7 recherche sur le mot-clé 'economic evaluation'

Treatments with versus without medication for children with behavioural difficulties in clinical practice: an economic evaluation with observational data / Hermien H. DIJK ; Barbara J. VAN DEN HOOFDAKKER ; Pieter J. HOEKSTRA ; Annabeth P. GROENMAN in Journal of Child Psychology and Psychiatry, 66-3 (March 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.289-300 Titre : Treatments with versus without medication for children with behavioural difficulties in clinical practice: an economic evaluation with observational data Type de document : texte imprimé Auteurs : Hermien H. DIJK, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Annabeth P. GROENMAN, Auteur Article en page(s) : p.289-300 Langues : Anglais (eng) Mots-clés : Economic evaluation  pharmacotherapy  behaviour problems  ADHD  longitudinal studies Index. décimale : PER Périodiques Résumé : Background Economic evaluations of treatments for children with behavioural difficulties (i.e., characteristics of attention-deficit/hyperactivity disorder (ADHD) and/or oppositional defiant disorder (ODD)) usually rely on data of randomised controlled trials or are model-based. Findings of such studies may not be representative of cost-effectiveness and cost-utility in clinical practice. The current longitudinal study aimed to perform an economic evaluation of treatments for children with hyperactivity, impulsive behaviours, inattention, and/or behavioural difficulties using observational data that were obtained in clinical practice. Methods Parents of 209 children (aged 5 12) who were referred to 1 of 10 Dutch youth mental healthcare institutions and who received treatment with (n 108) or without (n 101) the use of medication, filled out questionnaires at three timepoints (baseline, and ~ 6 and ~12 months later). Propensity score matching was used to make both groups comparable. Outcomes included quality-adjusted life years (QALYs), ADHD and ODD symptom severity, and impairment. Costs were measured from a societal perspective. Incremental cost-effectiveness ratios (ICERs) were estimated, and cost-effectiveness acceptability curves (CEACs) were derived to show uncertainty around the ICER. Results Results did not show statistically significant differences in costs and effects between children who were treated with medication (alone or in combination with non-medication treatment) and those who were treated without medication. CEAC suggested that medication treatment has a 55% probability of being cost-effective at the 80,000 threshold and 36% at the 20,000 threshold compared with treatment without medication. Conclusions Using observational data, our study did not provide clear evidence of the cost-effectiveness and cost-utility of treatment with medication compared with treatment without medication in clinical practice. En ligne : https://doi.org/10.1111/jcpp.14057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Treatments with versus without medication for children with behavioural difficulties in clinical practice: an economic evaluation with observational data [texte imprimé] / Hermien H. DIJK, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Annabeth P. GROENMAN, Auteur . - p.289-300. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.289-300 Mots-clés : Economic evaluation  pharmacotherapy  behaviour problems  ADHD  longitudinal studies Index. décimale : PER Périodiques Résumé : Background Economic evaluations of treatments for children with behavioural difficulties (i.e., characteristics of attention-deficit/hyperactivity disorder (ADHD) and/or oppositional defiant disorder (ODD)) usually rely on data of randomised controlled trials or are model-based. Findings of such studies may not be representative of cost-effectiveness and cost-utility in clinical practice. The current longitudinal study aimed to perform an economic evaluation of treatments for children with hyperactivity, impulsive behaviours, inattention, and/or behavioural difficulties using observational data that were obtained in clinical practice. Methods Parents of 209 children (aged 5 12) who were referred to 1 of 10 Dutch youth mental healthcare institutions and who received treatment with (n 108) or without (n 101) the use of medication, filled out questionnaires at three timepoints (baseline, and ~ 6 and ~12 months later). Propensity score matching was used to make both groups comparable. Outcomes included quality-adjusted life years (QALYs), ADHD and ODD symptom severity, and impairment. Costs were measured from a societal perspective. Incremental cost-effectiveness ratios (ICERs) were estimated, and cost-effectiveness acceptability curves (CEACs) were derived to show uncertainty around the ICER. Results Results did not show statistically significant differences in costs and effects between children who were treated with medication (alone or in combination with non-medication treatment) and those who were treated without medication. CEAC suggested that medication treatment has a 55% probability of being cost-effective at the 80,000 threshold and 36% at the 20,000 threshold compared with treatment without medication. Conclusions Using observational data, our study did not provide clear evidence of the cost-effectiveness and cost-utility of treatment with medication compared with treatment without medication in clinical practice. En ligne : https://doi.org/10.1111/jcpp.14057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Cost-effectiveness of cognitive therapy as an early intervention for post-traumatic stress disorder in children and adolescents: a trial based evaluation and model / Jane SHEARER in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.773-780 Titre : Cost-effectiveness of cognitive therapy as an early intervention for post-traumatic stress disorder in children and adolescents: a trial based evaluation and model Type de document : texte imprimé Auteurs : Jane SHEARER, Auteur ; Nestor PAPANIKOLAOU, Auteur ; Richard MEISER-STEDMAN, Auteur ; Anna MCKINNON, Auteur ; Tim DALGLEISH, Auteur ; Paula SMITH, Auteur ; Clare DIXON, Auteur ; Sarah BYFORD, Auteur Article en page(s) : p.773-780 Langues : Anglais (eng) Mots-clés : Economic evaluation  cognitive therapy  post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: Untreated post-traumatic stress disorder (PTSD) in children and adolescents is associated with a considerable economic burden on the health system, families and society. Recent research has demonstrated the potential efficacy of cognitive therapy as an early intervention for PTSD in children and adolescents. Children who experienced a single traumatic event in the previous two to six months and were randomized to cognitive therapy for PTSD (CT-PTSD) were significantly more likely to be PTSD-free compared to those randomized to usual care represented by waitlist control. The current study evaluated the economic impact of improvements in the treatment of PTSD in children and adolescents. METHODS: A cost-effectiveness analysis was conducted from the national health service/personal social services perspective with outcomes expressed as quality-adjusted life years (QALYs). Patient level costs and outcomes were collected during the 11 week clinical trial and extrapolated to a three year time horizon using economic modelling methods. Uncertainty was estimated using probabilistic sensitivity analysis and assumptions were tested using one way sensitivity analysis. RESULTS: The incremental cost-effectiveness ratio at 3 years was pound2,205 per QALY with a 60%-69% probability of CT-PTSD being cost-effective compared to usual care at the UK pound20,000 to pound30,000 per QALY decision threshold. CONCLUSIONS: This study provides preliminary evidence for the cost-effectiveness of cognitive therapy in this treatment population. Larger pragmatic trials with longer follow-up are indicated. En ligne : http://dx.doi.org/10.1111/jcpp.12851 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Cost-effectiveness of cognitive therapy as an early intervention for post-traumatic stress disorder in children and adolescents: a trial based evaluation and model [texte imprimé] / Jane SHEARER, Auteur ; Nestor PAPANIKOLAOU, Auteur ; Richard MEISER-STEDMAN, Auteur ; Anna MCKINNON, Auteur ; Tim DALGLEISH, Auteur ; Paula SMITH, Auteur ; Clare DIXON, Auteur ; Sarah BYFORD, Auteur . - p.773-780. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.773-780 Mots-clés : Economic evaluation  cognitive therapy  post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: Untreated post-traumatic stress disorder (PTSD) in children and adolescents is associated with a considerable economic burden on the health system, families and society. Recent research has demonstrated the potential efficacy of cognitive therapy as an early intervention for PTSD in children and adolescents. Children who experienced a single traumatic event in the previous two to six months and were randomized to cognitive therapy for PTSD (CT-PTSD) were significantly more likely to be PTSD-free compared to those randomized to usual care represented by waitlist control. The current study evaluated the economic impact of improvements in the treatment of PTSD in children and adolescents. METHODS: A cost-effectiveness analysis was conducted from the national health service/personal social services perspective with outcomes expressed as quality-adjusted life years (QALYs). Patient level costs and outcomes were collected during the 11 week clinical trial and extrapolated to a three year time horizon using economic modelling methods. Uncertainty was estimated using probabilistic sensitivity analysis and assumptions were tested using one way sensitivity analysis. RESULTS: The incremental cost-effectiveness ratio at 3 years was pound2,205 per QALY with a 60%-69% probability of CT-PTSD being cost-effective compared to usual care at the UK pound20,000 to pound30,000 per QALY decision threshold. CONCLUSIONS: This study provides preliminary evidence for the cost-effectiveness of cognitive therapy in this treatment population. Larger pragmatic trials with longer follow-up are indicated. En ligne : http://dx.doi.org/10.1111/jcpp.12851 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Autism Research Funding Allocation: Can Economics Tell Us If We Have Got It Right? / Jennifer D. ZWICKER in Autism Research, 7-6 (December 2014)  

Public ISBD [article]  inAutism Research > 7-6 (December 2014) . - p.704-711 Titre : Autism Research Funding Allocation: Can Economics Tell Us If We Have Got It Right? Type de document : texte imprimé Auteurs : Jennifer D. ZWICKER, Auteur ; J.C. Herbert EMERY, Auteur Article en page(s) : p.704-711 Langues : Anglais (eng) Mots-clés : autism  research funding  economic evaluation  funding allocation Index. décimale : PER Périodiques Résumé : There is a concern that the allocation of autism spectrum disorder (ASD) research funding may be misallocating resources, overemphasizing basic science at the expense of translational and clinical research. Anthony Bailey has proposed that an economic evaluation of autism research funding allocations could be beneficial for funding agencies by identifying under- or overfunded areas of research. In response to Bailey, we illustrate why economics cannot provide an objective, technical solution for identifying the “best” allocation of research resources. Economic evaluation has its greatest power as a late-stage research tool for interventions with identified objectives, outcomes, and data. This is not the case for evaluating whether research areas are over- or underfunded. Without an understanding of how research funding influences the likelihood and value of a discovery, or without a statement of the societal objectives for ASD research and level of risk aversion, economic analysis cannot provide a useful normative evaluation of ASD research. En ligne : http://dx.doi.org/10.1002/aur.1423 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Autism Research Funding Allocation: Can Economics Tell Us If We Have Got It Right? [texte imprimé] / Jennifer D. ZWICKER, Auteur ; J.C. Herbert EMERY, Auteur . - p.704-711. Langues : Anglais (eng) in Autism Research > 7-6 (December 2014) . - p.704-711 Mots-clés : autism  research funding  economic evaluation  funding allocation Index. décimale : PER Périodiques Résumé : There is a concern that the allocation of autism spectrum disorder (ASD) research funding may be misallocating resources, overemphasizing basic science at the expense of translational and clinical research. Anthony Bailey has proposed that an economic evaluation of autism research funding allocations could be beneficial for funding agencies by identifying under- or overfunded areas of research. In response to Bailey, we illustrate why economics cannot provide an objective, technical solution for identifying the “best” allocation of research resources. Economic evaluation has its greatest power as a late-stage research tool for interventions with identified objectives, outcomes, and data. This is not the case for evaluating whether research areas are over- or underfunded. Without an understanding of how research funding influences the likelihood and value of a discovery, or without a statement of the societal objectives for ASD research and level of risk aversion, economic analysis cannot provide a useful normative evaluation of ASD research. En ligne : http://dx.doi.org/10.1002/aur.1423 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

The population cost-effectiveness of a parenting intervention designed to prevent anxiety disorders in children / Cathrine MIHALOPOULOS in Journal of Child Psychology and Psychiatry, 56-9 (September 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-9 (September 2015) . - p.1026-1033 Titre : The population cost-effectiveness of a parenting intervention designed to prevent anxiety disorders in children Type de document : texte imprimé Auteurs : Cathrine MIHALOPOULOS, Auteur ; Theo VOS, Auteur ; Ronald M. RAPEE, Auteur ; Jane PIRKIS, Auteur ; Mary Lou CHATTERTON, Auteur ; Yu-Chen LEE, Auteur ; Rob CARTER, Auteur Article en page(s) : p.1026-1033 Langues : Anglais (eng) Mots-clés : Economic evaluation  anxiety disorders  children  prevention Index. décimale : PER Périodiques Résumé : Background Prevention and early intervention for anxiety disorders has lagged behind many other forms of mental disorder. Recent research has demonstrated the efficacy of a parent-focussed psycho-educational programme. The programme is directed at parents of inhibited preschool children and has been shown to reduce anxiety disorders at 1 and 3 years following intervention. The current study assesses the cost-effectiveness of this intervention to determine whether it could provide value-for-money across a population. Method A cost-utility economic framework, using Disability-Adjusted-Life-Years (DALYs) as the outcome, was adopted. Economic modelling techniques were used to assess the incremental cost-effectiveness ratio (ICER) of the intervention within the Australian population context, which was modelled as add-on to current practice. The perspective was the health sector. Uncertainty was measured using multivariate probabilistic testing and key assumptions were tested using univariate sensitivity analysis. Results The median ICER for the intervention was AUD$8,000 per DALY averted with 99.8% of the uncertainty iterations falling below the threshold value-for-money criterion of AUD$50,000 per DALY averted. The results were robust to sensitivity testing. Conclusions Screening young children in a preschool setting for an inhibited temperament and providing a brief intervention to the parents of children with high levels of inhibition appears to provide very good value-for-money and worth considering in any package of preventive care. Further evaluation of this intervention under routine health service conditions will strengthen conclusions. Acceptability issues associated with this intervention, particularly to preschool staff and parents, need to be considered before wide-scale adoption is undertaken. En ligne : http://dx.doi.org/10.1111/jcpp.12438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] The population cost-effectiveness of a parenting intervention designed to prevent anxiety disorders in children [texte imprimé] / Cathrine MIHALOPOULOS, Auteur ; Theo VOS, Auteur ; Ronald M. RAPEE, Auteur ; Jane PIRKIS, Auteur ; Mary Lou CHATTERTON, Auteur ; Yu-Chen LEE, Auteur ; Rob CARTER, Auteur . - p.1026-1033. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-9 (September 2015) . - p.1026-1033 Mots-clés : Economic evaluation  anxiety disorders  children  prevention Index. décimale : PER Périodiques Résumé : Background Prevention and early intervention for anxiety disorders has lagged behind many other forms of mental disorder. Recent research has demonstrated the efficacy of a parent-focussed psycho-educational programme. The programme is directed at parents of inhibited preschool children and has been shown to reduce anxiety disorders at 1 and 3 years following intervention. The current study assesses the cost-effectiveness of this intervention to determine whether it could provide value-for-money across a population. Method A cost-utility economic framework, using Disability-Adjusted-Life-Years (DALYs) as the outcome, was adopted. Economic modelling techniques were used to assess the incremental cost-effectiveness ratio (ICER) of the intervention within the Australian population context, which was modelled as add-on to current practice. The perspective was the health sector. Uncertainty was measured using multivariate probabilistic testing and key assumptions were tested using univariate sensitivity analysis. Results The median ICER for the intervention was AUD$8,000 per DALY averted with 99.8% of the uncertainty iterations falling below the threshold value-for-money criterion of AUD$50,000 per DALY averted. The results were robust to sensitivity testing. Conclusions Screening young children in a preschool setting for an inhibited temperament and providing a brief intervention to the parents of children with high levels of inhibition appears to provide very good value-for-money and worth considering in any package of preventive care. Further evaluation of this intervention under routine health service conditions will strengthen conclusions. Acceptability issues associated with this intervention, particularly to preschool staff and parents, need to be considered before wide-scale adoption is undertaken. En ligne : http://dx.doi.org/10.1111/jcpp.12438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

Societal costs of subclinical depressive symptoms in Dutch adolescents: a cost-of-illness study / Denise H.M. BODDEN in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.771-780 Titre : Societal costs of subclinical depressive symptoms in Dutch adolescents: a cost-of-illness study Type de document : texte imprimé Auteurs : Denise H.M. BODDEN, Auteur ; Marieke W.H. VAN DEN HEUVEL, Auteur ; Rutger C.M.E. ENGELS, Auteur ; Carmen D. DIRKSEN, Auteur Article en page(s) : p.771-780 Langues : Anglais (eng) Mots-clés : Adolescent  Cost-Benefit Analysis  Depression/epidemiology  Depressive Disorder, Major  Humans  Reproducibility of Results  Surveys and Questionnaires  Adolescence  depression  economic evaluation Index. décimale : PER Périodiques Résumé : BACKGROUND: Subclinical depressive symptoms are highly prevalent among adolescents and are associated with negative consequences, which may pose an economic burden for society. We conducted a prevalence-based cost-of-illness study using a societal perspective to investigate the cost-of-illness of subclinical depressive symptoms among adolescents. METHODS: Using a bottom-up approach, cost questionnaires were assessed to measure costs from 237 Dutch families with an adolescent aged 11-18 with subclinical depressive symptoms (of which 34 met the criteria of a depressive disorder). The study is registered in the Dutch Trial Register (Trial NL5584/NTR6176; www.trialregister.nl/trial/5584). RESULTS: Our calculations show that adolescents with subclinical depressive symptoms cost the Dutch society more than 42 million annually, expressed in costs related to depressive symptoms. Secondary analyses were performed to test the reliability and stability of the costs. When costs related to psychological problems were considered, the annual costs amounted to 67 million. The total societal costs related to physical problems amounted to approximately 126 million. All costs combined (depressive, psychological, behavioural and physical problems and other reasons) amounted to a 243 million. Total costs were highest for physical-related problems of the adolescent (52% of the total costs), followed by psychological (28%), depressive (17%) and behavioural problems (1%). Using an international prevalence rate, societal costs related to depressive symptoms resulted in 54 million a year. CONCLUSIONS: Cost-effective prevention programmes seem warranted given the high societal costs and risk of future costs as subclinical depressive symptoms could be a precursor of clinical depression later in life. En ligne : http://dx.doi.org/10.1111/jcpp.13517 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Societal costs of subclinical depressive symptoms in Dutch adolescents: a cost-of-illness study [texte imprimé] / Denise H.M. BODDEN, Auteur ; Marieke W.H. VAN DEN HEUVEL, Auteur ; Rutger C.M.E. ENGELS, Auteur ; Carmen D. DIRKSEN, Auteur . - p.771-780. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.771-780 Mots-clés : Adolescent  Cost-Benefit Analysis  Depression/epidemiology  Depressive Disorder, Major  Humans  Reproducibility of Results  Surveys and Questionnaires  Adolescence  depression  economic evaluation Index. décimale : PER Périodiques Résumé : BACKGROUND: Subclinical depressive symptoms are highly prevalent among adolescents and are associated with negative consequences, which may pose an economic burden for society. We conducted a prevalence-based cost-of-illness study using a societal perspective to investigate the cost-of-illness of subclinical depressive symptoms among adolescents. METHODS: Using a bottom-up approach, cost questionnaires were assessed to measure costs from 237 Dutch families with an adolescent aged 11-18 with subclinical depressive symptoms (of which 34 met the criteria of a depressive disorder). The study is registered in the Dutch Trial Register (Trial NL5584/NTR6176; www.trialregister.nl/trial/5584). RESULTS: Our calculations show that adolescents with subclinical depressive symptoms cost the Dutch society more than 42 million annually, expressed in costs related to depressive symptoms. Secondary analyses were performed to test the reliability and stability of the costs. When costs related to psychological problems were considered, the annual costs amounted to 67 million. The total societal costs related to physical problems amounted to approximately 126 million. All costs combined (depressive, psychological, behavioural and physical problems and other reasons) amounted to a 243 million. Total costs were highest for physical-related problems of the adolescent (52% of the total costs), followed by psychological (28%), depressive (17%) and behavioural problems (1%). Using an international prevalence rate, societal costs related to depressive symptoms resulted in 54 million a year. CONCLUSIONS: Cost-effective prevention programmes seem warranted given the high societal costs and risk of future costs as subclinical depressive symptoms could be a precursor of clinical depression later in life. En ligne : http://dx.doi.org/10.1111/jcpp.13517 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Cost-effectiveness of psychological interventions for children and young people with post-traumatic stress disorder / Ifigeneia MAVRANEZOULI in Journal of Child Psychology and Psychiatry, 61-6 (June 2020)  

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How do child and adolescent mental health problems influence public sector costs? Interindividual variations in a nationally representative British sample / Martin KNAPP in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

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