Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes / Li CHEN in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.137-150 Titre : Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes Type de document : texte imprimé Auteurs : Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur Article en page(s) : p.137-150 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes [texte imprimé] / Li CHEN, Auteur ; Hong PAN, Auteur ; Ta Anh TUAN, Auteur ; Ai Ling TEH, Auteur ; Julia L. MACISAAC, Auteur ; Sarah M. MAH, Auteur ; Lisa M. MCEWEN, Auteur ; Yue LI, Auteur ; Helen CHEN, Auteur ; Birit F.P. BROEKMAN, Auteur ; Jan Paul BUSCHDORF, Auteur ; Yap Seng CHONG, Auteur ; Kenneth KWEK, Auteur ; Seang Mei SAW, Auteur ; Peter D. GLUCKMAN, Auteur ; Marielle V. FORTIER, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael S. KOBOR, Auteur ; Anqi QIU, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur . - p.137-150. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.137-150 Index. décimale : PER Périodiques Résumé : Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal maternal anxiety associated with neonatal DNA methylation. We also examined the association between neonatal DNA methylation and brain substructure volume, as a function of BDNF genotype. Infant, but not maternal, BDNF genotype dramatically influences the association of antenatal anxiety on the epigenome at birth as well as that between the epigenome and neonatal brain structure. There was a greater impact of antenatal maternal anxiety on the DNA methylation of infants with the methionine (Met)/Met compared to both Met/valine (Val) and Val/Val genotypes. There were significantly more cytosine–phosphate–guanine sites where methylation levels covaried with right amygdala volume among Met/Met compared with both Met/Val and Val/Val carriers. In contrast, more cytosine–phosphate–guanine sites covaried with left hippocampus volume in Val/Val infants compared with infants of the Met/Val or Met/Met genotype. Thus, antenatal Maternal Anxiety × BDNF Val66Met Polymorphism interactions at the level of the epigenome are reflected differently in the structure of the amygdala and the hippocampus. These findings suggest that BDNF genotype regulates the sensitivity of the methylome to early environment and that differential susceptibility to specific environmental conditions may be both tissue and function specific. En ligne : http://dx.doi.org/10.1017/S0954579414001357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Epigenetic correlates of neonatal contact in humans / Sarah R. MOORE in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1517-1538 Titre : Epigenetic correlates of neonatal contact in humans Type de document : texte imprimé Auteurs : Sarah R. MOORE, Auteur ; Lisa M. MCEWEN, Auteur ; Jill QUIRT, Auteur ; Alex MORIN, Auteur ; Sarah M. MAH, Auteur ; Ronald G. BARR, Auteur ; W. Thomas BOYCE, Auteur ; Michael S. KOBOR, Auteur Article en page(s) : p.1517-1538 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Animal models of early postnatal mother–infant interactions have highlighted the importance of tactile contact for biobehavioral outcomes via the modification of DNA methylation (DNAm). The role of normative variation in contact in early human development has yet to be explored. In an effort to translate the animal work on tactile contact to humans, we applied a naturalistic daily diary strategy to assess the link between maternal contact with infants and epigenetic signatures in children 4–5 years later, with respect to multiple levels of child-level factors, including genetic variation and infant distress. We first investigated DNAm at four candidate genes: the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), μ-opioid receptor M1 (OPRM1) and oxytocin receptor (OXTR; related to the neurobiology of social bonds), and brain-derived neurotrophic factor (BDNF; involved in postnatal plasticity). Although no candidate gene DNAm sites significantly associated with early postnatal contact, when we next examined DNAm across the genome, differentially methylated regions were identified between high and low contact groups. Using a different application of epigenomic information, we also quantified epigenetic age, and report that for infants who received low contact from caregivers, greater infant distress was associated with younger epigenetic age. These results suggested that early postnatal contact has lasting associations with child biology. En ligne : http://dx.doi.org/10.1017/S0954579417001213 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Epigenetic correlates of neonatal contact in humans [texte imprimé] / Sarah R. MOORE, Auteur ; Lisa M. MCEWEN, Auteur ; Jill QUIRT, Auteur ; Alex MORIN, Auteur ; Sarah M. MAH, Auteur ; Ronald G. BARR, Auteur ; W. Thomas BOYCE, Auteur ; Michael S. KOBOR, Auteur . - p.1517-1538. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1517-1538 Index. décimale : PER Périodiques Résumé : Animal models of early postnatal mother–infant interactions have highlighted the importance of tactile contact for biobehavioral outcomes via the modification of DNA methylation (DNAm). The role of normative variation in contact in early human development has yet to be explored. In an effort to translate the animal work on tactile contact to humans, we applied a naturalistic daily diary strategy to assess the link between maternal contact with infants and epigenetic signatures in children 4–5 years later, with respect to multiple levels of child-level factors, including genetic variation and infant distress. We first investigated DNAm at four candidate genes: the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), μ-opioid receptor M1 (OPRM1) and oxytocin receptor (OXTR; related to the neurobiology of social bonds), and brain-derived neurotrophic factor (BDNF; involved in postnatal plasticity). Although no candidate gene DNAm sites significantly associated with early postnatal contact, when we next examined DNAm across the genome, differentially methylated regions were identified between high and low contact groups. Using a different application of epigenomic information, we also quantified epigenetic age, and report that for infants who received low contact from caregivers, greater infant distress was associated with younger epigenetic age. These results suggested that early postnatal contact has lasting associations with child biology. En ligne : http://dx.doi.org/10.1017/S0954579417001213 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

The early care environment and DNA methylome variation in childhood / Elika GARG in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.891-903 Titre : The early care environment and DNA methylome variation in childhood Type de document : texte imprimé Auteurs : Elika GARG, Auteur ; Li CHEN, Auteur ; Thao T.T. NGUYEN, Auteur ; Irina POKHVISNEVA, Auteur ; Lauwrence M. CHEN, Auteur ; Eva UNTERNAEHRER, Auteur ; Julia L. MACISAAC, Auteur ; Lisa M. MCEWEN, Auteur ; Sarah M. MAH, Auteur ; Helene GAUDREAU, Auteur ; Robert LEVITAN, Auteur ; Ellen MOSS, Auteur ; M.B. SOKOLOWSKI, Auteur ; James L. KENNEDY, Auteur ; Meir S. STEINER, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur ; Patricia P. SILVEIRA, Auteur ; Neerja KARNANI, Auteur ; Michael S. KOBOR, Auteur ; Kieran J. O'DONNELL, Auteur Année de publication : 2018 Article en page(s) : p.891-903 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Prenatal adversity shapes child neurodevelopment and risk for later mental health problems. The quality of the early care environment can buffer some of the negative effects of prenatal adversity on child development. Retrospective studies, in adult samples, highlight epigenetic modifications as sentinel markers of the quality of the early care environment; however, comparable data from pediatric cohorts are lacking. Participants were drawn from the Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) study, a longitudinal cohort with measures of infant attachment, infant development, and child mental health. Children provided buccal epithelial samples (mean age = 6.99, SD = 1.33 years, n = 226), which were used for analyses of genome-wide DNA methylation and genetic variation. We used a series of linear models to describe the association between infant attachment and (a) measures of child outcome and (b) DNA methylation across the genome. Paired genetic data was used to determine the genetic contribution to DNA methylation at attachment-associated sites. Infant attachment style was associated with infant cognitive development (Mental Development Index) and behavior (Behavior Rating Scale) assessed with the Bayley Scales of Infant Development at 36 months. Infant attachment style moderated the effects of prenatal adversity on Behavior Rating Scale scores at 36 months. Infant attachment was also significantly associated with a principal component that accounted for 11.9% of the variation in genome-wide DNA methylation. These effects were most apparent when comparing children with a secure versus a disorganized attachment style and most pronounced in females. The availability of paired genetic data revealed that DNA methylation at approximately half of all infant attachment-associated sites was best explained by considering both infant attachment and child genetic variation. This study provides further evidence that infant attachment can buffer some of the negative effects of early adversity on measures of infant behavior. We also highlight the interplay between infant attachment and child genotype in shaping variation in DNA methylation. Such findings provide preliminary evidence for a molecular signature of infant attachment and may help inform attachment-focused early intervention programs. En ligne : http://dx.doi.org/10.1017/s0954579418000627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] The early care environment and DNA methylome variation in childhood [texte imprimé] / Elika GARG, Auteur ; Li CHEN, Auteur ; Thao T.T. NGUYEN, Auteur ; Irina POKHVISNEVA, Auteur ; Lauwrence M. CHEN, Auteur ; Eva UNTERNAEHRER, Auteur ; Julia L. MACISAAC, Auteur ; Lisa M. MCEWEN, Auteur ; Sarah M. MAH, Auteur ; Helene GAUDREAU, Auteur ; Robert LEVITAN, Auteur ; Ellen MOSS, Auteur ; M.B. SOKOLOWSKI, Auteur ; James L. KENNEDY, Auteur ; Meir S. STEINER, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur ; Patricia P. SILVEIRA, Auteur ; Neerja KARNANI, Auteur ; Michael S. KOBOR, Auteur ; Kieran J. O'DONNELL, Auteur . - 2018 . - p.891-903. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.891-903 Index. décimale : PER Périodiques Résumé : Prenatal adversity shapes child neurodevelopment and risk for later mental health problems. The quality of the early care environment can buffer some of the negative effects of prenatal adversity on child development. Retrospective studies, in adult samples, highlight epigenetic modifications as sentinel markers of the quality of the early care environment; however, comparable data from pediatric cohorts are lacking. Participants were drawn from the Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) study, a longitudinal cohort with measures of infant attachment, infant development, and child mental health. Children provided buccal epithelial samples (mean age = 6.99, SD = 1.33 years, n = 226), which were used for analyses of genome-wide DNA methylation and genetic variation. We used a series of linear models to describe the association between infant attachment and (a) measures of child outcome and (b) DNA methylation across the genome. Paired genetic data was used to determine the genetic contribution to DNA methylation at attachment-associated sites. Infant attachment style was associated with infant cognitive development (Mental Development Index) and behavior (Behavior Rating Scale) assessed with the Bayley Scales of Infant Development at 36 months. Infant attachment style moderated the effects of prenatal adversity on Behavior Rating Scale scores at 36 months. Infant attachment was also significantly associated with a principal component that accounted for 11.9% of the variation in genome-wide DNA methylation. These effects were most apparent when comparing children with a secure versus a disorganized attachment style and most pronounced in females. The availability of paired genetic data revealed that DNA methylation at approximately half of all infant attachment-associated sites was best explained by considering both infant attachment and child genetic variation. This study provides further evidence that infant attachment can buffer some of the negative effects of early adversity on measures of infant behavior. We also highlight the interplay between infant attachment and child genotype in shaping variation in DNA methylation. Such findings provide preliminary evidence for a molecular signature of infant attachment and may help inform attachment-focused early intervention programs. En ligne : http://dx.doi.org/10.1017/s0954579418000627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

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