Contribution of the right temporoparietal junction and ventromedial prefrontal cortex to theory of mind in autism: A randomized, sham-controlled tDCS study / Mohammad Ali SALEHINEJAD in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1572-1584 Titre : Contribution of the right temporoparietal junction and ventromedial prefrontal cortex to theory of mind in autism: A randomized, sham-controlled tDCS study Type de document : texte imprimé Auteurs : Mohammad Ali SALEHINEJAD, Auteur ; Nasim PAKNIA, Auteur ; Amir Hossein HOSSEINPOUR, Auteur ; Fatemeh YAVARI, Auteur ; Carmelo M. VICARIO, Auteur ; Michael A. NITSCHE, Auteur ; Vahid NEJATI, Auteur Article en page(s) : p.1572-1584 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy  Autistic Disorder  Child  Humans  Pilot Projects  Prefrontal Cortex/diagnostic imaging  Theory of Mind  Transcranial Direct Current Stimulation  autism spectrum disorder  noninvasive brain stimulation  temporoparietal junction  ventromedial prefrontal cortex Index. décimale : PER Périodiques Résumé : Theory of mind (ToM) is the ability to attribute subjective mental states to oneself and others and is significantly impaired in autism spectrum disorder (ASD). A frontal-posterior network of regions including the ventromedial prefrontal cortex (vmPFC) and temporoparietal junction (TPJ) is involved in ToM. Previous studies show an underactivation of these regions in ASD. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation method for causally investigating brain-behavior relationships via induction of cortical excitability alterations. tDCS, mostly over the dorsolateral prefrontal cortex, has been increasingly applied for improving behavioral problems in ASD leaving other potentially interesting regions untouched. Here we investigated contribution of the vmPFC and right TPJ in ToM abilities of ASD children via tDCS in a pilot study. Sixteen children with ASD (mean age = 10.7 ± 1.9) underwent three tDCS sessions (1 mA, 20 min) in a randomized, sham-controlled design. Stimulation protocols included: (a) anodal vmPFC tDCS, (b) anodal r-TPJ tDCS, and (c) sham tDCS. ToM abilities were explored during tDCS using the theory of mind test (TOMT). Our results show that activation of the vmPFC with anodal tDCS significantly improved ToM in children with ASD compared with both, r-TPJ tDCS, and sham stimulation. Specifically, precursors of ToM (e.g., emotion recognition, perception, and imitation) and elementary ToM skills (e.g., first-order mental state reasoning) were significantly improved by anodal vmPFC tDCS. Based on these results, the vmPFC could be a potential target region for the reduction of ASD symptoms via noninvasive brain stimulation, which should be examined in larger detail in future studies. LAY SUMMARY: Theory of mind (ToM) is the ability to infer mental states of oneself and others, which is impaired in autism. Brain imaging studies have shown involvement of two brain regions in ToM (ventromedial prefrontal cortex, temporoparietal junction) which are underactivated in autism. We increased activation of these regions via noninvasive brain stimulation in this experiment to see how it would affect ToM abilities in autism. We found that increased activation of the ventromedial prefrontal cortex improved ToM abilities in children with autism. En ligne : http://dx.doi.org/10.1002/aur.2538 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Contribution of the right temporoparietal junction and ventromedial prefrontal cortex to theory of mind in autism: A randomized, sham-controlled tDCS study [texte imprimé] / Mohammad Ali SALEHINEJAD, Auteur ; Nasim PAKNIA, Auteur ; Amir Hossein HOSSEINPOUR, Auteur ; Fatemeh YAVARI, Auteur ; Carmelo M. VICARIO, Auteur ; Michael A. NITSCHE, Auteur ; Vahid NEJATI, Auteur . - p.1572-1584. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1572-1584 Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy  Autistic Disorder  Child  Humans  Pilot Projects  Prefrontal Cortex/diagnostic imaging  Theory of Mind  Transcranial Direct Current Stimulation  autism spectrum disorder  noninvasive brain stimulation  temporoparietal junction  ventromedial prefrontal cortex Index. décimale : PER Périodiques Résumé : Theory of mind (ToM) is the ability to attribute subjective mental states to oneself and others and is significantly impaired in autism spectrum disorder (ASD). A frontal-posterior network of regions including the ventromedial prefrontal cortex (vmPFC) and temporoparietal junction (TPJ) is involved in ToM. Previous studies show an underactivation of these regions in ASD. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation method for causally investigating brain-behavior relationships via induction of cortical excitability alterations. tDCS, mostly over the dorsolateral prefrontal cortex, has been increasingly applied for improving behavioral problems in ASD leaving other potentially interesting regions untouched. Here we investigated contribution of the vmPFC and right TPJ in ToM abilities of ASD children via tDCS in a pilot study. Sixteen children with ASD (mean age = 10.7 ± 1.9) underwent three tDCS sessions (1 mA, 20 min) in a randomized, sham-controlled design. Stimulation protocols included: (a) anodal vmPFC tDCS, (b) anodal r-TPJ tDCS, and (c) sham tDCS. ToM abilities were explored during tDCS using the theory of mind test (TOMT). Our results show that activation of the vmPFC with anodal tDCS significantly improved ToM in children with ASD compared with both, r-TPJ tDCS, and sham stimulation. Specifically, precursors of ToM (e.g., emotion recognition, perception, and imitation) and elementary ToM skills (e.g., first-order mental state reasoning) were significantly improved by anodal vmPFC tDCS. Based on these results, the vmPFC could be a potential target region for the reduction of ASD symptoms via noninvasive brain stimulation, which should be examined in larger detail in future studies. LAY SUMMARY: Theory of mind (ToM) is the ability to infer mental states of oneself and others, which is impaired in autism. Brain imaging studies have shown involvement of two brain regions in ToM (ventromedial prefrontal cortex, temporoparietal junction) which are underactivated in autism. We increased activation of these regions via noninvasive brain stimulation in this experiment to see how it would affect ToM abilities in autism. We found that increased activation of the ventromedial prefrontal cortex improved ToM abilities in children with autism. En ligne : http://dx.doi.org/10.1002/aur.2538 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Reading the mind in the face and voice in parents of children with Autism Spectrum Disorders / Maryam TAJMIRRIYAHI in Research in Autism Spectrum Disorders, 7-12 (December 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-12 (December 2013) . - p.1543-1550 Titre : Reading the mind in the face and voice in parents of children with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Maryam TAJMIRRIYAHI, Auteur ; Vahid NEJATI, Auteur ; Hamid Reza POURETEMAD, Auteur ; Rouhollah Mansuri SEPEHR, Auteur Article en page(s) : p.1543-1550 Langues : Anglais (eng) Mots-clés : Autism  Theory of mind  Reading the Mind in the Eyes  Reading the Mind in the Voice Index. décimale : PER Périodiques Résumé : Abstract One core feature of Autism Spectrum Disorders (ASD) is impairment in social functioning and inferring mental states and emotions referred to theory of mind (TOM). The “Broad Autism Phenotype” (BAP) proposes that defining features of autism express in milder form among first degree relatives of these patients. Theory of mind deficits has been examined using advanced TOM tasks such as “Reading the Mind in the Eyes”. This study has furthered previous findings using another test designed to tap higher TOM abilities named “Mind Reading in the Voice”. The objective of this study is to examine theory of mind abilities from two main communicative sources in parents of children with ASD in contrast to two groups, one clinical and one non-clinical. Forty-eight parents of individuals with autism, 31 parents of individuals with Down syndrome and 30 parents of typically developed children were administered two tests of mind-reading. Analysis revealed that although there is not a significant difference between three groups’ performance in “Mind Reading from Eyes”, parents of children with ASD have significantly lower performance in “Mind Reading from Voice”. It can be concluded that TOM deficits in parents of children with ASD are not restricted to inferring mental states form eyes and deficits in mind-reading from voice could also be a part of BAP. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.08.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Reading the mind in the face and voice in parents of children with Autism Spectrum Disorders [texte imprimé] / Maryam TAJMIRRIYAHI, Auteur ; Vahid NEJATI, Auteur ; Hamid Reza POURETEMAD, Auteur ; Rouhollah Mansuri SEPEHR, Auteur . - p.1543-1550. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-12 (December 2013) . - p.1543-1550 Mots-clés : Autism  Theory of mind  Reading the Mind in the Eyes  Reading the Mind in the Voice Index. décimale : PER Périodiques Résumé : Abstract One core feature of Autism Spectrum Disorders (ASD) is impairment in social functioning and inferring mental states and emotions referred to theory of mind (TOM). The “Broad Autism Phenotype” (BAP) proposes that defining features of autism express in milder form among first degree relatives of these patients. Theory of mind deficits has been examined using advanced TOM tasks such as “Reading the Mind in the Eyes”. This study has furthered previous findings using another test designed to tap higher TOM abilities named “Mind Reading in the Voice”. The objective of this study is to examine theory of mind abilities from two main communicative sources in parents of children with ASD in contrast to two groups, one clinical and one non-clinical. Forty-eight parents of individuals with autism, 31 parents of individuals with Down syndrome and 30 parents of typically developed children were administered two tests of mind-reading. Analysis revealed that although there is not a significant difference between three groups’ performance in “Mind Reading from Eyes”, parents of children with ASD have significantly lower performance in “Mind Reading from Voice”. It can be concluded that TOM deficits in parents of children with ASD are not restricted to inferring mental states form eyes and deficits in mind-reading from voice could also be a part of BAP. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.08.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

The effectiveness of transcranial electrical stimulation in individuals with specific learning disorder (SLD): systematic review and transfer analysis / Vahid NEJATI in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : The effectiveness of transcranial electrical stimulation in individuals with specific learning disorder (SLD): systematic review and transfer analysis Type de document : texte imprimé Auteurs : Vahid NEJATI, Auteur ; Fateme GHAFURI, Auteur ; Katayoon HOSSEINI, Auteur ; Roozbeh BEHROOZMAND, Auteur Langues : Anglais (eng) Mots-clés : Humans  Transcranial Direct Current Stimulation/methods  Learning Disabilities/therapy  Transfer, Psychology/physiology  Treatment Outcome  Effectiveness  Meta-analysis  Review  Specific learning disabilities (SLD)  Transcranial electrical stimulation (tES)  Transferability  meta-analysis study do not involve human subjects  hence, ethical approval and  consent to participate are not applicable. Consent for publication: All authors  consent to the publication of this study. Competing interests: The authors  declare that there is no conflict of interest. Index. décimale : PER Périodiques Résumé : This comprehensive review aimed to investigate the transferability of transcranial electrical Stimulation (tES) interventions in individuals with specific learning disabilities (SLD) based on the FIELD model, encompassing function, implements, ecology, level, and durability. A systematic search of electronic databases yielded a total of 13 eligible studies, 11 transcranial direct current stimulation (tDCS), 1 transcranial random noise stimulation (tRNS), and 1 transcranial alternating current stimulation (tACS), encompass 286 individuals with SLD, for inclusion. The overall effect size analysis revealed positive transfer effects in all domains of FIELD, indicating the potential effectiveness of non-invasive brain stimulations (NIBS) interventions in enhancing various aspects of learning and behavior in individuals with SLD. The subgroup analysis further underscored the positive impact of age, dose, and concurrent intervention on transferability. In conclusion, this study contributes valuable insights into the transferability of tES interventions and holds promise for improving learning and behavioral outcomes in individuals with SLD. En ligne : https://dx.doi.org/10.1186/s11689-025-09623-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] The effectiveness of transcranial electrical stimulation in individuals with specific learning disorder (SLD): systematic review and transfer analysis [texte imprimé] / Vahid NEJATI, Auteur ; Fateme GHAFURI, Auteur ; Katayoon HOSSEINI, Auteur ; Roozbeh BEHROOZMAND, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Transcranial Direct Current Stimulation/methods  Learning Disabilities/therapy  Transfer, Psychology/physiology  Treatment Outcome  Effectiveness  Meta-analysis  Review  Specific learning disabilities (SLD)  Transcranial electrical stimulation (tES)  Transferability  meta-analysis study do not involve human subjects  hence, ethical approval and  consent to participate are not applicable. Consent for publication: All authors  consent to the publication of this study. Competing interests: The authors  declare that there is no conflict of interest. Index. décimale : PER Périodiques Résumé : This comprehensive review aimed to investigate the transferability of transcranial electrical Stimulation (tES) interventions in individuals with specific learning disabilities (SLD) based on the FIELD model, encompassing function, implements, ecology, level, and durability. A systematic search of electronic databases yielded a total of 13 eligible studies, 11 transcranial direct current stimulation (tDCS), 1 transcranial random noise stimulation (tRNS), and 1 transcranial alternating current stimulation (tACS), encompass 286 individuals with SLD, for inclusion. The overall effect size analysis revealed positive transfer effects in all domains of FIELD, indicating the potential effectiveness of non-invasive brain stimulations (NIBS) interventions in enhancing various aspects of learning and behavior in individuals with SLD. The subgroup analysis further underscored the positive impact of age, dose, and concurrent intervention on transferability. In conclusion, this study contributes valuable insights into the transferability of tES interventions and holds promise for improving learning and behavioral outcomes in individuals with SLD. En ligne : https://dx.doi.org/10.1186/s11689-025-09623-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

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