Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study / Sebastian LUNDSTROM in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.702-710 Titre : Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study Type de document : texte imprimé Auteurs : Sebastian LUNDSTROM, Auteur ; Abraham REICHENBERG, Auteur ; Jonas MELKE, Auteur ; Maria RASTAM, Auteur ; Nora KEREKES, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Henrik ANCKARSATER, Auteur Article en page(s) : p.702-710 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  comorbidity  genetics  twins Index. décimale : PER Périodiques Résumé : Background Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. Methods Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. Results Half of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did not have any concomitant disorder. The ‘healthy co-twin’ in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). Conclusions Detailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically. En ligne : http://dx.doi.org/10.1111/jcpp.12329 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study [texte imprimé] / Sebastian LUNDSTROM, Auteur ; Abraham REICHENBERG, Auteur ; Jonas MELKE, Auteur ; Maria RASTAM, Auteur ; Nora KEREKES, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Henrik ANCKARSATER, Auteur . - p.702-710. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.702-710 Mots-clés : Autism spectrum disorders  comorbidity  genetics  twins Index. décimale : PER Périodiques Résumé : Background Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. Methods Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. Results Half of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did not have any concomitant disorder. The ‘healthy co-twin’ in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). Conclusions Detailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically. En ligne : http://dx.doi.org/10.1111/jcpp.12329 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Childhood Neurodevelopmental Disorders and Violent Criminality: A Sibling Control Study / Sebastian LUNDSTROM in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2707-2716 Titre : Childhood Neurodevelopmental Disorders and Violent Criminality: A Sibling Control Study Type de document : texte imprimé Auteurs : Sebastian LUNDSTROM, Auteur ; Mats FORSMAN, Auteur ; Henrik LARSSON, Auteur ; Nora KEREKES, Auteur ; Eva SERLACHIUS, Auteur ; Niklas LANGSTROM, Auteur ; Paul LICHTENSTEIN, Auteur Article en page(s) : p.2707-2716 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Attention deficit hyperactivity disorder  Neurodevelopmental disorders  Criminality  Familial confounding Index. décimale : PER Périodiques Résumé : The longitudinal relationship between attention deficit hyperactivity disorder (ADHD) and violent criminality has been extensively documented, while long-term effects of autism spectrum disorders (ASDs), tic disorders (TDs), and obsessive compulsive disorder (OCD) on criminality have been scarcely studied. Using population-based registers of all child and adolescent mental health services in Stockholm, we identified 3,391 children, born 1984–1994, with neurodevelopmental disorders, and compared their risk for subsequent violent criminality with matched controls. Individuals with ADHD or TDs were at elevated risk of committing violent crimes, no such association could be seen for ASDs or OCD. ADHD and TDs are risk factors for subsequent violent criminality, while ASDs and OCD are not associated with violent criminality. En ligne : http://dx.doi.org/10.1007/s10803-013-1873-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Childhood Neurodevelopmental Disorders and Violent Criminality: A Sibling Control Study [texte imprimé] / Sebastian LUNDSTROM, Auteur ; Mats FORSMAN, Auteur ; Henrik LARSSON, Auteur ; Nora KEREKES, Auteur ; Eva SERLACHIUS, Auteur ; Niklas LANGSTROM, Auteur ; Paul LICHTENSTEIN, Auteur . - p.2707-2716. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2707-2716 Mots-clés : Autism spectrum disorders  Attention deficit hyperactivity disorder  Neurodevelopmental disorders  Criminality  Familial confounding Index. décimale : PER Périodiques Résumé : The longitudinal relationship between attention deficit hyperactivity disorder (ADHD) and violent criminality has been extensively documented, while long-term effects of autism spectrum disorders (ASDs), tic disorders (TDs), and obsessive compulsive disorder (OCD) on criminality have been scarcely studied. Using population-based registers of all child and adolescent mental health services in Stockholm, we identified 3,391 children, born 1984–1994, with neurodevelopmental disorders, and compared their risk for subsequent violent criminality with matched controls. Individuals with ADHD or TDs were at elevated risk of committing violent crimes, no such association could be seen for ASDs or OCD. ADHD and TDs are risk factors for subsequent violent criminality, while ASDs and OCD are not associated with violent criminality. En ligne : http://dx.doi.org/10.1007/s10803-013-1873-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Correction to: Physical health in children with neurodevelopmental disorders / Setareh ALABAF in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.96-97 Titre : Correction to: Physical health in children with neurodevelopmental disorders Type de document : texte imprimé Auteurs : Setareh ALABAF, Auteur ; Christopher GILLBERG, Auteur ; Sebastian LUNDSTROM, Auteur ; Paul LICHTENSTEIN, Auteur ; Nora KEREKES, Auteur ; Maria RASTAM, Auteur ; Henrik ANCKARSATER, Auteur Article en page(s) : p.96-97 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The original version of this article unfortunately contained a mistake in Fig. 2 part labels, the label "d" was incorrectly labelled as "c" and the subsequent labels should be corrected as d, e, and f. The corrected Fig. 2 is given below. En ligne : http://dx.doi.org/10.1007/s10803-018-3758-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] Correction to: Physical health in children with neurodevelopmental disorders [texte imprimé] / Setareh ALABAF, Auteur ; Christopher GILLBERG, Auteur ; Sebastian LUNDSTROM, Auteur ; Paul LICHTENSTEIN, Auteur ; Nora KEREKES, Auteur ; Maria RASTAM, Auteur ; Henrik ANCKARSATER, Auteur . - p.96-97. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.96-97 Index. décimale : PER Périodiques Résumé : The original version of this article unfortunately contained a mistake in Fig. 2 part labels, the label "d" was incorrectly labelled as "c" and the subsequent labels should be corrected as d, e, and f. The corrected Fig. 2 is given below. En ligne : http://dx.doi.org/10.1007/s10803-018-3758-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

Motor function and perception in children with neuropsychiatric and conduct problems: results from a population based twin study / Peik GUSTAFSSON in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.11 Titre : Motor function and perception in children with neuropsychiatric and conduct problems: results from a population based twin study Type de document : texte imprimé Auteurs : Peik GUSTAFSSON, Auteur ; Nora KEREKES, Auteur ; Henrik ANCKARSATER, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Maria RASTAM, Auteur Article en page(s) : p.11 Langues : Anglais (eng) Mots-clés : A-tac  Attention-Deficit/Hyperactivity Disorder  Autism Spectrum Disorder  Conduct Disorder  Motor control  Perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with early symptomatic psychiatric disorders such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) have been found to have high rates of motor and/or perception difficulties. However, there have been few large-scale studies reporting on the association between Conduct Disorder (CD) and motor/perception functions. The aim of the present study was to investigate how motor function and perception relate to measures of ADHD, ASD, and CD. METHODS: Parents of 16,994 Swedish twins (ages nine and twelve years) were interviewed using the Autism-Tics, ADHD and other Comorbidities inventory (A-TAC), which has been validated as a screening instrument for early onset child psychiatric disorders and symptoms. Associations between categorical variables of scoring above previously validated cut-off values for diagnosing ADHD, ASD, and CD on the one hand and motor and/or perception problems on the other hand were analysed using cross-tabulations, and the Fisher exact test. Associations between the continuous scores for ADHD, ASD, CD, and the subdomains Concentration/Attention, Impulsiveness/Activity, Flexibility, Social Interaction and Language, and the categorical factors age and gender, on the one hand, and the dependent dichotomic variables Motor control and Perception problems, on the other hand, were analysed using binary logistic regression in general estimated equation models. RESULTS: Male gender was associated with increased risk of Motor control and/or Perception problems. Children scoring above the cut-off for ADHD, ASD, and/or CD, but not those who were 'CD positive' but 'ADHD/ASD negative', had more Motor control and/or Perception problems, compared with children who were screen-negative for all three diagnoses. In the multivariable model, CD and Impulsiveness/Activity had no positive associations with Motor control and/or Perception problems. CONCLUSIONS: CD symptoms or problems with Impulsiveness/Activity were associated with Motor control or Perception problems only in the presence of ASD symptoms and/or symptoms of inattention. Our results indicate that children with CD but without ASD or inattention do not show a deviant development of motor and perceptual functions. Therefore, all children with CD should be examined concerning motor control and perception. If problems are present, a suspicion of ADHD and/or ASD should be raised. En ligne : http://dx.doi.org/10.1186/1866-1955-6-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 [article] Motor function and perception in children with neuropsychiatric and conduct problems: results from a population based twin study [texte imprimé] / Peik GUSTAFSSON, Auteur ; Nora KEREKES, Auteur ; Henrik ANCKARSATER, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Maria RASTAM, Auteur . - p.11. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.11 Mots-clés : A-tac  Attention-Deficit/Hyperactivity Disorder  Autism Spectrum Disorder  Conduct Disorder  Motor control  Perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with early symptomatic psychiatric disorders such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) have been found to have high rates of motor and/or perception difficulties. However, there have been few large-scale studies reporting on the association between Conduct Disorder (CD) and motor/perception functions. The aim of the present study was to investigate how motor function and perception relate to measures of ADHD, ASD, and CD. METHODS: Parents of 16,994 Swedish twins (ages nine and twelve years) were interviewed using the Autism-Tics, ADHD and other Comorbidities inventory (A-TAC), which has been validated as a screening instrument for early onset child psychiatric disorders and symptoms. Associations between categorical variables of scoring above previously validated cut-off values for diagnosing ADHD, ASD, and CD on the one hand and motor and/or perception problems on the other hand were analysed using cross-tabulations, and the Fisher exact test. Associations between the continuous scores for ADHD, ASD, CD, and the subdomains Concentration/Attention, Impulsiveness/Activity, Flexibility, Social Interaction and Language, and the categorical factors age and gender, on the one hand, and the dependent dichotomic variables Motor control and Perception problems, on the other hand, were analysed using binary logistic regression in general estimated equation models. RESULTS: Male gender was associated with increased risk of Motor control and/or Perception problems. Children scoring above the cut-off for ADHD, ASD, and/or CD, but not those who were 'CD positive' but 'ADHD/ASD negative', had more Motor control and/or Perception problems, compared with children who were screen-negative for all three diagnoses. In the multivariable model, CD and Impulsiveness/Activity had no positive associations with Motor control and/or Perception problems. CONCLUSIONS: CD symptoms or problems with Impulsiveness/Activity were associated with Motor control or Perception problems only in the presence of ASD symptoms and/or symptoms of inattention. Our results indicate that children with CD but without ASD or inattention do not show a deviant development of motor and perceptual functions. Therefore, all children with CD should be examined concerning motor control and perception. If problems are present, a suspicion of ADHD and/or ASD should be raised. En ligne : http://dx.doi.org/10.1186/1866-1955-6-11 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346

Physical health in children with neurodevelopmental disorders / Setareh ALABAF in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.83-95 Titre : Physical health in children with neurodevelopmental disorders Type de document : texte imprimé Auteurs : Setareh ALABAF, Auteur ; Christopher GILLBERG, Auteur ; Sebastian LUNDSTROM, Auteur ; Paul LICHTENSTEIN, Auteur ; Nora KEREKES, Auteur ; Maria RASTAM, Auteur ; Henrik ANCKARSATER, Auteur Article en page(s) : p.83-95 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder (ADHD)  Autism spectrum disorder (ASD)  Learning disorder (LD)  Neurodevelopmental disorders  Physical health  Twins Index. décimale : PER Périodiques Résumé : With increasing numbers of children being diagnosed with neurodevelopmental disorders (NDDs) attention has been drawn to these children's physical health. We aimed to identify the prevalence of defined physical problems (epilepsy, migraine, asthma, cancer, diabetes, psoriasis, lactose intolerance, celiac disease, diarrhea, constipation, daytime enuresis, encopresis) in a nationwide population of 9- and 12-year-old twins subdivided into those with and without indications of NDDs. Parents of 28,058 twins participated in a well-validated telephone interview regarding their children's mental health and answered questions about their physical problems. The results indicate a high rate of physical problems in children with NDDs, particularly in those with indications of the presence of combinations of several NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3697-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] Physical health in children with neurodevelopmental disorders [texte imprimé] / Setareh ALABAF, Auteur ; Christopher GILLBERG, Auteur ; Sebastian LUNDSTROM, Auteur ; Paul LICHTENSTEIN, Auteur ; Nora KEREKES, Auteur ; Maria RASTAM, Auteur ; Henrik ANCKARSATER, Auteur . - p.83-95. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.83-95 Mots-clés : Attention-deficit/hyperactivity disorder (ADHD)  Autism spectrum disorder (ASD)  Learning disorder (LD)  Neurodevelopmental disorders  Physical health  Twins Index. décimale : PER Périodiques Résumé : With increasing numbers of children being diagnosed with neurodevelopmental disorders (NDDs) attention has been drawn to these children's physical health. We aimed to identify the prevalence of defined physical problems (epilepsy, migraine, asthma, cancer, diabetes, psoriasis, lactose intolerance, celiac disease, diarrhea, constipation, daytime enuresis, encopresis) in a nationwide population of 9- and 12-year-old twins subdivided into those with and without indications of NDDs. Parents of 28,058 twins participated in a well-validated telephone interview regarding their children's mental health and answered questions about their physical problems. The results indicate a high rate of physical problems in children with NDDs, particularly in those with indications of the presence of combinations of several NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3697-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

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