Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism / Janna GUILFOYLE in Journal of Autism and Developmental Disorders, 53-5 (May 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-5 (May 2023) . - p.1989-2005 Titre : Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism Type de document : Texte imprimé et/ou numérique Auteurs : Janna GUILFOYLE, Auteur ; Molly WINSTON, Auteur ; John SIDERIS, Auteur ; Gary E. MARTIN, Auteur ; Kritika NAYAR, Auteur ; Lauren BUSH, Auteur ; Tom WASSINK, Auteur ; Molly LOSH, Auteur Article en page(s) : p.1989-2005 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD), a heritable neurodevelopmental disorder, confers genetic liability that is often expressed among relatives through subclinical, genetically-meaningful traits, or endophenotypes. For instance, relative to controls, parents of individuals with ASD differ in language-related skills, with differences emerging in childhood. To examine ASD-related endophenotypes, this study investigated developmental academic profiles among clinically unaffected siblings of individuals with ASD (n=29). Lower performance in language-related skills among siblings mirrored previously-reported patterns among parents, which were also associated with greater subclinical ASD-related traits in themselves and their parents, and with greater symptom severity in their sibling with ASD. Findings demonstrated specific phenotypes, derived from standardized academic testing, that may represent childhood indicators of genetic liability to ASD in first-degree relatives. En ligne : https://doi.org/10.1007/s10803-022-05459-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism [Texte imprimé et/ou numérique] / Janna GUILFOYLE, Auteur ; Molly WINSTON, Auteur ; John SIDERIS, Auteur ; Gary E. MARTIN, Auteur ; Kritika NAYAR, Auteur ; Lauren BUSH, Auteur ; Tom WASSINK, Auteur ; Molly LOSH, Auteur . - p.1989-2005. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-5 (May 2023) . - p.1989-2005 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD), a heritable neurodevelopmental disorder, confers genetic liability that is often expressed among relatives through subclinical, genetically-meaningful traits, or endophenotypes. For instance, relative to controls, parents of individuals with ASD differ in language-related skills, with differences emerging in childhood. To examine ASD-related endophenotypes, this study investigated developmental academic profiles among clinically unaffected siblings of individuals with ASD (n=29). Lower performance in language-related skills among siblings mirrored previously-reported patterns among parents, which were also associated with greater subclinical ASD-related traits in themselves and their parents, and with greater symptom severity in their sibling with ASD. Findings demonstrated specific phenotypes, derived from standardized academic testing, that may represent childhood indicators of genetic liability to ASD in first-degree relatives. En ligne : https://doi.org/10.1007/s10803-022-05459-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study / Molly LOSH in Journal of Autism and Developmental Disorders, 47-3 (March 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-3 (March 2017) . - p.834-845 Titre : Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study Type de document : Texte imprimé et/ou numérique Auteurs : Molly LOSH, Auteur ; Gary E. MARTIN, Auteur ; Michelle LEE, Auteur ; Jessica KLUSEK, Auteur ; John SIDERIS, Auteur ; Sheila BARRON, Auteur ; Thomas WASSINK, Auteur Article en page(s) : p.834-845 Langues : Anglais (eng) Mots-clés : Autism  Genetics  Endophenotype  Longitudinal  Broad autism phenotype  Language Index. décimale : PER Périodiques Résumé : Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents’ childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents’ childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development across domains predicted ASD endophenotypes in adulthood for parents, and the severity of clinical symptoms in children with ASD. These findings may mark childhood indicators of genetic liability to ASD in parents, that could inform understanding of the subclinical expression of ASD genetic liability. En ligne : http://dx.doi.org/10.1007/s10803-016-2996-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study [Texte imprimé et/ou numérique] / Molly LOSH, Auteur ; Gary E. MARTIN, Auteur ; Michelle LEE, Auteur ; Jessica KLUSEK, Auteur ; John SIDERIS, Auteur ; Sheila BARRON, Auteur ; Thomas WASSINK, Auteur . - p.834-845. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-3 (March 2017) . - p.834-845 Mots-clés : Autism  Genetics  Endophenotype  Longitudinal  Broad autism phenotype  Language Index. décimale : PER Périodiques Résumé : Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents’ childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents’ childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development across domains predicted ASD endophenotypes in adulthood for parents, and the severity of clinical symptoms in children with ASD. These findings may mark childhood indicators of genetic liability to ASD in parents, that could inform understanding of the subclinical expression of ASD genetic liability. En ligne : http://dx.doi.org/10.1007/s10803-016-2996-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Neural Processing of Speech Sounds in ASD and First-Degree Relatives / Shivani P. PATEL in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3257-3271 Titre : Neural Processing of Speech Sounds in ASD and First-Degree Relatives Type de document : Texte imprimé et/ou numérique Auteurs : Shivani P. PATEL, Auteur ; Molly WINSTON, Auteur ; Janna GUILFOYLE, Auteur ; Trent NICOL, Auteur ; Gary E. MARTIN, Auteur ; Kritika NAYAR, Auteur ; Nina KRAUS, Auteur ; Molly LOSH, Auteur Article en page(s) : p.3257-3271 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Efficient neural encoding of sound plays a critical role in speech and language, and when impaired, may have reverberating effects on communication skills. This study investigated disruptions to neural processing of temporal and spectral properties of speech in individuals with ASD and their parents and found evidence of inefficient temporal encoding of speech sounds in both groups. The ASD group further demonstrated less robust neural representation of spectral properties of speech sounds. Associations between neural processing of speech sounds and language-related abilities were evident in both groups. Parent-child associations were also detected in neural pitch processing. Together, results suggest that atypical neural processing of speech sounds is a heritable ingredient contributing to the ASD language phenotype. En ligne : https://doi.org/10.1007/s10803-022-05562-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Neural Processing of Speech Sounds in ASD and First-Degree Relatives [Texte imprimé et/ou numérique] / Shivani P. PATEL, Auteur ; Molly WINSTON, Auteur ; Janna GUILFOYLE, Auteur ; Trent NICOL, Auteur ; Gary E. MARTIN, Auteur ; Kritika NAYAR, Auteur ; Nina KRAUS, Auteur ; Molly LOSH, Auteur . - p.3257-3271. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3257-3271 Index. décimale : PER Périodiques Résumé : Efficient neural encoding of sound plays a critical role in speech and language, and when impaired, may have reverberating effects on communication skills. This study investigated disruptions to neural processing of temporal and spectral properties of speech in individuals with ASD and their parents and found evidence of inefficient temporal encoding of speech sounds in both groups. The ASD group further demonstrated less robust neural representation of spectral properties of speech sounds. Associations between neural processing of speech sounds and language-related abilities were evident in both groups. Parent-child associations were also detected in neural pitch processing. Together, results suggest that atypical neural processing of speech sounds is a heritable ingredient contributing to the ASD language phenotype. En ligne : https://doi.org/10.1007/s10803-022-05562-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Sex differences and within-family associations in the broad autism phenotype / Jessica KLUSEK in Autism, 18-2 (February 2014)  

Public ISBD [article]  inAutism > 18-2 (February 2014) . - p.106-116 Titre : Sex differences and within-family associations in the broad autism phenotype Type de document : Texte imprimé et/ou numérique Auteurs : Jessica KLUSEK, Auteur ; Molly LOSH, Auteur ; Gary E. MARTIN, Auteur Article en page(s) : p.106-116 Langues : Anglais (eng) Mots-clés : autism  broad autism phenotype  endophenotype  gender  personality  pragmatic language  sex Index. décimale : PER Périodiques Résumé : While there is a strong sex bias in the presentation of autism, it is unknown whether this bias is also present in subclinical manifestations of autism among relatives, or the broad autism phenotype. This study examined this question and investigated patterns of co-occurrence of broad autism phenotype traits within families of individuals with autism. Pragmatic language and personality features of the broad autism phenotype were studied in 42 fathers and 50 mothers of individuals with autism using direct assessment tools used in prior family studies of the broad autism phenotype. Higher rates of aloof personality style were detected among fathers, while no sex differences were detected for other broad autism phenotype traits. Within individuals, pragmatic language features were associated with the social personality styles of the broad autism phenotype in mothers but not in fathers. A number of broad autism phenotype features were correlated within spousal pairs. Finally, the associations were detected between paternal broad autism phenotype characteristics and the severity of children’s autism symptoms in all three domains (social, communication, and repetitive behaviors). Mother–child correlations were detected for aspects of communication only. Together, the findings suggest that most features of the broad autism phenotype express comparably in males and females and raise some specific questions about how such features might inform studies of the genetic basis of autism. En ligne : http://dx.doi.org/10.1177/1362361312464529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223 [article] Sex differences and within-family associations in the broad autism phenotype [Texte imprimé et/ou numérique] / Jessica KLUSEK, Auteur ; Molly LOSH, Auteur ; Gary E. MARTIN, Auteur . - p.106-116. Langues : Anglais (eng) in Autism > 18-2 (February 2014) . - p.106-116 Mots-clés : autism  broad autism phenotype  endophenotype  gender  personality  pragmatic language  sex Index. décimale : PER Périodiques Résumé : While there is a strong sex bias in the presentation of autism, it is unknown whether this bias is also present in subclinical manifestations of autism among relatives, or the broad autism phenotype. This study examined this question and investigated patterns of co-occurrence of broad autism phenotype traits within families of individuals with autism. Pragmatic language and personality features of the broad autism phenotype were studied in 42 fathers and 50 mothers of individuals with autism using direct assessment tools used in prior family studies of the broad autism phenotype. Higher rates of aloof personality style were detected among fathers, while no sex differences were detected for other broad autism phenotype traits. Within individuals, pragmatic language features were associated with the social personality styles of the broad autism phenotype in mothers but not in fathers. A number of broad autism phenotype features were correlated within spousal pairs. Finally, the associations were detected between paternal broad autism phenotype characteristics and the severity of children’s autism symptoms in all three domains (social, communication, and repetitive behaviors). Mother–child correlations were detected for aspects of communication only. Together, the findings suggest that most features of the broad autism phenotype express comparably in males and females and raise some specific questions about how such features might inform studies of the genetic basis of autism. En ligne : http://dx.doi.org/10.1177/1362361312464529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223

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