Implicit sequence learning in juvenile anorexia nervosa: neural mechanisms and the impact of starvation / Christine FIRK in Journal of Child Psychology and Psychiatry, 56-11 (November 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1168-1176 Titre : Implicit sequence learning in juvenile anorexia nervosa: neural mechanisms and the impact of starvation Type de document : Texte imprimé et/ou numérique Auteurs : Christine FIRK, Auteur ; Verena MAINZ, Auteur ; Martin SCHULTE-RUETHER, Auteur ; Gereon FINK, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Kerstin KONRAD, Auteur Article en page(s) : p.1168-1176 Langues : Anglais (eng) Mots-clés : Anorexia nervosa  implicit sequence learning  serial reaction time task  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Background Previous studies have reported that cognitive deficits occur in patients with anorexia nervosa (AN) and that these deficits may represent a predisposition towards developing AN or perpetuate the disorder. Specifically, dysfunctional implicit learning may contribute to the development of highly resistant dieting behaviours that are fundamental to the persistence of the disorder. Thus, the aims of this study were (a) to investigate implicit sequence learning in adolescent patients with AN before and after weight recovery and (b) to elucidate the associated neural mechanisms in acute AN relative to healthy controls. Methods In a behavioural study, implicit sequence learning was assessed using a serial reaction time task in 27 adolescents with AN before (T1) and after weight recovery (T2) compared with age-matched healthy controls (HC) who were assessed at similar time intervals. The neural correlates of implicit sequence learning were subsequently investigated in 19 AN patients shortly after they were admitted to the hospital and 20 HC using functional magnetic resonance imaging (fMRI). Results At T1, AN patients showed reduced sequence learning compared with HC. However, no behavioural differences between HC and AN patients were found at T2. At the neural level, acute AN patients showed reduced thalamic activation during sequence learning compared with HC subjects. Conclusions Our data suggest that the impaired implicit learning observed in adolescent AN patients before weight gain is a state-related dysfunction that normalises with weight gain. Thus, implicit learning deficits do not appear to represent a predisposition towards developing AN; rather, these deficits should be considered when planning psychotherapeutic interventions for acute AN. Reduced thalamic activation during the acute stage of AN may indicate a starvation-induced dysfunction of the neural circuitry that is involved in behavioural flexibility. En ligne : http://dx.doi.org/10.1111/jcpp.12384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Implicit sequence learning in juvenile anorexia nervosa: neural mechanisms and the impact of starvation [Texte imprimé et/ou numérique] / Christine FIRK, Auteur ; Verena MAINZ, Auteur ; Martin SCHULTE-RUETHER, Auteur ; Gereon FINK, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Kerstin KONRAD, Auteur . - p.1168-1176. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1168-1176 Mots-clés : Anorexia nervosa  implicit sequence learning  serial reaction time task  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Background Previous studies have reported that cognitive deficits occur in patients with anorexia nervosa (AN) and that these deficits may represent a predisposition towards developing AN or perpetuate the disorder. Specifically, dysfunctional implicit learning may contribute to the development of highly resistant dieting behaviours that are fundamental to the persistence of the disorder. Thus, the aims of this study were (a) to investigate implicit sequence learning in adolescent patients with AN before and after weight recovery and (b) to elucidate the associated neural mechanisms in acute AN relative to healthy controls. Methods In a behavioural study, implicit sequence learning was assessed using a serial reaction time task in 27 adolescents with AN before (T1) and after weight recovery (T2) compared with age-matched healthy controls (HC) who were assessed at similar time intervals. The neural correlates of implicit sequence learning were subsequently investigated in 19 AN patients shortly after they were admitted to the hospital and 20 HC using functional magnetic resonance imaging (fMRI). Results At T1, AN patients showed reduced sequence learning compared with HC. However, no behavioural differences between HC and AN patients were found at T2. At the neural level, acute AN patients showed reduced thalamic activation during sequence learning compared with HC subjects. Conclusions Our data suggest that the impaired implicit learning observed in adolescent AN patients before weight gain is a state-related dysfunction that normalises with weight gain. Thus, implicit learning deficits do not appear to represent a predisposition towards developing AN; rather, these deficits should be considered when planning psychotherapeutic interventions for acute AN. Reduced thalamic activation during the acute stage of AN may indicate a starvation-induced dysfunction of the neural circuitry that is involved in behavioural flexibility. En ligne : http://dx.doi.org/10.1111/jcpp.12384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Intact mirror mechanisms for automatic facial emotions in children and adolescents with autism spectrum disorder / Martin SCHULTE-RUTHER in Autism Research, 10-2 (February 2017)  

Public ISBD [article]  inAutism Research > 10-2 (February 2017) . - p.298-310 Titre : Intact mirror mechanisms for automatic facial emotions in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Martin SCHULTE-RUTHER, Auteur ; Ellen OTTE, Auteur ; Kübra ADIGÜZEL, Auteur ; Christine FIRK, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Iring KOCH, Auteur ; Kerstin KONRAD, Auteur Article en page(s) : p.298-310 Langues : Anglais (eng) Mots-clés : mirror neuron system  electromyography  imitation  autism  perception action compatibility  facial emotions Index. décimale : PER Périodiques Résumé : It has been suggested that an early deficit in the human mirror neuron system (MNS) is an important feature of autism. Recent findings related to simple hand and finger movements do not support a general dysfunction of the MNS in autism. Studies investigating facial actions (e.g., emotional expressions) have been more consistent, however, mostly relied on passive observation tasks. We used a new variant of a compatibility task for the assessment of automatic facial mimicry responses that allowed for simultaneous control of attention to facial stimuli. We used facial electromyography in 18 children and adolescents with Autism spectrum disorder (ASD) and 18 typically developing controls (TDCs). We observed a robust compatibility effect in ASD, that is, the execution of a facial expression was facilitated if a congruent facial expression was observed. Time course analysis of RT distributions and comparison to a classic compatibility task (symbolic Simon task) revealed that the facial compatibility effect appeared early and increased with time, suggesting fast and sustained activation of motor codes during observation of facial expressions. We observed a negative correlation of the compatibility effect with age across participants and in ASD, and a positive correlation between self-rated empathy and congruency for smiling faces in TDC but not in ASD. This pattern of results suggests that basic motor mimicry is intact in ASD, but is not associated with complex social cognitive abilities such as emotion understanding and empathy. En ligne : http://dx.doi.org/10.1002/aur.1654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Intact mirror mechanisms for automatic facial emotions in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Martin SCHULTE-RUTHER, Auteur ; Ellen OTTE, Auteur ; Kübra ADIGÜZEL, Auteur ; Christine FIRK, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Iring KOCH, Auteur ; Kerstin KONRAD, Auteur . - p.298-310. Langues : Anglais (eng) in Autism Research > 10-2 (February 2017) . - p.298-310 Mots-clés : mirror neuron system  electromyography  imitation  autism  perception action compatibility  facial emotions Index. décimale : PER Périodiques Résumé : It has been suggested that an early deficit in the human mirror neuron system (MNS) is an important feature of autism. Recent findings related to simple hand and finger movements do not support a general dysfunction of the MNS in autism. Studies investigating facial actions (e.g., emotional expressions) have been more consistent, however, mostly relied on passive observation tasks. We used a new variant of a compatibility task for the assessment of automatic facial mimicry responses that allowed for simultaneous control of attention to facial stimuli. We used facial electromyography in 18 children and adolescents with Autism spectrum disorder (ASD) and 18 typically developing controls (TDCs). We observed a robust compatibility effect in ASD, that is, the execution of a facial expression was facilitated if a congruent facial expression was observed. Time course analysis of RT distributions and comparison to a classic compatibility task (symbolic Simon task) revealed that the facial compatibility effect appeared early and increased with time, suggesting fast and sustained activation of motor codes during observation of facial expressions. We observed a negative correlation of the compatibility effect with age across participants and in ASD, and a positive correlation between self-rated empathy and congruency for smiling faces in TDC but not in ASD. This pattern of results suggests that basic motor mimicry is intact in ASD, but is not associated with complex social cognitive abilities such as emotion understanding and empathy. En ligne : http://dx.doi.org/10.1002/aur.1654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

A mother–child intervention program for adolescent mothers: Results from a randomized controlled trial (the TeeMo study) / Christine FIRK in Development and Psychopathology, 33-3 (August 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-3 (August 2021) . - p.992-1005 Titre : A mother–child intervention program for adolescent mothers: Results from a randomized controlled trial (the TeeMo study) Type de document : Texte imprimé et/ou numérique Auteurs : Christine FIRK, Auteur ; Brigitte DAHMEN, Auteur ; Astrid DEMPFLE, Auteur ; Anke NIESSEN, Auteur ; Christin BAUMANN, Auteur ; Reinhild SCHWARTE, Auteur ; Julia KOSLOWSKI, Auteur ; Kerstin KELBERLAU, Auteur ; Kerstin KONRAD, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur Article en page(s) : p.992-1005 Langues : Anglais (eng) Mots-clés : adolescent parenting  child development  child mental health  early mother–child intervention  maternal sensitivity Index. décimale : PER Périodiques Résumé : Children of adolescent mothers are a high-risk group for negative child development. Previous findings suggest that early interventions may enhance child development by improving mother–child interaction. The purpose of the current study was to evaluate a mother–child intervention (STEEP-b) program in high-risk adolescent mother–infant dyads (N = 56) within a randomized controlled trial (RCT). Mother–child interaction was assessed at baseline (T1), postintervention (T2), and follow-up (T3). The primary outcome was the change in maternal sensitivity and child responsiveness from T1 to T2 that was measured by blinded ratings of videotaped mother–child-interaction with the Emotional Availability Scales. A modified intention-to-treat analysis was performed to examine the data. No intervention effect was found for maternal sensitivity, 95% CI [-0.59–0.60], p = .99, and child responsiveness, 95% CI [-0.51–0.62], p = .84. Maternal sensitivity and child responsiveness did not change over time in both groups (all ps > .05). A statistically nonsignificant, but potentially clinically meaningful difference emerged between rates of serious adverse events, SC: 4 (14.8%), STEEP-b: 1 (3.4%), possibly driven by different intensity of surveillance of dyads in the treatment groups. The current findings question the effectiveness of STEEP-b for high-risk adolescent mothers and do not justify the broad implementation of this approach. En ligne : http://dx.doi.org/10.1017/S0954579420000280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] A mother–child intervention program for adolescent mothers: Results from a randomized controlled trial (the TeeMo study) [Texte imprimé et/ou numérique] / Christine FIRK, Auteur ; Brigitte DAHMEN, Auteur ; Astrid DEMPFLE, Auteur ; Anke NIESSEN, Auteur ; Christin BAUMANN, Auteur ; Reinhild SCHWARTE, Auteur ; Julia KOSLOWSKI, Auteur ; Kerstin KELBERLAU, Auteur ; Kerstin KONRAD, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur . - p.992-1005. Langues : Anglais (eng) in Development and Psychopathology > 33-3 (August 2021) . - p.992-1005 Mots-clés : adolescent parenting  child development  child mental health  early mother–child intervention  maternal sensitivity Index. décimale : PER Périodiques Résumé : Children of adolescent mothers are a high-risk group for negative child development. Previous findings suggest that early interventions may enhance child development by improving mother–child interaction. The purpose of the current study was to evaluate a mother–child intervention (STEEP-b) program in high-risk adolescent mother–infant dyads (N = 56) within a randomized controlled trial (RCT). Mother–child interaction was assessed at baseline (T1), postintervention (T2), and follow-up (T3). The primary outcome was the change in maternal sensitivity and child responsiveness from T1 to T2 that was measured by blinded ratings of videotaped mother–child-interaction with the Emotional Availability Scales. A modified intention-to-treat analysis was performed to examine the data. No intervention effect was found for maternal sensitivity, 95% CI [-0.59–0.60], p = .99, and child responsiveness, 95% CI [-0.51–0.62], p = .84. Maternal sensitivity and child responsiveness did not change over time in both groups (all ps > .05). A statistically nonsignificant, but potentially clinically meaningful difference emerged between rates of serious adverse events, SC: 4 (14.8%), STEEP-b: 1 (3.4%), possibly driven by different intensity of surveillance of dyads in the treatment groups. The current findings question the effectiveness of STEEP-b for high-risk adolescent mothers and do not justify the broad implementation of this approach. En ligne : http://dx.doi.org/10.1017/S0954579420000280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

---

1 (1 - 3 / 3)