Biochemistry of the cingulate cortex in autism: An MR spectroscopy study / Lauren E. LIBERO in Autism Research, 9-6 (June 2016)  

Public ISBD [article]  inAutism Research > 9-6 (June 2016) . - p.643-657 Titre : Biochemistry of the cingulate cortex in autism: An MR spectroscopy study Type de document : Texte imprimé et/ou numérique Auteurs : Lauren E. LIBERO, Auteur ; Meredith A. REID, Auteur ; David M. WHITE, Auteur ; Nouha SALIBI, Auteur ; Adrienne C. LAHTI, Auteur ; Rajesh K. KANA, Auteur Article en page(s) : p.643-657 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  cingulate cortex  1H-MRS  MR spectroscopy  neurochemicals  biochemistry Index. décimale : PER Périodiques Résumé : Neuroimaging studies have uncovered structural and functional alterations in the cingulate cortex in individuals with autism spectrum disorders (ASD). Such abnormalities may underlie neurochemical imbalance. In order to characterize the neurochemical profile, the current study examined the concentration of brain metabolites in dorsal ACC (dACC) and posterior cingulate cortex (PCC) in high-functioning adults with ASD. Twenty high-functioning adults with ASD and 20 age-and-IQ-matched typically developing (TD) peers participated in this Proton magnetic resonance spectroscopy (1H-MRS) study. LCModel was used in analyzing the spectra to measure the levels of N-Acetyl aspartate (NAA), choline (Cho), creatine (Cr), and glutamate/glutamine (Glx) in dACC and PCC. Groups were compared using means for the ratio of each metabolite to their respective Cr levels as well as on absolute internal-water-referenced measures of each metabolite. There was a significant increase in Cho in PCC for ASD adults, with a marginal increase in dACC. A reduction in NAA/Cr in dACC was found in ASD participants, compared to their TD peers. No significant differences in Glx/Cr or Cho/Cr were found in dACC. There were no statistically significant group differences in the absolute concentration of NAA, Cr, Glx, or NAA/Cr, Cho/Cr, and Glx/Cr in the PCC. Differences in the metabolic properties of dACC compared to PCC were also found. Results of this study provide evidence for possible cellular and metabolic differences in the dACC and PCC in adults with ASD. This may suggest neuronal dysfunction in these regions and may contribute to the neuropathology of ASD. Autism Res 2016, 9: 643–657. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1562 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] Biochemistry of the cingulate cortex in autism: An MR spectroscopy study [Texte imprimé et/ou numérique] / Lauren E. LIBERO, Auteur ; Meredith A. REID, Auteur ; David M. WHITE, Auteur ; Nouha SALIBI, Auteur ; Adrienne C. LAHTI, Auteur ; Rajesh K. KANA, Auteur . - p.643-657. Langues : Anglais (eng) in Autism Research > 9-6 (June 2016) . - p.643-657 Mots-clés : autism spectrum disorder  cingulate cortex  1H-MRS  MR spectroscopy  neurochemicals  biochemistry Index. décimale : PER Périodiques Résumé : Neuroimaging studies have uncovered structural and functional alterations in the cingulate cortex in individuals with autism spectrum disorders (ASD). Such abnormalities may underlie neurochemical imbalance. In order to characterize the neurochemical profile, the current study examined the concentration of brain metabolites in dorsal ACC (dACC) and posterior cingulate cortex (PCC) in high-functioning adults with ASD. Twenty high-functioning adults with ASD and 20 age-and-IQ-matched typically developing (TD) peers participated in this Proton magnetic resonance spectroscopy (1H-MRS) study. LCModel was used in analyzing the spectra to measure the levels of N-Acetyl aspartate (NAA), choline (Cho), creatine (Cr), and glutamate/glutamine (Glx) in dACC and PCC. Groups were compared using means for the ratio of each metabolite to their respective Cr levels as well as on absolute internal-water-referenced measures of each metabolite. There was a significant increase in Cho in PCC for ASD adults, with a marginal increase in dACC. A reduction in NAA/Cr in dACC was found in ASD participants, compared to their TD peers. No significant differences in Glx/Cr or Cho/Cr were found in dACC. There were no statistically significant group differences in the absolute concentration of NAA, Cr, Glx, or NAA/Cr, Cho/Cr, and Glx/Cr in the PCC. Differences in the metabolic properties of dACC compared to PCC were also found. Results of this study provide evidence for possible cellular and metabolic differences in the dACC and PCC in adults with ASD. This may suggest neuronal dysfunction in these regions and may contribute to the neuropathology of ASD. Autism Res 2016, 9: 643–657. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1562 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

Macrocephaly and megalencephaly in autism spectrum disorder / Lauren E. LIBERO

Public ISBD in Autism imaging and Devices / Manuel F. CASANOVA Titre : Macrocephaly and megalencephaly in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana D. LI, Auteur ; David G. AMARAL, Auteur Importance : p.171-188 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 in Autism imaging and Devices / Manuel F. CASANOVA Macrocephaly and megalencephaly in autism spectrum disorder [Texte imprimé et/ou numérique] / Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana D. LI, Auteur ; David G. AMARAL, Auteur . - [s.d.] . - p.171-188. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382

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Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder / Lauren E. LIBERO in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1169-1182 Titre : Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana D. LI, Auteur ; Emilio FERRER, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1169-1182 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  MRI  longitudinal  brain development  disproportionate megalencephaly Index. décimale : PER Périodiques Résumé : A recurring finding in autism spectrum disorder research is that head and brain growth is disproportionate to body growth in early childhood. Nordahl et al. (2011) demonstrated that this occurs in approximately 15% of boys with autism. While the literature suggests that brain growth normalizes at older ages, this has never been evaluated in a longitudinal study. The current study evaluated head circumference and total cerebral volume in 129 male children with autism and 49 age-matched, typically developing controls. We determined whether 3-year-old boys with brain size disproportionate to height (which we call disproportionate megalencephaly) demonstrated an abnormal trajectory of head growth from birth and whether they maintained an enlarged brain at 5 years of age. Findings were based on longitudinal, structural MRI data collected around 3, 4, and 5 years of age and head circumference data from medical records. At 3 years of age, 19 boys with autism had enlarged brains while 110 had brain sizes in the normal range. Boys with disproportionate megalencephaly had greater total cerebral, gray matter, and white matter volumes from 3–5 years compared to boys with autism and normal sized brains and typically developing boys, but no differences in body size. While head circumference did not differ between groups at birth, it was significantly greater in the disproportionate megalencephaly group by around 2 years. These data suggest that there is a subgroup of boys with autism who have brains disproportionate to body size and that this continues until at least 5 years of age. En ligne : http://dx.doi.org/10.1002/aur.1643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder [Texte imprimé et/ou numérique] / Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana D. LI, Auteur ; Emilio FERRER, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur . - p.1169-1182. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1169-1182 Mots-clés : autism spectrum disorder  MRI  longitudinal  brain development  disproportionate megalencephaly Index. décimale : PER Périodiques Résumé : A recurring finding in autism spectrum disorder research is that head and brain growth is disproportionate to body growth in early childhood. Nordahl et al. (2011) demonstrated that this occurs in approximately 15% of boys with autism. While the literature suggests that brain growth normalizes at older ages, this has never been evaluated in a longitudinal study. The current study evaluated head circumference and total cerebral volume in 129 male children with autism and 49 age-matched, typically developing controls. We determined whether 3-year-old boys with brain size disproportionate to height (which we call disproportionate megalencephaly) demonstrated an abnormal trajectory of head growth from birth and whether they maintained an enlarged brain at 5 years of age. Findings were based on longitudinal, structural MRI data collected around 3, 4, and 5 years of age and head circumference data from medical records. At 3 years of age, 19 boys with autism had enlarged brains while 110 had brain sizes in the normal range. Boys with disproportionate megalencephaly had greater total cerebral, gray matter, and white matter volumes from 3–5 years compared to boys with autism and normal sized brains and typically developing boys, but no differences in body size. While head circumference did not differ between groups at birth, it was significantly greater in the disproportionate megalencephaly group by around 2 years. These data suggest that there is a subgroup of boys with autism who have brains disproportionate to body size and that this continues until at least 5 years of age. En ligne : http://dx.doi.org/10.1002/aur.1643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

The role of mirroring and mentalizing networks in mediating action intentions in autism / Lauren E. LIBERO in Molecular Autism, (October 2014)  

Public ISBD [article]  inMolecular Autism > (October 2014) . - p.1-13 Titre : The role of mirroring and mentalizing networks in mediating action intentions in autism Type de document : Texte imprimé et/ou numérique Auteurs : Lauren E. LIBERO, Auteur ; Jose O. MAXIMO, Auteur ; Hrishikesh D. DESHPANDE, Auteur ; Laura G. KLINGER, Auteur ; Mark R. KLINGER, Auteur ; Rajesh K. KANA, Auteur Article en page(s) : p.1-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The ability to interpret agents’ intent from their actions is a vital skill in successful social interaction. However, individuals with autism spectrum disorders (ASD) have been found to have difficulty in attributing intentions to others. The present study investigated the neural mechanisms of inferring intentions from actions in individuals with ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-5-50 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] The role of mirroring and mentalizing networks in mediating action intentions in autism [Texte imprimé et/ou numérique] / Lauren E. LIBERO, Auteur ; Jose O. MAXIMO, Auteur ; Hrishikesh D. DESHPANDE, Auteur ; Laura G. KLINGER, Auteur ; Mark R. KLINGER, Auteur ; Rajesh K. KANA, Auteur . - p.1-13. Langues : Anglais (eng) in Molecular Autism > (October 2014) . - p.1-13 Index. décimale : PER Périodiques Résumé : The ability to interpret agents’ intent from their actions is a vital skill in successful social interaction. However, individuals with autism spectrum disorders (ASD) have been found to have difficulty in attributing intentions to others. The present study investigated the neural mechanisms of inferring intentions from actions in individuals with ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-5-50 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

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