Dépouillements

Expanding Perspectives on Visual Mental Imagery in Autism: Aphantasia, Enhanced Abilities, and Future Directions / Lien-Chung WEI ; Cheng-Hsien Sung in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.236-237 Titre : Expanding Perspectives on Visual Mental Imagery in Autism: Aphantasia, Enhanced Abilities, and Future Directions : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Lien-Chung WEI, Auteur ; Cheng-Hsien Sung, Auteur Article en page(s) : p.236-237 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.3311 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Expanding Perspectives on Visual Mental Imagery in Autism: Aphantasia, Enhanced Abilities, and Future Directions : Autism Research [Texte imprimé et/ou numérique] / Lien-Chung WEI, Auteur ; Cheng-Hsien Sung, Auteur . - p.236-237. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.236-237 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.3311 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Action execution and observation in autistic adults: A systematic review of fMRI studies / Sara Stillesjö ; Hanna Hjärtström ; Anna-Maria Johansson ; Thomas Rudolfsson ; Daniel Säfström ; Erik DOMELLÖF in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.238-260 Titre : Action execution and observation in autistic adults: A systematic review of fMRI studies : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Sara Stillesjö, Auteur ; Hanna Hjärtström, Auteur ; Anna-Maria Johansson, Auteur ; Thomas Rudolfsson, Auteur ; Daniel Säfström, Auteur ; Erik DOMELLÖF, Auteur Article en page(s) : p.238-260 Langues : Anglais (eng) Mots-clés : action execution action imitation action observation autism autism spectrum disorder fMRI motor Index. décimale : PER Périodiques Résumé : Abstract Motor impairments are common in individuals with autism spectrum disorder (ASD) although less is known about the neural mechanisms related to such difficulties. This review provides an outline of functional magnetic resonance imaging (fMRI) findings associated with execution and observation of naturalistic actions in autistic adults. Summarized outcomes revealed that adults with ASD recruit similar brain regions as neurotypical adults during action execution and during action observation, although with a difference in direction and/or magnitude. For action execution, this included higher and lower activity bilaterally in the precentral cortex, the parietal cortex, the inferior frontal gyrus (IFG), the middle temporal gyrus (MTG), the occipital cortex, and the cerebellum. For action observation, differences mainly concerned both higher and lower activity in bilateral IFG and right precentral gyrus, and lower activity in MTG. Activity overlaps between action execution and observation highlight atypical recruitment of IFG, MTG, precentral, and parieto-occipital regions in ASD. The results show atypical recruitment of brain regions subserving motor planning and/or predictive control in ASD. Atypical brain activations during action observation, and the pattern of activity overlaps, indicate an association with difficulties in understanding others' actions and intentions. En ligne : https://doi.org/10.1002/aur.3291 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Action execution and observation in autistic adults: A systematic review of fMRI studies : Autism Research [Texte imprimé et/ou numérique] / Sara Stillesjö, Auteur ; Hanna Hjärtström, Auteur ; Anna-Maria Johansson, Auteur ; Thomas Rudolfsson, Auteur ; Daniel Säfström, Auteur ; Erik DOMELLÖF, Auteur . - p.238-260. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.238-260 Mots-clés : action execution action imitation action observation autism autism spectrum disorder fMRI motor Index. décimale : PER Périodiques Résumé : Abstract Motor impairments are common in individuals with autism spectrum disorder (ASD) although less is known about the neural mechanisms related to such difficulties. This review provides an outline of functional magnetic resonance imaging (fMRI) findings associated with execution and observation of naturalistic actions in autistic adults. Summarized outcomes revealed that adults with ASD recruit similar brain regions as neurotypical adults during action execution and during action observation, although with a difference in direction and/or magnitude. For action execution, this included higher and lower activity bilaterally in the precentral cortex, the parietal cortex, the inferior frontal gyrus (IFG), the middle temporal gyrus (MTG), the occipital cortex, and the cerebellum. For action observation, differences mainly concerned both higher and lower activity in bilateral IFG and right precentral gyrus, and lower activity in MTG. Activity overlaps between action execution and observation highlight atypical recruitment of IFG, MTG, precentral, and parieto-occipital regions in ASD. The results show atypical recruitment of brain regions subserving motor planning and/or predictive control in ASD. Atypical brain activations during action observation, and the pattern of activity overlaps, indicate an association with difficulties in understanding others' actions and intentions. En ligne : https://doi.org/10.1002/aur.3291 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Toward improved understanding and treatment of self-injurious behaviors in autistic individuals with profound intellectual disability / Emily F. FERGUSON ; Kaylin M. RUSSELL ; Sarely J. Licona ; Ru Ying CAI ; Thomas W. FRAZIER ; Giacomo VIVANTI ; Grace W. GENGOUX ; Antonio Y. HARDAN ; Mirko ULJAREVI? in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.261-272 Titre : Toward improved understanding and treatment of self-injurious behaviors in autistic individuals with profound intellectual disability : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Emily F. FERGUSON, Auteur ; Kaylin M. RUSSELL, Auteur ; Sarely J. Licona, Auteur ; Ru Ying CAI, Auteur ; Thomas W. FRAZIER, Auteur ; Giacomo VIVANTI, Auteur ; Grace W. GENGOUX, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVI?, Auteur Article en page(s) : p.261-272 Langues : Anglais (eng) Mots-clés : autism challenging behaviors emotion regulation externalizing intellectual disability self-harm self-injury Index. décimale : PER Périodiques Résumé : Abstract Self-injurious behaviors (SIB) commonly occur in autism spectrum disorder (ASD) and span diverse topographies of self-inflicted behaviors ranging from head banging to hitting oneself against hard objects. Despite the high rates of SIB in autistic individuals, relatively little research has focused on psychological factors associated with the development and maintenance of SIB in individuals with autism and moderate-profound intellectual disability (ID). This commentary synthesizes existing literature on SIB and highlights the need for more research focused on psychological correlates and mechanisms in autistic individuals with moderate-profound ID. We highlight the key role of difficulties in emotion regulation (ER) and co-occurring internalizing symptoms in the manifestation of self-harm behaviors in clinical samples and autism. Furthermore, this commentary proposes a framework for understanding the interplay between poor ER and internalizing symptoms in the development and maintenance of SIB in autistic individuals with moderate-profound ID. Specifically, we explore the emergence of SIB in the context of precipitating cues that trigger strong emotions, ER processes and strategy deployment, and co-occurring internalizing symptoms. Future directions and implications for longitudinal research, measurement development, and clinical treatments are discussed. En ligne : https://doi.org/10.1002/aur.3289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Toward improved understanding and treatment of self-injurious behaviors in autistic individuals with profound intellectual disability : Autism Research [Texte imprimé et/ou numérique] / Emily F. FERGUSON, Auteur ; Kaylin M. RUSSELL, Auteur ; Sarely J. Licona, Auteur ; Ru Ying CAI, Auteur ; Thomas W. FRAZIER, Auteur ; Giacomo VIVANTI, Auteur ; Grace W. GENGOUX, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVI?, Auteur . - p.261-272. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.261-272 Mots-clés : autism challenging behaviors emotion regulation externalizing intellectual disability self-harm self-injury Index. décimale : PER Périodiques Résumé : Abstract Self-injurious behaviors (SIB) commonly occur in autism spectrum disorder (ASD) and span diverse topographies of self-inflicted behaviors ranging from head banging to hitting oneself against hard objects. Despite the high rates of SIB in autistic individuals, relatively little research has focused on psychological factors associated with the development and maintenance of SIB in individuals with autism and moderate-profound intellectual disability (ID). This commentary synthesizes existing literature on SIB and highlights the need for more research focused on psychological correlates and mechanisms in autistic individuals with moderate-profound ID. We highlight the key role of difficulties in emotion regulation (ER) and co-occurring internalizing symptoms in the manifestation of self-harm behaviors in clinical samples and autism. Furthermore, this commentary proposes a framework for understanding the interplay between poor ER and internalizing symptoms in the development and maintenance of SIB in autistic individuals with moderate-profound ID. Specifically, we explore the emergence of SIB in the context of precipitating cues that trigger strong emotions, ER processes and strategy deployment, and co-occurring internalizing symptoms. Future directions and implications for longitudinal research, measurement development, and clinical treatments are discussed. En ligne : https://doi.org/10.1002/aur.3289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

What We Know and Do Not Know About Camouflaging, Impression Management, and Mental Health and Wellbeing in Autistic People / Valeria KHUDIAKOVA ; Mishel Alexandrovsky ; Wei Ai ; Meng-Chuan LAI in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.273-280 Titre : What We Know and Do Not Know About Camouflaging, Impression Management, and Mental Health and Wellbeing in Autistic People : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Valeria KHUDIAKOVA, Auteur ; Mishel Alexandrovsky, Auteur ; Wei Ai, Auteur ; Meng-Chuan LAI, Auteur Article en page(s) : p.273-280 Langues : Anglais (eng) Mots-clés : autism camouflaging impression management mental health stigma wellbeing Index. décimale : PER Périodiques Résumé : ABSTRACT Camouflaging is an impression management strategy employed by some autistic people, widely seen as a response to the pervasive stigma surrounding autism in society. Autistic narratives and lived experiences consistently link camouflaging to anxiety, depression, suicide risks, and autistic burnout. Quantitative research is yet to determine the nature of these relationships, with a significant portion of recent studies providing inconsistent evidence. While camouflaging can be a compelled survival strategy in social environments, it might also contribute to positive outcomes such as securing employment and forming positive social relationships, implicating a complex interrelationship with mental health and wellbeing. We advocate for using a transactional impression management framework to understand camouflaging and wellbeing and address the inconsistencies in research. Through examining the transactions among a person's individual and cognitive characteristics, behavior modification strategies, and the particular social contexts they find themselves in, this framework guides new empirical research directions to delineate the relationships between camouflaging, impression management, mental health, and wellbeing. There is a need to develop multiple measures of camouflaging that delineate the motivations, ability, effortfulness, and perceived effectiveness of camouflaging and examine how a person's social behaviors are perceived in different social environments. Research should also focus on intersectionality, sociocultural influences, and diverse autistic voices to study context-sensitive camouflaging experiences across the autistic population. En ligne : https://doi.org/10.1002/aur.3299 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] What We Know and Do Not Know About Camouflaging, Impression Management, and Mental Health and Wellbeing in Autistic People : Autism Research [Texte imprimé et/ou numérique] / Valeria KHUDIAKOVA, Auteur ; Mishel Alexandrovsky, Auteur ; Wei Ai, Auteur ; Meng-Chuan LAI, Auteur . - p.273-280. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.273-280 Mots-clés : autism camouflaging impression management mental health stigma wellbeing Index. décimale : PER Périodiques Résumé : ABSTRACT Camouflaging is an impression management strategy employed by some autistic people, widely seen as a response to the pervasive stigma surrounding autism in society. Autistic narratives and lived experiences consistently link camouflaging to anxiety, depression, suicide risks, and autistic burnout. Quantitative research is yet to determine the nature of these relationships, with a significant portion of recent studies providing inconsistent evidence. While camouflaging can be a compelled survival strategy in social environments, it might also contribute to positive outcomes such as securing employment and forming positive social relationships, implicating a complex interrelationship with mental health and wellbeing. We advocate for using a transactional impression management framework to understand camouflaging and wellbeing and address the inconsistencies in research. Through examining the transactions among a person's individual and cognitive characteristics, behavior modification strategies, and the particular social contexts they find themselves in, this framework guides new empirical research directions to delineate the relationships between camouflaging, impression management, mental health, and wellbeing. There is a need to develop multiple measures of camouflaging that delineate the motivations, ability, effortfulness, and perceived effectiveness of camouflaging and examine how a person's social behaviors are perceived in different social environments. Research should also focus on intersectionality, sociocultural influences, and diverse autistic voices to study context-sensitive camouflaging experiences across the autistic population. En ligne : https://doi.org/10.1002/aur.3299 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Cognitive flexibility in autism: How task predictability and sex influence performances / Adeline LACROIX ; Emma Torija ; Alexander Logemann ; Monica BACIU ; Renata CSERJESI ; Frédéric DUTHEIL ; Marie GOMOT ; Martial MERMILLOD in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.281-294 Titre : Cognitive flexibility in autism: How task predictability and sex influence performances : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Adeline LACROIX, Auteur ; Emma Torija, Auteur ; Alexander Logemann, Auteur ; Monica BACIU, Auteur ; Renata CSERJESI, Auteur ; Frédéric DUTHEIL, Auteur ; Marie GOMOT, Auteur ; Martial MERMILLOD, Auteur Article en page(s) : p.281-294 Langues : Anglais (eng) Mots-clés : autism cognitive flexibility gender differences predictive brain sex differences Index. décimale : PER Périodiques Résumé : Abstract While cognitive flexibility challenges are frequently reported in autistic individuals, inconsistencies in the findings prompt further investigation into the factors influencing this flexibility. We suggest that unique aspects of the predictive brain in autistic individuals might contribute to these challenges, potentially varying by sex. Our study aimed to test these hypotheses by examining cognitive flexibility under different predictability conditions in a sample including a similar number of males and females. We conducted an online study with 263 adults (127 with an autism diagnosis), where participants completed a flexibility task under varying levels of predictability (unpredictable, moderately predictable, and predictable). Our results indicate that as task predictability increases, performance improves; however, the response time gap between autistic and non-autistic individuals also widens. Moreover, we observe significant differences between autistic males and females, which differ from non-autistic individuals, highlighting the need to consider sex differences in research related to the cognition of autistic individuals. Overall, our findings contribute to a better understanding of cognitive flexibility and sex differences in autism in light of predictive brain theories and suggest avenues for further research. En ligne : https://doi.org/10.1002/aur.3281 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Cognitive flexibility in autism: How task predictability and sex influence performances : Autism Research [Texte imprimé et/ou numérique] / Adeline LACROIX, Auteur ; Emma Torija, Auteur ; Alexander Logemann, Auteur ; Monica BACIU, Auteur ; Renata CSERJESI, Auteur ; Frédéric DUTHEIL, Auteur ; Marie GOMOT, Auteur ; Martial MERMILLOD, Auteur . - p.281-294. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.281-294 Mots-clés : autism cognitive flexibility gender differences predictive brain sex differences Index. décimale : PER Périodiques Résumé : Abstract While cognitive flexibility challenges are frequently reported in autistic individuals, inconsistencies in the findings prompt further investigation into the factors influencing this flexibility. We suggest that unique aspects of the predictive brain in autistic individuals might contribute to these challenges, potentially varying by sex. Our study aimed to test these hypotheses by examining cognitive flexibility under different predictability conditions in a sample including a similar number of males and females. We conducted an online study with 263 adults (127 with an autism diagnosis), where participants completed a flexibility task under varying levels of predictability (unpredictable, moderately predictable, and predictable). Our results indicate that as task predictability increases, performance improves; however, the response time gap between autistic and non-autistic individuals also widens. Moreover, we observe significant differences between autistic males and females, which differ from non-autistic individuals, highlighting the need to consider sex differences in research related to the cognition of autistic individuals. Overall, our findings contribute to a better understanding of cognitive flexibility and sex differences in autism in light of predictive brain theories and suggest avenues for further research. En ligne : https://doi.org/10.1002/aur.3281 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Altered category learning and reduced generalization in autistic adults / Jaana VAN OVERWALLE ; Stephanie VAN DER DONCK ; Birte GEUSENS ; Bart BOETS ; Johan WAGEMANS in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.295-311 Titre : Altered category learning and reduced generalization in autistic adults : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Jaana VAN OVERWALLE, Auteur ; Stephanie VAN DER DONCK, Auteur ; Birte GEUSENS, Auteur ; Bart BOETS, Auteur ; Johan WAGEMANS, Auteur Article en page(s) : p.295-311 Langues : Anglais (eng) Mots-clés : autism categorization electroencephalography generalization intolerance to uncertainty perceptual learning predictive processing Index. décimale : PER Périodiques Résumé : Abstract Individuals with autism spectrum condition (ASC) are suggested to experience difficulties with categorization and generalization. However, empirical studies have mainly focused on one process at a time, and neglected underlying neural mechanisms. Here, we investigated categorization and generalization at a behavioral and neural level in 38 autistic and 38 neurotypical (NT) adults. By presenting shapes sampled from an artificial multidimensional stimulus space, we investigated (1) behavioral and neural underpinnings of category learning and (2) behavioral generalization of trained categorization to both an extended version of the stimulus space and a novel stimulus space. Our previous findings showed that individuals with autism were slower in category learning. In this study, we demonstrate that this slower learning in autism was not related to differences in applied categorization strategy. In contrast, electroencephalography recordings during training did reveal a reduced amplitude of the N1 component in the right occipital temporal cortex after stimulus presentation in autistic participants, which suggests atypical categorical proficiency. In addition, we observed delayed and higher activation in the frontal regions after receiving (negative) feedback in the autistic group, potentially suggesting more explicit feedback processing or a higher salience of prediction errors in autism. Finally, autistic and NT individuals were able to generalize their learned categorization after training. However, when generalizing to a novel set of shapes, autistic individuals were significantly less accurate. Reduced generalization significantly correlated with increased intolerance to uncertainty scores. This multi-level approach reveals behavioral and neural differences in learning and generalization that could be related to clinical symptoms in autism. En ligne : https://doi.org/10.1002/aur.3286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Altered category learning and reduced generalization in autistic adults : Autism Research [Texte imprimé et/ou numérique] / Jaana VAN OVERWALLE, Auteur ; Stephanie VAN DER DONCK, Auteur ; Birte GEUSENS, Auteur ; Bart BOETS, Auteur ; Johan WAGEMANS, Auteur . - p.295-311. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.295-311 Mots-clés : autism categorization electroencephalography generalization intolerance to uncertainty perceptual learning predictive processing Index. décimale : PER Périodiques Résumé : Abstract Individuals with autism spectrum condition (ASC) are suggested to experience difficulties with categorization and generalization. However, empirical studies have mainly focused on one process at a time, and neglected underlying neural mechanisms. Here, we investigated categorization and generalization at a behavioral and neural level in 38 autistic and 38 neurotypical (NT) adults. By presenting shapes sampled from an artificial multidimensional stimulus space, we investigated (1) behavioral and neural underpinnings of category learning and (2) behavioral generalization of trained categorization to both an extended version of the stimulus space and a novel stimulus space. Our previous findings showed that individuals with autism were slower in category learning. In this study, we demonstrate that this slower learning in autism was not related to differences in applied categorization strategy. In contrast, electroencephalography recordings during training did reveal a reduced amplitude of the N1 component in the right occipital temporal cortex after stimulus presentation in autistic participants, which suggests atypical categorical proficiency. In addition, we observed delayed and higher activation in the frontal regions after receiving (negative) feedback in the autistic group, potentially suggesting more explicit feedback processing or a higher salience of prediction errors in autism. Finally, autistic and NT individuals were able to generalize their learned categorization after training. However, when generalizing to a novel set of shapes, autistic individuals were significantly less accurate. Reduced generalization significantly correlated with increased intolerance to uncertainty scores. This multi-level approach reveals behavioral and neural differences in learning and generalization that could be related to clinical symptoms in autism. En ligne : https://doi.org/10.1002/aur.3286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Robust Autism Spectrum Disorder-Related Spatial Covariance Gray Matter Pattern Revealed With a Large-Scale Multi-Center Dataset / Sheng-Zhi Ma ; Xing-Ke Wang ; Chen YANG ; Wen-Qiang Dong ; Dan-Dan Chen ; Chao Song ; Qiu-Rong Zhang ; Yu-Feng Zang ; Li-Xia Yuan in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.312-324 Titre : Robust Autism Spectrum Disorder-Related Spatial Covariance Gray Matter Pattern Revealed With a Large-Scale Multi-Center Dataset : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Sheng-Zhi Ma, Auteur ; Xing-Ke Wang, Auteur ; Chen YANG, Auteur ; Wen-Qiang Dong, Auteur ; Dan-Dan Chen, Auteur ; Chao Song, Auteur ; Qiu-Rong Zhang, Auteur ; Yu-Feng Zang, Auteur ; Li-Xia Yuan, Auteur Article en page(s) : p.312-324 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD) gray matter (GM) volume robustness spatial covariance pattern structural MRI images (sMRI) Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder and its underlying neuroanatomical mechanisms still remain unclear. The scaled subprofile model of principal component analysis (SSM-PCA) is a data-driven multivariate technique for capturing stable disease-related spatial covariance pattern. Here, SSM-PCA is innovatively applied to obtain robust ASD-related gray matter volume pattern associated with clinical symptoms. We utilized T1-weighted structural MRI images (sMRI) of 576 subjects (288 ASDs and 288 typically developing (TD) controls) aged 7?29?years from the Autism Brain Imaging Data Exchange II (ABIDE II) dataset. These images were analyzed with SSM-PCA to identify the ASD-related spatial covariance pattern. Subsequently, we investigated the relationship between the pattern and clinical symptoms and verified its robustness. Then, the applicability of the pattern under different age stages were further explored. The results revealed that the ASD-related pattern primarily involves the thalamus, putamen, parahippocampus, orbitofrontal cortex, and cerebellum. The expression of this pattern correlated with Social Response Scale and Social Communication Questionnaire scores. Moreover, the ASD-related pattern was robust for the ABIDE I dataset. Regarding the applicability of the pattern for different age stages, the effect sizes of its expression in ASD were medium in the children and adults, while small in adolescents. This study identified a robust ASD-related pattern based on gray matter volume that is associated with social deficits. Our findings provide new insights into the neuroanatomical mechanisms of ASD and may facilitate its future intervention. En ligne : https://doi.org/10.1002/aur.3303 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Robust Autism Spectrum Disorder-Related Spatial Covariance Gray Matter Pattern Revealed With a Large-Scale Multi-Center Dataset : Autism Research [Texte imprimé et/ou numérique] / Sheng-Zhi Ma, Auteur ; Xing-Ke Wang, Auteur ; Chen YANG, Auteur ; Wen-Qiang Dong, Auteur ; Dan-Dan Chen, Auteur ; Chao Song, Auteur ; Qiu-Rong Zhang, Auteur ; Yu-Feng Zang, Auteur ; Li-Xia Yuan, Auteur . - p.312-324. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.312-324 Mots-clés : autism spectrum disorder (ASD) gray matter (GM) volume robustness spatial covariance pattern structural MRI images (sMRI) Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder and its underlying neuroanatomical mechanisms still remain unclear. The scaled subprofile model of principal component analysis (SSM-PCA) is a data-driven multivariate technique for capturing stable disease-related spatial covariance pattern. Here, SSM-PCA is innovatively applied to obtain robust ASD-related gray matter volume pattern associated with clinical symptoms. We utilized T1-weighted structural MRI images (sMRI) of 576 subjects (288 ASDs and 288 typically developing (TD) controls) aged 7?29?years from the Autism Brain Imaging Data Exchange II (ABIDE II) dataset. These images were analyzed with SSM-PCA to identify the ASD-related spatial covariance pattern. Subsequently, we investigated the relationship between the pattern and clinical symptoms and verified its robustness. Then, the applicability of the pattern under different age stages were further explored. The results revealed that the ASD-related pattern primarily involves the thalamus, putamen, parahippocampus, orbitofrontal cortex, and cerebellum. The expression of this pattern correlated with Social Response Scale and Social Communication Questionnaire scores. Moreover, the ASD-related pattern was robust for the ABIDE I dataset. Regarding the applicability of the pattern for different age stages, the effect sizes of its expression in ASD were medium in the children and adults, while small in adolescents. This study identified a robust ASD-related pattern based on gray matter volume that is associated with social deficits. Our findings provide new insights into the neuroanatomical mechanisms of ASD and may facilitate its future intervention. En ligne : https://doi.org/10.1002/aur.3303 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Structure and dynamics of anxiety in people with ASD and ID: A network analysis / Gema P. SÁEZ-SUANES in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.325-333 Titre : Structure and dynamics of anxiety in people with ASD and ID: A network analysis : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Gema P. SÁEZ-SUANES, Auteur Article en page(s) : p.325-333 Langues : Anglais (eng) Mots-clés : adults anxiety autism comorbidity network analysis Index. décimale : PER Périodiques Résumé : Abstract Anxiety is a very common mental health disorder in the ASD population. Despite the common comorbidity this association is not well understood. To understand the relationship between anxiety symptoms and ASD in a sample of people with ASD and intellectual disability, a network analysis was carried out. One hundred and twenty-eight adults (M?=?36.63 age, SD?=?8,54) were evaluated to know the structure of anxiety symptoms in autism and their relationship with ASD symptomatology. The results showed a single network where both symptomatologies were mixed. Bridging symptoms such as fear of being touched, fear of something bad happening to them, and the need for invariance and anticipation were identified. Moreover, social issues such as difficulty in making friends were associated with anxiety symptoms. Knowing and identifying ASD symptoms that are strongly linked to the anxiety network has important implications for the prevention of anxiety in this case in people with autism and intellectual disabilities. En ligne : https://doi.org/10.1002/aur.3285 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Structure and dynamics of anxiety in people with ASD and ID: A network analysis : Autism Research [Texte imprimé et/ou numérique] / Gema P. SÁEZ-SUANES, Auteur . - p.325-333. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.325-333 Mots-clés : adults anxiety autism comorbidity network analysis Index. décimale : PER Périodiques Résumé : Abstract Anxiety is a very common mental health disorder in the ASD population. Despite the common comorbidity this association is not well understood. To understand the relationship between anxiety symptoms and ASD in a sample of people with ASD and intellectual disability, a network analysis was carried out. One hundred and twenty-eight adults (M?=?36.63 age, SD?=?8,54) were evaluated to know the structure of anxiety symptoms in autism and their relationship with ASD symptomatology. The results showed a single network where both symptomatologies were mixed. Bridging symptoms such as fear of being touched, fear of something bad happening to them, and the need for invariance and anticipation were identified. Moreover, social issues such as difficulty in making friends were associated with anxiety symptoms. Knowing and identifying ASD symptoms that are strongly linked to the anxiety network has important implications for the prevention of anxiety in this case in people with autism and intellectual disabilities. En ligne : https://doi.org/10.1002/aur.3285 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Remote monitoring of social attention in neurogenetic syndromes and idiopathic neurodevelopmental disability / Thomas W. FRAZIER ; Robyn M. BUSCH ; Patricia KLAAS ; Katherine Lachlan ; Shafali JESTE ; Alexander KOLEVZON ; Eva LOTH ; Jacqueline Harris ; Tom Pepper ; Kristin Anthony ; J. Michael Graglia ; Kathryn Helde ; Christal Delagrammatikas ; Sandra Bedrosian-Sermone ; Constance Smith-Hicks ; Mustafa SAHIN ; Eric A. YOUNGSTROM ; Charis ENG ; Lacey CHETCUTI ; Antonio Y. HARDAN ; Mirko ULJAREVIC in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.334-348 Titre : Remote monitoring of social attention in neurogenetic syndromes and idiopathic neurodevelopmental disability : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Robyn M. BUSCH, Auteur ; Patricia KLAAS, Auteur ; Katherine Lachlan, Auteur ; Shafali JESTE, Auteur ; Alexander KOLEVZON, Auteur ; Eva LOTH, Auteur ; Jacqueline Harris, Auteur ; Tom Pepper, Auteur ; Kristin Anthony, Auteur ; J. Michael Graglia, Auteur ; Kathryn Helde, Auteur ; Christal Delagrammatikas, Auteur ; Sandra Bedrosian-Sermone, Auteur ; Constance Smith-Hicks, Auteur ; Mustafa SAHIN, Auteur ; Eric A. YOUNGSTROM, Auteur ; Charis ENG, Auteur ; Lacey CHETCUTI, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVIC, Auteur Article en page(s) : p.334-348 Langues : Anglais (eng) Mots-clés : autism spectrum disorder online reliability remote monitoring social attention validity Index. décimale : PER Périodiques Résumé : Abstract Social attention is a key aspect of neurodevelopment and is significantly altered in neurodevelopmental genetic syndromes and many individuals with idiopathic autism spectrum disorder (ASD). The primary aim of the present study was to examine the psychometric properties of webcam-collected social attention measurements, including four new specific aspects of social attention, in three genetic syndromes (PTEN Hamartoma Tumor Syndrome?PHTS; Malan Syndrome?NFIX; and SYNGAP1-related disorder?SYNGAP1), a mixed group of other neurodevelopmental genetic syndromes (Other NDGS), and individuals with a range of idiopathic neurodevelopmental disorder (NDD). The secondary aim was to evaluate the construct validity of these social attention measurements, including evaluating known-groups validity across study groups and concurrent validity for separating ASD and non-ASD cases. Participants (N?=?467, age 3?45; PHTS n?=?102, NFIX n?=?23, SYNGAP1 n?=?42, other NDGS n?=?63, idiopathic NDD n?=?53, neurotypical siblings n?=?71, and unrelated neurotypical controls n?=?113) completed a 4-min online-administered social attention paradigm that includes a variety of distinct stimuli at three timepoints (baseline, 1-month, and 4-month follow-up). Social attention measures had good scale and test?retest reliability, with the exception of measures of non-social preference and face-specific processing. Unique patterns of social attention emerged across study groups, with near neurotypical levels in PHTS and weaker social attention in NFIX and SYNGAP1 relative to controls. Global social attention had good accuracy in detecting ASD within NDGS participants. Remote monitoring social attention, including distinct aspects of social attention, may be useful for characterizing phenotypic profiles and tracking the natural history of distinct NDGS and idiopathic NDD as well as identifying ASD within NDGS. Given their reproducibility and stability, global social attention and several distinct social attention measures may be useful outcomes for future clinical trials. En ligne : https://doi.org/10.1002/aur.3290 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Remote monitoring of social attention in neurogenetic syndromes and idiopathic neurodevelopmental disability : Autism Research [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Robyn M. BUSCH, Auteur ; Patricia KLAAS, Auteur ; Katherine Lachlan, Auteur ; Shafali JESTE, Auteur ; Alexander KOLEVZON, Auteur ; Eva LOTH, Auteur ; Jacqueline Harris, Auteur ; Tom Pepper, Auteur ; Kristin Anthony, Auteur ; J. Michael Graglia, Auteur ; Kathryn Helde, Auteur ; Christal Delagrammatikas, Auteur ; Sandra Bedrosian-Sermone, Auteur ; Constance Smith-Hicks, Auteur ; Mustafa SAHIN, Auteur ; Eric A. YOUNGSTROM, Auteur ; Charis ENG, Auteur ; Lacey CHETCUTI, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVIC, Auteur . - p.334-348. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.334-348 Mots-clés : autism spectrum disorder online reliability remote monitoring social attention validity Index. décimale : PER Périodiques Résumé : Abstract Social attention is a key aspect of neurodevelopment and is significantly altered in neurodevelopmental genetic syndromes and many individuals with idiopathic autism spectrum disorder (ASD). The primary aim of the present study was to examine the psychometric properties of webcam-collected social attention measurements, including four new specific aspects of social attention, in three genetic syndromes (PTEN Hamartoma Tumor Syndrome?PHTS; Malan Syndrome?NFIX; and SYNGAP1-related disorder?SYNGAP1), a mixed group of other neurodevelopmental genetic syndromes (Other NDGS), and individuals with a range of idiopathic neurodevelopmental disorder (NDD). The secondary aim was to evaluate the construct validity of these social attention measurements, including evaluating known-groups validity across study groups and concurrent validity for separating ASD and non-ASD cases. Participants (N?=?467, age 3?45; PHTS n?=?102, NFIX n?=?23, SYNGAP1 n?=?42, other NDGS n?=?63, idiopathic NDD n?=?53, neurotypical siblings n?=?71, and unrelated neurotypical controls n?=?113) completed a 4-min online-administered social attention paradigm that includes a variety of distinct stimuli at three timepoints (baseline, 1-month, and 4-month follow-up). Social attention measures had good scale and test?retest reliability, with the exception of measures of non-social preference and face-specific processing. Unique patterns of social attention emerged across study groups, with near neurotypical levels in PHTS and weaker social attention in NFIX and SYNGAP1 relative to controls. Global social attention had good accuracy in detecting ASD within NDGS participants. Remote monitoring social attention, including distinct aspects of social attention, may be useful for characterizing phenotypic profiles and tracking the natural history of distinct NDGS and idiopathic NDD as well as identifying ASD within NDGS. Given their reproducibility and stability, global social attention and several distinct social attention measures may be useful outcomes for future clinical trials. En ligne : https://doi.org/10.1002/aur.3290 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment / Julius Hennig ; Arne Doose ; Clara Marie Breier ; Alexander Soutschek ; Nicole Beyer ; Stefan Schweinberger ; Ingeborg Kamp-Becker ; Luise POUSTKA ; Katja Albertowski ; Veit ROESSNER ; Stefan EHRLICH in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.349-361 Titre : Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Julius Hennig, Auteur ; Arne Doose, Auteur ; Clara Marie Breier, Auteur ; Alexander Soutschek, Auteur ; Nicole Beyer, Auteur ; Stefan Schweinberger, Auteur ; Ingeborg Kamp-Becker, Auteur ; Luise POUSTKA, Auteur ; Katja Albertowski, Auteur ; Veit ROESSNER, Auteur ; Stefan EHRLICH, Auteur Article en page(s) : p.349-361 Langues : Anglais (eng) Mots-clés : autism face aftereffects gender processing hierarchical drift diffusion modeling perceptual processing Index. décimale : PER Périodiques Résumé : Abstract Existing literature has documented diminished norm-based adaptation (aftereffects) across several perceptual domains in autism. However, the exact underlying mechanisms, such as sensory dominance possibly caused by imprecise priors and/or increased sensory precision, remain elusive. The ?Bayesian brain? framework offers refined methods to investigate these mechanisms. This study utilized both model-free (frequentist statistics) and model-based (hierarchical Drift Diffusion Modeling) analytical approaches to compare gender face aftereffects in male adolescents with autism (n?=?29) to neurotypical controls (n?=?39) using a behavioral choice experiment. Contrary to our initial hypotheses, our analyses did not find support for imprecise priors or increased sensory precision within the autistic group. Instead, we observed generally decreased drift rates towards male but not female stimuli in the autistic group. Thus, our findings suggest a lack of own-gender bias in face processing among the autistic participants. These findings align with more recent behavioral and neurophysiological research observing intact priors in individuals with autism, suggesting that other mechanisms may better explain the perceptual challenges in autism. Our study contributes to the ongoing discourse on perceptual processing in autism, emphasizing the necessity for more nuanced analytical approaches in order to unravel the complexity of this condition. En ligne : https://doi.org/10.1002/aur.3283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Disentangling the perceptual underpinnings of autism: Evidence from a face aftereffects experiment : Autism Research [Texte imprimé et/ou numérique] / Julius Hennig, Auteur ; Arne Doose, Auteur ; Clara Marie Breier, Auteur ; Alexander Soutschek, Auteur ; Nicole Beyer, Auteur ; Stefan Schweinberger, Auteur ; Ingeborg Kamp-Becker, Auteur ; Luise POUSTKA, Auteur ; Katja Albertowski, Auteur ; Veit ROESSNER, Auteur ; Stefan EHRLICH, Auteur . - p.349-361. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.349-361 Mots-clés : autism face aftereffects gender processing hierarchical drift diffusion modeling perceptual processing Index. décimale : PER Périodiques Résumé : Abstract Existing literature has documented diminished norm-based adaptation (aftereffects) across several perceptual domains in autism. However, the exact underlying mechanisms, such as sensory dominance possibly caused by imprecise priors and/or increased sensory precision, remain elusive. The ?Bayesian brain? framework offers refined methods to investigate these mechanisms. This study utilized both model-free (frequentist statistics) and model-based (hierarchical Drift Diffusion Modeling) analytical approaches to compare gender face aftereffects in male adolescents with autism (n?=?29) to neurotypical controls (n?=?39) using a behavioral choice experiment. Contrary to our initial hypotheses, our analyses did not find support for imprecise priors or increased sensory precision within the autistic group. Instead, we observed generally decreased drift rates towards male but not female stimuli in the autistic group. Thus, our findings suggest a lack of own-gender bias in face processing among the autistic participants. These findings align with more recent behavioral and neurophysiological research observing intact priors in individuals with autism, suggesting that other mechanisms may better explain the perceptual challenges in autism. Our study contributes to the ongoing discourse on perceptual processing in autism, emphasizing the necessity for more nuanced analytical approaches in order to unravel the complexity of this condition. En ligne : https://doi.org/10.1002/aur.3283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Adaptive and Behavioral Profiles in Down Syndrome and Co-Occurring Autism Spectrum Disorder: A Case-Control Study / Elisa FUCA ; Stefano VICARI ; Floriana COSTANZO in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.362-369 Titre : Adaptive and Behavioral Profiles in Down Syndrome and Co-Occurring Autism Spectrum Disorder: A Case-Control Study : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Elisa FUCA, Auteur ; Stefano VICARI, Auteur ; Floriana COSTANZO, Auteur Article en page(s) : p.362-369 Langues : Anglais (eng) Mots-clés : Aberrant Behavior Checklist diagnosis intellectual disability repetitive behaviors Index. décimale : PER Périodiques Résumé : ABSTRACT Down syndrome (DS) is the most frequent genetic cause of intellectual disability (ID). Individuals with DS exhibit an elevated risk of other neurodevelopmental disorders, including autism spectrum disorder (ASD). The primary objective of this study was to explore the clinical characteristics of co-occurring ASD in children and adolescents with DS using a case?control approach. We compared the adaptive and behavioral profiles of a group of participants with both DS and ASD (ASD group) with a group of participants with DS-only matched by age, sex, and IQ (CON group). Participants in the ASD group exhibited significantly lower adaptive skills than the CON group, despite the IQ-matching in the moderate/severe ID range. No group differences emerged on internalizing or externalizing behavioral symptoms, but participants in the ASD group exhibited significantly higher social withdrawal, stereotyped behavior, and restricted interests. These findings indicate that, although children with DS?with or without ASD?who have similar low cognitive functioning often exhibit common behavioral traits, paying close attention to the elevation of stereotyped behaviors or restricted interests can improve the detection of co-occurring ASD in this population, enabling more personalized interventions. Conversely, the presence of ritualistic behaviors or behaviors related to insistence on sameness may not be a strong indicator of underlying ASD in children with DS. Additionally, acknowledging that the presence of ASD contributes to adaptive behavior deficits beyond the impact of moderate-to-severe ID alone highlights the critical need for early interventions to enhance daily living skills in this population. En ligne : https://doi.org/10.1002/aur.3294 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Adaptive and Behavioral Profiles in Down Syndrome and Co-Occurring Autism Spectrum Disorder: A Case-Control Study : Autism Research [Texte imprimé et/ou numérique] / Elisa FUCA, Auteur ; Stefano VICARI, Auteur ; Floriana COSTANZO, Auteur . - p.362-369. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.362-369 Mots-clés : Aberrant Behavior Checklist diagnosis intellectual disability repetitive behaviors Index. décimale : PER Périodiques Résumé : ABSTRACT Down syndrome (DS) is the most frequent genetic cause of intellectual disability (ID). Individuals with DS exhibit an elevated risk of other neurodevelopmental disorders, including autism spectrum disorder (ASD). The primary objective of this study was to explore the clinical characteristics of co-occurring ASD in children and adolescents with DS using a case?control approach. We compared the adaptive and behavioral profiles of a group of participants with both DS and ASD (ASD group) with a group of participants with DS-only matched by age, sex, and IQ (CON group). Participants in the ASD group exhibited significantly lower adaptive skills than the CON group, despite the IQ-matching in the moderate/severe ID range. No group differences emerged on internalizing or externalizing behavioral symptoms, but participants in the ASD group exhibited significantly higher social withdrawal, stereotyped behavior, and restricted interests. These findings indicate that, although children with DS?with or without ASD?who have similar low cognitive functioning often exhibit common behavioral traits, paying close attention to the elevation of stereotyped behaviors or restricted interests can improve the detection of co-occurring ASD in this population, enabling more personalized interventions. Conversely, the presence of ritualistic behaviors or behaviors related to insistence on sameness may not be a strong indicator of underlying ASD in children with DS. Additionally, acknowledging that the presence of ASD contributes to adaptive behavior deficits beyond the impact of moderate-to-severe ID alone highlights the critical need for early interventions to enhance daily living skills in this population. En ligne : https://doi.org/10.1002/aur.3294 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Utilizing network analysis to identify core items of quality of life for children with autism spectrum disorder / Jin LIU ; Laura C. CHEZAN ; Yue Zhao ; Sarah K. Hood ; Erik DRASGOW ; Han Wang in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.370-386 Titre : Utilizing network analysis to identify core items of quality of life for children with autism spectrum disorder : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Jin LIU, Auteur ; Laura C. CHEZAN, Auteur ; Yue Zhao, Auteur ; Sarah K. Hood, Auteur ; Erik DRASGOW, Auteur ; Han Wang, Auteur Article en page(s) : p.370-386 Langues : Anglais (eng) Mots-clés : autism spectrum disorder demographic network analysis quality of life ultra-short scale Index. décimale : PER Périodiques Résumé : Abstract The purpose of this study was to develop and validate an ultra-short scale called the Quality of Life for Children with Autism Spectrum Disorder 3 (QOLASD-C3) from the full 16-item QOLASD-C scale. We first used network analysis to identify three core items to be retained on the QOLASD-C3 scale. Second, we used Cronbach's alpha and Pearson Product Moment correlations to determine the reliability and validity of the scale. Third, an optimal cut-off score of 6 was identified for the using receiver operating characteristic curve analysis. Finally, we used logistic regression to examine the similarities in the classification status based on demographic characteristics between the quality of life (QOL) status using the QOLASD-C and the QOLASD-C3 scales. Results were similar across the two versions and suggested variations in QOL status based on race/ethnicity, autism spectrum disorder (ASD) severity, and parents' socio-economic status. Implications for research and practice are discussed. En ligne : https://doi.org/10.1002/aur.3292 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Utilizing network analysis to identify core items of quality of life for children with autism spectrum disorder : Autism Research [Texte imprimé et/ou numérique] / Jin LIU, Auteur ; Laura C. CHEZAN, Auteur ; Yue Zhao, Auteur ; Sarah K. Hood, Auteur ; Erik DRASGOW, Auteur ; Han Wang, Auteur . - p.370-386. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.370-386 Mots-clés : autism spectrum disorder demographic network analysis quality of life ultra-short scale Index. décimale : PER Périodiques Résumé : Abstract The purpose of this study was to develop and validate an ultra-short scale called the Quality of Life for Children with Autism Spectrum Disorder 3 (QOLASD-C3) from the full 16-item QOLASD-C scale. We first used network analysis to identify three core items to be retained on the QOLASD-C3 scale. Second, we used Cronbach's alpha and Pearson Product Moment correlations to determine the reliability and validity of the scale. Third, an optimal cut-off score of 6 was identified for the using receiver operating characteristic curve analysis. Finally, we used logistic regression to examine the similarities in the classification status based on demographic characteristics between the quality of life (QOL) status using the QOLASD-C and the QOLASD-C3 scales. Results were similar across the two versions and suggested variations in QOL status based on race/ethnicity, autism spectrum disorder (ASD) severity, and parents' socio-economic status. Implications for research and practice are discussed. En ligne : https://doi.org/10.1002/aur.3292 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Examining the Relationship Between Parental Broader Autism Phenotype Traits, Offspring Autism, and Parental Mental Health / Fátima El-Bouhali-Abdellaoui ; Núria VOLTAS ; Paula MORALES-HIDALGO ; Josefa CANALS in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.387-401 Titre : Examining the Relationship Between Parental Broader Autism Phenotype Traits, Offspring Autism, and Parental Mental Health : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Fátima El-Bouhali-Abdellaoui, Auteur ; Núria VOLTAS, Auteur ; Paula MORALES-HIDALGO, Auteur ; Josefa CANALS, Auteur Article en page(s) : p.387-401 Langues : Anglais (eng) Mots-clés : autism autistic traits broad autism phenotype children parental mental health Index. décimale : PER Périodiques Résumé : ABSTRACT Broader Autism Phenotype (BAP) traits may be present in parents of children on the autism spectrum. However, the prevalence and impact of these traits on parental mental health is poorly understood. We explore BAP traits and its relationship to mental health in 228 fathers and 261 mothers from a sample of 266 scholars from the EPINED study (Spain) grouped as follows: non-autism (N?=?122), autism traits (N?=?93: 38 subthreshold autism and 55 autism symptoms) and autism (N?=?51). BAP rates were higher in fathers (36.9%) than in mothers (26.1%). Moreover, BAP was significantly more frequent in fathers of autistic children (52.3%) than in fathers of children without autistic traits (28.0%), with no differences between autistic conditions groups. Mothers of autistic children exhibited higher psychological distress (36.0%) than mothers of comparison group (19.2%). Fathers with BAP obtained significantly higher scores in emotional problems than fathers without BAP. Multivariate analyses showed that, fathers' emotional problems were associated with their BAP traits, whereas in mothers they were associated with having a child with autism as well as the child's emotional dysregulation. Identifying BAP in parents of autistic conditions children can help professionals to provide specific strategies for improving the well-being of children and parents. En ligne : https://doi.org/10.1002/aur.3295 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Examining the Relationship Between Parental Broader Autism Phenotype Traits, Offspring Autism, and Parental Mental Health : Autism Research [Texte imprimé et/ou numérique] / Fátima El-Bouhali-Abdellaoui, Auteur ; Núria VOLTAS, Auteur ; Paula MORALES-HIDALGO, Auteur ; Josefa CANALS, Auteur . - p.387-401. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.387-401 Mots-clés : autism autistic traits broad autism phenotype children parental mental health Index. décimale : PER Périodiques Résumé : ABSTRACT Broader Autism Phenotype (BAP) traits may be present in parents of children on the autism spectrum. However, the prevalence and impact of these traits on parental mental health is poorly understood. We explore BAP traits and its relationship to mental health in 228 fathers and 261 mothers from a sample of 266 scholars from the EPINED study (Spain) grouped as follows: non-autism (N?=?122), autism traits (N?=?93: 38 subthreshold autism and 55 autism symptoms) and autism (N?=?51). BAP rates were higher in fathers (36.9%) than in mothers (26.1%). Moreover, BAP was significantly more frequent in fathers of autistic children (52.3%) than in fathers of children without autistic traits (28.0%), with no differences between autistic conditions groups. Mothers of autistic children exhibited higher psychological distress (36.0%) than mothers of comparison group (19.2%). Fathers with BAP obtained significantly higher scores in emotional problems than fathers without BAP. Multivariate analyses showed that, fathers' emotional problems were associated with their BAP traits, whereas in mothers they were associated with having a child with autism as well as the child's emotional dysregulation. Identifying BAP in parents of autistic conditions children can help professionals to provide specific strategies for improving the well-being of children and parents. En ligne : https://doi.org/10.1002/aur.3295 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Acoustic Exaggeration Enhances Speech Discrimination in Young Autistic Children / Luodi YU ; Lizhi BAN ; Aiwen Yi ; Jing Xin ; Suping Li ; Suiping WANG ; Laurent MOTTRON in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.402-414 Titre : Acoustic Exaggeration Enhances Speech Discrimination in Young Autistic Children : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Luodi YU, Auteur ; Lizhi BAN, Auteur ; Aiwen Yi, Auteur ; Jing Xin, Auteur ; Suping Li, Auteur ; Suiping WANG, Auteur ; Laurent MOTTRON, Auteur Article en page(s) : p.402-414 Langues : Anglais (eng) Mots-clés : auditory processing autism spectrum disorders EEG multivariate pattern analysis speech processing Index. décimale : PER Périodiques Résumé : ABSTRACT Child-directed speech (CDS), which amplifies acoustic and social features of speech during interactions with young children, promotes typical phonetic and language development. In autism, both behavioral and brain data indicate reduced sensitivity to human speech, which predicts absent, decreased, or atypical benefits of exaggerated speech signals such as CDS. This study investigates the impact of exaggerated fundamental frequency (F0) and voice-onset time on the neural processing of speech sounds in 22 Chinese-speaking autistic children aged 2?7?years old with a history of speech delays, compared with 25 typically developing (TD) peers. Electroencephalography (EEG) data were collected during passive listening to exaggerated and non-exaggerated syllables. A time-resolved multivariate pattern analysis (MVPA) was used to evaluate the potential effects of acoustic exaggeration on syllable discrimination in terms of neural decoding accuracy. For non-exaggerated syllables, neither the autism nor the TD group achieved above-chance decoding accuracy. In contrast, for exaggerated syllables, both groups achieved above-chance decoding, indicating significant syllable discrimination, with no difference in accuracy between the autism and TD groups. However, the temporal generalization patterns in the MVPA results revealed distinct neural mechanisms supporting syllable discrimination between the groups. Although the TD group demonstrated a left-hemisphere advantage for decoding and generalization, the autism group displayed similar decoding patterns between hemispheres. These findings highlight the potential of selective acoustic exaggeration to support speech learning in autistic children, underscoring the importance of tailored, sensory-based interventions. En ligne : https://doi.org/10.1002/aur.3301 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Acoustic Exaggeration Enhances Speech Discrimination in Young Autistic Children : Autism Research [Texte imprimé et/ou numérique] / Luodi YU, Auteur ; Lizhi BAN, Auteur ; Aiwen Yi, Auteur ; Jing Xin, Auteur ; Suping Li, Auteur ; Suiping WANG, Auteur ; Laurent MOTTRON, Auteur . - p.402-414. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.402-414 Mots-clés : auditory processing autism spectrum disorders EEG multivariate pattern analysis speech processing Index. décimale : PER Périodiques Résumé : ABSTRACT Child-directed speech (CDS), which amplifies acoustic and social features of speech during interactions with young children, promotes typical phonetic and language development. In autism, both behavioral and brain data indicate reduced sensitivity to human speech, which predicts absent, decreased, or atypical benefits of exaggerated speech signals such as CDS. This study investigates the impact of exaggerated fundamental frequency (F0) and voice-onset time on the neural processing of speech sounds in 22 Chinese-speaking autistic children aged 2?7?years old with a history of speech delays, compared with 25 typically developing (TD) peers. Electroencephalography (EEG) data were collected during passive listening to exaggerated and non-exaggerated syllables. A time-resolved multivariate pattern analysis (MVPA) was used to evaluate the potential effects of acoustic exaggeration on syllable discrimination in terms of neural decoding accuracy. For non-exaggerated syllables, neither the autism nor the TD group achieved above-chance decoding accuracy. In contrast, for exaggerated syllables, both groups achieved above-chance decoding, indicating significant syllable discrimination, with no difference in accuracy between the autism and TD groups. However, the temporal generalization patterns in the MVPA results revealed distinct neural mechanisms supporting syllable discrimination between the groups. Although the TD group demonstrated a left-hemisphere advantage for decoding and generalization, the autism group displayed similar decoding patterns between hemispheres. These findings highlight the potential of selective acoustic exaggeration to support speech learning in autistic children, underscoring the importance of tailored, sensory-based interventions. En ligne : https://doi.org/10.1002/aur.3301 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Atypical Regional Accent in Autistic Children: A Perception Study / Federica Beccaria ; Gloria Gagliardi ; Mikhail KISSINE in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.415-426 Titre : Atypical Regional Accent in Autistic Children: A Perception Study : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Federica Beccaria, Auteur ; Gloria Gagliardi, Auteur ; Mikhail KISSINE, Auteur Article en page(s) : p.415-426 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children are frequently said to speak with accents that markedly differ from those of their linguistic communities. To date, these anecdotal reports have never been tested or explained. We ran two perception studies using short audio recordings of autistic and typically developing children from the Campania region in Italy. The variety of Italian to which children are exposed in this region markedly differs from those spoken in the rest of Italy. Participant responses about the children's geographical origin show: (a) That autistic children's accent is devoid of the regional features of their community; (b) resembles the standard variety used in cartoons and child television programs. The judgments about children's accents are, furthermore, independent of the overall perception of speech atypicality. This paper shows that the accent of autistic children may diverge from that of their caregivers and peers because of the lasting influence of non-interactional, screen sources on their speech. En ligne : https://doi.org/10.1002/aur.3300 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Atypical Regional Accent in Autistic Children: A Perception Study : Autism Research [Texte imprimé et/ou numérique] / Federica Beccaria, Auteur ; Gloria Gagliardi, Auteur ; Mikhail KISSINE, Auteur . - p.415-426. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.415-426 Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children are frequently said to speak with accents that markedly differ from those of their linguistic communities. To date, these anecdotal reports have never been tested or explained. We ran two perception studies using short audio recordings of autistic and typically developing children from the Campania region in Italy. The variety of Italian to which children are exposed in this region markedly differs from those spoken in the rest of Italy. Participant responses about the children's geographical origin show: (a) That autistic children's accent is devoid of the regional features of their community; (b) resembles the standard variety used in cartoons and child television programs. The judgments about children's accents are, furthermore, independent of the overall perception of speech atypicality. This paper shows that the accent of autistic children may diverge from that of their caregivers and peers because of the lasting influence of non-interactional, screen sources on their speech. En ligne : https://doi.org/10.1002/aur.3300 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study / Yong Zhang ; Fang Xie ; Sheng LI ; Ying LI ; Liting Yang ; Zhen Wang ; Jinlin Lei ; Huailan Guo in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.427-436 Titre : Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Yong Zhang, Auteur ; Fang Xie, Auteur ; Sheng LI, Auteur ; Ying LI, Auteur ; Liting Yang, Auteur ; Zhen Wang, Auteur ; Jinlin Lei, Auteur ; Huailan Guo, Auteur Article en page(s) : p.427-436 Langues : Anglais (eng) Mots-clés : autism spectrum disorder Bayesian kernel machine regression model mediation oxidative stress trace element Index. décimale : PER Périodiques Résumé : ABSTRACT Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case?control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges. En ligne : https://doi.org/10.1002/aur.3302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study : Autism Research [Texte imprimé et/ou numérique] / Yong Zhang, Auteur ; Fang Xie, Auteur ; Sheng LI, Auteur ; Ying LI, Auteur ; Liting Yang, Auteur ; Zhen Wang, Auteur ; Jinlin Lei, Auteur ; Huailan Guo, Auteur . - p.427-436. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.427-436 Mots-clés : autism spectrum disorder Bayesian kernel machine regression model mediation oxidative stress trace element Index. décimale : PER Périodiques Résumé : ABSTRACT Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case?control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges. En ligne : https://doi.org/10.1002/aur.3302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Gross Motor Development in Children With Autism: Longitudinal Trajectories From the Growing Up in New Zealand Study / Paula Araya ; Katrina Phillips ; Karen WALDIE ; Lisa UNDERWOOD in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.437-448 Titre : Gross Motor Development in Children With Autism: Longitudinal Trajectories From the Growing Up in New Zealand Study : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Paula Araya, Auteur ; Katrina Phillips, Auteur ; Karen WALDIE, Auteur ; Lisa UNDERWOOD, Auteur Article en page(s) : p.437-448 Langues : Anglais (eng) Mots-clés : autism cohort gross motor development longitudinal research milestones Index. décimale : PER Périodiques Résumé : ABSTRACT This study explored gross motor development (GMD) trajectories among 6359 children, with and without autism, from the Growing Up in New Zealand longitudinal cohort study. By the age of 8, 173 children had either an autism diagnosis (n?=?108) or parent-reported autism concerns (n?=?65). Gross motor milestones were reported by mothers when children were 9, 24, and 54?months of age. We found that irrespective of autism diagnosis, GMD delays at 24?months of age were more likely among girls, children born preterm, and those whose mothers identified as European. A mixed-effect logistic regression model, controlling for antenatal maternal and child covariates, revealed that the proportion of children with GMD delay (relative to their peers) increased significantly from 9 to 54?months for all three groups, but the increase was greater for those with autism concerns (OR?=?1.28, 95% CI?=?1.08?1.52) or an autism diagnosis (OR?=?1.26, 95% CI?=?1.10?1.43) compared to the no autism group (OR?=?1.06, 95% CI?=?1.02?1.10). Differences in the changes in GMD performance among children with an autism diagnosis compared to those without autism occurred between 9 and 24?months (OR?=?2.16, 95% CI?=?1.13?4.13). No significant GMD delay differences were found at any time between children with an autism diagnosis versus those with autism concerns. Children with a GMD delay should be screened for autism at 24?m. Early identification is the first step toward knowledge-based, effective intervention of developmental difficulties. En ligne : https://doi.org/10.1002/aur.3304 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Gross Motor Development in Children With Autism: Longitudinal Trajectories From the Growing Up in New Zealand Study : Autism Research [Texte imprimé et/ou numérique] / Paula Araya, Auteur ; Katrina Phillips, Auteur ; Karen WALDIE, Auteur ; Lisa UNDERWOOD, Auteur . - p.437-448. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.437-448 Mots-clés : autism cohort gross motor development longitudinal research milestones Index. décimale : PER Périodiques Résumé : ABSTRACT This study explored gross motor development (GMD) trajectories among 6359 children, with and without autism, from the Growing Up in New Zealand longitudinal cohort study. By the age of 8, 173 children had either an autism diagnosis (n?=?108) or parent-reported autism concerns (n?=?65). Gross motor milestones were reported by mothers when children were 9, 24, and 54?months of age. We found that irrespective of autism diagnosis, GMD delays at 24?months of age were more likely among girls, children born preterm, and those whose mothers identified as European. A mixed-effect logistic regression model, controlling for antenatal maternal and child covariates, revealed that the proportion of children with GMD delay (relative to their peers) increased significantly from 9 to 54?months for all three groups, but the increase was greater for those with autism concerns (OR?=?1.28, 95% CI?=?1.08?1.52) or an autism diagnosis (OR?=?1.26, 95% CI?=?1.10?1.43) compared to the no autism group (OR?=?1.06, 95% CI?=?1.02?1.10). Differences in the changes in GMD performance among children with an autism diagnosis compared to those without autism occurred between 9 and 24?months (OR?=?2.16, 95% CI?=?1.13?4.13). No significant GMD delay differences were found at any time between children with an autism diagnosis versus those with autism concerns. Children with a GMD delay should be screened for autism at 24?m. Early identification is the first step toward knowledge-based, effective intervention of developmental difficulties. En ligne : https://doi.org/10.1002/aur.3304 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Longitudinal Symptom Burden and Pharmacologic Management of Catatonia in Autism With Intellectual Disability: An Observational Study / Joshua Ryan Smith ; Seri Lim ; Snehal Bindra ; Sarah MARLER ; Bavani Rajah ; Zachary J. WILLIAMS ; Isaac Baldwin ; Nausheen Hossain ; Jo Ellen Wilson ; D. Catherine Fuchs ; James LUCCARELLI in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.449-462 Titre : Longitudinal Symptom Burden and Pharmacologic Management of Catatonia in Autism With Intellectual Disability: An Observational Study : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Joshua Ryan Smith, Auteur ; Seri Lim, Auteur ; Snehal Bindra, Auteur ; Sarah MARLER, Auteur ; Bavani Rajah, Auteur ; Zachary J. WILLIAMS, Auteur ; Isaac Baldwin, Auteur ; Nausheen Hossain, Auteur ; Jo Ellen Wilson, Auteur ; D. Catherine Fuchs, Auteur ; James LUCCARELLI, Auteur Article en page(s) : p.449-462 Langues : Anglais (eng) Mots-clés : aggression autism catatonia electroconvulsive therapy psychopharmacology self-injurious behavior Index. décimale : PER Périodiques Résumé : ABSTRACT Catatonia is a highly morbid psychomotor and affective disorder, which can affect autistic individuals with and without intellectual disability. Catatonic symptoms are treatable with pharmacotherapy and electroconvulsive therapy, but the longitudinal effectiveness of these treatments in autistic individuals has not been described. We conducted a prospective observational cohort study of patients with autism and co-morbid catatonia who received outpatient care in a specialized outpatient clinic from July 1, 2021 to May 31, 2024. Data investigating pharmacologic interventions, and clinical measures including the Bush Francis Catatonia Rating Scale (BFCRS), Kanner Catatonia Severity Scale (KCS), Kanner Catatonia Examination (KCE), and Clinical Global Impression?Improvement (CGI-I) were collected. Forty-five autistic patients with co-morbid catatonia were treated during the study period. The mean age was 15.6 (SD?=?7.9) years [Mdn?=?16.0, range 6.0?31.0]. Forty-one patients (91.1%) met criteria for autism with co-occurring intellectual disability. All patients received pharmacotherapy. Forty-four (97.8%) were treated with benzodiazepines with a mean maximal daily dose of 17.4?mg (SD?=?15.8) lorazepam equivalents. Thirty-five patients (77.8%) required more than one medication class for treatment. Sixteen (35.6%) patients received electroconvulsive therapy. Fourteen patients (31.1%) attempted to taper off benzodiazepines after achieving clinical improvement during the study period; of these, 5 patients (11.1%) were successfully tapered off, and the remaining 9 (17.8%) discontinued the taper due to a return of catatonic symptoms. Statistically significant improvement was observed across all clinical domains except the KCS. However, the majority remained at least partially symptomatic over the study period. Three patients (6.7%) died over the study period. Despite clinical improvements while receiving the gold standard for psychopharmacologic management of catatonia, chronic symptoms remained for the majority of catatonia patients over the study period, and few were able to taper and discontinue benzodiazepine treatment. Notably, the open label design of this study is a limiting factor when interpreting the results. En ligne : https://doi.org/10.1002/aur.3315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Longitudinal Symptom Burden and Pharmacologic Management of Catatonia in Autism With Intellectual Disability: An Observational Study : Autism Research [Texte imprimé et/ou numérique] / Joshua Ryan Smith, Auteur ; Seri Lim, Auteur ; Snehal Bindra, Auteur ; Sarah MARLER, Auteur ; Bavani Rajah, Auteur ; Zachary J. WILLIAMS, Auteur ; Isaac Baldwin, Auteur ; Nausheen Hossain, Auteur ; Jo Ellen Wilson, Auteur ; D. Catherine Fuchs, Auteur ; James LUCCARELLI, Auteur . - p.449-462. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.449-462 Mots-clés : aggression autism catatonia electroconvulsive therapy psychopharmacology self-injurious behavior Index. décimale : PER Périodiques Résumé : ABSTRACT Catatonia is a highly morbid psychomotor and affective disorder, which can affect autistic individuals with and without intellectual disability. Catatonic symptoms are treatable with pharmacotherapy and electroconvulsive therapy, but the longitudinal effectiveness of these treatments in autistic individuals has not been described. We conducted a prospective observational cohort study of patients with autism and co-morbid catatonia who received outpatient care in a specialized outpatient clinic from July 1, 2021 to May 31, 2024. Data investigating pharmacologic interventions, and clinical measures including the Bush Francis Catatonia Rating Scale (BFCRS), Kanner Catatonia Severity Scale (KCS), Kanner Catatonia Examination (KCE), and Clinical Global Impression?Improvement (CGI-I) were collected. Forty-five autistic patients with co-morbid catatonia were treated during the study period. The mean age was 15.6 (SD?=?7.9) years [Mdn?=?16.0, range 6.0?31.0]. Forty-one patients (91.1%) met criteria for autism with co-occurring intellectual disability. All patients received pharmacotherapy. Forty-four (97.8%) were treated with benzodiazepines with a mean maximal daily dose of 17.4?mg (SD?=?15.8) lorazepam equivalents. Thirty-five patients (77.8%) required more than one medication class for treatment. Sixteen (35.6%) patients received electroconvulsive therapy. Fourteen patients (31.1%) attempted to taper off benzodiazepines after achieving clinical improvement during the study period; of these, 5 patients (11.1%) were successfully tapered off, and the remaining 9 (17.8%) discontinued the taper due to a return of catatonic symptoms. Statistically significant improvement was observed across all clinical domains except the KCS. However, the majority remained at least partially symptomatic over the study period. Three patients (6.7%) died over the study period. Despite clinical improvements while receiving the gold standard for psychopharmacologic management of catatonia, chronic symptoms remained for the majority of catatonia patients over the study period, and few were able to taper and discontinue benzodiazepine treatment. Notably, the open label design of this study is a limiting factor when interpreting the results. En ligne : https://doi.org/10.1002/aur.3315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547