Parent?child relationship quality buffers the association between mothers' adverse childhood experiences and physiological synchrony / Sarah A. O. Gray in Journal of Child Psychology and Psychiatry, 66-7 (July 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-7 (July 2025) . - p.956-966 Titre : Parent?child relationship quality buffers the association between mothers' adverse childhood experiences and physiological synchrony Type de document : texte imprimé Auteurs : Sarah A. O. Gray, Auteur ; Jonas G. MILLER, Auteur ; Erin B. Glackin, Auteur ; Virginia HATCH, Auteur ; Stacy S. DRURY, Auteur Article en page(s) : p.956-966 Langues : Anglais (eng) Mots-clés : Trauma  violence  parent?child interaction  parent?child relationships  biomarkers Index. décimale : PER Périodiques Résumé : Background Family environment plays a critical role in shaping stress response systems. Concordance between mothers' and children's physiological states, specifically their Respiratory Sinus Arrhythmia (RSA), reflects dyadic co-regulation. Negative or weakened RSA synchrony during interactions is linked to various psychosocial risks, but existing research has focused on risks in the mother or child as opposed to the dyad. This study examined the association between maternal-child RSA synchrony and maternal ACEs, given documented associations with offspring RSA, as well as more proximal documented risks, including maternal psychopathology and children's early adversity and psychopathology. Given that sensitive parent?child relationships are a powerful source of resilience, we tested whether parent?child relationship quality buffered associations between maternal ACEs and RSA synchrony. Methods In a community sample of mother?child dyads experiencing high sociodemographic risk and oversampled for exposure to adversity, mothers (n 123) reported on their ACEs (43.1% 4), their 3 5-year-old children's exposure to violence, and psychological symptoms. Dyads completed a puzzle task while EKG was recorded, from which maternal and child RSA was derived; parent?child relationship quality during interactions was coded observationally. Multilevel models examined within-dyad mother?child RSA synchrony across the interaction and between-dyad predictors of synchrony. Results Parent?child relationship quality and maternal ACEs co-contributed to offspring and dyadic physiology. Maternal ACEs predicted dampened RSA in the child and dampened RSA synchrony in the dyad, only among dyads with low observer-rated parent?child relationship quality during the interaction. In other words, high-quality parent?child relationship quality buffered the association between maternal ACEs and dampened offspring and dyadic physiology. Conclusions Results suggest that mothers' early adversity may disrupt physiological regulation at both the individual child and dyadic level. High-quality parent?child relationships mitigated this effect. En ligne : https://doi.org/10.1111/jcpp.14108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=562 [article] Parent?child relationship quality buffers the association between mothers' adverse childhood experiences and physiological synchrony [texte imprimé] / Sarah A. O. Gray, Auteur ; Jonas G. MILLER, Auteur ; Erin B. Glackin, Auteur ; Virginia HATCH, Auteur ; Stacy S. DRURY, Auteur . - p.956-966. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-7 (July 2025) . - p.956-966 Mots-clés : Trauma  violence  parent?child interaction  parent?child relationships  biomarkers Index. décimale : PER Périodiques Résumé : Background Family environment plays a critical role in shaping stress response systems. Concordance between mothers' and children's physiological states, specifically their Respiratory Sinus Arrhythmia (RSA), reflects dyadic co-regulation. Negative or weakened RSA synchrony during interactions is linked to various psychosocial risks, but existing research has focused on risks in the mother or child as opposed to the dyad. This study examined the association between maternal-child RSA synchrony and maternal ACEs, given documented associations with offspring RSA, as well as more proximal documented risks, including maternal psychopathology and children's early adversity and psychopathology. Given that sensitive parent?child relationships are a powerful source of resilience, we tested whether parent?child relationship quality buffered associations between maternal ACEs and RSA synchrony. Methods In a community sample of mother?child dyads experiencing high sociodemographic risk and oversampled for exposure to adversity, mothers (n 123) reported on their ACEs (43.1% 4), their 3 5-year-old children's exposure to violence, and psychological symptoms. Dyads completed a puzzle task while EKG was recorded, from which maternal and child RSA was derived; parent?child relationship quality during interactions was coded observationally. Multilevel models examined within-dyad mother?child RSA synchrony across the interaction and between-dyad predictors of synchrony. Results Parent?child relationship quality and maternal ACEs co-contributed to offspring and dyadic physiology. Maternal ACEs predicted dampened RSA in the child and dampened RSA synchrony in the dyad, only among dyads with low observer-rated parent?child relationship quality during the interaction. In other words, high-quality parent?child relationship quality buffered the association between maternal ACEs and dampened offspring and dyadic physiology. Conclusions Results suggest that mothers' early adversity may disrupt physiological regulation at both the individual child and dyadic level. High-quality parent?child relationships mitigated this effect. En ligne : https://doi.org/10.1111/jcpp.14108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=562

Pre-COVID respiratory sinus arrhythmia moderates associations between COVID-19 stress and child externalizing behaviors: Testing neurobiological stress theories / Hilary Skov ; Erin B. Glackin ; Stacy S. DRURY ; Jeffrey Lockman ; Sarah A. O. Gray in Development and Psychopathology, 37-1 (February 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-1 (February 2025) . - p.403-414 Titre : Pre-COVID respiratory sinus arrhythmia moderates associations between COVID-19 stress and child externalizing behaviors: Testing neurobiological stress theories : Development and Psychopathology Type de document : texte imprimé Auteurs : Hilary Skov, Auteur ; Erin B. Glackin, Auteur ; Stacy S. DRURY, Auteur ; Jeffrey Lockman, Auteur ; Sarah A. O. Gray, Auteur Article en page(s) : p.403-414 Langues : Anglais (eng) Mots-clés : COVID-19 pandemic  biological sensitivity to context  diathesis stress  respiratory sinus arrhythmia  stress Index. décimale : PER Périodiques Résumé : Exposure to stress related to the COVID-19 pandemic contributes to psychopathology risk, yet not all children are negatively impacted. The current study examined a parasympathetic biomarker of stress sensitivity, respiratory sinus arrhythmia (RSA), as a moderator of the effects of exposure to pandemic stress on child internalizing and externalizing behaviors in a sample of children experiencing economic marginalization. Three to five years pre-pandemic, when children were preschool-aged, RSA during baseline and a challenging parent-child interaction were collected. Mid-pandemic, between November 2020 and March 2021, children s exposure to pandemic stress and internalizing and externalizing behaviors were collected. Results demonstrated that children who, pre-pandemic, demonstrated blunted parasympathetic reactivity (i.e., no change in RSA relative to baseline) during the dyadic challenge exhibited elevated risk for externalizing behaviors mid-pandemic. Further, this risk was greatest for children exposed to high and moderate levels of pandemic stress. Consistent with diathesis stress and polyvagal frameworks, these conditional effects suggest that blunted parasympathetic reactivity in response to stress in early childhood may escalate the development of externalizing behaviors following stress exposure at school age. En ligne : https://dx.doi.org/10.1017/S0954579423001682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Pre-COVID respiratory sinus arrhythmia moderates associations between COVID-19 stress and child externalizing behaviors: Testing neurobiological stress theories : Development and Psychopathology [texte imprimé] / Hilary Skov, Auteur ; Erin B. Glackin, Auteur ; Stacy S. DRURY, Auteur ; Jeffrey Lockman, Auteur ; Sarah A. O. Gray, Auteur . - p.403-414. Langues : Anglais (eng) in Development and Psychopathology > 37-1 (February 2025) . - p.403-414 Mots-clés : COVID-19 pandemic  biological sensitivity to context  diathesis stress  respiratory sinus arrhythmia  stress Index. décimale : PER Périodiques Résumé : Exposure to stress related to the COVID-19 pandemic contributes to psychopathology risk, yet not all children are negatively impacted. The current study examined a parasympathetic biomarker of stress sensitivity, respiratory sinus arrhythmia (RSA), as a moderator of the effects of exposure to pandemic stress on child internalizing and externalizing behaviors in a sample of children experiencing economic marginalization. Three to five years pre-pandemic, when children were preschool-aged, RSA during baseline and a challenging parent-child interaction were collected. Mid-pandemic, between November 2020 and March 2021, children s exposure to pandemic stress and internalizing and externalizing behaviors were collected. Results demonstrated that children who, pre-pandemic, demonstrated blunted parasympathetic reactivity (i.e., no change in RSA relative to baseline) during the dyadic challenge exhibited elevated risk for externalizing behaviors mid-pandemic. Further, this risk was greatest for children exposed to high and moderate levels of pandemic stress. Consistent with diathesis stress and polyvagal frameworks, these conditional effects suggest that blunted parasympathetic reactivity in response to stress in early childhood may escalate the development of externalizing behaviors following stress exposure at school age. En ligne : https://dx.doi.org/10.1017/S0954579423001682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior / Zoë H. BRETT in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.7-18 Titre : Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior Type de document : texte imprimé Auteurs : Zoë H. BRETT, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Anna T. SMYKE, Auteur ; Mary Margaret GLEASON, Auteur ; Charles A. NELSON, Auteur ; Charles H. ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Stacy S. DRURY, Auteur Article en page(s) : p.7-18 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined caregiver report of externalizing behavior from 12 to 54 months of age in 102 children randomized to care as usual in institutions or to newly created high-quality foster care. At baseline no differences by group or genotype in externalizing were found. However, changes in externalizing from baseline to 42 months of age were moderated by the serotonin transporter linked polymorphic region genotype and intervention group, where the slope for short–short (S/S) individuals differed as a function of intervention group. The slope for individuals carrying the long allele did not significantly differ between groups. At 54 months of age, S/S children in the foster care group had the lowest levels of externalizing behavior, while children with the S/S genotype in the care as usual group demonstrated the highest rates of externalizing behavior. No intervention group differences were found in externalizing behavior among children who carried the long allele. These findings, within a randomized controlled trial of foster care compared to continued care as usual, indicate that the serotonin transporter linked polymorphic region genotype moderates the relation between early caregiving environments to predict externalizing behavior in children exposed to early institutional care in a manner most consistent with differential susceptibility. En ligne : http://dx.doi.org/10.1017/S0954579414001266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior [texte imprimé] / Zoë H. BRETT, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Anna T. SMYKE, Auteur ; Mary Margaret GLEASON, Auteur ; Charles A. NELSON, Auteur ; Charles H. ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Stacy S. DRURY, Auteur . - p.7-18. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.7-18 Index. décimale : PER Périodiques Résumé : We examined caregiver report of externalizing behavior from 12 to 54 months of age in 102 children randomized to care as usual in institutions or to newly created high-quality foster care. At baseline no differences by group or genotype in externalizing were found. However, changes in externalizing from baseline to 42 months of age were moderated by the serotonin transporter linked polymorphic region genotype and intervention group, where the slope for short–short (S/S) individuals differed as a function of intervention group. The slope for individuals carrying the long allele did not significantly differ between groups. At 54 months of age, S/S children in the foster care group had the lowest levels of externalizing behavior, while children with the S/S genotype in the care as usual group demonstrated the highest rates of externalizing behavior. No intervention group differences were found in externalizing behavior among children who carried the long allele. These findings, within a randomized controlled trial of foster care compared to continued care as usual, indicate that the serotonin transporter linked polymorphic region genotype moderates the relation between early caregiving environments to predict externalizing behavior in children exposed to early institutional care in a manner most consistent with differential susceptibility. En ligne : http://dx.doi.org/10.1017/S0954579414001266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation / Stacy S. DRURY in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1539-1551 Titre : Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation Type de document : texte imprimé Auteurs : Stacy S. DRURY, Auteur ; Brittany R. HOWELL, Auteur ; Christopher JONES, Auteur ; Kyle ESTEVES, Auteur ; Elyse MORIN, Auteur ; Reid SCHLESINGER, Auteur ; Jerrold S. MEYER, Auteur ; Kate BAKER, Auteur ; Mar M. SANCHEZ, Auteur Article en page(s) : p.1539-1551 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The molecular, neurobiological, and physical health impacts of child maltreatment are well established, yet mechanistic pathways remain inadequately defined. Telomere length (TL) decline is an emerging molecular indicator of stress exposure with definitive links to negative health outcomes in maltreated individuals. The multiple confounders endemic to human maltreatment research impede the identification of causal pathways. This study leverages a unique randomized, cross-foster, study design in a naturalistic translational nonhuman primate model of infant maltreatment. At birth, newborn macaques were randomly assigned to either a maltreating or a competent control mother, balancing for sex, biological mother parenting history, and social rank. Offspring TL was measured longitudinally across the first 6 months of life (infancy) from peripheral blood. Hair cortisol accumulation was also determined at 6, 12, and 18 months of age. TL decline was greater in animals randomized to maltreatment, but also interacted with biological mother group. Shorter TL at 6 months was associated with higher mean cortisol levels through 18 months (juvenile period) when controlling for relevant covariates. These results suggest that even under the equivalent social, nutritional, and environmental conditions feasible in naturalistic translational nonhuman primate models, early adverse caregiving results in lasting molecular scars that foreshadow elevated health risk and physiologic dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579417001225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation [texte imprimé] / Stacy S. DRURY, Auteur ; Brittany R. HOWELL, Auteur ; Christopher JONES, Auteur ; Kyle ESTEVES, Auteur ; Elyse MORIN, Auteur ; Reid SCHLESINGER, Auteur ; Jerrold S. MEYER, Auteur ; Kate BAKER, Auteur ; Mar M. SANCHEZ, Auteur . - p.1539-1551. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1539-1551 Index. décimale : PER Périodiques Résumé : The molecular, neurobiological, and physical health impacts of child maltreatment are well established, yet mechanistic pathways remain inadequately defined. Telomere length (TL) decline is an emerging molecular indicator of stress exposure with definitive links to negative health outcomes in maltreated individuals. The multiple confounders endemic to human maltreatment research impede the identification of causal pathways. This study leverages a unique randomized, cross-foster, study design in a naturalistic translational nonhuman primate model of infant maltreatment. At birth, newborn macaques were randomly assigned to either a maltreating or a competent control mother, balancing for sex, biological mother parenting history, and social rank. Offspring TL was measured longitudinally across the first 6 months of life (infancy) from peripheral blood. Hair cortisol accumulation was also determined at 6, 12, and 18 months of age. TL decline was greater in animals randomized to maltreatment, but also interacted with biological mother group. Shorter TL at 6 months was associated with higher mean cortisol levels through 18 months (juvenile period) when controlling for relevant covariates. These results suggest that even under the equivalent social, nutritional, and environmental conditions feasible in naturalistic translational nonhuman primate models, early adverse caregiving results in lasting molecular scars that foreshadow elevated health risk and physiologic dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579417001225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

The development of the cortisol response to dyadic stressors in Black and White infants / Andrew DISMUKES in Development and Psychopathology, 30-5 (December 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-5 (December 2018) . - p.1995-2008 Titre : The development of the cortisol response to dyadic stressors in Black and White infants Type de document : texte imprimé Auteurs : Andrew DISMUKES, Auteur ; Elizabeth SHIRTCLIFF, Auteur ; Christopher W. JONES, Auteur ; Charles ZEANAH, Auteur ; Katherine THEALL, Auteur ; Stacy S. DRURY, Auteur Article en page(s) : p.1995-2008 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Acute reactivity of the stress hormone cortisol is reflective of early adversity and stress exposure, with some studies finding that the impact of adversity on the stress response differs by race. The objectives of the current study were to characterize cortisol reactivity to two dyadically based stress paradigms across the first year of life, to examine cortisol reactivity within Black and White infants, and to assess the impact of correlates of racial inequity including socioeconomic status, experiences of discrimination, and urban life stressors, as well as the buffering by racial socialization on cortisol patterns. Salivary cortisol reactivity was assessed at 4 months of age during the Still Face paradigm (N = 207) and at 12 months of age across the Strange Situation procedure (N = 129). Infants demonstrated the steepest recovery after the Still Face paradigm and steepest reactivity to the Strange Situation procedure. Race differences in cortisol were not present at 4 months but emerged at 12 months of age, with Black infants having higher cortisol. Experiences of discrimination contributed to cortisol differences within Black infants, suggesting that racial discrimination is already “under the skin” by 1 year of age. These findings suggest that race-related differences in hypothalamic–pituitary–adrenal reactivity are present in infancy, and that the first year of life is a crucial time period during which interventions and prevention efforts for maternal–infant dyads are most likely able to shape hypothalamic–pituitary–adrenal reactivity thereby mitigating health disparities early across the life course. En ligne : http://dx.doi.org/10.1017/S0954579418001232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] The development of the cortisol response to dyadic stressors in Black and White infants [texte imprimé] / Andrew DISMUKES, Auteur ; Elizabeth SHIRTCLIFF, Auteur ; Christopher W. JONES, Auteur ; Charles ZEANAH, Auteur ; Katherine THEALL, Auteur ; Stacy S. DRURY, Auteur . - p.1995-2008. Langues : Anglais (eng) in Development and Psychopathology > 30-5 (December 2018) . - p.1995-2008 Index. décimale : PER Périodiques Résumé : Acute reactivity of the stress hormone cortisol is reflective of early adversity and stress exposure, with some studies finding that the impact of adversity on the stress response differs by race. The objectives of the current study were to characterize cortisol reactivity to two dyadically based stress paradigms across the first year of life, to examine cortisol reactivity within Black and White infants, and to assess the impact of correlates of racial inequity including socioeconomic status, experiences of discrimination, and urban life stressors, as well as the buffering by racial socialization on cortisol patterns. Salivary cortisol reactivity was assessed at 4 months of age during the Still Face paradigm (N = 207) and at 12 months of age across the Strange Situation procedure (N = 129). Infants demonstrated the steepest recovery after the Still Face paradigm and steepest reactivity to the Strange Situation procedure. Race differences in cortisol were not present at 4 months but emerged at 12 months of age, with Black infants having higher cortisol. Experiences of discrimination contributed to cortisol differences within Black infants, suggesting that racial discrimination is already “under the skin” by 1 year of age. These findings suggest that race-related differences in hypothalamic–pituitary–adrenal reactivity are present in infancy, and that the first year of life is a crucial time period during which interventions and prevention efforts for maternal–infant dyads are most likely able to shape hypothalamic–pituitary–adrenal reactivity thereby mitigating health disparities early across the life course. En ligne : http://dx.doi.org/10.1017/S0954579418001232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Using cross-species comparisons and a neurobiological framework to understand early social deprivation effects on behavioral development / Zoë H. BRETT in Development and Psychopathology, 27-2 (May 2015)  

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