An atlas of genetic correlations between gestational age and common psychiatric disorders / Yao YAO in Autism Research, 15-6 (June 2022)  

Public ISBD [article]  inAutism Research > 15-6 (June 2022) . - p.1008-1017 Titre : An atlas of genetic correlations between gestational age and common psychiatric disorders Type de document : Texte imprimé et/ou numérique Auteurs : Yao YAO, Auteur ; Chun'e LI, Auteur ; Peilin MENG, Auteur ; Bolun CHENG, Auteur ; Shiqiang CHENG, Auteur ; Li LIU, Auteur ; Xuena YANG, Auteur ; Yumeng JIA, Auteur ; Yan WEN, Auteur ; Feng ZHANG, Auteur Article en page(s) : p.1008-1017 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/genetics  Autism Spectrum Disorder/genetics  Depressive Disorder, Major/genetics  Female  Genetic Predisposition to Disease  Genome-Wide Association Study  Gestational Age  Humans  Infant, Newborn  Mendelian Randomization Analysis  Premature Birth/genetics  Proteomics  genetic correlation  linkage disequilibrium score regression  psychiatric disorders Index. décimale : PER Périodiques Résumé : We aim to systematically explore the potential genetic correlations between five major psychiatric disorders and gestational ages. Genome-wide association study (GWAS) summary datasets of attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD) in discovery were downloaded from the Psychiatric GWAS Consortium (PGC) website. Suggestive (Raw p? En ligne : http://dx.doi.org/10.1002/aur.2719 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] An atlas of genetic correlations between gestational age and common psychiatric disorders [Texte imprimé et/ou numérique] / Yao YAO, Auteur ; Chun'e LI, Auteur ; Peilin MENG, Auteur ; Bolun CHENG, Auteur ; Shiqiang CHENG, Auteur ; Li LIU, Auteur ; Xuena YANG, Auteur ; Yumeng JIA, Auteur ; Yan WEN, Auteur ; Feng ZHANG, Auteur . - p.1008-1017. Langues : Anglais (eng) in Autism Research > 15-6 (June 2022) . - p.1008-1017 Mots-clés : Attention Deficit Disorder with Hyperactivity/genetics  Autism Spectrum Disorder/genetics  Depressive Disorder, Major/genetics  Female  Genetic Predisposition to Disease  Genome-Wide Association Study  Gestational Age  Humans  Infant, Newborn  Mendelian Randomization Analysis  Premature Birth/genetics  Proteomics  genetic correlation  linkage disequilibrium score regression  psychiatric disorders Index. décimale : PER Périodiques Résumé : We aim to systematically explore the potential genetic correlations between five major psychiatric disorders and gestational ages. Genome-wide association study (GWAS) summary datasets of attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD) in discovery were downloaded from the Psychiatric GWAS Consortium (PGC) website. Suggestive (Raw p? En ligne : http://dx.doi.org/10.1002/aur.2719 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis / Ya-Min LI in Journal of Autism and Developmental Disorders, 46-1 (January 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.95-102 Titre : Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Ya-Min LI, Auteur ; Jian-Jun OU, Auteur ; Li LIU, Auteur ; Dan ZHANG, Auteur ; Jing-Ping ZHAO, Auteur ; Si-Yuan TANG, Auteur Année de publication : 2016 Article en page(s) : p.95-102 Langues : Anglais (eng) Mots-clés : Obésité maternelle  Maternal obesity  Autism spectrum disorder  Offspring  Meta-analysis Index. décimale : PER Périodiques Résumé : As the link between maternal obesity and risk of autism among offspring is unclear, the present study assessed this association. A systematic search of an electronic database was performed to identify observational studies that examined the association between maternal obesity and autism. The outcome measures were odds ratios comparing offspring autism risk between obese and normal-weight mothers. Five observational studies were included in the meta-analysis. A fixed-effects model was used since low heterogeneity was observed between studies. The pooled adjusted odds ratio was 1.47 (95 % CI 1.24–1.74). The meta-analysis results support an increased risk of autism spectrum disorder in children of women who were obese during pregnancy. However, further study is warranted to confirm these results. En ligne : http://dx.doi.org/10.1007/s10803-015-2549-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis [Texte imprimé et/ou numérique] / Ya-Min LI, Auteur ; Jian-Jun OU, Auteur ; Li LIU, Auteur ; Dan ZHANG, Auteur ; Jing-Ping ZHAO, Auteur ; Si-Yuan TANG, Auteur . - 2016 . - p.95-102. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.95-102 Mots-clés : Obésité maternelle  Maternal obesity  Autism spectrum disorder  Offspring  Meta-analysis Index. décimale : PER Périodiques Résumé : As the link between maternal obesity and risk of autism among offspring is unclear, the present study assessed this association. A systematic search of an electronic database was performed to identify observational studies that examined the association between maternal obesity and autism. The outcome measures were odds ratios comparing offspring autism risk between obese and normal-weight mothers. Five observational studies were included in the meta-analysis. A fixed-effects model was used since low heterogeneity was observed between studies. The pooled adjusted odds ratio was 1.47 (95 % CI 1.24–1.74). The meta-analysis results support an increased risk of autism spectrum disorder in children of women who were obese during pregnancy. However, further study is warranted to confirm these results. En ligne : http://dx.doi.org/10.1007/s10803-015-2549-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics / Li LIU in Molecular Autism, (March 2014)  

Public ISBD [article]  inMolecular Autism > (March 2014) . - p.1-18 Titre : DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics Type de document : Texte imprimé et/ou numérique Auteurs : Li LIU, Auteur ; Jing LEI, Auteur ; Stephan J. SANDERS, Auteur ; Arthur Jeremy WILLSEY, Auteur ; Yan KOU, Auteur ; Abdullah Ercument CICEK, Auteur ; Lambertus KLEI, Auteur ; Cong LU, Auteur ; Xin HE, Auteur ; Mingfeng LI, Auteur ; Rebecca A. MUHLE, Auteur ; Avi MA’AYAN, Auteur ; James P. NOONAN, Auteur ; Nenad ŠESTAN, Auteur ; Kathryn A. MCFADDEN, Auteur ; Matthew W. STATE, Auteur ; Joseph D. BUXBAUM, Auteur ; Bernie DEVLIN, Auteur ; Kathryn ROEDER, Auteur Article en page(s) : p.1-18 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : De novo loss-of-function (dnLoF) mutations are found twofold more often in autism spectrum disorder (ASD) probands than their unaffected siblings. Multiple independent dnLoF mutations in the same gene implicate the gene in risk and hence provide a systematic, albeit arduous, path forward for ASD genetics. It is likely that using additional non-genetic data will enhance the ability to identify ASD genes. En ligne : http://dx.doi.org/10.1186/2040-2392-5-22 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics [Texte imprimé et/ou numérique] / Li LIU, Auteur ; Jing LEI, Auteur ; Stephan J. SANDERS, Auteur ; Arthur Jeremy WILLSEY, Auteur ; Yan KOU, Auteur ; Abdullah Ercument CICEK, Auteur ; Lambertus KLEI, Auteur ; Cong LU, Auteur ; Xin HE, Auteur ; Mingfeng LI, Auteur ; Rebecca A. MUHLE, Auteur ; Avi MA’AYAN, Auteur ; James P. NOONAN, Auteur ; Nenad ŠESTAN, Auteur ; Kathryn A. MCFADDEN, Auteur ; Matthew W. STATE, Auteur ; Joseph D. BUXBAUM, Auteur ; Bernie DEVLIN, Auteur ; Kathryn ROEDER, Auteur . - p.1-18. Langues : Anglais (eng) in Molecular Autism > (March 2014) . - p.1-18 Index. décimale : PER Périodiques Résumé : De novo loss-of-function (dnLoF) mutations are found twofold more often in autism spectrum disorder (ASD) probands than their unaffected siblings. Multiple independent dnLoF mutations in the same gene implicate the gene in risk and hence provide a systematic, albeit arduous, path forward for ASD genetics. It is likely that using additional non-genetic data will enhance the ability to identify ASD genes. En ligne : http://dx.doi.org/10.1186/2040-2392-5-22 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases / Wen-Xiong CHEN in Journal of Autism and Developmental Disorders, 54-4 (April 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1567-1581 Titre : Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases Type de document : Texte imprimé et/ou numérique Auteurs : Wen-Xiong CHEN, Auteur ; Yi-Ru CHEN, Auteur ; Min-Zhi PENG, Auteur ; Xian LIU, Auteur ; Yan-Na CAI, Auteur ; Zhi-Fang HUANG, Auteur ; Si-Yuan YANG, Auteur ; Jing-Yu HUANG, Auteur ; Ruo-Han WANG, Auteur ; Peng YI, Auteur ; Li LIU, Auteur Article en page(s) : p.1567-1581 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : To retrospectively explore the characteristics of plasma amino acids (PAAs) in children with autism spectrum disorder and their clinical association via case-control study. A total of 110 autistic and 55 healthy children were recruited from 2014 to 2018. The clinical phenotypes included severity of autism, cognition, adaptability, and regression. Compared with the control group, autistic children had significantly elevated glutamate, ?-Amino-n-butyric acid, glutamine, sarcosine, ?-aminolevulinic acid, glycine and citrulline. In contrast, their plasma level of ethanolamine, phenylalanine, tryptophan, homocysteine, pyroglutamic acid, hydroxyproline, ornithine, histidine, lysine, and glutathione were significantly lower. Elevated neuroactive amino acids (glutamate) and decreased essential amino acids were mostly distinct characteristics of PAAs of autistic children. Increased level of tryptophan might be associated with severity of autism. En ligne : https://doi.org/10.1007/s10803-022-05829-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases [Texte imprimé et/ou numérique] / Wen-Xiong CHEN, Auteur ; Yi-Ru CHEN, Auteur ; Min-Zhi PENG, Auteur ; Xian LIU, Auteur ; Yan-Na CAI, Auteur ; Zhi-Fang HUANG, Auteur ; Si-Yuan YANG, Auteur ; Jing-Yu HUANG, Auteur ; Ruo-Han WANG, Auteur ; Peng YI, Auteur ; Li LIU, Auteur . - p.1567-1581. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1567-1581 Index. décimale : PER Périodiques Résumé : To retrospectively explore the characteristics of plasma amino acids (PAAs) in children with autism spectrum disorder and their clinical association via case-control study. A total of 110 autistic and 55 healthy children were recruited from 2014 to 2018. The clinical phenotypes included severity of autism, cognition, adaptability, and regression. Compared with the control group, autistic children had significantly elevated glutamate, ?-Amino-n-butyric acid, glutamine, sarcosine, ?-aminolevulinic acid, glycine and citrulline. In contrast, their plasma level of ethanolamine, phenylalanine, tryptophan, homocysteine, pyroglutamic acid, hydroxyproline, ornithine, histidine, lysine, and glutathione were significantly lower. Elevated neuroactive amino acids (glutamate) and decreased essential amino acids were mostly distinct characteristics of PAAs of autistic children. Increased level of tryptophan might be associated with severity of autism. En ligne : https://doi.org/10.1007/s10803-022-05829-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

Rare deleterious mutations of the gene EFR3A in autism spectrum disorders / Abha R. GUPTA in Molecular Autism, (April 2014)  

Public ISBD [article]  inMolecular Autism > (April 2014) . - p.1-14 Titre : Rare deleterious mutations of the gene EFR3A in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Abha R. GUPTA, Auteur ; Michelle PIRRUCCELLO, Auteur ; Feng CHENG, Auteur ; Hyo Jung KANG, Auteur ; Thomas V. FERNANDEZ, Auteur ; Jeremy M. BASKIN, Auteur ; Murim CHOI, Auteur ; Li LIU, Auteur ; Adife Gulhan ERCAN-SENCICEK, Auteur ; John D. MURDOCH, Auteur ; Lambertus KLEI, Auteur ; Benjamin M. NEALE, Auteur ; Daniel FRANJIC, Auteur ; Mark J. DALY, Auteur ; Richard P. LIFTON, Auteur ; Pietro DE CAMILLI, Auteur ; Hongyu ZHAO, Auteur ; Nenad ŠESTAN, Auteur ; Matthew W. STATE, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Whole-exome sequencing studies in autism spectrum disorder (ASD) have identified de novo mutations in novel candidate genes, including the synaptic gene Eighty-five Requiring 3A (EFR3A). EFR3A is a critical component of a protein complex required for the synthesis of the phosphoinositide PtdIns4P, which has a variety of functions at the neural synapse. We hypothesized that deleterious mutations in EFR3A would be significantly associated with ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-5-31 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Rare deleterious mutations of the gene EFR3A in autism spectrum disorders [Texte imprimé et/ou numérique] / Abha R. GUPTA, Auteur ; Michelle PIRRUCCELLO, Auteur ; Feng CHENG, Auteur ; Hyo Jung KANG, Auteur ; Thomas V. FERNANDEZ, Auteur ; Jeremy M. BASKIN, Auteur ; Murim CHOI, Auteur ; Li LIU, Auteur ; Adife Gulhan ERCAN-SENCICEK, Auteur ; John D. MURDOCH, Auteur ; Lambertus KLEI, Auteur ; Benjamin M. NEALE, Auteur ; Daniel FRANJIC, Auteur ; Mark J. DALY, Auteur ; Richard P. LIFTON, Auteur ; Pietro DE CAMILLI, Auteur ; Hongyu ZHAO, Auteur ; Nenad ŠESTAN, Auteur ; Matthew W. STATE, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (April 2014) . - p.1-14 Index. décimale : PER Périodiques Résumé : Whole-exome sequencing studies in autism spectrum disorder (ASD) have identified de novo mutations in novel candidate genes, including the synaptic gene Eighty-five Requiring 3A (EFR3A). EFR3A is a critical component of a protein complex required for the synthesis of the phosphoinositide PtdIns4P, which has a variety of functions at the neural synapse. We hypothesized that deleterious mutations in EFR3A would be significantly associated with ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-5-31 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

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