Atypical resting state neuromagnetic connectivity and spectral power in very preterm children / Nataliia KOZHEMIAKO in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.975-987 Titre : Atypical resting state neuromagnetic connectivity and spectral power in very preterm children Type de document : texte imprimé Auteurs : Nataliia KOZHEMIAKO, Auteur ; Adonay NUNES, Auteur ; Vasily A. VAKORIN, Auteur ; C.M.Y. CHAU, Auteur ; Alexander MOISEEV, Auteur ; Urs RIBARY, Auteur ; Ruth E. GRUNAU, Auteur ; Sam M. DOESBURG, Auteur Article en page(s) : p.975-987 Langues : Anglais (eng) Mots-clés : Very preterm  children  early adversity  magnetoencephalography  neonatal stress  pain  resting state connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born very preterm often display selective cognitive difficulties at school age even in the absence of major brain injury. Alterations in neurophysiological activity underpinning such difficulties, as well as their relation to specific aspects of adverse neonatal experience, remain poorly understood. In the present study, we examined interregional connectivity and spectral power in very preterm children at school age, and their relationship with clinical neonatal variables and long-term outcomes (IQ, executive functions, externalizing/internalizing behavior, visual-motor integration). METHODS: We collected resting state magnetoencephalographic (MEG) and psychometric data from a cohort at the age of 8 years followed prospectively since birth, which included three groups: Extremely Low Gestational Age (ELGA, 24-28 weeks GA n = 24, age 7.7 +/- 0.38, 10 girls), Very Low Gestational Age (VLGA, 29-32 weeks GA n = 37, age 7.7 +/- 0.39, 24 girls), and full-term children (38-41 weeks GA n = 39, age 7.9 +/- 1.02, 24 girls). Interregional phase synchrony and spectral power were tested for group differences, and associations with neonatal and outcome variables were examined using mean-centered and behavioral Partial Least Squares (PLS) analyses, respectively. RESULTS: We found greater connectivity in the theta band in the ELGA group compared to VLGA and full-term groups, primarily involving frontal connections. Spectral power analysis demonstrated overall lower power in the ELGA and VLGA compared to full-term group. PLS indicated strong associations between neurophysiological connectivity at school age, adverse neonatal experience and cognitive performance, and behavior. Resting spectral power was associated only with behavioral scores. CONCLUSIONS: Our findings indicate significant atypicalities of neuromagnetic brain activity and connectivity in very preterm children at school age, with alterations in connectivity mainly observed only in the ELGA group. We demonstrate a significant relationship between connectivity, adverse neonatal experience, and long-term outcome, indicating that the disruption of developing neurophysiological networks may mediate relationships between neonatal events and cognitive and behavioral difficulties at school age. En ligne : http://dx.doi.org/10.1111/jcpp.13026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Atypical resting state neuromagnetic connectivity and spectral power in very preterm children [texte imprimé] / Nataliia KOZHEMIAKO, Auteur ; Adonay NUNES, Auteur ; Vasily A. VAKORIN, Auteur ; C.M.Y. CHAU, Auteur ; Alexander MOISEEV, Auteur ; Urs RIBARY, Auteur ; Ruth E. GRUNAU, Auteur ; Sam M. DOESBURG, Auteur . - p.975-987. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.975-987 Mots-clés : Very preterm  children  early adversity  magnetoencephalography  neonatal stress  pain  resting state connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born very preterm often display selective cognitive difficulties at school age even in the absence of major brain injury. Alterations in neurophysiological activity underpinning such difficulties, as well as their relation to specific aspects of adverse neonatal experience, remain poorly understood. In the present study, we examined interregional connectivity and spectral power in very preterm children at school age, and their relationship with clinical neonatal variables and long-term outcomes (IQ, executive functions, externalizing/internalizing behavior, visual-motor integration). METHODS: We collected resting state magnetoencephalographic (MEG) and psychometric data from a cohort at the age of 8 years followed prospectively since birth, which included three groups: Extremely Low Gestational Age (ELGA, 24-28 weeks GA n = 24, age 7.7 +/- 0.38, 10 girls), Very Low Gestational Age (VLGA, 29-32 weeks GA n = 37, age 7.7 +/- 0.39, 24 girls), and full-term children (38-41 weeks GA n = 39, age 7.9 +/- 1.02, 24 girls). Interregional phase synchrony and spectral power were tested for group differences, and associations with neonatal and outcome variables were examined using mean-centered and behavioral Partial Least Squares (PLS) analyses, respectively. RESULTS: We found greater connectivity in the theta band in the ELGA group compared to VLGA and full-term groups, primarily involving frontal connections. Spectral power analysis demonstrated overall lower power in the ELGA and VLGA compared to full-term group. PLS indicated strong associations between neurophysiological connectivity at school age, adverse neonatal experience and cognitive performance, and behavior. Resting spectral power was associated only with behavioral scores. CONCLUSIONS: Our findings indicate significant atypicalities of neuromagnetic brain activity and connectivity in very preterm children at school age, with alterations in connectivity mainly observed only in the ELGA group. We demonstrate a significant relationship between connectivity, adverse neonatal experience, and long-term outcome, indicating that the disruption of developing neurophysiological networks may mediate relationships between neonatal events and cognitive and behavioral difficulties at school age. En ligne : http://dx.doi.org/10.1111/jcpp.13026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces / Fahimeh MAMASHLI in Autism Research, 14-6 (June 2021)  

Public ISBD [article]  inAutism Research > 14-6 (June 2021) . - p.1101-1114 Titre : Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces Type de document : texte imprimé Auteurs : Fahimeh MAMASHLI, Auteur ; Nataliia KOZHEMIAKO, Auteur ; Sheraz KHAN, Auteur ; Adonay NUNES, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Ainsley LOSH, Auteur ; Robert M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; Sam M. DOESBURG, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur Article en page(s) : p.1101-1114 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging  Child  Gamma Rhythm  Humans  Magnetic Resonance Imaging  Magnetoencephalography  Prefrontal Cortex  autism spectrum disorder  functional connectivity  inverted faces  phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18 years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces [texte imprimé] / Fahimeh MAMASHLI, Auteur ; Nataliia KOZHEMIAKO, Auteur ; Sheraz KHAN, Auteur ; Adonay NUNES, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Ainsley LOSH, Auteur ; Robert M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; Sam M. DOESBURG, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur . - p.1101-1114. Langues : Anglais (eng) in Autism Research > 14-6 (June 2021) . - p.1101-1114 Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging  Child  Gamma Rhythm  Humans  Magnetic Resonance Imaging  Magnetoencephalography  Prefrontal Cortex  autism spectrum disorder  functional connectivity  inverted faces  phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18 years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Increased Intra-Subject Variability of Reaction Times and Single-Trial Event-Related Potential Components in Children With Autism Spectrum Disorder / Justine R. MAGNUSON in Autism Research, 13-2 (February 2020)  

Public ISBD [article]  inAutism Research > 13-2 (February 2020) . - p.221-229 Titre : Increased Intra-Subject Variability of Reaction Times and Single-Trial Event-Related Potential Components in Children With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Justine R. MAGNUSON, Auteur ; Grace IAROCCI, Auteur ; Sam M. DOESBURG, Auteur ; Sylvain MORENO, Auteur Article en page(s) : p.221-229 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  electroencephalography (EEG)  emotion processing  event-related potentials (ERP)  inhibition  intra-subject variability Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is an increasingly common neurodevelopmental disorder that affects 1 in 59 children. The cognitive profiles of individuals with ASD are varied, and the neurophysiological underpinnings of these developmental difficulties are unclear. While many studies have focused on overall group differences in the amplitude or latency of event related potential (ERP) responses, recent research suggests that increased intra-subject neural variability may also be a reliable indicator of atypical brain function in ASD. This study aimed to identify behavioral and neural variability responses during an emotional inhibitory control task in children with ASD compared to typically developing (TD) children. Children with ASD showed increased variability in response to both inhibitory and emotional stimuli, evidenced by greater reaction time variability and single-trial ERP variability of N200 and N170 amplitudes and/or latencies compared to TD children. These results suggest that the physiological basis of ASD may be more accurately explained by increased intra-subject variability, in addition to characteristic increases or decreases in the amplitude or latency of neural responses. Autism Res 2020, 13:221-229. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The cognitive functions including memory, attention, executive functions, and perception, of individuals with ASD are varied, and the physiological underpinnings of these profiles are unclear. In this study, children with ASD showed increased intra-subject neural and behavioral variability in response to an emotional inhibitory control task compared to typically developing children. These results suggest that the physiological basis of ASD may also be explained by increased behavioral and neural variability in people with ASD, rather than simply characteristic increases or decreases in averaged brain responses. En ligne : http://dx.doi.org/10.1002/aur.2210 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] Increased Intra-Subject Variability of Reaction Times and Single-Trial Event-Related Potential Components in Children With Autism Spectrum Disorder [texte imprimé] / Justine R. MAGNUSON, Auteur ; Grace IAROCCI, Auteur ; Sam M. DOESBURG, Auteur ; Sylvain MORENO, Auteur . - p.221-229. Langues : Anglais (eng) in Autism Research > 13-2 (February 2020) . - p.221-229 Mots-clés : autism spectrum disorder  electroencephalography (EEG)  emotion processing  event-related potentials (ERP)  inhibition  intra-subject variability Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is an increasingly common neurodevelopmental disorder that affects 1 in 59 children. The cognitive profiles of individuals with ASD are varied, and the neurophysiological underpinnings of these developmental difficulties are unclear. While many studies have focused on overall group differences in the amplitude or latency of event related potential (ERP) responses, recent research suggests that increased intra-subject neural variability may also be a reliable indicator of atypical brain function in ASD. This study aimed to identify behavioral and neural variability responses during an emotional inhibitory control task in children with ASD compared to typically developing (TD) children. Children with ASD showed increased variability in response to both inhibitory and emotional stimuli, evidenced by greater reaction time variability and single-trial ERP variability of N200 and N170 amplitudes and/or latencies compared to TD children. These results suggest that the physiological basis of ASD may be more accurately explained by increased intra-subject variability, in addition to characteristic increases or decreases in the amplitude or latency of neural responses. Autism Res 2020, 13:221-229. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The cognitive functions including memory, attention, executive functions, and perception, of individuals with ASD are varied, and the physiological underpinnings of these profiles are unclear. In this study, children with ASD showed increased intra-subject neural and behavioral variability in response to an emotional inhibitory control task compared to typically developing children. These results suggest that the physiological basis of ASD may also be explained by increased behavioral and neural variability in people with ASD, rather than simply characteristic increases or decreases in averaged brain responses. En ligne : http://dx.doi.org/10.1002/aur.2210 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

Reduced beta connectivity during emotional face processing in adolescents with autism / Rachel C. LEUNG in Molecular Autism, (October 2014)  

Public ISBD [article]  inMolecular Autism > (October 2014) . - p.1-13 Titre : Reduced beta connectivity during emotional face processing in adolescents with autism Type de document : texte imprimé Auteurs : Rachel C. LEUNG, Auteur ; Annette X. YE, Auteur ; Simeon M. WONG, Auteur ; Margot J. TAYLOR, Auteur ; Sam M. DOESBURG, Auteur Article en page(s) : p.1-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social cognition. The biological basis of deficits in social cognition in ASD, and their difficulty in processing emotional face information in particular, remains unclear. Atypical communication within and between brain regions has been reported in ASD. Interregional phase-locking is a neurophysiological mechanism mediating communication among brain areas and is understood to support cognitive functions. In the present study we investigated interregional magnetoencephalographic phase synchronization during the perception of emotional faces in adolescents with ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-5-51 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Reduced beta connectivity during emotional face processing in adolescents with autism [texte imprimé] / Rachel C. LEUNG, Auteur ; Annette X. YE, Auteur ; Simeon M. WONG, Auteur ; Margot J. TAYLOR, Auteur ; Sam M. DOESBURG, Auteur . - p.1-13. Langues : Anglais (eng) in Molecular Autism > (October 2014) . - p.1-13 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social cognition. The biological basis of deficits in social cognition in ASD, and their difficulty in processing emotional face information in particular, remains unclear. Atypical communication within and between brain regions has been reported in ASD. Interregional phase-locking is a neurophysiological mechanism mediating communication among brain areas and is understood to support cognitive functions. In the present study we investigated interregional magnetoencephalographic phase synchronization during the perception of emotional faces in adolescents with ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-5-51 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

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