Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations? / Joseph M. BRAUN in Journal of Autism and Developmental Disorders, 44-10 (October 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2602-2607 Titre : Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations? Type de document : Texte imprimé et/ou numérique Auteurs : Joseph M. BRAUN, Auteur ; Tanya FROEHLICH, Auteur ; Amy E. KALKBRENNER, Auteur ; Christine M. PFEIFFER, Auteur ; Zia FAZILI, Auteur ; Kimberly YOLTON, Auteur ; Bruce P. LANPHEAR, Auteur Article en page(s) : p.2602-2607 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Folate  Pregnancy  Prenatal vitamins Index. décimale : PER Périodiques Résumé : Prenatal multivitamin/folic acid supplement use may reduce the risk of autism spectrum disorders. We investigated whether 2nd trimester prenatal vitamin use and maternal whole blood folate (WBF) concentrations were associated with Social Responsiveness Scale (SRS) scores at 4–5 years of age in a prospective cohort of 209 mother–child pairs. After confounder adjustment, children born to women taking prenatal vitamins weekly/daily (n = 179) had lower odds of clinically elevated SRS scores (odds ratio 0.26; 95 % confidence interval 0.08, 0.89) than those who rarely/never took them (n = 30). WBF concentrations were not associated with SRS scores. The lack of association between WBF and autistic-behaviors may be due to the timing of biomarker measures relative to critical periods of brain development, confounding, or other modifying factors. En ligne : http://dx.doi.org/10.1007/s10803-014-2114-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240 [article] Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations? [Texte imprimé et/ou numérique] / Joseph M. BRAUN, Auteur ; Tanya FROEHLICH, Auteur ; Amy E. KALKBRENNER, Auteur ; Christine M. PFEIFFER, Auteur ; Zia FAZILI, Auteur ; Kimberly YOLTON, Auteur ; Bruce P. LANPHEAR, Auteur . - p.2602-2607. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2602-2607 Mots-clés : Autism spectrum disorders  Folate  Pregnancy  Prenatal vitamins Index. décimale : PER Périodiques Résumé : Prenatal multivitamin/folic acid supplement use may reduce the risk of autism spectrum disorders. We investigated whether 2nd trimester prenatal vitamin use and maternal whole blood folate (WBF) concentrations were associated with Social Responsiveness Scale (SRS) scores at 4–5 years of age in a prospective cohort of 209 mother–child pairs. After confounder adjustment, children born to women taking prenatal vitamins weekly/daily (n = 179) had lower odds of clinically elevated SRS scores (odds ratio 0.26; 95 % confidence interval 0.08, 0.89) than those who rarely/never took them (n = 30). WBF concentrations were not associated with SRS scores. The lack of association between WBF and autistic-behaviors may be due to the timing of biomarker measures relative to critical periods of brain development, confounding, or other modifying factors. En ligne : http://dx.doi.org/10.1007/s10803-014-2114-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240

Gestational thyroid hormones and autism-related traits in the EARLI and HOME studies / Caichen ZHONG in Autism Research, 17-4 (April 2024)  

Public ISBD [article]  inAutism Research > 17-4 (April 2024) . - p.716-727 Titre : Gestational thyroid hormones and autism-related traits in the EARLI and HOME studies Type de document : Texte imprimé et/ou numérique Auteurs : Caichen ZHONG, Auteur ; Juliette RANDO, Auteur ; Marisa A. PATTI, Auteur ; Joseph M. BRAUN, Auteur ; Aimin CHEN, Auteur ; Yingying XU, Auteur ; Bruce P. LANPHEAR, Auteur ; Kimberly YOLTON, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.716-727 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Thyroid hormones are essential for neurodevelopment. Few studies have considered associations with quantitatively measured autism spectrum disorder (ASD)-related traits, which may help elucidate associations for a broader population. Participants were drawn from two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI), enrolling pregnant women who already had a child with ASD, and the Health Outcomes and Measures of the Environment (HOME) Study, following pregnant women from the greater Cincinnati, OH area. Gestational thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured in mid-pregnancy 16 (+3) weeks gestation serum samples. ASD-related traits were measured using the Social Responsiveness Scale (SRS) at ages 3-8?years. The association was examined using quantile regression, adjusting for maternal and sociodemographic factors. 278 participants (132 from EARLI, 146 from HOME) were included. TSH distributions were similar across cohorts, while FT4 levels were higher in EARLI compared to HOME. In pooled analyses, particularly for those in the highest SRS quantile (95th percentile), higher FT4 levels were associated with increasing SRS scores (? = 5.21, 95% CI = 0.93, 9.48), and higher TSH levels were associated with decreasing SRS scores (? = ?6.94, 95% CI = ?11.04, ?2.83). The association between TSH and SRS remained significant in HOME for the 95% percentile of SRS scores (? = ?6.48, 95% CI = ?12.16, ?0.80), but not EARLI. Results for FT4 were attenuated when examined in the individual cohorts. Our results add to evidence that gestational thyroid hormones may be associated with ASD-related outcomes by suggesting that relationships may differ across the distribution of ASD-related traits and by familial likelihood of ASD. En ligne : https://doi.org/10.1002/aur.3115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Gestational thyroid hormones and autism-related traits in the EARLI and HOME studies [Texte imprimé et/ou numérique] / Caichen ZHONG, Auteur ; Juliette RANDO, Auteur ; Marisa A. PATTI, Auteur ; Joseph M. BRAUN, Auteur ; Aimin CHEN, Auteur ; Yingying XU, Auteur ; Bruce P. LANPHEAR, Auteur ; Kimberly YOLTON, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.716-727. Langues : Anglais (eng) in Autism Research > 17-4 (April 2024) . - p.716-727 Index. décimale : PER Périodiques Résumé : Abstract Thyroid hormones are essential for neurodevelopment. Few studies have considered associations with quantitatively measured autism spectrum disorder (ASD)-related traits, which may help elucidate associations for a broader population. Participants were drawn from two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI), enrolling pregnant women who already had a child with ASD, and the Health Outcomes and Measures of the Environment (HOME) Study, following pregnant women from the greater Cincinnati, OH area. Gestational thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured in mid-pregnancy 16 (+3) weeks gestation serum samples. ASD-related traits were measured using the Social Responsiveness Scale (SRS) at ages 3-8?years. The association was examined using quantile regression, adjusting for maternal and sociodemographic factors. 278 participants (132 from EARLI, 146 from HOME) were included. TSH distributions were similar across cohorts, while FT4 levels were higher in EARLI compared to HOME. In pooled analyses, particularly for those in the highest SRS quantile (95th percentile), higher FT4 levels were associated with increasing SRS scores (? = 5.21, 95% CI = 0.93, 9.48), and higher TSH levels were associated with decreasing SRS scores (? = ?6.94, 95% CI = ?11.04, ?2.83). The association between TSH and SRS remained significant in HOME for the 95% percentile of SRS scores (? = ?6.48, 95% CI = ?12.16, ?0.80), but not EARLI. Results for FT4 were attenuated when examined in the individual cohorts. Our results add to evidence that gestational thyroid hormones may be associated with ASD-related outcomes by suggesting that relationships may differ across the distribution of ASD-related traits and by familial likelihood of ASD. En ligne : https://doi.org/10.1002/aur.3115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

The Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies / Rachel VECCHIONE in Journal of Autism and Developmental Disorders, 51-2 (February 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-2 (February 2021) . - p.487-500 Titre : The Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies Type de document : Texte imprimé et/ou numérique Auteurs : Rachel VECCHIONE, Auteur ; Chelsea VIGNA, Auteur ; Casey WHITMAN, Auteur ; Elizabeth M. KAUFFMAN, Auteur ; Joseph M. BRAUN, Auteur ; Aimin CHEN, Auteur ; Yingying XU, Auteur ; Ghassan B. HAMRA, Auteur ; Bruce P. LANPHEAR, Auteur ; Kimberly YOLTON, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.487-500 Langues : Anglais (eng) Mots-clés : Autism  Maternal fish intake  Prenatal diet  Quantitative traits  Social responsiveness scale Index. décimale : PER Périodiques Résumé : We examined the association between prenatal fish intake and child autism-related traits according to Social Responsiveness Scale (SRS) and cognitive development scores in two US prospective pregnancy cohorts. In adjusted linear regression analyses, higher maternal fish intake in the second half of pregnancy was associated with increased child autism traits (higher raw SRS scores; ß?=?5.60, 95%CI 1.76, 12.97). Differences by fish type were suggested; shellfish and large fish species were associated with increases, and salmon with decreases, in child SRS scores. Clear patterns with cognitive scores in the two cohorts were not observed. Future work should further evaluate potential critical windows of prenatal fish intake, and the role of different fish types in association with child autism-related outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04546-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] The Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies [Texte imprimé et/ou numérique] / Rachel VECCHIONE, Auteur ; Chelsea VIGNA, Auteur ; Casey WHITMAN, Auteur ; Elizabeth M. KAUFFMAN, Auteur ; Joseph M. BRAUN, Auteur ; Aimin CHEN, Auteur ; Yingying XU, Auteur ; Ghassan B. HAMRA, Auteur ; Bruce P. LANPHEAR, Auteur ; Kimberly YOLTON, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.487-500. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-2 (February 2021) . - p.487-500 Mots-clés : Autism  Maternal fish intake  Prenatal diet  Quantitative traits  Social responsiveness scale Index. décimale : PER Périodiques Résumé : We examined the association between prenatal fish intake and child autism-related traits according to Social Responsiveness Scale (SRS) and cognitive development scores in two US prospective pregnancy cohorts. In adjusted linear regression analyses, higher maternal fish intake in the second half of pregnancy was associated with increased child autism traits (higher raw SRS scores; ß?=?5.60, 95%CI 1.76, 12.97). Differences by fish type were suggested; shellfish and large fish species were associated with increases, and salmon with decreases, in child SRS scores. Clear patterns with cognitive scores in the two cohorts were not observed. Future work should further evaluate potential critical windows of prenatal fish intake, and the role of different fish types in association with child autism-related outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04546-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

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