Inter-trial theta phase consistency during face processing in infants is associated with later emerging autism / Stefon VAN NOORDT in Autism Research, 15-5 (May 2022)  

Public ISBD [article]  inAutism Research > 15-5 (May 2022) . - p.834-846 Titre : Inter-trial theta phase consistency during face processing in infants is associated with later emerging autism Type de document : Texte imprimé et/ou numérique Auteurs : Stefon VAN NOORDT, Auteur ; James A. DESJARDINS, Auteur ; THE BASIS TEAM, Auteur ; Mayada ELSABBAGH, Auteur Article en page(s) : p.834-846 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Brain  Child  Facial Recognition  Humans  Infant  Siblings  autism  faces  infants  risk  theta coherence Index. décimale : PER Périodiques Résumé : A growing body of research suggests that consistency in cortical activity may be a promising neurophysiological marker of autism spectrum disorder (ASD). In the current study we examined inter-trial coherence, a measure of phase consistency across trials, in the theta range (t-ITC: 3-6 Hz), as theta has been implicated in the processing of social and emotional stimuli in infants and adults. The sample included infants who had an older sibling with a confirmed ASD diagnosis and typically developing (TD) infants with no family history of ASD. The data were collected as part of the British Autism Study of Infant Siblings (BASIS) study. Infants between 6 and 10 months of age (M(age) =7.34, SD(age) =1.21) performed a visual face processing task that included faces and scrambled, "face noise", stimuli. Follow-up assessments in higher likelihood infants were completed at 24 and again at 36 months to determine diagnostic outcomes. Analysis focused on posterior t-ITC during early (0-200 ms) and late (200-500 ms) visual processing stages commonly investigated in infant studies. t-ITC over posterior scalp regions during late stage face processing was significantly higher in TD and higher likelihood infants without ASD (HRA-), indicating reduced consistency in theta-band responses in higher likelihood infants who eventually receive a diagnosis of ASD (HRA+). These findings indicate that the temporal dynamics of theta during face processing relate to ASD outcomes. Reduced consistency of oscillatory dynamics at basic levels of infant sensory processing could have downstream effects on learning and social communication. LAY SUMMARY: We examined the consistency in brain responses to faces in infants at lower or higher familial likelihood for autism. Our results show that the consistency of EEG responses was lower during face processing in higher likelihood infants who eventually received a diagnosis of autism. These findings highlight that reduced consistency in brain activity during face processing in the first year of life is related to emerging autism. En ligne : http://dx.doi.org/10.1002/aur.2701 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Inter-trial theta phase consistency during face processing in infants is associated with later emerging autism [Texte imprimé et/ou numérique] / Stefon VAN NOORDT, Auteur ; James A. DESJARDINS, Auteur ; THE BASIS TEAM, Auteur ; Mayada ELSABBAGH, Auteur . - p.834-846. Langues : Anglais (eng) in Autism Research > 15-5 (May 2022) . - p.834-846 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Brain  Child  Facial Recognition  Humans  Infant  Siblings  autism  faces  infants  risk  theta coherence Index. décimale : PER Périodiques Résumé : A growing body of research suggests that consistency in cortical activity may be a promising neurophysiological marker of autism spectrum disorder (ASD). In the current study we examined inter-trial coherence, a measure of phase consistency across trials, in the theta range (t-ITC: 3-6 Hz), as theta has been implicated in the processing of social and emotional stimuli in infants and adults. The sample included infants who had an older sibling with a confirmed ASD diagnosis and typically developing (TD) infants with no family history of ASD. The data were collected as part of the British Autism Study of Infant Siblings (BASIS) study. Infants between 6 and 10 months of age (M(age) =7.34, SD(age) =1.21) performed a visual face processing task that included faces and scrambled, "face noise", stimuli. Follow-up assessments in higher likelihood infants were completed at 24 and again at 36 months to determine diagnostic outcomes. Analysis focused on posterior t-ITC during early (0-200 ms) and late (200-500 ms) visual processing stages commonly investigated in infant studies. t-ITC over posterior scalp regions during late stage face processing was significantly higher in TD and higher likelihood infants without ASD (HRA-), indicating reduced consistency in theta-band responses in higher likelihood infants who eventually receive a diagnosis of ASD (HRA+). These findings indicate that the temporal dynamics of theta during face processing relate to ASD outcomes. Reduced consistency of oscillatory dynamics at basic levels of infant sensory processing could have downstream effects on learning and social communication. LAY SUMMARY: We examined the consistency in brain responses to faces in infants at lower or higher familial likelihood for autism. Our results show that the consistency of EEG responses was lower during face processing in higher likelihood infants who eventually received a diagnosis of autism. These findings highlight that reduced consistency in brain activity during face processing in the first year of life is related to emerging autism. En ligne : http://dx.doi.org/10.1002/aur.2701 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Motor development in children at risk of autism: A follow-up study of infant siblings / Hayley C. LEONARD in Autism, 18-3 (April 2014)  

Public ISBD [article]  inAutism > 18-3 (April 2014) . - p.281-291 Titre : Motor development in children at risk of autism: A follow-up study of infant siblings Type de document : Texte imprimé et/ou numérique Auteurs : Hayley C. LEONARD, Auteur ; Rachael BEDFORD, Auteur ; Tony CHARMAN, Auteur ; Mayada ELSABBAGH, Auteur ; Mark H. JOHNSON, Auteur ; Elisabeth L. HILL, Auteur ; THE BASIS TEAM, Auteur Article en page(s) : p.281-291 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  broader autism phenotype  face processing  infant siblings  motor development Index. décimale : PER Périodiques Résumé : Recently, evidence of poor or atypical motor skills in autism spectrum disorder has led some to argue that motor impairment is a core feature of the condition. The current study uses a longitudinal prospective design to assess the development of motor skills of 20 children at increased risk of developing autism spectrum disorder, who were recruited and tested at 9 and 40 months of age, on the basis of having an older sibling diagnosed with the condition. All children completed a range of motor, face processing, IQ and diagnostic assessments at a follow-up visit (aged 5–7 years), providing a detailed profile of development in this group from a number of standardised, parental report and experimental measures. A higher proportion of children than expected demonstrated motor difficulties at the follow-up visit and those highlighted by parental report as having poor motor skills as infants and toddlers were also more likely to have lower face processing scores and elevated autism-related social symptoms at 5–7 years, despite having similar IQ levels. These data lend support to the argument that early motor difficulties may be a risk factor for later motor impairment as well as differences in social communication and cognition, traits that are related to autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361312470037 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=229 [article] Motor development in children at risk of autism: A follow-up study of infant siblings [Texte imprimé et/ou numérique] / Hayley C. LEONARD, Auteur ; Rachael BEDFORD, Auteur ; Tony CHARMAN, Auteur ; Mayada ELSABBAGH, Auteur ; Mark H. JOHNSON, Auteur ; Elisabeth L. HILL, Auteur ; THE BASIS TEAM, Auteur . - p.281-291. Langues : Anglais (eng) in Autism > 18-3 (April 2014) . - p.281-291 Mots-clés : autism spectrum disorder  broader autism phenotype  face processing  infant siblings  motor development Index. décimale : PER Périodiques Résumé : Recently, evidence of poor or atypical motor skills in autism spectrum disorder has led some to argue that motor impairment is a core feature of the condition. The current study uses a longitudinal prospective design to assess the development of motor skills of 20 children at increased risk of developing autism spectrum disorder, who were recruited and tested at 9 and 40 months of age, on the basis of having an older sibling diagnosed with the condition. All children completed a range of motor, face processing, IQ and diagnostic assessments at a follow-up visit (aged 5–7 years), providing a detailed profile of development in this group from a number of standardised, parental report and experimental measures. A higher proportion of children than expected demonstrated motor difficulties at the follow-up visit and those highlighted by parental report as having poor motor skills as infants and toddlers were also more likely to have lower face processing scores and elevated autism-related social symptoms at 5–7 years, despite having similar IQ levels. These data lend support to the argument that early motor difficulties may be a risk factor for later motor impairment as well as differences in social communication and cognition, traits that are related to autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361312470037 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=229

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