Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model / Jane C. NAVIAUX in Molecular Autism, (January 2015)  

Public ISBD [article]  inMolecular Autism > (January 2015) . - p.1-20 Titre : Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model Type de document : texte imprimé Auteurs : Jane C. NAVIAUX, Auteur ; Lin WANG, Auteur ; Kefeng LI, Auteur ; A. Taylor BRIGHT, Auteur ; William A. ALAYNICK, Auteur ; Kenneth R. WILLIAMS, Auteur ; Susan B. POWELL, Auteur ; Robert K. NAVIAUX, Auteur Article en page(s) : p.1-20 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study was designed to test a new approach to drug treatment of autism spectrum disorders (ASDs) in the Fragile X (Fmr1) knockout mouse model. En ligne : http://dx.doi.org/10.1186/2040-2392-6-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model [texte imprimé] / Jane C. NAVIAUX, Auteur ; Lin WANG, Auteur ; Kefeng LI, Auteur ; A. Taylor BRIGHT, Auteur ; William A. ALAYNICK, Auteur ; Kenneth R. WILLIAMS, Auteur ; Susan B. POWELL, Auteur ; Robert K. NAVIAUX, Auteur . - p.1-20. Langues : Anglais (eng) in Molecular Autism > (January 2015) . - p.1-20 Index. décimale : PER Périodiques Résumé : This study was designed to test a new approach to drug treatment of autism spectrum disorders (ASDs) in the Fragile X (Fmr1) knockout mouse model. En ligne : http://dx.doi.org/10.1186/2040-2392-6-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Daily Mindfulness and Depressive Symptoms Among Parents of Autistic Children: A Dynamic Structural Equation Modelling Study / Lin WANG in Autism, 30-6 (June 2026)  

Public ISBD [article]  inAutism > 30-6 (June 2026) . - p.1576-1592 Titre : Daily Mindfulness and Depressive Symptoms Among Parents of Autistic Children: A Dynamic Structural Equation Modelling Study Type de document : texte imprimé Auteurs : Lin WANG, Auteur ; Meng HUA, Auteur ; Xinyi HU, Auteur ; Yifan WANG, Auteur ; Qinxing XIE, Auteur ; Guang YANG, Auteur ; Yuan CHEN, Auteur Article en page(s) : p.1576-1592 Langues : Anglais (eng) Mots-clés : child externalising problems  daily diary study  depressive symptoms  dynamic structural equation modelling  mindfulness  parents of autistic children  perceived social support Index. décimale : PER Périodiques Résumé : Elevated depressive symptoms among parents of autistic children are well documented and associated with poorer mental health. Mindfulness has been identified as a protective factor against mental health difficulties, but its day-to-day associations with depressive symptoms in this population remain unclear. A total of 210 Chinese parents of autistic children participated in this 15-day diary study, during which they completed daily measures of mindfulness and depressive symptoms. The data were analysed using dynamic structural equation modelling. Results indicated that (1) parents’ daily mindfulness and depressive symptoms exhibited autoregressive stability and showed significant negative reciprocal cross-lagged associations at the within-person level. At the between-person level, (2) higher perceived social support was associated with lower mean depressive symptoms and higher mean mindfulness, and it strengthened the negative cross-lagged effect of daily mindfulness on next-day depressive symptoms; and (3) child externalising problems were positively associated with parents’ overall mean depressive symptoms and negatively associated with both parents’ overall mean daily mindfulness and the autoregressive effects of daily mindfulness and depressive symptoms. Findings underscore the importance of fostering daily mindfulness within a supportive resource context and highlight the need to maintain the day-to-day persistence of mindfulness in families of autistic children with higher externalising problems.Lay Abstract Parents of autistic children tended to feel fewer depressive symptoms on the day after they felt more mindful; likewise, they tended to feel less mindful the day after they felt more depressed. We asked 210 parents in China to complete a short daily questionnaire for 15 days about their daily mindfulness and depressive symptoms. We also looked at two factors that might affect day-to-day mindfulness and depressive symptoms: the level of perceived social support and children’s challenging externalising behaviours directed towards parents. We focused on how parents’ mindfulness and depressive symptoms shift from one day to the next to identify practical ways to improve parents’ mental well-being. We found that more perceived social support was linked to a stronger next-day connection between feeling more mindful and feeling less depressed, whereas more frequent behavioural challenges were linked to more ups and downs from one day to the next in both mindfulness and mood. The findings of this work can guide researchers and practitioners to design simple, everyday actions, such as brief mindfulness moments and better support for families, that help parents feel less low from one day to the next. En ligne : https://dx.doi.org/10.1177/13623613261439930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Daily Mindfulness and Depressive Symptoms Among Parents of Autistic Children: A Dynamic Structural Equation Modelling Study [texte imprimé] / Lin WANG, Auteur ; Meng HUA, Auteur ; Xinyi HU, Auteur ; Yifan WANG, Auteur ; Qinxing XIE, Auteur ; Guang YANG, Auteur ; Yuan CHEN, Auteur . - p.1576-1592. Langues : Anglais (eng) in Autism > 30-6 (June 2026) . - p.1576-1592 Mots-clés : child externalising problems  daily diary study  depressive symptoms  dynamic structural equation modelling  mindfulness  parents of autistic children  perceived social support Index. décimale : PER Périodiques Résumé : Elevated depressive symptoms among parents of autistic children are well documented and associated with poorer mental health. Mindfulness has been identified as a protective factor against mental health difficulties, but its day-to-day associations with depressive symptoms in this population remain unclear. A total of 210 Chinese parents of autistic children participated in this 15-day diary study, during which they completed daily measures of mindfulness and depressive symptoms. The data were analysed using dynamic structural equation modelling. Results indicated that (1) parents’ daily mindfulness and depressive symptoms exhibited autoregressive stability and showed significant negative reciprocal cross-lagged associations at the within-person level. At the between-person level, (2) higher perceived social support was associated with lower mean depressive symptoms and higher mean mindfulness, and it strengthened the negative cross-lagged effect of daily mindfulness on next-day depressive symptoms; and (3) child externalising problems were positively associated with parents’ overall mean depressive symptoms and negatively associated with both parents’ overall mean daily mindfulness and the autoregressive effects of daily mindfulness and depressive symptoms. Findings underscore the importance of fostering daily mindfulness within a supportive resource context and highlight the need to maintain the day-to-day persistence of mindfulness in families of autistic children with higher externalising problems.Lay Abstract Parents of autistic children tended to feel fewer depressive symptoms on the day after they felt more mindful; likewise, they tended to feel less mindful the day after they felt more depressed. We asked 210 parents in China to complete a short daily questionnaire for 15 days about their daily mindfulness and depressive symptoms. We also looked at two factors that might affect day-to-day mindfulness and depressive symptoms: the level of perceived social support and children’s challenging externalising behaviours directed towards parents. We focused on how parents’ mindfulness and depressive symptoms shift from one day to the next to identify practical ways to improve parents’ mental well-being. We found that more perceived social support was linked to a stronger next-day connection between feeling more mindful and feeling less depressed, whereas more frequent behavioural challenges were linked to more ups and downs from one day to the next in both mindfulness and mood. The findings of this work can guide researchers and practitioners to design simple, everyday actions, such as brief mindfulness moments and better support for families, that help parents feel less low from one day to the next. En ligne : https://dx.doi.org/10.1177/13623613261439930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Functional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder / Lin WANG in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 75 p. Titre : Functional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder Type de document : texte imprimé Auteurs : Lin WANG, Auteur ; Yi ZHANG, Auteur ; Kuokuo LI, Auteur ; Zheng WANG, Auteur ; Xiaomeng WANG, Auteur ; Bin LI, Auteur ; Guihu ZHAO, Auteur ; Zhenghuan FANG, Auteur ; Zhengbao LING, Auteur ; Tengfei LUO, Auteur ; Lu XIA, Auteur ; Yanping LI, Auteur ; Hui GUO, Auteur ; Zhengmao HU, Auteur ; Jinchen LI, Auteur ; Zhongsheng SUN, Auteur ; Kun XIA, Auteur Article en page(s) : 75 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  De novo variant  Expression pattern  Functional network  Recessive inherited variant Index. décimale : PER Périodiques Résumé : BACKGROUND: Both de novo variants and recessive inherited variants were associated with autism spectrum disorder (ASD). This study aimed to use exome data to prioritize recessive inherited genes (RIGs) with biallelically inherited variants in autosomes or X-linked inherited variants in males and investigate the functional relationships between RIGs and genes with de novo variants (DNGs). METHODS: We used a bioinformatics pipeline to analyze whole-exome sequencing data from 1799 ASD quads (containing one proband, one unaffected sibling, and their parents) from the Simons Simplex Collection and prioritize candidate RIGs with rare biallelically inherited variants in autosomes or X-linked inherited variants in males. The relationships between RIGs and DNGs were characterized based on different genetic perspectives, including genetic variants, functional networks, and brain expression patterns. RESULTS: Among the biallelically or hemizygous constrained genes that were expressed in the brain, ASD probands carried significantly more biallelically inherited protein-truncating variants (PTVs) in autosomes (p = 0.038) and X-linked inherited PTVs in males (p = 0.026) than those in unaffected siblings. We prioritized eight autosomal, and 13 X-linked candidate RIGs, including 11 genes already associated with neurodevelopmental disorders. In total, we detected biallelically inherited variants or X-linked inherited variants of these 21 candidate RIGs in 26 (1.4%) of 1799 probands. We then integrated previously reported known or candidate genes in ASD, ultimately obtaining 70 RIGs and 87 DNGs for analysis. We found that RIGs were less likely to carry multiple recessive inherited variants than DNGs were to carry multiple de novo variants. Additionally, RIGs and DNGs were significantly co-expressed and interacted with each other, forming a network enriched in known functional ASD clusters, although RIGs were less likely to be enriched in these functional clusters compared with DNGs. Furthermore, although RIGs and DNGs presented comparable expression patterns in the human brain, RIGs were less likely to be associated with prenatal brain regions, the middle cortical layers, and excitatory neurons than DNGs. LIMITATIONS: The RIGs analyzed in this study require functional validation, and the results should be replicated in more patients with ASD. CONCLUSIONS: ASD RIGs were functionally associated with DNGs; however, they exhibited higher heterogeneity than DNGs. En ligne : http://dx.doi.org/10.1186/s13229-020-00382-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Functional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder [texte imprimé] / Lin WANG, Auteur ; Yi ZHANG, Auteur ; Kuokuo LI, Auteur ; Zheng WANG, Auteur ; Xiaomeng WANG, Auteur ; Bin LI, Auteur ; Guihu ZHAO, Auteur ; Zhenghuan FANG, Auteur ; Zhengbao LING, Auteur ; Tengfei LUO, Auteur ; Lu XIA, Auteur ; Yanping LI, Auteur ; Hui GUO, Auteur ; Zhengmao HU, Auteur ; Jinchen LI, Auteur ; Zhongsheng SUN, Auteur ; Kun XIA, Auteur . - 75 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 75 p. Mots-clés : Autism spectrum disorder  De novo variant  Expression pattern  Functional network  Recessive inherited variant Index. décimale : PER Périodiques Résumé : BACKGROUND: Both de novo variants and recessive inherited variants were associated with autism spectrum disorder (ASD). This study aimed to use exome data to prioritize recessive inherited genes (RIGs) with biallelically inherited variants in autosomes or X-linked inherited variants in males and investigate the functional relationships between RIGs and genes with de novo variants (DNGs). METHODS: We used a bioinformatics pipeline to analyze whole-exome sequencing data from 1799 ASD quads (containing one proband, one unaffected sibling, and their parents) from the Simons Simplex Collection and prioritize candidate RIGs with rare biallelically inherited variants in autosomes or X-linked inherited variants in males. The relationships between RIGs and DNGs were characterized based on different genetic perspectives, including genetic variants, functional networks, and brain expression patterns. RESULTS: Among the biallelically or hemizygous constrained genes that were expressed in the brain, ASD probands carried significantly more biallelically inherited protein-truncating variants (PTVs) in autosomes (p = 0.038) and X-linked inherited PTVs in males (p = 0.026) than those in unaffected siblings. We prioritized eight autosomal, and 13 X-linked candidate RIGs, including 11 genes already associated with neurodevelopmental disorders. In total, we detected biallelically inherited variants or X-linked inherited variants of these 21 candidate RIGs in 26 (1.4%) of 1799 probands. We then integrated previously reported known or candidate genes in ASD, ultimately obtaining 70 RIGs and 87 DNGs for analysis. We found that RIGs were less likely to carry multiple recessive inherited variants than DNGs were to carry multiple de novo variants. Additionally, RIGs and DNGs were significantly co-expressed and interacted with each other, forming a network enriched in known functional ASD clusters, although RIGs were less likely to be enriched in these functional clusters compared with DNGs. Furthermore, although RIGs and DNGs presented comparable expression patterns in the human brain, RIGs were less likely to be associated with prenatal brain regions, the middle cortical layers, and excitatory neurons than DNGs. LIMITATIONS: The RIGs analyzed in this study require functional validation, and the results should be replicated in more patients with ASD. CONCLUSIONS: ASD RIGs were functionally associated with DNGs; however, they exhibited higher heterogeneity than DNGs. En ligne : http://dx.doi.org/10.1186/s13229-020-00382-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Witnessing substance use increases same-day antisocial behavior among at-risk adolescents: Gene–environment interaction in a 30-day ecological momentary assessment study / Michael A. RUSSELL in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1441-1456 Titre : Witnessing substance use increases same-day antisocial behavior among at-risk adolescents: Gene–environment interaction in a 30-day ecological momentary assessment study Type de document : texte imprimé Auteurs : Michael A. RUSSELL, Auteur ; Lin WANG, Auteur ; Candice L. ODGERS, Auteur Article en page(s) : p.1441-1456 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Many young adolescents are embedded in neighborhoods, schools, and homes where alcohol and drugs are frequently used. However, little is known about (a) how witnessing others' substance use affects adolescents in their daily lives and (b) which adolescents will be most affected. The current study used ecological momentary assessment with 151 young adolescents (ages 11–15) to examine the daily association between witnessing substance use and antisocial behavior across 38 consecutive days. Results from multilevel logistic regression models indicated that adolescents were more likely to engage in antisocial behavior on days when they witnessed others using substances, an association that held when substance use was witnessed inside the home as well as outside the home (e.g., at school or in their neighborhoods). A significant Gene × Environment interaction suggested that the same-day association between witnessing substance use and antisocial behavior was significantly stronger among adolescents with, versus without, the dopamine receptor D4 seven repeat (DRD4-7R) allele. The implications of the findings for theory and research related to adolescent antisocial behavior are discussed. En ligne : http://dx.doi.org/10.1017/s0954579415001182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Witnessing substance use increases same-day antisocial behavior among at-risk adolescents: Gene–environment interaction in a 30-day ecological momentary assessment study [texte imprimé] / Michael A. RUSSELL, Auteur ; Lin WANG, Auteur ; Candice L. ODGERS, Auteur . - p.1441-1456. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1441-1456 Index. décimale : PER Périodiques Résumé : Many young adolescents are embedded in neighborhoods, schools, and homes where alcohol and drugs are frequently used. However, little is known about (a) how witnessing others' substance use affects adolescents in their daily lives and (b) which adolescents will be most affected. The current study used ecological momentary assessment with 151 young adolescents (ages 11–15) to examine the daily association between witnessing substance use and antisocial behavior across 38 consecutive days. Results from multilevel logistic regression models indicated that adolescents were more likely to engage in antisocial behavior on days when they witnessed others using substances, an association that held when substance use was witnessed inside the home as well as outside the home (e.g., at school or in their neighborhoods). A significant Gene × Environment interaction suggested that the same-day association between witnessing substance use and antisocial behavior was significantly stronger among adolescents with, versus without, the dopamine receptor D4 seven repeat (DRD4-7R) allele. The implications of the findings for theory and research related to adolescent antisocial behavior are discussed. En ligne : http://dx.doi.org/10.1017/s0954579415001182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

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