Multilevel assessment of the neurobiological threat system in depressed adolescents: Interplay between the limbic system and hypothalamic–pituitary–adrenal axis / Bonnie KLIMES-DOUGAN in Development and Psychopathology, 26-4 (Part 2) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1321-1335 Titre : Multilevel assessment of the neurobiological threat system in depressed adolescents: Interplay between the limbic system and hypothalamic–pituitary–adrenal axis Type de document : Texte imprimé et/ou numérique Auteurs : Bonnie KLIMES-DOUGAN, Auteur ; Lynn E. EBERLY, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Patrick KURKIEWICZ, Auteur ; Alaa HOURI, Auteur ; Amanda SCHLESINGER, Auteur ; Kathleen M. THOMAS, Auteur ; Bryon A. MUELLER, Auteur ; Kelvin O. LIM, Auteur ; Kathryn R. CULLEN, Auteur Année de publication : 2014 Article en page(s) : p.1321-1335 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Integrative, multilevel approaches investigating neurobiological systems relevant to threat detection promise to advance understanding of the pathophysiology of major depressive disorder (MDD). In this study we considered key neuronal and hormonal systems in adolescents with MDD and healthy controls (HC). The goals of this study were to identify group differences and to examine the association of neuronal and hormonal systems. MDD and HC adolescents (N = 79) aged 12–19 years were enrolled. Key brain measures included amygdala volume and amygdala activation to an emotion face-viewing task. Key hormone measures included cortisol levels during a social stress task and during the brain scan. MDD and HC adolescents showed group differences on amygdala functioning and patterns of cortisol levels. Amygdala activation in response to emotional stimuli was positively associated with cortisol responses. In addition, amygdala volume was correlated with cortisol responses, but the pattern differed in depressed versus healthy adolescents, most notably for unmedicated MDD adolescents. The findings highlight the value of using multilevel assessment strategies to enhance understanding of pathophysiology of adolescent MDD, particularly regarding how closely related biological threat systems function together while undergoing significant developmental shifts. En ligne : http://dx.doi.org/10.1017/S0954579414001059 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245 [article] Multilevel assessment of the neurobiological threat system in depressed adolescents: Interplay between the limbic system and hypothalamic–pituitary–adrenal axis [Texte imprimé et/ou numérique] / Bonnie KLIMES-DOUGAN, Auteur ; Lynn E. EBERLY, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Patrick KURKIEWICZ, Auteur ; Alaa HOURI, Auteur ; Amanda SCHLESINGER, Auteur ; Kathleen M. THOMAS, Auteur ; Bryon A. MUELLER, Auteur ; Kelvin O. LIM, Auteur ; Kathryn R. CULLEN, Auteur . - 2014 . - p.1321-1335. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1321-1335 Index. décimale : PER Périodiques Résumé : Integrative, multilevel approaches investigating neurobiological systems relevant to threat detection promise to advance understanding of the pathophysiology of major depressive disorder (MDD). In this study we considered key neuronal and hormonal systems in adolescents with MDD and healthy controls (HC). The goals of this study were to identify group differences and to examine the association of neuronal and hormonal systems. MDD and HC adolescents (N = 79) aged 12–19 years were enrolled. Key brain measures included amygdala volume and amygdala activation to an emotion face-viewing task. Key hormone measures included cortisol levels during a social stress task and during the brain scan. MDD and HC adolescents showed group differences on amygdala functioning and patterns of cortisol levels. Amygdala activation in response to emotional stimuli was positively associated with cortisol responses. In addition, amygdala volume was correlated with cortisol responses, but the pattern differed in depressed versus healthy adolescents, most notably for unmedicated MDD adolescents. The findings highlight the value of using multilevel assessment strategies to enhance understanding of pathophysiology of adolescent MDD, particularly regarding how closely related biological threat systems function together while undergoing significant developmental shifts. En ligne : http://dx.doi.org/10.1017/S0954579414001059 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245

Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury / Zeynep BA?GÖZE in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1774-1792 Titre : Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury Type de document : Texte imprimé et/ou numérique Auteurs : Zeynep BA?GÖZE, Auteur ; Salahudeen A. MIRZA, Auteur ; Thanharat SILAMONGKOL, Auteur ; Dawson HILL, Auteur ; Conner FALKE, Auteur ; Michelle THAI, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Anna M. PARENTEAU, Auteur ; Donovan J. ROEDIGER, Auteur ; Timothy J. HENDRICKSON, Auteur ; Bryon A. MUELLER, Auteur ; Mark B. FIECAS, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Kathryn R. CULLEN, Auteur Article en page(s) : p.1774-1792 Langues : Anglais (eng) Mots-clés : adolescents  nonsuicidal self-injury  RDoC  sustained threat Index. décimale : PER Périodiques Résumé : Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala–mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala–mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI. En ligne : http://dx.doi.org/10.1017/S0954579421000754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury [Texte imprimé et/ou numérique] / Zeynep BA?GÖZE, Auteur ; Salahudeen A. MIRZA, Auteur ; Thanharat SILAMONGKOL, Auteur ; Dawson HILL, Auteur ; Conner FALKE, Auteur ; Michelle THAI, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Anna M. PARENTEAU, Auteur ; Donovan J. ROEDIGER, Auteur ; Timothy J. HENDRICKSON, Auteur ; Bryon A. MUELLER, Auteur ; Mark B. FIECAS, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Kathryn R. CULLEN, Auteur . - p.1774-1792. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1774-1792 Mots-clés : adolescents  nonsuicidal self-injury  RDoC  sustained threat Index. décimale : PER Périodiques Résumé : Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala–mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala–mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI. En ligne : http://dx.doi.org/10.1017/S0954579421000754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Seeing adolescents grow from many angles using a multilevel approach: A tribute to the contributions of Dante Cicchetti to the field of developmental psychopathology / Bonnie KLIMES-DOUGAN ; Andrea WIGLESWORTH ; Zeynep Ba?göze ; Kathryn R. CULLEN in Development and Psychopathology, 36-5 (December 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-5 (December 2024) . - p.2173-2185 Titre : Seeing adolescents grow from many angles using a multilevel approach: A tribute to the contributions of Dante Cicchetti to the field of developmental psychopathology : Development and Psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Bonnie KLIMES-DOUGAN, Auteur ; Andrea WIGLESWORTH, Auteur ; Zeynep Ba?göze, Auteur ; Kathryn R. CULLEN, Auteur Année de publication : 2024 Article en page(s) : p.2173-2185 Langues : Anglais (eng) Mots-clés : adolescence  depression  developmental psychopathology  multilevel approach  multiple units of analysis  non-suicidal self-injury  suicide risk Index. décimale : PER Périodiques Résumé : Dante Cicchetti propelled forward the field of developmental psychopathology by advancing this framework and championing new methods, including emphasizing the central role that multilevel analysis holds for explicating pathways of risk and resilience. His work continues to change the face of existing science. It has also paved the way for the formation of new projects, like the Research Domain Criteria initiative. This paper uses our laboratory?s work on multilevel approaches to studying adolescent depression, non-suicidal self-injury, and suicidal thoughts and behaviors to shine a spotlight on Dr Cicchetti?s contributions. In addition, we review recent developments, ongoing challenges, and promising future directions within developmental psychopathology as we endeavor to carry on the tradition of growth in the field. En ligne : https://dx.doi.org/10.1017/S0954579424001123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] Seeing adolescents grow from many angles using a multilevel approach: A tribute to the contributions of Dante Cicchetti to the field of developmental psychopathology : Development and Psychopathology [Texte imprimé et/ou numérique] / Bonnie KLIMES-DOUGAN, Auteur ; Andrea WIGLESWORTH, Auteur ; Zeynep Ba?göze, Auteur ; Kathryn R. CULLEN, Auteur . - 2024 . - p.2173-2185. Langues : Anglais (eng) in Development and Psychopathology > 36-5 (December 2024) . - p.2173-2185 Mots-clés : adolescence  depression  developmental psychopathology  multilevel approach  multiple units of analysis  non-suicidal self-injury  suicide risk Index. décimale : PER Périodiques Résumé : Dante Cicchetti propelled forward the field of developmental psychopathology by advancing this framework and championing new methods, including emphasizing the central role that multilevel analysis holds for explicating pathways of risk and resilience. His work continues to change the face of existing science. It has also paved the way for the formation of new projects, like the Research Domain Criteria initiative. This paper uses our laboratory?s work on multilevel approaches to studying adolescent depression, non-suicidal self-injury, and suicidal thoughts and behaviors to shine a spotlight on Dr Cicchetti?s contributions. In addition, we review recent developments, ongoing challenges, and promising future directions within developmental psychopathology as we endeavor to carry on the tradition of growth in the field. En ligne : https://dx.doi.org/10.1017/S0954579424001123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

Stress system concordance as a predictor of longitudinal patterns of resilience in adolescence / Jessica BUTTS ; Katherine A. CAROSELLA ; Kathryn R. CULLEN ; Bonnie KLIMES-DOUGAN ; Salahudeen MIRZA ; Victoria PAPKE ; Andrea WIGLESWORTH in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2384-2401 Titre : Stress system concordance as a predictor of longitudinal patterns of resilience in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BUTTS, Auteur ; Katherine A. CAROSELLA, Auteur ; Kathryn R. CULLEN, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Salahudeen MIRZA, Auteur ; Victoria PAPKE, Auteur ; Andrea WIGLESWORTH, Auteur Article en page(s) : p.2384-2401 Mots-clés : adolescence  depressive symptoms  resilience  self-worth  stress response Index. décimale : PER Périodiques Résumé : Resilience promotes positive adaptation to challenges and may facilitate recovery for adolescents experiencing psychopathology. This work examined concordance across the experience, expression, and physiological response to stress as a protective factor that may predict longitudinal patterns of psychopathology and well-being that mark resilience. Adolescents aged 14?17 at recruitment (oversampled for histories of non-suicidal self-injury; NSSI) were part of a three-wave (T1, T2, T3) longitudinal study. Multi-trajectory modeling produced four distinct profiles of stress experience, expression, and physiology at T1 (High-High-High, Low-Low-Low, High-Low-Moderate, and High-High-Low, respectively). Linear mixed-effect regressions modeled whether the profiles predicted depressive symptoms, suicide ideation, NSSI engagement, positive affect, satisfaction with life, and self-worth over time. Broadly, concordant stress response profiles (Low-Low-Low, High-High-High) were associated with resilient-like patterns of psychopathology and well-being over time. Adolescents with a concordant High-High-High stress response profile showed a trend of greater reduction in depressive symptoms (B = 0.71, p = 0.052), as well as increased global self-worth (B = ?0.88, p = 0.055), from T2 to T3 compared to the discordant High-High-Low profile. Concordance across multi-level stress responses may be protective and promote future resilience, whereas blunted physiological responses in the presence of high perceived and expressed stress may indicate poorer outcomes over time. En ligne : https://dx.doi.org/10.1017/S0954579423000731 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Stress system concordance as a predictor of longitudinal patterns of resilience in adolescence [Texte imprimé et/ou numérique] / Jessica BUTTS, Auteur ; Katherine A. CAROSELLA, Auteur ; Kathryn R. CULLEN, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Salahudeen MIRZA, Auteur ; Victoria PAPKE, Auteur ; Andrea WIGLESWORTH, Auteur . - p.2384-2401. in Development and Psychopathology > 35-5 (December 2023) . - p.2384-2401 Mots-clés : adolescence  depressive symptoms  resilience  self-worth  stress response Index. décimale : PER Périodiques Résumé : Resilience promotes positive adaptation to challenges and may facilitate recovery for adolescents experiencing psychopathology. This work examined concordance across the experience, expression, and physiological response to stress as a protective factor that may predict longitudinal patterns of psychopathology and well-being that mark resilience. Adolescents aged 14?17 at recruitment (oversampled for histories of non-suicidal self-injury; NSSI) were part of a three-wave (T1, T2, T3) longitudinal study. Multi-trajectory modeling produced four distinct profiles of stress experience, expression, and physiology at T1 (High-High-High, Low-Low-Low, High-Low-Moderate, and High-High-Low, respectively). Linear mixed-effect regressions modeled whether the profiles predicted depressive symptoms, suicide ideation, NSSI engagement, positive affect, satisfaction with life, and self-worth over time. Broadly, concordant stress response profiles (Low-Low-Low, High-High-High) were associated with resilient-like patterns of psychopathology and well-being over time. Adolescents with a concordant High-High-High stress response profile showed a trend of greater reduction in depressive symptoms (B = 0.71, p = 0.052), as well as increased global self-worth (B = ?0.88, p = 0.055), from T2 to T3 compared to the discordant High-High-Low profile. Concordance across multi-level stress responses may be protective and promote future resilience, whereas blunted physiological responses in the presence of high perceived and expressed stress may indicate poorer outcomes over time. En ligne : https://dx.doi.org/10.1017/S0954579423000731 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

The development of thought problems: A longitudinal family risk study of offspring of bipolar, unipolar, and well parents / Bonnie KLIMES-DOUGAN in Development and Psychopathology, 25-4 (November 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-4 (November 2013) . - p.1079-1091 Titre : The development of thought problems: A longitudinal family risk study of offspring of bipolar, unipolar, and well parents Type de document : Texte imprimé et/ou numérique Auteurs : Bonnie KLIMES-DOUGAN, Auteur ; Christopher David DESJARDINS, Auteur ; Matthew G. JAMES, Auteur ; Angela J. NARAYAN, Auteur ; Jeffrey D. LONG, Auteur ; Kathryn R. CULLEN, Auteur ; Philip W. GOLD, Auteur ; Pedro E. MARTINEZ, Auteur Article en page(s) : p.1079-1091 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There is growing evidence that many offspring of parents with bipolar disorder (BD) will develop moderate to severe forms of psychopathology during childhood and adolescence, including thought problems. The purpose of this study was to evaluate the developmental progression of thought problems within the context of a family risk study. Repeated assessments of thought problems, spanning approximately 15 years, were conducted in offspring (N = 192 from 98 families) of parents diagnosed with BD (O-BD), unipolar depression (O-UNI), or no significant psychiatric or medical problems (O-WELL). Survival analysis showed that the O-BD group had the greatest estimated probability of developing thought problems over time, followed by O-UNI, and then O-WELL and O-BD exhibiting higher levels of persistence than O-WELL. Parent-reported thought problems in childhood and adolescence predicted a range of problems in young adulthood. Disturbances in reality testing and other atypical behaviors are likely to disrupt progression through important developmental periods and to associate with poor outcomes. These findings are likely relevant to preventing the occurrence or progression of problems in offspring of bipolar parents. The study of thought problems across development represents an important area of continued research in children at risk for development of affective disorders. En ligne : http://dx.doi.org/10.1017/S0954579413000382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] The development of thought problems: A longitudinal family risk study of offspring of bipolar, unipolar, and well parents [Texte imprimé et/ou numérique] / Bonnie KLIMES-DOUGAN, Auteur ; Christopher David DESJARDINS, Auteur ; Matthew G. JAMES, Auteur ; Angela J. NARAYAN, Auteur ; Jeffrey D. LONG, Auteur ; Kathryn R. CULLEN, Auteur ; Philip W. GOLD, Auteur ; Pedro E. MARTINEZ, Auteur . - p.1079-1091. Langues : Anglais (eng) in Development and Psychopathology > 25-4 (November 2013) . - p.1079-1091 Index. décimale : PER Périodiques Résumé : There is growing evidence that many offspring of parents with bipolar disorder (BD) will develop moderate to severe forms of psychopathology during childhood and adolescence, including thought problems. The purpose of this study was to evaluate the developmental progression of thought problems within the context of a family risk study. Repeated assessments of thought problems, spanning approximately 15 years, were conducted in offspring (N = 192 from 98 families) of parents diagnosed with BD (O-BD), unipolar depression (O-UNI), or no significant psychiatric or medical problems (O-WELL). Survival analysis showed that the O-BD group had the greatest estimated probability of developing thought problems over time, followed by O-UNI, and then O-WELL and O-BD exhibiting higher levels of persistence than O-WELL. Parent-reported thought problems in childhood and adolescence predicted a range of problems in young adulthood. Disturbances in reality testing and other atypical behaviors are likely to disrupt progression through important developmental periods and to associate with poor outcomes. These findings are likely relevant to preventing the occurrence or progression of problems in offspring of bipolar parents. The study of thought problems across development represents an important area of continued research in children at risk for development of affective disorders. En ligne : http://dx.doi.org/10.1017/S0954579413000382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

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