Association of Autism Spectrum Disorders and Inflammatory Bowel Disease / Michelle LEE in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1523-1529 Titre : Association of Autism Spectrum Disorders and Inflammatory Bowel Disease Type de document : texte imprimé Auteurs : Michelle LEE, Auteur ; Jayasree KRISHNAMURTHY, Auteur ; Apryl SUSI, Auteur ; Carolyn SULLIVAN, Auteur ; Gregory H. GORMAN, Auteur ; Elizabeth HISLE-GORMAN, Auteur ; Christine R. ERDIE-LALENA, Auteur ; Cade M. NYLUND, Auteur Article en page(s) : p.1523-1529 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders (ASD)  Crohn's disease (CD)  Inflammatory bowel disease (IBD)  Ulcerative colitis (UC) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) and inflammatory bowel disease (IBD) both have multifactorial pathogenesis with an increasing number of studies demonstrating gut-brain associations. We aim to examine the association between ASD and IBD using strict classification criteria for IBD. We conducted a retrospective case-cohort study using records from the Military Health System database with IBD defined as having one encounter with an ICD-9-CM diagnostic code for IBD and at least one outpatient prescription dispensed for a medication to treat IBD. Children with ASD were more likely to meet criteria for Crohn's disease (CD) and Ulcerative colitis (UC) compared to controls. This higher prevalence of CD and UC in children with ASD compared to controls confirms the association of ASD with IBD. En ligne : http://dx.doi.org/10.1007/s10803-017-3409-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355 [article] Association of Autism Spectrum Disorders and Inflammatory Bowel Disease [texte imprimé] / Michelle LEE, Auteur ; Jayasree KRISHNAMURTHY, Auteur ; Apryl SUSI, Auteur ; Carolyn SULLIVAN, Auteur ; Gregory H. GORMAN, Auteur ; Elizabeth HISLE-GORMAN, Auteur ; Christine R. ERDIE-LALENA, Auteur ; Cade M. NYLUND, Auteur . - p.1523-1529. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1523-1529 Mots-clés : Autism spectrum disorders (ASD)  Crohn's disease (CD)  Inflammatory bowel disease (IBD)  Ulcerative colitis (UC) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) and inflammatory bowel disease (IBD) both have multifactorial pathogenesis with an increasing number of studies demonstrating gut-brain associations. We aim to examine the association between ASD and IBD using strict classification criteria for IBD. We conducted a retrospective case-cohort study using records from the Military Health System database with IBD defined as having one encounter with an ICD-9-CM diagnostic code for IBD and at least one outpatient prescription dispensed for a medication to treat IBD. Children with ASD were more likely to meet criteria for Crohn's disease (CD) and Ulcerative colitis (UC) compared to controls. This higher prevalence of CD and UC in children with ASD compared to controls confirms the association of ASD with IBD. En ligne : http://dx.doi.org/10.1007/s10803-017-3409-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355

Developing an Adaptive Behavior Curriculum across the Age and Ability Range / Michelle LEE

Public ISBD in The SAGE Handbook of Autism and Education / Rita JORDAN Titre : Developing an Adaptive Behavior Curriculum across the Age and Ability Range Type de document : texte imprimé Auteurs : Michelle LEE, Auteur ; Kathryn SCHWEERS, Auteur ; Rachel LOFTIN, Auteur Année de publication : 2019 Importance : p.276-288 Langues : Anglais (eng) Index. décimale : APP-D APP-D - Interventions Educatives - Généralités Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=417 in The SAGE Handbook of Autism and Education / Rita JORDAN Developing an Adaptive Behavior Curriculum across the Age and Ability Range [texte imprimé] / Michelle LEE, Auteur ; Kathryn SCHWEERS, Auteur ; Rachel LOFTIN, Auteur . - 2019 . - p.276-288. Langues : Anglais (eng) Index. décimale : APP-D APP-D - Interventions Educatives - Généralités Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=417

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A developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome / Michelle LEE in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.47 Titre : A developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome Type de document : texte imprimé Auteurs : Michelle LEE, Auteur ; Gary E. MARTIN, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Molly LOSH, Auteur Article en page(s) : p.47 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Endophenotype  FMR1 gene  Fragile X syndrome  Language  Longitudinal  Pragmatics  Social behavior Index. décimale : PER Périodiques Résumé : BACKGROUND: Targeting overlapping behavioral phenotypes in neurogenetic disorders can help elucidate gene-behavior relationships. Fragile X syndrome (FXS) and autism spectrum disorder (ASD) have been studied as a model for this approach, and important areas of phenotypic overlap and divergence have been documented. However, few studies have examined how the manifestation of ASD-related phenotypes in FXS may change over development, a question which has important implications for conceptualizing shared etiologies of these disorders and their constituent phenotypes. The goal of this study was to characterize ASD phenotypes in boys and girls with FXS across development, as well as to compare individual component phenotypes among boys with FXS and boys with idiopathic ASD (ASD-O) over time. METHODS: Sixty-five boys and girls with FXS and 19 boys with ASD-O completed a battery of diagnostic, cognitive, and language assessments at two time points (mean 2.5 years apart). Nonparametric tests assessed changes in diagnostic classification in FXS over time, and hierarchical linear modeling and repeated measures assessed changes in individual ASD symptoms in FXS over time. Additionally, ANCOVAs compared ASD symptom severity and component phenotypes in boys with FXS-O, FXS-ASD, and ASD-O at both time points. RESULTS: Overall, ASD symptom manifestation for children with FXS significantly increased over time, and developmental predictors varied based on the domain of symptoms assessed. The greatest degree of overlap was observed between boys with FXS-ASD and ASD-O in the domain of reciprocal social communication across time points, whereas boys with ASD-O demonstrated greater impairment in restricted and repetitive behaviors at the later time point. CONCLUSIONS: ASD symptoms increased in FXS with age, and social language impairment emerged as a potential core shared feature of FXS and ASD that may help elucidate underlying molecular genetic variation related to phenotypic variance, and aid intervention planning for subgroups of children showing distinct phenotypes. Results highlight the value of a developmental perspective, and longitudinal data in particular, in evaluating shared behavioral phenotypes across genetic conditions, lending insight into underlying cognitive, neural, and genetic mechanisms associated with key developmental phenotypes in ASD and FXS. En ligne : http://dx.doi.org/10.1186/s11689-016-9179-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 [article] A developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome [texte imprimé] / Michelle LEE, Auteur ; Gary E. MARTIN, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Molly LOSH, Auteur . - p.47. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.47 Mots-clés : Autism spectrum disorder  Endophenotype  FMR1 gene  Fragile X syndrome  Language  Longitudinal  Pragmatics  Social behavior Index. décimale : PER Périodiques Résumé : BACKGROUND: Targeting overlapping behavioral phenotypes in neurogenetic disorders can help elucidate gene-behavior relationships. Fragile X syndrome (FXS) and autism spectrum disorder (ASD) have been studied as a model for this approach, and important areas of phenotypic overlap and divergence have been documented. However, few studies have examined how the manifestation of ASD-related phenotypes in FXS may change over development, a question which has important implications for conceptualizing shared etiologies of these disorders and their constituent phenotypes. The goal of this study was to characterize ASD phenotypes in boys and girls with FXS across development, as well as to compare individual component phenotypes among boys with FXS and boys with idiopathic ASD (ASD-O) over time. METHODS: Sixty-five boys and girls with FXS and 19 boys with ASD-O completed a battery of diagnostic, cognitive, and language assessments at two time points (mean 2.5 years apart). Nonparametric tests assessed changes in diagnostic classification in FXS over time, and hierarchical linear modeling and repeated measures assessed changes in individual ASD symptoms in FXS over time. Additionally, ANCOVAs compared ASD symptom severity and component phenotypes in boys with FXS-O, FXS-ASD, and ASD-O at both time points. RESULTS: Overall, ASD symptom manifestation for children with FXS significantly increased over time, and developmental predictors varied based on the domain of symptoms assessed. The greatest degree of overlap was observed between boys with FXS-ASD and ASD-O in the domain of reciprocal social communication across time points, whereas boys with ASD-O demonstrated greater impairment in restricted and repetitive behaviors at the later time point. CONCLUSIONS: ASD symptoms increased in FXS with age, and social language impairment emerged as a potential core shared feature of FXS and ASD that may help elucidate underlying molecular genetic variation related to phenotypic variance, and aid intervention planning for subgroups of children showing distinct phenotypes. Results highlight the value of a developmental perspective, and longitudinal data in particular, in evaluating shared behavioral phenotypes across genetic conditions, lending insight into underlying cognitive, neural, and genetic mechanisms associated with key developmental phenotypes in ASD and FXS. En ligne : http://dx.doi.org/10.1186/s11689-016-9179-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349

Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study / Molly LOSH in Journal of Autism and Developmental Disorders, 47-3 (March 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-3 (March 2017) . - p.834-845 Titre : Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study Type de document : texte imprimé Auteurs : Molly LOSH, Auteur ; Gary E. MARTIN, Auteur ; Michelle LEE, Auteur ; Jessica KLUSEK, Auteur ; John SIDERIS, Auteur ; Sheila BARRON, Auteur ; Thomas WASSINK, Auteur Article en page(s) : p.834-845 Langues : Anglais (eng) Mots-clés : Autism  Genetics  Endophenotype  Longitudinal  Broad autism phenotype  Language Index. décimale : PER Périodiques Résumé : Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents’ childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents’ childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development across domains predicted ASD endophenotypes in adulthood for parents, and the severity of clinical symptoms in children with ASD. These findings may mark childhood indicators of genetic liability to ASD in parents, that could inform understanding of the subclinical expression of ASD genetic liability. En ligne : http://dx.doi.org/10.1007/s10803-016-2996-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study [texte imprimé] / Molly LOSH, Auteur ; Gary E. MARTIN, Auteur ; Michelle LEE, Auteur ; Jessica KLUSEK, Auteur ; John SIDERIS, Auteur ; Sheila BARRON, Auteur ; Thomas WASSINK, Auteur . - p.834-845. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-3 (March 2017) . - p.834-845 Mots-clés : Autism  Genetics  Endophenotype  Longitudinal  Broad autism phenotype  Language Index. décimale : PER Périodiques Résumé : Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents’ childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents’ childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development across domains predicted ASD endophenotypes in adulthood for parents, and the severity of clinical symptoms in children with ASD. These findings may mark childhood indicators of genetic liability to ASD in parents, that could inform understanding of the subclinical expression of ASD genetic liability. En ligne : http://dx.doi.org/10.1007/s10803-016-2996-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Erratum to: A developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome / Michelle LEE in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.10 Titre : Erratum to: A developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome Type de document : texte imprimé Auteurs : Michelle LEE, Auteur ; Gary E. MARTIN, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Molly LOSH, Auteur Article en page(s) : p.10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : [This corrects the article DOI: 10.1186/s11689-016-9179-0.]. En ligne : http://dx.doi.org/10.1186/s11689-017-9192-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 [article] Erratum to: A developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome [texte imprimé] / Michelle LEE, Auteur ; Gary E. MARTIN, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Molly LOSH, Auteur . - p.10. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.10 Index. décimale : PER Périodiques Résumé : [This corrects the article DOI: 10.1186/s11689-016-9179-0.]. En ligne : http://dx.doi.org/10.1186/s11689-017-9192-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350

Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children / Mohammad H. RAHBAR in Journal of Autism and Developmental Disorders, 51-6 (June 2021)  

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Links between looking and speaking in autism and first-degree relatives: insights into the expression of genetic liability to autism / Kritika NAYAR in Molecular Autism, 9 (2018)  

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Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children / MacKinsey A. CHRISTIAN in Journal of Autism and Developmental Disorders, 48-8 (August 2018)