Erratum: Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder / Christine W. NORDAHL in Molecular Autism, (June 2015)  

Public ISBD [article]  inMolecular Autism > (June 2015) . - p.1-1 Titre : Erratum: Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder Type de document : texte imprimé Auteurs : Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Lee Michael PERRY, Auteur ; Robert DOUGHERTY, Auteur ; Aaron LEE, Auteur ; Deana LI, Auteur ; Michael H. BUONOCORE, Auteur ; Tony SIMON, Auteur ; Sally J. ROGERS, Auteur ; Brian WANDELL, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1-1 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-015-0030-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Erratum: Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder [texte imprimé] / Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Lee Michael PERRY, Auteur ; Robert DOUGHERTY, Auteur ; Aaron LEE, Auteur ; Deana LI, Auteur ; Michael H. BUONOCORE, Auteur ; Tony SIMON, Auteur ; Sally J. ROGERS, Auteur ; Brian WANDELL, Auteur ; David G. AMARAL, Auteur . - p.1-1. Langues : Anglais (eng) in Molecular Autism > (June 2015) . - p.1-1 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-015-0030-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

In pursuit of neurophenotypes: The consequences of having autism and a big brain / David G. AMARAL in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.711-722 Titre : In pursuit of neurophenotypes: The consequences of having autism and a big brain Type de document : texte imprimé Auteurs : David G. AMARAL, Auteur ; Deana LI, Auteur ; Lauren E. LIBERO, Auteur ; Marjorie SOLOMON, Auteur ; Judy VAN DE WATER, Auteur ; Ann M. MASTERGEORGE, Auteur ; Letitia R. NAIGLES, Auteur ; Sally J. ROGERS, Auteur ; Christine W. NORDAHL, Auteur Article en page(s) : p.711-722 Langues : Anglais (eng) Mots-clés : brain development  magnetic resonance imaging  megalencephaly  phenotype  subtypes Index. décimale : PER Périodiques Résumé : A consensus has emerged that despite common core features, autism spectrum disorder (ASD) has multiple etiologies and various genetic and biological characteristics. The fact that there are likely to be subtypes of ASD has complicated attempts to develop effective therapies. The UC Davis MIND Institute Autism Phenome Project is a longitudinal, multidisciplinary analysis of children with autism and age-matched typically developing controls; nearly 400 families are participating in this study. The overarching goal is to gather sufficient biological, medical, and behavioral data to allow definition of clinically meaningful subtypes of ASD. One reasonable hypothesis is that different subtypes of autism will demonstrate different patterns of altered brain organization or development i.e., different neurophenotypes. In this Commentary, we discuss one neurophenotype that is defined by megalencephaly, or having brain size that is large and disproportionate to body size. We have found that 15% of the boys with autism demonstrate this neurophenotype, though it is far less common in girls. We review behavioral and medical characteristics of the large-brained group of boys with autism in comparison to those with typically sized brains. While brain size in typically developing individuals is positively correlated with cognitive function, the children with autism and larger brains have more severe disabilities and poorer prognosis. This research indicates that phenotyping in autism, like genotyping, requires a very substantial cohort of subjects. Moreover, since brain and behavior relationships may emerge at different times during development, this effort highlights the need for longitudinal analyses to carry out meaningful phenotyping. En ligne : http://dx.doi.org/10.1002/aur.1755 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] In pursuit of neurophenotypes: The consequences of having autism and a big brain [texte imprimé] / David G. AMARAL, Auteur ; Deana LI, Auteur ; Lauren E. LIBERO, Auteur ; Marjorie SOLOMON, Auteur ; Judy VAN DE WATER, Auteur ; Ann M. MASTERGEORGE, Auteur ; Letitia R. NAIGLES, Auteur ; Sally J. ROGERS, Auteur ; Christine W. NORDAHL, Auteur . - p.711-722. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.711-722 Mots-clés : brain development  magnetic resonance imaging  megalencephaly  phenotype  subtypes Index. décimale : PER Périodiques Résumé : A consensus has emerged that despite common core features, autism spectrum disorder (ASD) has multiple etiologies and various genetic and biological characteristics. The fact that there are likely to be subtypes of ASD has complicated attempts to develop effective therapies. The UC Davis MIND Institute Autism Phenome Project is a longitudinal, multidisciplinary analysis of children with autism and age-matched typically developing controls; nearly 400 families are participating in this study. The overarching goal is to gather sufficient biological, medical, and behavioral data to allow definition of clinically meaningful subtypes of ASD. One reasonable hypothesis is that different subtypes of autism will demonstrate different patterns of altered brain organization or development i.e., different neurophenotypes. In this Commentary, we discuss one neurophenotype that is defined by megalencephaly, or having brain size that is large and disproportionate to body size. We have found that 15% of the boys with autism demonstrate this neurophenotype, though it is far less common in girls. We review behavioral and medical characteristics of the large-brained group of boys with autism in comparison to those with typically sized brains. While brain size in typically developing individuals is positively correlated with cognitive function, the children with autism and larger brains have more severe disabilities and poorer prognosis. This research indicates that phenotyping in autism, like genotyping, requires a very substantial cohort of subjects. Moreover, since brain and behavior relationships may emerge at different times during development, this effort highlights the need for longitudinal analyses to carry out meaningful phenotyping. En ligne : http://dx.doi.org/10.1002/aur.1755 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Macrocephaly and megalencephaly in autism spectrum disorder / Lauren E. LIBERO

Public ISBD in Autism imaging and Devices / Manuel F. CASANOVA Titre : Macrocephaly and megalencephaly in autism spectrum disorder Type de document : texte imprimé Auteurs : Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana LI, Auteur ; David G. AMARAL, Auteur Importance : p.171-188 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 in Autism imaging and Devices / Manuel F. CASANOVA Macrocephaly and megalencephaly in autism spectrum disorder [texte imprimé] / Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana LI, Auteur ; David G. AMARAL, Auteur . - [s.d.] . - p.171-188. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382

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Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder / Lauren E. LIBERO in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1169-1182 Titre : Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder Type de document : texte imprimé Auteurs : Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana LI, Auteur ; Emilio FERRER, Auteur ; Sally J. ROGERS, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1169-1182 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  MRI  longitudinal  brain development  disproportionate megalencephaly Index. décimale : PER Périodiques Résumé : A recurring finding in autism spectrum disorder research is that head and brain growth is disproportionate to body growth in early childhood. Nordahl et al. (2011) demonstrated that this occurs in approximately 15% of boys with autism. While the literature suggests that brain growth normalizes at older ages, this has never been evaluated in a longitudinal study. The current study evaluated head circumference and total cerebral volume in 129 male children with autism and 49 age-matched, typically developing controls. We determined whether 3-year-old boys with brain size disproportionate to height (which we call disproportionate megalencephaly) demonstrated an abnormal trajectory of head growth from birth and whether they maintained an enlarged brain at 5 years of age. Findings were based on longitudinal, structural MRI data collected around 3, 4, and 5 years of age and head circumference data from medical records. At 3 years of age, 19 boys with autism had enlarged brains while 110 had brain sizes in the normal range. Boys with disproportionate megalencephaly had greater total cerebral, gray matter, and white matter volumes from 3–5 years compared to boys with autism and normal sized brains and typically developing boys, but no differences in body size. While head circumference did not differ between groups at birth, it was significantly greater in the disproportionate megalencephaly group by around 2 years. These data suggest that there is a subgroup of boys with autism who have brains disproportionate to body size and that this continues until at least 5 years of age. En ligne : http://dx.doi.org/10.1002/aur.1643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder [texte imprimé] / Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana LI, Auteur ; Emilio FERRER, Auteur ; Sally J. ROGERS, Auteur ; David G. AMARAL, Auteur . - p.1169-1182. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1169-1182 Mots-clés : autism spectrum disorder  MRI  longitudinal  brain development  disproportionate megalencephaly Index. décimale : PER Périodiques Résumé : A recurring finding in autism spectrum disorder research is that head and brain growth is disproportionate to body growth in early childhood. Nordahl et al. (2011) demonstrated that this occurs in approximately 15% of boys with autism. While the literature suggests that brain growth normalizes at older ages, this has never been evaluated in a longitudinal study. The current study evaluated head circumference and total cerebral volume in 129 male children with autism and 49 age-matched, typically developing controls. We determined whether 3-year-old boys with brain size disproportionate to height (which we call disproportionate megalencephaly) demonstrated an abnormal trajectory of head growth from birth and whether they maintained an enlarged brain at 5 years of age. Findings were based on longitudinal, structural MRI data collected around 3, 4, and 5 years of age and head circumference data from medical records. At 3 years of age, 19 boys with autism had enlarged brains while 110 had brain sizes in the normal range. Boys with disproportionate megalencephaly had greater total cerebral, gray matter, and white matter volumes from 3–5 years compared to boys with autism and normal sized brains and typically developing boys, but no differences in body size. While head circumference did not differ between groups at birth, it was significantly greater in the disproportionate megalencephaly group by around 2 years. These data suggest that there is a subgroup of boys with autism who have brains disproportionate to body size and that this continues until at least 5 years of age. En ligne : http://dx.doi.org/10.1002/aur.1643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder / Christine W. NORDAHL in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-11 Titre : Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder Type de document : texte imprimé Auteurs : Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Lee Michael PERRY, Auteur ; Robert DOUGHERTY, Auteur ; Aaron LEE, Auteur ; Deana LI, Auteur ; Michael H. BUONOCORE, Auteur ; Tony SIMON, Auteur ; Sally J. ROGERS, Auteur ; Brian WANDELL, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion characteristics have also not been evaluated fully in ASD. En ligne : http://dx.doi.org/10.1186/s13229-015-0005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder [texte imprimé] / Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Lee Michael PERRY, Auteur ; Robert DOUGHERTY, Auteur ; Aaron LEE, Auteur ; Deana LI, Auteur ; Michael H. BUONOCORE, Auteur ; Tony SIMON, Auteur ; Sally J. ROGERS, Auteur ; Brian WANDELL, Auteur ; David G. AMARAL, Auteur . - p.1-11. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-11 Index. décimale : PER Périodiques Résumé : Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion characteristics have also not been evaluated fully in ASD. En ligne : http://dx.doi.org/10.1186/s13229-015-0005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

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