Co-development of early adolescent alcohol use and depressive feelings: The role of the mu-opioid receptor A118G polymorphism / Marloes KLEINJAN in Development and Psychopathology, 27-3 (August 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-3 (August 2015) . - p.915-925 Titre : Co-development of early adolescent alcohol use and depressive feelings: The role of the mu-opioid receptor A118G polymorphism Type de document : texte imprimé Auteurs : Marloes KLEINJAN, Auteur ; Mayke ROZING, Auteur ; Rutger C. M. E. ENGELS, Auteur ; Maaike VERHAGEN, Auteur Article en page(s) : p.915-925 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Alcohol use and depressive feelings are often related among early adolescents. However, the nature and underlying mechanisms of this association are not yet clear. The aim of this study was to investigate the co-development of alcohol use and depressive feelings over time and to examine the effects of the mu-opioid receptor (OPRM1) A118G genotype on such co-development. Data from a five-wave longitudinal, genetically informed survey study, with intervals of 4 months among a group of 739 normative early adolescents (12–13 years of age at baseline), were analyzed using a dual latent growth curve approach. OPRM1 status was evaluated from saliva-derived DNA samples. The results indicated a positive association between alcohol use and depressive feelings both at the initial levels and over time, indicating co-development in early adolescence. Compared to OPRM1 118G carriers, homozygous 118A carriers showed a greater increase in frequency of alcohol use and higher levels of depressive feelings over time. Evidence for co-development was only found within the group of homozygous 118A carriers, whereas in OPRM1 118G carriers the development of alcohol use and depressive feelings over time were not significantly associated. These results highlight the potential of OPRM1 as a common etiological factor for the development of alcohol use and depressive feelings in early adolescence. En ligne : http://dx.doi.org/10.1017/S0954579414000911 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Co-development of early adolescent alcohol use and depressive feelings: The role of the mu-opioid receptor A118G polymorphism [texte imprimé] / Marloes KLEINJAN, Auteur ; Mayke ROZING, Auteur ; Rutger C. M. E. ENGELS, Auteur ; Maaike VERHAGEN, Auteur . - p.915-925. Langues : Anglais (eng) in Development and Psychopathology > 27-3 (August 2015) . - p.915-925 Index. décimale : PER Périodiques Résumé : Alcohol use and depressive feelings are often related among early adolescents. However, the nature and underlying mechanisms of this association are not yet clear. The aim of this study was to investigate the co-development of alcohol use and depressive feelings over time and to examine the effects of the mu-opioid receptor (OPRM1) A118G genotype on such co-development. Data from a five-wave longitudinal, genetically informed survey study, with intervals of 4 months among a group of 739 normative early adolescents (12–13 years of age at baseline), were analyzed using a dual latent growth curve approach. OPRM1 status was evaluated from saliva-derived DNA samples. The results indicated a positive association between alcohol use and depressive feelings both at the initial levels and over time, indicating co-development in early adolescence. Compared to OPRM1 118G carriers, homozygous 118A carriers showed a greater increase in frequency of alcohol use and higher levels of depressive feelings over time. Evidence for co-development was only found within the group of homozygous 118A carriers, whereas in OPRM1 118G carriers the development of alcohol use and depressive feelings over time were not significantly associated. These results highlight the potential of OPRM1 as a common etiological factor for the development of alcohol use and depressive feelings in early adolescence. En ligne : http://dx.doi.org/10.1017/S0954579414000911 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Societal costs of subclinical depressive symptoms in Dutch adolescents: a cost-of-illness study / Denise H. M. BODDEN in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.771-780 Titre : Societal costs of subclinical depressive symptoms in Dutch adolescents: a cost-of-illness study Type de document : texte imprimé Auteurs : Denise H. M. BODDEN, Auteur ; Marieke W. H. VAN DEN HEUVEL, Auteur ; Rutger C. M. E. ENGELS, Auteur ; Carmen D. DIRKSEN, Auteur Article en page(s) : p.771-780 Langues : Anglais (eng) Mots-clés : Adolescent  Cost-Benefit Analysis  Depression/epidemiology  Depressive Disorder, Major  Humans  Reproducibility of Results  Surveys and Questionnaires  Adolescence  depression  economic evaluation Index. décimale : PER Périodiques Résumé : BACKGROUND: Subclinical depressive symptoms are highly prevalent among adolescents and are associated with negative consequences, which may pose an economic burden for society. We conducted a prevalence-based cost-of-illness study using a societal perspective to investigate the cost-of-illness of subclinical depressive symptoms among adolescents. METHODS: Using a bottom-up approach, cost questionnaires were assessed to measure costs from 237 Dutch families with an adolescent aged 11-18 with subclinical depressive symptoms (of which 34 met the criteria of a depressive disorder). The study is registered in the Dutch Trial Register (Trial NL5584/NTR6176; www.trialregister.nl/trial/5584). RESULTS: Our calculations show that adolescents with subclinical depressive symptoms cost the Dutch society more than 42 million annually, expressed in costs related to depressive symptoms. Secondary analyses were performed to test the reliability and stability of the costs. When costs related to psychological problems were considered, the annual costs amounted to 67 million. The total societal costs related to physical problems amounted to approximately 126 million. All costs combined (depressive, psychological, behavioural and physical problems and other reasons) amounted to a 243 million. Total costs were highest for physical-related problems of the adolescent (52% of the total costs), followed by psychological (28%), depressive (17%) and behavioural problems (1%). Using an international prevalence rate, societal costs related to depressive symptoms resulted in 54 million a year. CONCLUSIONS: Cost-effective prevention programmes seem warranted given the high societal costs and risk of future costs as subclinical depressive symptoms could be a precursor of clinical depression later in life. En ligne : http://dx.doi.org/10.1111/jcpp.13517 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Societal costs of subclinical depressive symptoms in Dutch adolescents: a cost-of-illness study [texte imprimé] / Denise H. M. BODDEN, Auteur ; Marieke W. H. VAN DEN HEUVEL, Auteur ; Rutger C. M. E. ENGELS, Auteur ; Carmen D. DIRKSEN, Auteur . - p.771-780. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.771-780 Mots-clés : Adolescent  Cost-Benefit Analysis  Depression/epidemiology  Depressive Disorder, Major  Humans  Reproducibility of Results  Surveys and Questionnaires  Adolescence  depression  economic evaluation Index. décimale : PER Périodiques Résumé : BACKGROUND: Subclinical depressive symptoms are highly prevalent among adolescents and are associated with negative consequences, which may pose an economic burden for society. We conducted a prevalence-based cost-of-illness study using a societal perspective to investigate the cost-of-illness of subclinical depressive symptoms among adolescents. METHODS: Using a bottom-up approach, cost questionnaires were assessed to measure costs from 237 Dutch families with an adolescent aged 11-18 with subclinical depressive symptoms (of which 34 met the criteria of a depressive disorder). The study is registered in the Dutch Trial Register (Trial NL5584/NTR6176; www.trialregister.nl/trial/5584). RESULTS: Our calculations show that adolescents with subclinical depressive symptoms cost the Dutch society more than 42 million annually, expressed in costs related to depressive symptoms. Secondary analyses were performed to test the reliability and stability of the costs. When costs related to psychological problems were considered, the annual costs amounted to 67 million. The total societal costs related to physical problems amounted to approximately 126 million. All costs combined (depressive, psychological, behavioural and physical problems and other reasons) amounted to a 243 million. Total costs were highest for physical-related problems of the adolescent (52% of the total costs), followed by psychological (28%), depressive (17%) and behavioural problems (1%). Using an international prevalence rate, societal costs related to depressive symptoms resulted in 54 million a year. CONCLUSIONS: Cost-effective prevention programmes seem warranted given the high societal costs and risk of future costs as subclinical depressive symptoms could be a precursor of clinical depression later in life. En ligne : http://dx.doi.org/10.1111/jcpp.13517 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

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