Developmental changes in attention to social information from childhood to adolescence in autism spectrum disorders: a comparative study / Toru FUJIOKA in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 24 p. Titre : Developmental changes in attention to social information from childhood to adolescence in autism spectrum disorders: a comparative study Type de document : texte imprimé Auteurs : Toru FUJIOKA, Auteur ; Kenji J. TSUCHIYA, Auteur ; Manabu SAITO, Auteur ; Yoshiyuki HIRANO, Auteur ; Muneaki MATSUO, Auteur ; Mitsuru KIKUCHI, Auteur ; Yoshihiro MAEGAKI, Auteur ; Damee CHOI, Auteur ; Sumi KATO, Auteur ; Tokiko YOSHIDA, Auteur ; Yuko YOSHIMURA, Auteur ; Sawako OOBA, Auteur ; Yoshifumi MIZUNO, Auteur ; Shinichiro TAKIGUCHI, Auteur ; Hideo MATSUZAKI, Auteur ; Akemi TOMODA, Auteur ; Katsuyuki SHUDO, Auteur ; Masaru NINOMIYA, Auteur ; Taiichi KATAYAMA, Auteur ; Hirotaka KOSAKA, Auteur Article en page(s) : 24 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Developmental change  Eye-tracking  Social information Index. décimale : PER Périodiques Résumé : BACKGROUND: Elucidating developmental changes in the symptoms of autism spectrum disorder (ASD) is important to support individuals with ASD. However, no report has clarified the developmental changes in attention to social information for a broad age range. The aim of this study was to investigate the developmental changes in attention to social information from early childhood to adolescence in individuals with ASD and typically developed (TD) children. METHODS: We recruited children with ASD (n = 83) and TD participants (n = 307) between 2 and 18 years of age. Using the all-in-one-eye-tracking system, Gazefinder, we measured the percentage fixation time allocated to areas of interest (AoIs) depicted in movies (the eyes and mouth in movies of a human face with/without mouth motion, upright and inverted biological motion in movies showing these stimuli simultaneously, people and geometry in preference paradigm movies showing these stimuli simultaneously, and objects with/without finger-pointing in a movie showing a woman pointing toward an object). We conducted a three-way analysis of variance, 2 (diagnosis: ASD and TD) by 2 (sex: male and female) by 3 (age group: 0-5, 6-11, and 12-18 years) and locally weighted the scatterplot smoothing (LOESS) regression curve on each AoI. RESULTS: In the face stimuli, the percentage fixation time to the eye region for the TD group increased with age, whereas the one for the ASD group did not. In the ASD group, the LOESS curves of the gaze ratios at the eye region increased up to approximately 10 years of age and thereafter tended to decrease. For the percentage fixation time to the people region in the preference paradigm, the ASD group gazed more briefly at people than did the TD group. LIMITATIONS: It is possible that due to the cross-sectional design, the degree of severity and of social interest might have differed according to the subjects' age. CONCLUSIONS: There may be qualitative differences in abnormal eye contact in ASD between individuals in early childhood and those older than 10 years. En ligne : http://dx.doi.org/10.1186/s13229-020-00321-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Developmental changes in attention to social information from childhood to adolescence in autism spectrum disorders: a comparative study [texte imprimé] / Toru FUJIOKA, Auteur ; Kenji J. TSUCHIYA, Auteur ; Manabu SAITO, Auteur ; Yoshiyuki HIRANO, Auteur ; Muneaki MATSUO, Auteur ; Mitsuru KIKUCHI, Auteur ; Yoshihiro MAEGAKI, Auteur ; Damee CHOI, Auteur ; Sumi KATO, Auteur ; Tokiko YOSHIDA, Auteur ; Yuko YOSHIMURA, Auteur ; Sawako OOBA, Auteur ; Yoshifumi MIZUNO, Auteur ; Shinichiro TAKIGUCHI, Auteur ; Hideo MATSUZAKI, Auteur ; Akemi TOMODA, Auteur ; Katsuyuki SHUDO, Auteur ; Masaru NINOMIYA, Auteur ; Taiichi KATAYAMA, Auteur ; Hirotaka KOSAKA, Auteur . - 24 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 24 p. Mots-clés : Autism spectrum disorder  Developmental change  Eye-tracking  Social information Index. décimale : PER Périodiques Résumé : BACKGROUND: Elucidating developmental changes in the symptoms of autism spectrum disorder (ASD) is important to support individuals with ASD. However, no report has clarified the developmental changes in attention to social information for a broad age range. The aim of this study was to investigate the developmental changes in attention to social information from early childhood to adolescence in individuals with ASD and typically developed (TD) children. METHODS: We recruited children with ASD (n = 83) and TD participants (n = 307) between 2 and 18 years of age. Using the all-in-one-eye-tracking system, Gazefinder, we measured the percentage fixation time allocated to areas of interest (AoIs) depicted in movies (the eyes and mouth in movies of a human face with/without mouth motion, upright and inverted biological motion in movies showing these stimuli simultaneously, people and geometry in preference paradigm movies showing these stimuli simultaneously, and objects with/without finger-pointing in a movie showing a woman pointing toward an object). We conducted a three-way analysis of variance, 2 (diagnosis: ASD and TD) by 2 (sex: male and female) by 3 (age group: 0-5, 6-11, and 12-18 years) and locally weighted the scatterplot smoothing (LOESS) regression curve on each AoI. RESULTS: In the face stimuli, the percentage fixation time to the eye region for the TD group increased with age, whereas the one for the ASD group did not. In the ASD group, the LOESS curves of the gaze ratios at the eye region increased up to approximately 10 years of age and thereafter tended to decrease. For the percentage fixation time to the people region in the preference paradigm, the ASD group gazed more briefly at people than did the TD group. LIMITATIONS: It is possible that due to the cross-sectional design, the degree of severity and of social interest might have differed according to the subjects' age. CONCLUSIONS: There may be qualitative differences in abnormal eye contact in ASD between individuals in early childhood and those older than 10 years. En ligne : http://dx.doi.org/10.1186/s13229-020-00321-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults / Toru FUJIOKA in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 19p. Titre : Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults Type de document : texte imprimé Auteurs : Toru FUJIOKA, Auteur ; Keisuke INOHARA, Auteur ; Yuko OKAMOTO, Auteur ; Yasuhiro MASUYA, Auteur ; Makoto ISHITOBI, Auteur ; Daisuke N. SAITO, Auteur ; Matthias JUNG, Auteur ; Sumiyoshi ARAI, Auteur ; Yukiko MATSUMURA, Auteur ; Takashi X. FUJISAWA, Auteur ; Kosuke NARITA, Auteur ; Kota SUZUKI, Auteur ; Kenji J. TSUCHIYA, Auteur ; Norio MORI, Auteur ; Taiichi KATAYAMA, Auteur ; Makoto SATO, Auteur ; Toshio MUNESUE, Auteur ; Hidehiko OKAZAWA, Auteur ; Akemi TOMODA, Auteur ; Yuji WADA, Auteur ; Hirotaka KOSAKA, Auteur Article en page(s) : 19p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Area Under Curve  Autism Spectrum Disorder/diagnosis/physiopathology  Case-Control Studies  Discriminant Analysis  Fixation, Ocular/physiology  Humans  Male  Ocular Physiological Phenomena  Photic Stimulation  Psychometrics  ROC Curve  Social Behavior  Time Factors  Autism spectrum disorder  Biological motion  Eye-tracking  Face  Fixation  Gaze abnormality  Geometry Index. décimale : PER Périodiques Résumé : BACKGROUND: Gaze abnormality is a diagnostic criterion for autism spectrum disorder (ASD). However, few easy-to-use clinical tools exist to evaluate the unique eye-gaze patterns of ASD. Recently, we developed Gazefinder, an all-in-one eye-tracking system for early detection of ASD in toddlers. Because abnormal gaze patterns have been documented in various ASD age groups, we predicted that Gazefinder might also detect gaze abnormality in adolescents and adults. In this study, we tested whether Gazefinder could identify unique gaze patterns in adolescents and adults with ASD. METHODS: We measured the percentage of eye fixation time allocated to particular objects depicted in movies (i.e., eyes and mouth in human face movies, upright and inverted biological motion in movies that presented these stimuli simultaneously, and people and geometry in movies that presented these stimuli simultaneously) by male adolescents and adults with ASD (N = 26) and age-matched males with typical development (TD; N = 35). We compared these percentages between the two groups (ASD and TD) and with scores on the social responsiveness scale (SRS). Further, we conducted discriminant analyses to determine if fixation times allocated to particular objects could be used to discriminate between individuals with and without ASD. RESULTS: Compared with the TD group, the ASD group showed significantly less fixation time at locations of salient social information (i.e., eyes in the movie of human faces without lip movement and people in the movie of people and geometry), while there were no significant groupwise differences in the responses to movies of human faces with lip movement or biological motion. In a within-group correlation analysis, a few of the fixation-time items correlated with SRS, although most of them did not. No items significantly correlated with SRS in both ASD and TD groups. The percentage fixation times to eyes and people, which exhibited large effect sizes for the group difference, could differentiate ASD and TD with a sensitivity of 81.0% and a specificity of 80.0%. CONCLUSIONS: These findings suggest that Gazefinder is potentially a valuable and easy-to-use tool for objectively measuring unique gaze patterns and discriminating between ASD and TD in male adolescents and adults. En ligne : http://dx.doi.org/10.1186/s13229-016-0083-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults [texte imprimé] / Toru FUJIOKA, Auteur ; Keisuke INOHARA, Auteur ; Yuko OKAMOTO, Auteur ; Yasuhiro MASUYA, Auteur ; Makoto ISHITOBI, Auteur ; Daisuke N. SAITO, Auteur ; Matthias JUNG, Auteur ; Sumiyoshi ARAI, Auteur ; Yukiko MATSUMURA, Auteur ; Takashi X. FUJISAWA, Auteur ; Kosuke NARITA, Auteur ; Kota SUZUKI, Auteur ; Kenji J. TSUCHIYA, Auteur ; Norio MORI, Auteur ; Taiichi KATAYAMA, Auteur ; Makoto SATO, Auteur ; Toshio MUNESUE, Auteur ; Hidehiko OKAZAWA, Auteur ; Akemi TOMODA, Auteur ; Yuji WADA, Auteur ; Hirotaka KOSAKA, Auteur . - 19p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 19p. Mots-clés : Adolescent  Adult  Area Under Curve  Autism Spectrum Disorder/diagnosis/physiopathology  Case-Control Studies  Discriminant Analysis  Fixation, Ocular/physiology  Humans  Male  Ocular Physiological Phenomena  Photic Stimulation  Psychometrics  ROC Curve  Social Behavior  Time Factors  Autism spectrum disorder  Biological motion  Eye-tracking  Face  Fixation  Gaze abnormality  Geometry Index. décimale : PER Périodiques Résumé : BACKGROUND: Gaze abnormality is a diagnostic criterion for autism spectrum disorder (ASD). However, few easy-to-use clinical tools exist to evaluate the unique eye-gaze patterns of ASD. Recently, we developed Gazefinder, an all-in-one eye-tracking system for early detection of ASD in toddlers. Because abnormal gaze patterns have been documented in various ASD age groups, we predicted that Gazefinder might also detect gaze abnormality in adolescents and adults. In this study, we tested whether Gazefinder could identify unique gaze patterns in adolescents and adults with ASD. METHODS: We measured the percentage of eye fixation time allocated to particular objects depicted in movies (i.e., eyes and mouth in human face movies, upright and inverted biological motion in movies that presented these stimuli simultaneously, and people and geometry in movies that presented these stimuli simultaneously) by male adolescents and adults with ASD (N = 26) and age-matched males with typical development (TD; N = 35). We compared these percentages between the two groups (ASD and TD) and with scores on the social responsiveness scale (SRS). Further, we conducted discriminant analyses to determine if fixation times allocated to particular objects could be used to discriminate between individuals with and without ASD. RESULTS: Compared with the TD group, the ASD group showed significantly less fixation time at locations of salient social information (i.e., eyes in the movie of human faces without lip movement and people in the movie of people and geometry), while there were no significant groupwise differences in the responses to movies of human faces with lip movement or biological motion. In a within-group correlation analysis, a few of the fixation-time items correlated with SRS, although most of them did not. No items significantly correlated with SRS in both ASD and TD groups. The percentage fixation times to eyes and people, which exhibited large effect sizes for the group difference, could differentiate ASD and TD with a sensitivity of 81.0% and a specificity of 80.0%. CONCLUSIONS: These findings suggest that Gazefinder is potentially a valuable and easy-to-use tool for objectively measuring unique gaze patterns and discriminating between ASD and TD in male adolescents and adults. En ligne : http://dx.doi.org/10.1186/s13229-016-0083-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Sex-different abnormalities in the right second to fourth digit ratio in Japanese individuals with autism spectrum disorders / Yasuhiro MASUYA in Molecular Autism, (June 2015)  

Public ISBD [article]  inMolecular Autism > (June 2015) . - p.1-10 Titre : Sex-different abnormalities in the right second to fourth digit ratio in Japanese individuals with autism spectrum disorders Type de document : texte imprimé Auteurs : Yasuhiro MASUYA, Auteur ; Yuko OKAMOTO, Auteur ; Keisuke INOHARA, Auteur ; Yukiko MATSUMURA, Auteur ; Toru FUJIOKA, Auteur ; Yuji WADA, Auteur ; Hirotaka KOSAKA, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The prevalence of autism spectrum disorders (ASDs) is higher in men than in women. The extreme male brain theory proposes that excessive prenatal testosterone activity could be a risk factor for ASDs. However, it is unclear whether prenatal sex hormone activity is a risk factor for women. The ratio of the length of the second to fourth digits (2D:4D) is considered to be a biomarker of the prenatal ratio of testosterone to estrogen. Therefore, this study compared the 2D:4D ratios of women with and without ASDs to determine if prenatal sex hormone activity could be a risk factor for ASDs in women. En ligne : http://dx.doi.org/10.1186/s13229-015-0028-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Sex-different abnormalities in the right second to fourth digit ratio in Japanese individuals with autism spectrum disorders [texte imprimé] / Yasuhiro MASUYA, Auteur ; Yuko OKAMOTO, Auteur ; Keisuke INOHARA, Auteur ; Yukiko MATSUMURA, Auteur ; Toru FUJIOKA, Auteur ; Yuji WADA, Auteur ; Hirotaka KOSAKA, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (June 2015) . - p.1-10 Index. décimale : PER Périodiques Résumé : The prevalence of autism spectrum disorders (ASDs) is higher in men than in women. The extreme male brain theory proposes that excessive prenatal testosterone activity could be a risk factor for ASDs. However, it is unclear whether prenatal sex hormone activity is a risk factor for women. The ratio of the length of the second to fourth digits (2D:4D) is considered to be a biomarker of the prenatal ratio of testosterone to estrogen. Therefore, this study compared the 2D:4D ratios of women with and without ASDs to determine if prenatal sex hormone activity could be a risk factor for ASDs in women. En ligne : http://dx.doi.org/10.1186/s13229-015-0028-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

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