7 recherche sur le mot-clé 'Obsessive compulsive disorder'

Association of Autism Spectrum Disorder with Obsessive-Compulsive and Attention-Deficit/Hyperactivity Traits and Response Inhibition in a Community Sample / Ellen VAN DER PLAS in Journal of Autism and Developmental Disorders, 46-9 (September 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.3115-3125 Titre : Association of Autism Spectrum Disorder with Obsessive-Compulsive and Attention-Deficit/Hyperactivity Traits and Response Inhibition in a Community Sample Type de document : Texte imprimé et/ou numérique Auteurs : Ellen VAN DER PLAS, Auteur ; Annie DUPUIS, Auteur ; Paul ARNOLD, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur Article en page(s) : p.3115-3125 Langues : Anglais (eng) Mots-clés : Autism  Attention/deficits hyperactivity disorder  Obsessive compulsive disorder  Familial  Traits  Community sample Index. décimale : PER Périodiques Résumé : We examined co-occurrence of autism spectrum disorder (ASD) with (traits of) attention-deficit/hyperactivity (ADHD), obsessive-compulsive (OCD) and inhibition deficits in a community sample (n = 16,676) and tested whether having a sibling with ASD manifested in increased features of ADHD, OCD or inhibition deficits. Individuals with ASD had increased ADHD and OCD traits compared with individuals without ASD. Individuals with a sibling with ASD exhibited more ADHD traits than did individuals whose sibling did not have ASD. The “sibling effect” on manifestation of ADHD traits was observed in individuals with and without ASD. Having a sibling with ASD did not affect OCD traits. Inhibition was impaired in individuals with ASD who had a sibling with ASD only. En ligne : http://dx.doi.org/10.1007/s10803-016-2853-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 [article] Association of Autism Spectrum Disorder with Obsessive-Compulsive and Attention-Deficit/Hyperactivity Traits and Response Inhibition in a Community Sample [Texte imprimé et/ou numérique] / Ellen VAN DER PLAS, Auteur ; Annie DUPUIS, Auteur ; Paul ARNOLD, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur . - p.3115-3125. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.3115-3125 Mots-clés : Autism  Attention/deficits hyperactivity disorder  Obsessive compulsive disorder  Familial  Traits  Community sample Index. décimale : PER Périodiques Résumé : We examined co-occurrence of autism spectrum disorder (ASD) with (traits of) attention-deficit/hyperactivity (ADHD), obsessive-compulsive (OCD) and inhibition deficits in a community sample (n = 16,676) and tested whether having a sibling with ASD manifested in increased features of ADHD, OCD or inhibition deficits. Individuals with ASD had increased ADHD and OCD traits compared with individuals without ASD. Individuals with a sibling with ASD exhibited more ADHD traits than did individuals whose sibling did not have ASD. The “sibling effect” on manifestation of ADHD traits was observed in individuals with and without ASD. Having a sibling with ASD did not affect OCD traits. Inhibition was impaired in individuals with ASD who had a sibling with ASD only. En ligne : http://dx.doi.org/10.1007/s10803-016-2853-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292

Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization / Nicole WOLFF in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.939-949 Titre : Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization Type de document : Texte imprimé et/ou numérique Auteurs : Nicole WOLFF, Auteur ; Judith BUSE, Auteur ; Jadwiga TOST, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur Article en page(s) : p.939-949 Langues : Anglais (eng) Mots-clés : Obsessive compulsive disorder  perception  neurophysiology  event-related potential Index. décimale : PER Périodiques Résumé : Background Despite cognitive inflexibility is trait like in obsessive compulsive disorder (OCD) patients and underlies clinical symptomatology, it is elusive at what stage of information processing deficits, leading to cognitive inflexibility, emerges. We hypothesize that inhibitory control mechanisms during early stimulus categorization and integration into a knowledge system underlie these deficits. Methods We examined N = 25 adolescent OCD patients and matched healthy controls (HC) in a paradigm manipulating the importance of the knowledge system to perform task switching. This was done using a paradigm in which task switches were signaled either by visual stimuli or by working memory processes. This was combined with event-related potential recordings and source localization. Results Obsessive compulsive disorder patients showed increased switch costs in the memory as compared with the cue-based block, while HC showed similar switch costs in both blocks. At the neurophysiological level, these changes in OCD were not reflected by the N2 and P3 reflecting response-associated processes but by the P1 reflecting inhibitory control during sensory categorization processes. Activation differences in the right inferior frontal gyrus and superior temporal gyrus are associated with the P1 effect. Conclusions Cognitive flexibility in adolescent OCD patients is strongly modulated by working memory load. Contrary to common sense, not response-associated processes, but inhibitory control mechanisms during early stimulus categorization processes are likely to underlie cognitive inflexibility in OCD. These processes are associated with right inferior frontal and superior temporal gyrus mechanisms. En ligne : http://dx.doi.org/10.1111/jcpp.12733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Modulations of cognitive flexibility in obsessive compulsive disorder reflect dysfunctions of perceptual categorization [Texte imprimé et/ou numérique] / Nicole WOLFF, Auteur ; Judith BUSE, Auteur ; Jadwiga TOST, Auteur ; Veit ROESSNER, Auteur ; Christian BESTE, Auteur . - p.939-949. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.939-949 Mots-clés : Obsessive compulsive disorder  perception  neurophysiology  event-related potential Index. décimale : PER Périodiques Résumé : Background Despite cognitive inflexibility is trait like in obsessive compulsive disorder (OCD) patients and underlies clinical symptomatology, it is elusive at what stage of information processing deficits, leading to cognitive inflexibility, emerges. We hypothesize that inhibitory control mechanisms during early stimulus categorization and integration into a knowledge system underlie these deficits. Methods We examined N = 25 adolescent OCD patients and matched healthy controls (HC) in a paradigm manipulating the importance of the knowledge system to perform task switching. This was done using a paradigm in which task switches were signaled either by visual stimuli or by working memory processes. This was combined with event-related potential recordings and source localization. Results Obsessive compulsive disorder patients showed increased switch costs in the memory as compared with the cue-based block, while HC showed similar switch costs in both blocks. At the neurophysiological level, these changes in OCD were not reflected by the N2 and P3 reflecting response-associated processes but by the P1 reflecting inhibitory control during sensory categorization processes. Activation differences in the right inferior frontal gyrus and superior temporal gyrus are associated with the P1 effect. Conclusions Cognitive flexibility in adolescent OCD patients is strongly modulated by working memory load. Contrary to common sense, not response-associated processes, but inhibitory control mechanisms during early stimulus categorization processes are likely to underlie cognitive inflexibility in OCD. These processes are associated with right inferior frontal and superior temporal gyrus mechanisms. En ligne : http://dx.doi.org/10.1111/jcpp.12733 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? / Tim CADMAN in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.477-485 Titre : Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? Type de document : Texte imprimé et/ou numérique Auteurs : Tim CADMAN, Auteur ; Debbie SPAIN, Auteur ; Patrick JOHNSTON, Auteur ; Ailsa RUSSELL, Auteur ; David MATAIX-COLS, Auteur ; Michael C. CRAIG, Auteur ; Quinton DEELEY, Auteur ; Dene ROBERTSON, Auteur ; Clodagh M. MURPHY, Auteur ; Nicola GILLAN, Auteur ; C. Ellie WILSON, Auteur ; Maria MENDEZ, Auteur ; Christine ECKER, Auteur ; Eileen DALY, Auteur ; James FINDON, Auteur ; Karen GLASER, Auteur ; Mrc Aims CONSORTIUM, Auteur ; Francesca HAPPE, Auteur ; Declan MURPHY, Auteur Article en page(s) : p.477-485 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  adults  obsessive compulsive disorder  obsessive-compulsive inventory-revised  hoarding  self-report questionnaire Index. décimale : PER Périodiques Résumé : Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD in ASD. We sought to describe the symptom profiles of adults with ASD, OCD, and ASD?+?OCD using the Obsessive Compulsive Inventory-Revised (OCI-R), and to assess the utility of the OCI-R as a screening measure in a high-functioning adult ASD sample. Individuals with ASD (n?=?171), OCD (n?=?108), ASD?+?OCD (n?=?54) and control participants (n?=?92) completed the OCI-R. Individuals with ASD?+?OCD reported significantly higher levels of obsessive-compulsive symptoms than those with ASD alone. OCD symptoms were not significantly correlated with core ASD repetitive behaviors as measured on the ADI-R or ADOS-G. The OCI-R showed good psychometric properties and corresponded well with clinician diagnosis of OCD. Receiver operating characteristic analysis suggested cut-offs for OCI-R Total and Checking scores that discriminated well between ASD?+?versus –OCD, and fairly well between ASD-alone and OCD-alone. OCD manifests separately from ASD and is characterized by a different profile of repetitive thoughts and behaviors. The OCI-R appears to be useful as a screening tool in the ASD adult population. Autism Res 2015, 8: 477–485. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1461 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? [Texte imprimé et/ou numérique] / Tim CADMAN, Auteur ; Debbie SPAIN, Auteur ; Patrick JOHNSTON, Auteur ; Ailsa RUSSELL, Auteur ; David MATAIX-COLS, Auteur ; Michael C. CRAIG, Auteur ; Quinton DEELEY, Auteur ; Dene ROBERTSON, Auteur ; Clodagh M. MURPHY, Auteur ; Nicola GILLAN, Auteur ; C. Ellie WILSON, Auteur ; Maria MENDEZ, Auteur ; Christine ECKER, Auteur ; Eileen DALY, Auteur ; James FINDON, Auteur ; Karen GLASER, Auteur ; Mrc Aims CONSORTIUM, Auteur ; Francesca HAPPE, Auteur ; Declan MURPHY, Auteur . - p.477-485. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.477-485 Mots-clés : autism spectrum disorder  adults  obsessive compulsive disorder  obsessive-compulsive inventory-revised  hoarding  self-report questionnaire Index. décimale : PER Périodiques Résumé : Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD in ASD. We sought to describe the symptom profiles of adults with ASD, OCD, and ASD?+?OCD using the Obsessive Compulsive Inventory-Revised (OCI-R), and to assess the utility of the OCI-R as a screening measure in a high-functioning adult ASD sample. Individuals with ASD (n?=?171), OCD (n?=?108), ASD?+?OCD (n?=?54) and control participants (n?=?92) completed the OCI-R. Individuals with ASD?+?OCD reported significantly higher levels of obsessive-compulsive symptoms than those with ASD alone. OCD symptoms were not significantly correlated with core ASD repetitive behaviors as measured on the ADI-R or ADOS-G. The OCI-R showed good psychometric properties and corresponded well with clinician diagnosis of OCD. Receiver operating characteristic analysis suggested cut-offs for OCI-R Total and Checking scores that discriminated well between ASD?+?versus –OCD, and fairly well between ASD-alone and OCD-alone. OCD manifests separately from ASD and is characterized by a different profile of repetitive thoughts and behaviors. The OCI-R appears to be useful as a screening tool in the ASD adult population. Autism Res 2015, 8: 477–485. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1461 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder / Sarah MARLER in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1673-1681 Titre : Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sarah MARLER, Auteur ; Bradley J. FERGUSON, Auteur ; Evon BATEY LEE, Auteur ; Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Erin MCDONNELL, Auteur ; Eric A. MACKLIN, Auteur ; Pat LEVITT, Auteur ; Kara GROSS MARGOLIS, Auteur ; David Q. BEVERSDORF, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.1673-1681 Langues : Anglais (eng) Mots-clés : Developmental  Gut  Enteric Medical comorbidity  Obsessive compulsive disorder  Serotonin  Microbiome Index. décimale : PER Périodiques Résumé : Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms—Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales—Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-free children, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations. En ligne : http://dx.doi.org/10.1007/s10803-017-3084-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Sarah MARLER, Auteur ; Bradley J. FERGUSON, Auteur ; Evon BATEY LEE, Auteur ; Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Erin MCDONNELL, Auteur ; Eric A. MACKLIN, Auteur ; Pat LEVITT, Auteur ; Kara GROSS MARGOLIS, Auteur ; David Q. BEVERSDORF, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.1673-1681. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1673-1681 Mots-clés : Developmental  Gut  Enteric Medical comorbidity  Obsessive compulsive disorder  Serotonin  Microbiome Index. décimale : PER Périodiques Résumé : Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms—Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales—Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-free children, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations. En ligne : http://dx.doi.org/10.1007/s10803-017-3084-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders / Holly R. ROBERTSON in Journal of Child Psychology and Psychiatry, 52-4 (April 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.442-475 Titre : Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders Type de document : Texte imprimé et/ou numérique Auteurs : Holly R. ROBERTSON, Auteur ; Guoping FENG, Auteur Année de publication : 2011 Article en page(s) : p.442-475 Langues : Anglais (eng) Mots-clés : Animal disorders  Attention Deficit Hyperactivity Disorder  autism  Obsessive Compulsive Disorder  mood disorders Index. décimale : PER Périodiques Résumé : Childhood-onset psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum disorders (OCSD), and schizophrenia (SZ), affect many school-age children, leading to a lower quality of life, including difficulties in school and personal relationships that persist into adulthood. Currently, the causes of these psychiatric disorders are poorly understood, resulting in difficulty diagnosing affected children, and insufficient treatment options. Family and twin studies implicate a genetic contribution for ADHD, ASD, mood disorders, OCSD, and SZ. Identification of candidate genes and chromosomal regions associated with a particular disorder provide targets for directed research, and understanding how these genes influence the disease state will provide valuable insights for improving the diagnosis and treatment of children with psychiatric disorders. Transgenic mouse models are one important approach in the study of human diseases, allowing for the use of a variety of experimental approaches to dissect the contribution of a specific chromosomal or genetic abnormality in human disorders. While it is impossible to model an entire psychiatric disorder in a single mouse model, these models can be extremely valuable in dissecting out the specific role of a gene, pathway, neuron subtype, or brain region in a particular abnormal behavior. In this review we discuss existing transgenic mouse models for childhood-onset psychiatric disorders. We compare the strength and weakness of various transgenic mouse models proposed for each of the common childhood-onset psychiatric disorders, and discuss future directions for the study of these disorders using cutting-edge genetic tools. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02380.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 [article] Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders [Texte imprimé et/ou numérique] / Holly R. ROBERTSON, Auteur ; Guoping FENG, Auteur . - 2011 . - p.442-475. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.442-475 Mots-clés : Animal disorders  Attention Deficit Hyperactivity Disorder  autism  Obsessive Compulsive Disorder  mood disorders Index. décimale : PER Périodiques Résumé : Childhood-onset psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum disorders (OCSD), and schizophrenia (SZ), affect many school-age children, leading to a lower quality of life, including difficulties in school and personal relationships that persist into adulthood. Currently, the causes of these psychiatric disorders are poorly understood, resulting in difficulty diagnosing affected children, and insufficient treatment options. Family and twin studies implicate a genetic contribution for ADHD, ASD, mood disorders, OCSD, and SZ. Identification of candidate genes and chromosomal regions associated with a particular disorder provide targets for directed research, and understanding how these genes influence the disease state will provide valuable insights for improving the diagnosis and treatment of children with psychiatric disorders. Transgenic mouse models are one important approach in the study of human diseases, allowing for the use of a variety of experimental approaches to dissect the contribution of a specific chromosomal or genetic abnormality in human disorders. While it is impossible to model an entire psychiatric disorder in a single mouse model, these models can be extremely valuable in dissecting out the specific role of a gene, pathway, neuron subtype, or brain region in a particular abnormal behavior. In this review we discuss existing transgenic mouse models for childhood-onset psychiatric disorders. We compare the strength and weakness of various transgenic mouse models proposed for each of the common childhood-onset psychiatric disorders, and discuss future directions for the study of these disorders using cutting-edge genetic tools. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02380.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119

Prevalence of Anxiety in Autism Spectrum Disorders / Rachel KENT  

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Obsessional thinking and autistic traits are each uniquely associated with greater traits of gender dysphoria in clinical and nonclinical adult samples / Dheeraj RAI ; Punit SHAH ; Chris ASHWIN in Molecular Autism, 16 (2025)  

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