Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis / Xuejun KONG in Journal of Autism and Developmental Disorders, 51-1 (January 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.144-157 Titre : Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Xuejun KONG, Auteur ; Jun LIU, Auteur ; Kevin LIU, Auteur ; Madelyn KOH, Auteur ; Ruiyi TIAN, Auteur ; Clara HOBBIE, Auteur ; Michelle FONG, Auteur ; Qiuyi CHEN, Auteur ; Minxuan ZHAO, Auteur ; Christoph BUDJAN, Auteur ; Jian KONG, Auteur Article en page(s) : p.144-157 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders (ASD)  Autonomic dysfunction  Biomarker  Gut microbiome  Gut-brain-axis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurological and developmental disorder, and a growing body of literature suggests the presence of autonomic nervous system (ANS) dysfunction in individuals with ASD. ANS is part of the "gut brain axis", which consists of an intricate interplay between the gut microbiome, mucosal immune system, enteric nervous system, ANS, and central processes receiving input from the vagus nerve. Measurements of the gut microbiome and the autonomic indices can serve as non-invasive markers of the status of the gut-brain axis in ASD. To our knowledge, no previous studies have explored the relationship between ANS and gut microbiome in individuals with ASD. Furthermore, while previous studies investigated the use of autonomic indices and gut microbiome independently as markers of ASD-related comorbidities, such as anxiety, cardiovascular issues, and gastrointestinal dysfunction, the use of combined autonomic indices and gut microbiome factors to classify ASD and control subjects has not been explored. In this study, we characterized autonomic function of a group of individuals with ASD in comparison to their paired, first-degree relative controls. Second, we explored the ASD gut-brain-axis through the relationship between gut microbiome markers and autonomic indices, as well as the correlation between the gut-brain-axis and clinical presentation of ASD. Lastly, this study explores the predictive capability of gut-brain-axis biomarkers (including autonomic and microbiome indices) in subtyping ASD cases, serving as a starting point to investigate the possibility of assisting in ASD screening and diagnosis that still heavily relies on psychological testing, which may be based on highly subjective standards. En ligne : http://dx.doi.org/10.1007/s10803-020-04524-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis [Texte imprimé et/ou numérique] / Xuejun KONG, Auteur ; Jun LIU, Auteur ; Kevin LIU, Auteur ; Madelyn KOH, Auteur ; Ruiyi TIAN, Auteur ; Clara HOBBIE, Auteur ; Michelle FONG, Auteur ; Qiuyi CHEN, Auteur ; Minxuan ZHAO, Auteur ; Christoph BUDJAN, Auteur ; Jian KONG, Auteur . - p.144-157. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.144-157 Mots-clés : Autism spectrum disorders (ASD)  Autonomic dysfunction  Biomarker  Gut microbiome  Gut-brain-axis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurological and developmental disorder, and a growing body of literature suggests the presence of autonomic nervous system (ANS) dysfunction in individuals with ASD. ANS is part of the "gut brain axis", which consists of an intricate interplay between the gut microbiome, mucosal immune system, enteric nervous system, ANS, and central processes receiving input from the vagus nerve. Measurements of the gut microbiome and the autonomic indices can serve as non-invasive markers of the status of the gut-brain axis in ASD. To our knowledge, no previous studies have explored the relationship between ANS and gut microbiome in individuals with ASD. Furthermore, while previous studies investigated the use of autonomic indices and gut microbiome independently as markers of ASD-related comorbidities, such as anxiety, cardiovascular issues, and gastrointestinal dysfunction, the use of combined autonomic indices and gut microbiome factors to classify ASD and control subjects has not been explored. In this study, we characterized autonomic function of a group of individuals with ASD in comparison to their paired, first-degree relative controls. Second, we explored the ASD gut-brain-axis through the relationship between gut microbiome markers and autonomic indices, as well as the correlation between the gut-brain-axis and clinical presentation of ASD. Lastly, this study explores the predictive capability of gut-brain-axis biomarkers (including autonomic and microbiome indices) in subtyping ASD cases, serving as a starting point to investigate the possibility of assisting in ASD screening and diagnosis that still heavily relies on psychological testing, which may be based on highly subjective standards. En ligne : http://dx.doi.org/10.1007/s10803-020-04524-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Autoantibody and autism spectrum disorder: A systematic review / Tianle ZOU in Research in Autism Spectrum Disorders, 75 (July 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 75 (July 2020) . - p.101568 Titre : Autoantibody and autism spectrum disorder: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Tianle ZOU, Auteur ; Jun LIU, Auteur ; Xueying ZHANG, Auteur ; Huilin TANG, Auteur ; Yiqing SONG, Auteur ; Xuejun KONG, Auteur Article en page(s) : p.101568 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Autoimmune  Autoantibody  Immune-mediated autism Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1.7 % of US pediatric population, with a growing prevalence world-wide. Autoimmunity is one of potential pathogenic factors for ASD, which is attracting much attention and undergoing extensive investigations. For more than a decade, many groups have been studying the association between autoantibodies and ASD. Although several narrative reviews have been published on autoantibodies and ASD, no systematic review or meta-analysis has been performed. In this study, we conducted the first systematic review and evaluated available evidence for the association between ASD and major autoantibodies to identifiable antigens, together with a broader discussion of autoantibodies with no identifiable antigens. The goal is to examine studies of pediatric subjects specifically and overall, we found that children with ASD expressed trends of higher levels of antibodies reactive to folate receptor ? autoantibody, anti-myelin basic protein antibodies, anti-myelin-associated glycoprotein antibodies, anti-ribosomal P protein antibodies, anti-endothelial cell antibodies, and anti-nuclear antibody, compared to healthy controls. However, the quality of evidence is low across the board because most studies were small and many did not include comparison controls. In addition, we were not able to perform a meta-analysis due to large between-study heterogeneity or lack of quantitative measures in most studies. Finally, we discussed future directions for the development of diagnostic guidelines and therapeutic targets for possible autoimmune-mediated ASD subtypes. En ligne : https://doi.org/10.1016/j.rasd.2020.101568 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Autoantibody and autism spectrum disorder: A systematic review [Texte imprimé et/ou numérique] / Tianle ZOU, Auteur ; Jun LIU, Auteur ; Xueying ZHANG, Auteur ; Huilin TANG, Auteur ; Yiqing SONG, Auteur ; Xuejun KONG, Auteur . - p.101568. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 75 (July 2020) . - p.101568 Mots-clés : Autism spectrum disorder  Autoimmune  Autoantibody  Immune-mediated autism Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1.7 % of US pediatric population, with a growing prevalence world-wide. Autoimmunity is one of potential pathogenic factors for ASD, which is attracting much attention and undergoing extensive investigations. For more than a decade, many groups have been studying the association between autoantibodies and ASD. Although several narrative reviews have been published on autoantibodies and ASD, no systematic review or meta-analysis has been performed. In this study, we conducted the first systematic review and evaluated available evidence for the association between ASD and major autoantibodies to identifiable antigens, together with a broader discussion of autoantibodies with no identifiable antigens. The goal is to examine studies of pediatric subjects specifically and overall, we found that children with ASD expressed trends of higher levels of antibodies reactive to folate receptor ? autoantibody, anti-myelin basic protein antibodies, anti-myelin-associated glycoprotein antibodies, anti-ribosomal P protein antibodies, anti-endothelial cell antibodies, and anti-nuclear antibody, compared to healthy controls. However, the quality of evidence is low across the board because most studies were small and many did not include comparison controls. In addition, we were not able to perform a meta-analysis due to large between-study heterogeneity or lack of quantitative measures in most studies. Finally, we discussed future directions for the development of diagnostic guidelines and therapeutic targets for possible autoimmune-mediated ASD subtypes. En ligne : https://doi.org/10.1016/j.rasd.2020.101568 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

A Systematic Network of Autism Primary Care Services (SYNAPSE): A Model of Coproduction for the Management of Autism Spectrum Disorder / Xuejun KONG in Journal of Autism and Developmental Disorders, 50-5 (May 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1847-1853 Titre : A Systematic Network of Autism Primary Care Services (SYNAPSE): A Model of Coproduction for the Management of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Xuejun KONG, Auteur ; Jun LIU, Auteur ; Tiffany CHIEN, Auteur ; Maren BATALDEN, Auteur ; David A HIRSH, Auteur Article en page(s) : p.1847-1853 Langues : Anglais (eng) Mots-clés : Autism  Care transformation  Co-occurring conditions  Primary care Index. décimale : PER Périodiques Résumé : The prevalence of Autism Spectrum Disorder (ASD) is growing rapidly, affecting 1 in 59 children in the United States in 2018. Individuals with ASD currently receive fragmented care that threatens their health and well-being. Challenges of autism care include disconnections between the medical system and school supports, poor care coordination between primary care and specialists, and saturation of neuropsychiatry-based centers' capacity to care for the ASD population. ASD treatment also lacks of a coordinated system of care for patients' multi-system comorbidities. Families are calling for an ASD care delivery system to meet their needs and the needs of their children. To serve people with ASD and their medical and other providers, we propose a coordinated approach to care grounded in primary care. We call the model the "Systematic Network of Autism Primary Care Services (SYNAPSE)." We develop the model by applying the frameworks of "coproduction" of care and chronic disease management. In this Commentary we discuss the model's rationale, underpinnings, and the implications for clinical practice. We advance these ideas to align with policy makers' recognition of the importance of primary care for ASD, as reflected by the most recent Interagency Autism Coordinating Committee (IACC) meeting at the National Institute of Mental Health. En ligne : http://dx.doi.org/10.1007/s10803-019-03922-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] A Systematic Network of Autism Primary Care Services (SYNAPSE): A Model of Coproduction for the Management of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Xuejun KONG, Auteur ; Jun LIU, Auteur ; Tiffany CHIEN, Auteur ; Maren BATALDEN, Auteur ; David A HIRSH, Auteur . - p.1847-1853. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1847-1853 Mots-clés : Autism  Care transformation  Co-occurring conditions  Primary care Index. décimale : PER Périodiques Résumé : The prevalence of Autism Spectrum Disorder (ASD) is growing rapidly, affecting 1 in 59 children in the United States in 2018. Individuals with ASD currently receive fragmented care that threatens their health and well-being. Challenges of autism care include disconnections between the medical system and school supports, poor care coordination between primary care and specialists, and saturation of neuropsychiatry-based centers' capacity to care for the ASD population. ASD treatment also lacks of a coordinated system of care for patients' multi-system comorbidities. Families are calling for an ASD care delivery system to meet their needs and the needs of their children. To serve people with ASD and their medical and other providers, we propose a coordinated approach to care grounded in primary care. We call the model the "Systematic Network of Autism Primary Care Services (SYNAPSE)." We develop the model by applying the frameworks of "coproduction" of care and chronic disease management. In this Commentary we discuss the model's rationale, underpinnings, and the implications for clinical practice. We advance these ideas to align with policy makers' recognition of the importance of primary care for ASD, as reflected by the most recent Interagency Autism Coordinating Committee (IACC) meeting at the National Institute of Mental Health. En ligne : http://dx.doi.org/10.1007/s10803-019-03922-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders / Angela TSENG in Journal of Autism and Developmental Disorders, 44-6 (June 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1332-1346 Titre : Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Angela TSENG, Auteur ; Ravi BANSAL, Auteur ; Jun LIU, Auteur ; Andrew J. GERBER, Auteur ; Suzanne GOH, Auteur ; Jonathan POSNER, Auteur ; Tiziano COLIBAZZI, Auteur ; Molly ALGERMISSEN, Auteur ; I. Chin CHIANG, Auteur ; James A. RUSSELL, Auteur ; Bradley S. PETERSON, Auteur Article en page(s) : p.1332-1346 Langues : Anglais (eng) Mots-clés : Circumplex model of affect  Valence  Arousal  Autism spectrum disorders  Facial emotion Index. décimale : PER Périodiques Résumé : The Affective Circumplex Model holds that emotions can be described as linear combinations of two underlying, independent neurophysiological systems (arousal, valence). Given research suggesting individuals with autism spectrum disorders (ASD) have difficulty processing emotions, we used the circumplex model to compare how individuals with ASD and typically-developing (TD) individuals respond to facial emotions. Participants (51 ASD, 80 TD) rated facial expressions along arousal and valence dimensions; we fitted closed, smooth, 2-dimensional curves to their ratings to examine overall circumplex contours. We modeled individual and group influences on parameters describing curve contours to identify differences in dimensional effects across groups. Significant main effects of diagnosis indicated the ASD-group’s ratings were constricted for the entire circumplex, suggesting range constriction across all emotions. Findings did not change when covarying for overall intelligence. En ligne : http://dx.doi.org/10.1007/s10803-013-1993-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 [article] Using the Circumplex Model of Affect to Study Valence and Arousal Ratings of Emotional Faces by Children and Adults with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Angela TSENG, Auteur ; Ravi BANSAL, Auteur ; Jun LIU, Auteur ; Andrew J. GERBER, Auteur ; Suzanne GOH, Auteur ; Jonathan POSNER, Auteur ; Tiziano COLIBAZZI, Auteur ; Molly ALGERMISSEN, Auteur ; I. Chin CHIANG, Auteur ; James A. RUSSELL, Auteur ; Bradley S. PETERSON, Auteur . - p.1332-1346. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1332-1346 Mots-clés : Circumplex model of affect  Valence  Arousal  Autism spectrum disorders  Facial emotion Index. décimale : PER Périodiques Résumé : The Affective Circumplex Model holds that emotions can be described as linear combinations of two underlying, independent neurophysiological systems (arousal, valence). Given research suggesting individuals with autism spectrum disorders (ASD) have difficulty processing emotions, we used the circumplex model to compare how individuals with ASD and typically-developing (TD) individuals respond to facial emotions. Participants (51 ASD, 80 TD) rated facial expressions along arousal and valence dimensions; we fitted closed, smooth, 2-dimensional curves to their ratings to examine overall circumplex contours. We modeled individual and group influences on parameters describing curve contours to identify differences in dimensional effects across groups. Significant main effects of diagnosis indicated the ASD-group’s ratings were constricted for the entire circumplex, suggesting range constriction across all emotions. Findings did not change when covarying for overall intelligence. En ligne : http://dx.doi.org/10.1007/s10803-013-1993-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233

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