur ; Sue C. CLEVELAND, Auteur ; Andrea TORRES, Auteur ; Jennifer PHILLIPS, Auteur ; Brianne COHEN, Auteur ; Tiffany TORIGOE, Auteur ; Janet MILLER, Auteur ; Angie FEDELE, Auteur ; Jack COLLINS, Auteur ; Karen SMITH, Auteur ; Linda J. LOTSPEICH, Auteur ; Lisa A. CROEN, Auteur ; Sally OZONOFF, Auteur ; Clara LAJONCHERE, Auteur ; Judith K. GRETHER, Auteur ; Joachim F. HALLMAYER, Auteur Article en page(s) : p.2026-2037 Langues : Anglais (eng) Mots-clés : Macrocephaly  Head circumference  Twins  Endophenotype  Genetics Index. décimale : PER Périodiques Résumé : To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4–18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs. En ligne : http://dx.doi.org/10.1007/s10803-012-1751-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Head Circumferences in Twins With and Without Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Wendy FROEHLICH, Auteur ; Sue C. CLEVELAND, Auteur ; Andrea TORRES, Auteur ; Jennifer PHILLIPS, Auteur ; Brianne COHEN, Auteur ; Tiffany TORIGOE, Auteur ; Janet MILLER, Auteur ; Angie FEDELE, Auteur ; Jack COLLINS, Auteur ; Karen SMITH, Auteur ; Linda J. LOTSPEICH, Auteur ; Lisa A. CROEN, Auteur ; Sally OZONOFF, Auteur ; Clara LAJONCHERE, Auteur ; Judith K. GRETHER, Auteur ; Joachim F. HALLMAYER, Auteur . - p.2026-2037. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-9 (September 2013) . - p.2026-2037 Mots-clés : Macrocephaly  Head circumference  Twins  Endophenotype  Genetics Index. décimale : PER Périodiques Résumé : To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4–18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs. En ligne : http://dx.doi.org/10.1007/s10803-012-1751-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

A randomized controlled trial of Pivotal Response Treatment Group for parents of children with autism / Antonio Y. HARDAN in Journal of Child Psychology and Psychiatry, 56-8 (August 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-8 (August 2015) . - p.884-892 Titre : A randomized controlled trial of Pivotal Response Treatment Group for parents of children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Antonio Y. HARDAN, Auteur ; Grace W. GENGOUX, Auteur ; Kari L. BERQUIST, Auteur ; Robin A. LIBOVE, Auteur ; Christina M. ARDEL, Auteur ; Jennifer PHILLIPS, Auteur ; Thomas W. FRAZIER, Auteur ; Mendy B. MINJAREZ, Auteur Article en page(s) : p.884-892 Langues : Anglais (eng) Mots-clés : Language deficits  treatment fidelity  group parent training  social communication  naturalistic developmental behavior intervention Index. décimale : PER Périodiques Résumé : Background With rates of autism diagnosis continuing to rise, there is an urgent need for effective and efficient service delivery models. Pivotal Response Treatment (PRT) is considered an established treatment for autism spectrum disorder (ASD); however, there have been few well-controlled studies with adequate sample size. The aim of this study was to conduct a randomized controlled trial to evaluate PRT parent training group (PRTG) for targeting language deficits in young children with ASD. Methods Fifty-three children with autism and significant language delay between 2 and 6 years old were randomized to PRTG (N = 27) or psychoeducation group (PEG; N = 26) for 12 weeks. The PRTG taught parents behavioral techniques to facilitate language development. The PEG taught general information about ASD (clinical trial NCT01881750; http://www.clinicaltrials.gov). Results Analysis of child utterances during the structured laboratory observation (primary outcome) indicated that, compared with children in the PEG, children in the PRTG demonstrated greater improvement in frequency of utterances (F(2, 43) = 3.53, p = .038, d = 0.42). Results indicated that parents were able to learn PRT in a group format, as the majority of parents in the PRTG (84%) met fidelity of implementation criteria after 12 weeks. Children also demonstrated greater improvement in adaptive communication skills (Vineland-II) following PRTG and baseline Mullen visual reception scores predicted treatment response to PRTG. Conclusions This is the first randomized controlled trial of group-delivered PRT and one of the largest experimental investigations of the PRT model to date. The findings suggest that specific instruction in PRT results in greater skill acquisition for both parents and children, especially in functional and adaptive communication skills. Further research in PRT is warranted to replicate the observed results and address other core ASD symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] A randomized controlled trial of Pivotal Response Treatment Group for parents of children with autism [Texte imprimé et/ou numérique] / Antonio Y. HARDAN, Auteur ; Grace W. GENGOUX, Auteur ; Kari L. BERQUIST, Auteur ; Robin A. LIBOVE, Auteur ; Christina M. ARDEL, Auteur ; Jennifer PHILLIPS, Auteur ; Thomas W. FRAZIER, Auteur ; Mendy B. MINJAREZ, Auteur . - p.884-892. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-8 (August 2015) . - p.884-892 Mots-clés : Language deficits  treatment fidelity  group parent training  social communication  naturalistic developmental behavior intervention Index. décimale : PER Périodiques Résumé : Background With rates of autism diagnosis continuing to rise, there is an urgent need for effective and efficient service delivery models. Pivotal Response Treatment (PRT) is considered an established treatment for autism spectrum disorder (ASD); however, there have been few well-controlled studies with adequate sample size. The aim of this study was to conduct a randomized controlled trial to evaluate PRT parent training group (PRTG) for targeting language deficits in young children with ASD. Methods Fifty-three children with autism and significant language delay between 2 and 6 years old were randomized to PRTG (N = 27) or psychoeducation group (PEG; N = 26) for 12 weeks. The PRTG taught parents behavioral techniques to facilitate language development. The PEG taught general information about ASD (clinical trial NCT01881750; http://www.clinicaltrials.gov). Results Analysis of child utterances during the structured laboratory observation (primary outcome) indicated that, compared with children in the PEG, children in the PRTG demonstrated greater improvement in frequency of utterances (F(2, 43) = 3.53, p = .038, d = 0.42). Results indicated that parents were able to learn PRT in a group format, as the majority of parents in the PRTG (84%) met fidelity of implementation criteria after 12 weeks. Children also demonstrated greater improvement in adaptive communication skills (Vineland-II) following PRTG and baseline Mullen visual reception scores predicted treatment response to PRTG. Conclusions This is the first randomized controlled trial of group-delivered PRT and one of the largest experimental investigations of the PRT model to date. The findings suggest that specific instruction in PRT results in greater skill acquisition for both parents and children, especially in functional and adaptive communication skills. Further research in PRT is warranted to replicate the observed results and address other core ASD symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12354 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

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