Cortical Changes Across the Autism Lifespan / Karol OSIPOWICZ in Autism Research, 8-4 (August 2015)  

Public ISBD [article]  inAutism Research > 8-4 (August 2015) . - p.379-385 Titre : Cortical Changes Across the Autism Lifespan Type de document : Texte imprimé et/ou numérique Auteurs : Karol OSIPOWICZ, Auteur ; Danielle D. BOSENBARK, Auteur ; Kristina E. PATRICK, Auteur Article en page(s) : p.379-385 Langues : Anglais (eng) Mots-clés : autism  neuroimaging  brain development  gray matter Index. décimale : PER Périodiques Résumé : Although it is widely accepted that autism spectrum disorder (ASD) involves neuroanatomical abnormalities and atypical neurodevelopmental patterns, there is little consensus regarding the precise pattern of neuroanatomical differences or how these differences relate to autism symptomology. Furthermore, there is limited research related to neuroanatomical correlates of autism symptomology in individuals with ASD and the studies that do exist primarily include small samples. This study was the first to investigate gray matter (GM) changes throughout the ASD lifespan, using voxel-based morphometry to determine whether significant differences exist in the GM volumes of a large sample of individuals with ASD compared to age- and IQ-matched typical controls. We examined GM volume across the lifespan in 531 individuals diagnosed with ASD and 571 neurotypical controls, aged 7–64. We compared groups and correlated GM with age and autism severity in the ASD group. Findings suggest bilateral decreased GM volume for individuals with ASD in regions extending from the thalamus to the cerebellum, anterior medial temporal lobes, and orbitofrontal regions. Higher autism severity was associated with decreased GM volumes in prefrontal cortex, inferior parietal and temporal regions, and temporal poles. Similar relationships were found between GM volume and age. ASD diagnosis and severity were not associated with increased GM volumes in any region. Autism Res 2015, 8: 379–385. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1453 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Cortical Changes Across the Autism Lifespan [Texte imprimé et/ou numérique] / Karol OSIPOWICZ, Auteur ; Danielle D. BOSENBARK, Auteur ; Kristina E. PATRICK, Auteur . - p.379-385. Langues : Anglais (eng) in Autism Research > 8-4 (August 2015) . - p.379-385 Mots-clés : autism  neuroimaging  brain development  gray matter Index. décimale : PER Périodiques Résumé : Although it is widely accepted that autism spectrum disorder (ASD) involves neuroanatomical abnormalities and atypical neurodevelopmental patterns, there is little consensus regarding the precise pattern of neuroanatomical differences or how these differences relate to autism symptomology. Furthermore, there is limited research related to neuroanatomical correlates of autism symptomology in individuals with ASD and the studies that do exist primarily include small samples. This study was the first to investigate gray matter (GM) changes throughout the ASD lifespan, using voxel-based morphometry to determine whether significant differences exist in the GM volumes of a large sample of individuals with ASD compared to age- and IQ-matched typical controls. We examined GM volume across the lifespan in 531 individuals diagnosed with ASD and 571 neurotypical controls, aged 7–64. We compared groups and correlated GM with age and autism severity in the ASD group. Findings suggest bilateral decreased GM volume for individuals with ASD in regions extending from the thalamus to the cerebellum, anterior medial temporal lobes, and orbitofrontal regions. Higher autism severity was associated with decreased GM volumes in prefrontal cortex, inferior parietal and temporal regions, and temporal poles. Similar relationships were found between GM volume and age. ASD diagnosis and severity were not associated with increased GM volumes in any region. Autism Res 2015, 8: 379–385. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1453 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Driving Behaviors in Adults with Autism Spectrum Disorders / Brian P. DALY in Journal of Autism and Developmental Disorders, 44-12 (December 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.3119-3128 Titre : Driving Behaviors in Adults with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Brian P. DALY, Auteur ; Elizabeth G. NICHOLLS, Auteur ; Kristina E. PATRICK, Auteur ; Danielle D. BRINCKMAN, Auteur ; Maria T. SCHULTHEIS, Auteur Article en page(s) : p.3119-3128 Langues : Anglais (eng) Mots-clés : Autism  Adults  Driving  Violations Index. décimale : PER Périodiques Résumé : This pilot study investigated driving history and driving behaviors between adults diagnosed with autism spectrum disorders (ASD) as compared to non-ASD adult drivers. Seventy-eight licensed drivers with ASD and 94 non-ASD comparison participants completed the Driver Behavior Questionnaire. Drivers with ASD endorsed significantly lower ratings of their ability to drive, and higher numbers of traffic accidents and citations relative to non-ASD drivers. Drivers with ASD also endorsed significantly greater numbers of difficulties on the following subscales: intentional violations, F(1, 162) = 6.15, p = .01, ? p 2 = .04; mistakes, F(1, 162) = 10.15, p = .002, ? p 2 = .06; and slips/lapses, F(1, 162) = 11.33, p = .001, ? p 2 = .07. These findings suggest that individuals with ASD who are current drivers may experience more difficulties in driving behaviors and engage in more problematic driving behaviors relative to non-ASD drivers. En ligne : http://dx.doi.org/10.1007/s10803-014-2166-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Driving Behaviors in Adults with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Brian P. DALY, Auteur ; Elizabeth G. NICHOLLS, Auteur ; Kristina E. PATRICK, Auteur ; Danielle D. BRINCKMAN, Auteur ; Maria T. SCHULTHEIS, Auteur . - p.3119-3128. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.3119-3128 Mots-clés : Autism  Adults  Driving  Violations Index. décimale : PER Périodiques Résumé : This pilot study investigated driving history and driving behaviors between adults diagnosed with autism spectrum disorders (ASD) as compared to non-ASD adult drivers. Seventy-eight licensed drivers with ASD and 94 non-ASD comparison participants completed the Driver Behavior Questionnaire. Drivers with ASD endorsed significantly lower ratings of their ability to drive, and higher numbers of traffic accidents and citations relative to non-ASD drivers. Drivers with ASD also endorsed significantly greater numbers of difficulties on the following subscales: intentional violations, F(1, 162) = 6.15, p = .01, ? p 2 = .04; mistakes, F(1, 162) = 10.15, p = .002, ? p 2 = .06; and slips/lapses, F(1, 162) = 11.33, p = .001, ? p 2 = .07. These findings suggest that individuals with ASD who are current drivers may experience more difficulties in driving behaviors and engage in more problematic driving behaviors relative to non-ASD drivers. En ligne : http://dx.doi.org/10.1007/s10803-014-2166-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

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