Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome / V. PETRUO in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.953-962 Titre : Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome Type de document : Texte imprimé et/ou numérique Auteurs : V. PETRUO, Auteur ; B. BODMER, Auteur ; V. C. BRANDT, Auteur ; L. BAUMUNG, Auteur ; V. ROESSNER, Auteur ; A. MUNCHAU, Auteur ; Christian BESTE, Auteur Article en page(s) : p.953-962 Langues : Anglais (eng) Mots-clés : Tourette syndrome  cognitive control  event related potential  neurophysiology  response inhibition, inferior parietal cortex, theory of event coding Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette Syndrome (GTS) is a multifaceted neuropsychiatric developmental disorder with onset in childhood or adolescence and frequent remissions in early adulthood. A rather new emerging concept of this syndrome suggests that it is a disorder of purposeful actions, in which sensory processes and their relation to motor responses (actions) play a particularly important role. Thus, this syndrome might be conceived as a condition of altered 'perception-action binding'. In the current study, we test this novel concept in the context of inhibitory control. METHODS: We examined N = 35 adolescent GTS patients and N = 39 healthy controls in a Go/Nogo-task manipulating the complexity of sensory information triggering identical actions; i.e. to inhibit a motor response. This was combined with event-related potential recordings, EEG data decomposition and source localization. RESULTS: GTS patients showed worse performance compared to controls and larger performance differences when inhibitory control had to be exerted using unimodal visual compared to bimodal auditory-visual stimuli. This suggests increased binding between bimodal stimuli and responses leading to increased costs of switching between responses instructed by bimodal and those instructed by unimodal stimuli. The neurophysiological data showed that this was related to mechanisms mediating between stimulus evaluation and response selection; i.e. perception-action binding processes in the right inferior parietal cortex (BA40). CONCLUSIONS: Stimulus-action inhibition binding is stronger in GTS patients than healthy controls and affects inhibitory control corroborating the concept suggesting that GTS might be a condition of altered perception-action integration (binding); i.e. a disorder of purposeful actions. En ligne : http://dx.doi.org/10.1111/jcpp.12938 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome [Texte imprimé et/ou numérique] / V. PETRUO, Auteur ; B. BODMER, Auteur ; V. C. BRANDT, Auteur ; L. BAUMUNG, Auteur ; V. ROESSNER, Auteur ; A. MUNCHAU, Auteur ; Christian BESTE, Auteur . - p.953-962. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.953-962 Mots-clés : Tourette syndrome  cognitive control  event related potential  neurophysiology  response inhibition, inferior parietal cortex, theory of event coding Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette Syndrome (GTS) is a multifaceted neuropsychiatric developmental disorder with onset in childhood or adolescence and frequent remissions in early adulthood. A rather new emerging concept of this syndrome suggests that it is a disorder of purposeful actions, in which sensory processes and their relation to motor responses (actions) play a particularly important role. Thus, this syndrome might be conceived as a condition of altered 'perception-action binding'. In the current study, we test this novel concept in the context of inhibitory control. METHODS: We examined N = 35 adolescent GTS patients and N = 39 healthy controls in a Go/Nogo-task manipulating the complexity of sensory information triggering identical actions; i.e. to inhibit a motor response. This was combined with event-related potential recordings, EEG data decomposition and source localization. RESULTS: GTS patients showed worse performance compared to controls and larger performance differences when inhibitory control had to be exerted using unimodal visual compared to bimodal auditory-visual stimuli. This suggests increased binding between bimodal stimuli and responses leading to increased costs of switching between responses instructed by bimodal and those instructed by unimodal stimuli. The neurophysiological data showed that this was related to mechanisms mediating between stimulus evaluation and response selection; i.e. perception-action binding processes in the right inferior parietal cortex (BA40). CONCLUSIONS: Stimulus-action inhibition binding is stronger in GTS patients than healthy controls and affects inhibitory control corroborating the concept suggesting that GTS might be a condition of altered perception-action integration (binding); i.e. a disorder of purposeful actions. En ligne : http://dx.doi.org/10.1111/jcpp.12938 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Editorial Perspective: How to optimise frequency band neurofeedback for ADHD / Annet BLUSCHKE in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.457-461 Titre : Editorial Perspective: How to optimise frequency band neurofeedback for ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Annet BLUSCHKE, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur Article en page(s) : p.457-461 Langues : Anglais (eng) Mots-clés : ADHD  cognitive deficits  neurofeedback  treatment optimisation Index. décimale : PER Périodiques Résumé : Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent paediatric neuropsychiatric disorders and is characterised by hyperactivity, inattention and increased impulsivity. Children with ADHD are often also characterised by deficits in a variety of cognitive domains, including problems in working memory, a generally slower and more variable style of information processing and deficits in temporal processing, inhibitory functions and delay processing. Overarching executive functions like information updating, response inhibition and mental set shifting are also impaired in many, but not all, children with ADHD, demonstrating the neuropsychological heterogeneity characterising this disorder. Deficits in executive functions can persist into adulthood and have a substantial negative impact on everyday life. A variety of approaches are commonly considered for the treatment of ADHD (including pharmacological interventions, patient-centred cognitive-behavioural therapy approaches and specific teacher/parent training programmes). More recently, adding to this multimodal treatment approach, neurofeedback has grown in popularity as an intervention option for patients with ADHD. This article considers this intervention approach and the opportunities for optimising treatment for executive control dysfunctions in ADHD using theta/beta neurofeedback. En ligne : http://dx.doi.org/10.1111/jcpp.12521 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 [article] Editorial Perspective: How to optimise frequency band neurofeedback for ADHD [Texte imprimé et/ou numérique] / Annet BLUSCHKE, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur . - p.457-461. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.457-461 Mots-clés : ADHD  cognitive deficits  neurofeedback  treatment optimisation Index. décimale : PER Périodiques Résumé : Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent paediatric neuropsychiatric disorders and is characterised by hyperactivity, inattention and increased impulsivity. Children with ADHD are often also characterised by deficits in a variety of cognitive domains, including problems in working memory, a generally slower and more variable style of information processing and deficits in temporal processing, inhibitory functions and delay processing. Overarching executive functions like information updating, response inhibition and mental set shifting are also impaired in many, but not all, children with ADHD, demonstrating the neuropsychological heterogeneity characterising this disorder. Deficits in executive functions can persist into adulthood and have a substantial negative impact on everyday life. A variety of approaches are commonly considered for the treatment of ADHD (including pharmacological interventions, patient-centred cognitive-behavioural therapy approaches and specific teacher/parent training programmes). More recently, adding to this multimodal treatment approach, neurofeedback has grown in popularity as an intervention option for patients with ADHD. This article considers this intervention approach and the opportunities for optimising treatment for executive control dysfunctions in ADHD using theta/beta neurofeedback. En ligne : http://dx.doi.org/10.1111/jcpp.12521 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285

Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization / Nicole WOLFF in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.939-949 Titre : Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization Type de document : Texte imprimé et/ou numérique Auteurs : Nicole WOLFF, Auteur ; Judith BUSE, Auteur ; Jadwiga TOST, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur Article en page(s) : p.939-949 Langues : Anglais (eng) Mots-clés : Obsessive compulsive disorder  perception  neurophysiology  event-related potential Index. décimale : PER Périodiques Résumé : Background Despite cognitive inflexibility is trait like in obsessive compulsive disorder (OCD) patients and underlies clinical symptomatology, it is elusive at what stage of information processing deficits, leading to cognitive inflexibility, emerges. We hypothesize that inhibitory control mechanisms during early stimulus categorization and integration into a knowledge system underlie these deficits. Methods We examined N = 25 adolescent OCD patients and matched healthy controls (HC) in a paradigm manipulating the importance of the knowledge system to perform task switching. This was done using a paradigm in which task switches were signaled either by visual stimuli or by working memory processes. This was combined with event-related potential recordings and source localization. Results Obsessive compulsive disorder patients showed increased switch costs in the memory as compared with the cue-based block, while HC showed similar switch costs in both blocks. At the neurophysiological level, these changes in OCD were not reflected by the N2 and P3 reflecting response-associated processes but by the P1 reflecting inhibitory control during sensory categorization processes. Activation differences in the right inferior frontal gyrus and superior temporal gyrus are associated with the P1 effect. Conclusions Cognitive flexibility in adolescent OCD patients is strongly modulated by working memory load. Contrary to common sense, not response-associated processes, but inhibitory control mechanisms during early stimulus categorization processes are likely to underlie cognitive inflexibility in OCD. These processes are associated with right inferior frontal and superior temporal gyrus mechanisms. En ligne : http://dx.doi.org/10.1111/jcpp.12733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization [Texte imprimé et/ou numérique] / Nicole WOLFF, Auteur ; Judith BUSE, Auteur ; Jadwiga TOST, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur . - p.939-949. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.939-949 Mots-clés : Obsessive compulsive disorder  perception  neurophysiology  event-related potential Index. décimale : PER Périodiques Résumé : Background Despite cognitive inflexibility is trait like in obsessive compulsive disorder (OCD) patients and underlies clinical symptomatology, it is elusive at what stage of information processing deficits, leading to cognitive inflexibility, emerges. We hypothesize that inhibitory control mechanisms during early stimulus categorization and integration into a knowledge system underlie these deficits. Methods We examined N = 25 adolescent OCD patients and matched healthy controls (HC) in a paradigm manipulating the importance of the knowledge system to perform task switching. This was done using a paradigm in which task switches were signaled either by visual stimuli or by working memory processes. This was combined with event-related potential recordings and source localization. Results Obsessive compulsive disorder patients showed increased switch costs in the memory as compared with the cue-based block, while HC showed similar switch costs in both blocks. At the neurophysiological level, these changes in OCD were not reflected by the N2 and P3 reflecting response-associated processes but by the P1 reflecting inhibitory control during sensory categorization processes. Activation differences in the right inferior frontal gyrus and superior temporal gyrus are associated with the P1 effect. Conclusions Cognitive flexibility in adolescent OCD patients is strongly modulated by working memory load. Contrary to common sense, not response-associated processes, but inhibitory control mechanisms during early stimulus categorization processes are likely to underlie cognitive inflexibility in OCD. These processes are associated with right inferior frontal and superior temporal gyrus mechanisms. En ligne : http://dx.doi.org/10.1111/jcpp.12733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

When repetitive mental sets increase cognitive flexibility in adolescent obsessive–compulsive disorder / Nicole WOLFF in Journal of Child Psychology and Psychiatry, 59-9 (September 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.1024-1032 Titre : When repetitive mental sets increase cognitive flexibility in adolescent obsessive–compulsive disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nicole WOLFF, Auteur ; Franziska GILLER, Auteur ; Judith BUSE, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur Article en page(s) : p.1024-1032 Langues : Anglais (eng) Mots-clés : Obsessive–compulsive disorder  cognitive flexibility  neurophysiology  event-related potential Index. décimale : PER Périodiques Résumé : Background A major facet of obsessive?compulsive disorder (OCD) is cognitive inflexibility. However, sometimes, cognitive flexibility can be needed to reuse recently abandoned mental sets. Therefore, cognitive flexibility can in certain cases be useful to reinstate some form of rigid, repetitive behavior characterizing OCD. We test the counterintuitive hypothesis that under such circumstances, cognitive flexibility is better in OCD patients than controls. Methods We examined N = 20 adolescent OCD patients and N = 22 controls in a backward inhibition (BI) paradigm. This was combined with event-related potential (ERP) recordings and source localization. The BI effect describes the cost of overcoming the inhibition of a recently abandoned mental set that is relevant again. Therefore, a strong BI effect is disadvantageous for cognitive flexibility. Results Compared to controls, OCD patients revealed a smaller backward inhibition effect. The EEG data revealed larger P1 amplitudes in backward inhibition trials in the OCD group, which was due to activation differences in the inferior frontal gyrus (BA47). The severity of clinical symptoms predicted these neurophysiological modulations. The power of the observed effects was about 95%. Conclusions The study shows that cognitive flexibility can be better in OCD than controls. This may be the case in situations where superior abilities in the reactivation of repeating mental sets and difficulties to process new ones coincide. This may be accomplished by intensified inhibitory control mechanisms. The results challenge the view on OCD, since OCD is not generally associated with cognitive inflexibility. En ligne : https://doi.org/10.1111/jcpp.12901 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] When repetitive mental sets increase cognitive flexibility in adolescent obsessive–compulsive disorder [Texte imprimé et/ou numérique] / Nicole WOLFF, Auteur ; Franziska GILLER, Auteur ; Judith BUSE, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur . - p.1024-1032. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.1024-1032 Mots-clés : Obsessive–compulsive disorder  cognitive flexibility  neurophysiology  event-related potential Index. décimale : PER Périodiques Résumé : Background A major facet of obsessive?compulsive disorder (OCD) is cognitive inflexibility. However, sometimes, cognitive flexibility can be needed to reuse recently abandoned mental sets. Therefore, cognitive flexibility can in certain cases be useful to reinstate some form of rigid, repetitive behavior characterizing OCD. We test the counterintuitive hypothesis that under such circumstances, cognitive flexibility is better in OCD patients than controls. Methods We examined N = 20 adolescent OCD patients and N = 22 controls in a backward inhibition (BI) paradigm. This was combined with event-related potential (ERP) recordings and source localization. The BI effect describes the cost of overcoming the inhibition of a recently abandoned mental set that is relevant again. Therefore, a strong BI effect is disadvantageous for cognitive flexibility. Results Compared to controls, OCD patients revealed a smaller backward inhibition effect. The EEG data revealed larger P1 amplitudes in backward inhibition trials in the OCD group, which was due to activation differences in the inferior frontal gyrus (BA47). The severity of clinical symptoms predicted these neurophysiological modulations. The power of the observed effects was about 95%. Conclusions The study shows that cognitive flexibility can be better in OCD than controls. This may be the case in situations where superior abilities in the reactivation of repeating mental sets and difficulties to process new ones coincide. This may be accomplished by intensified inhibitory control mechanisms. The results challenge the view on OCD, since OCD is not generally associated with cognitive inflexibility. En ligne : https://doi.org/10.1111/jcpp.12901 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

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