Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder / Yumi UMESAWA in Journal of Autism and Developmental Disorders, 50-8 (August 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2710-2722 Titre : Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yumi UMESAWA, Auteur ; Kanae MATSUSHIMA, Auteur ; Takeshi ATSUMI, Auteur ; Toshihiro KATO, Auteur ; Reiko FUKATSU, Auteur ; Makoto WADA, Auteur ; Masakazu IDE, Auteur Article en page(s) : p.2710-2722 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Developmental coordination disorder  Gamma-aminobutyric acid  Magnetic resonance spectroscopy  Primary motor area  Supplementary motor area Index. décimale : PER Périodiques Résumé : Several motor disabilities accompanied with autism spectrum disorder (ASD) are widely known despite limited reports of underlying neural mechanisms. Gamma-aminobutyric acid (GABA) levels in the motor-related cortical areas modulate several motor performances in healthy participants. We hypothesized that abnormal GABA concentrations in the primary motor area (M1) and supplementary motor area (SMA) associate with different motor difficulties for ASD adolescents/adults. We found that increased GABA concentrations in M1 measured using (1)H-magnetic resonance spectroscopy exhibited lower motor performance in tasks requiring increased muscle strength while lower GABA concentrations in SMA were associated with lower scores in tests measuring body coordination. The degrees of neural inhibition in the M1 and SMA regions would contribute to different dimensions of motor disabilities in autism. En ligne : http://dx.doi.org/10.1007/s10803-020-04382-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428 [article] Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Yumi UMESAWA, Auteur ; Kanae MATSUSHIMA, Auteur ; Takeshi ATSUMI, Auteur ; Toshihiro KATO, Auteur ; Reiko FUKATSU, Auteur ; Makoto WADA, Auteur ; Masakazu IDE, Auteur . - p.2710-2722. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2710-2722 Mots-clés : Autism spectrum disorder  Developmental coordination disorder  Gamma-aminobutyric acid  Magnetic resonance spectroscopy  Primary motor area  Supplementary motor area Index. décimale : PER Périodiques Résumé : Several motor disabilities accompanied with autism spectrum disorder (ASD) are widely known despite limited reports of underlying neural mechanisms. Gamma-aminobutyric acid (GABA) levels in the motor-related cortical areas modulate several motor performances in healthy participants. We hypothesized that abnormal GABA concentrations in the primary motor area (M1) and supplementary motor area (SMA) associate with different motor difficulties for ASD adolescents/adults. We found that increased GABA concentrations in M1 measured using (1)H-magnetic resonance spectroscopy exhibited lower motor performance in tasks requiring increased muscle strength while lower GABA concentrations in SMA were associated with lower scores in tests measuring body coordination. The degrees of neural inhibition in the M1 and SMA regions would contribute to different dimensions of motor disabilities in autism. En ligne : http://dx.doi.org/10.1007/s10803-020-04382-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428

Comparison of the Social Responsiveness Scale-2 among Individuals with Autism Spectrum Disorder and Williams Syndrome in Japan / Kosuke ASADA ; Takeo KATO ; Takahiro IKEDA ; Yoko HAKUNO ; Ayaka IKEDA ; Kanae MATSUSHIMA ; Tomonari AWAYA ; Shin OKAZAKI ; Toshihiro KATO ; Yasuko FUNABIKI ; Toshiya MURAI ; Toshio HEIKE ; Masatoshi HAGIWARA ; Takanori YAMAGATA ; Kiyotaka TOMIWA ; Ryo KIMURA in Journal of Autism and Developmental Disorders, 54-8 (August 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-8 (August 2024) . - p.3176-3184 Titre : Comparison of the Social Responsiveness Scale-2 among Individuals with Autism Spectrum Disorder and Williams Syndrome in Japan Type de document : Texte imprimé et/ou numérique Auteurs : Kosuke ASADA, Auteur ; Takeo KATO, Auteur ; Takahiro IKEDA, Auteur ; Yoko HAKUNO, Auteur ; Ayaka IKEDA, Auteur ; Kanae MATSUSHIMA, Auteur ; Tomonari AWAYA, Auteur ; Shin OKAZAKI, Auteur ; Toshihiro KATO, Auteur ; Yasuko FUNABIKI, Auteur ; Toshiya MURAI, Auteur ; Toshio HEIKE, Auteur ; Masatoshi HAGIWARA, Auteur ; Takanori YAMAGATA, Auteur ; Kiyotaka TOMIWA, Auteur ; Ryo KIMURA, Auteur Article en page(s) : p.3176-3184 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined the similarities/differences between the social phenotypes of Williams syndrome (WS) and autism spectrum disorder (ASD). As cultural norms may affect symptom evaluation, this study administered the Social Responsiveness Scale-2 to Japanese individuals with WS (n = 78, 4.4-44.0 years) and ASD (n = 75, 4.7-55.4 years). The scores for Social Motivation and Social Communication were significantly more severe in the ASD than WS group. Overall, the similarities and differences between the social phenotypes of the syndromes were consistent with the findings of a recent study conducted in the UK, except for the social awareness subscale score. This highlights the importance of cross-cultural investigations of WS and ASD. En ligne : https://doi.org/10.1007/s10803-022-05740-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Comparison of the Social Responsiveness Scale-2 among Individuals with Autism Spectrum Disorder and Williams Syndrome in Japan [Texte imprimé et/ou numérique] / Kosuke ASADA, Auteur ; Takeo KATO, Auteur ; Takahiro IKEDA, Auteur ; Yoko HAKUNO, Auteur ; Ayaka IKEDA, Auteur ; Kanae MATSUSHIMA, Auteur ; Tomonari AWAYA, Auteur ; Shin OKAZAKI, Auteur ; Toshihiro KATO, Auteur ; Yasuko FUNABIKI, Auteur ; Toshiya MURAI, Auteur ; Toshio HEIKE, Auteur ; Masatoshi HAGIWARA, Auteur ; Takanori YAMAGATA, Auteur ; Kiyotaka TOMIWA, Auteur ; Ryo KIMURA, Auteur . - p.3176-3184. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-8 (August 2024) . - p.3176-3184 Index. décimale : PER Périodiques Résumé : This study examined the similarities/differences between the social phenotypes of Williams syndrome (WS) and autism spectrum disorder (ASD). As cultural norms may affect symptom evaluation, this study administered the Social Responsiveness Scale-2 to Japanese individuals with WS (n = 78, 4.4-44.0 years) and ASD (n = 75, 4.7-55.4 years). The scores for Social Motivation and Social Communication were significantly more severe in the ASD than WS group. Overall, the similarities and differences between the social phenotypes of the syndromes were consistent with the findings of a recent study conducted in the UK, except for the social awareness subscale score. This highlights the importance of cross-cultural investigations of WS and ASD. En ligne : https://doi.org/10.1007/s10803-022-05740-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Correction to: Comparison of the social responsiveness scale-2 among individuals with Autism Spectrum Disorder and Williams Syndrome in Japan / Masahiro HIRAI in Journal of Autism and Developmental Disorders, 53-4 (April 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1737-1737 Titre : Correction to: Comparison of the social responsiveness scale-2 among individuals with Autism Spectrum Disorder and Williams Syndrome in Japan Type de document : Texte imprimé et/ou numérique Auteurs : Masahiro HIRAI, Auteur ; Kosuke ASADA, Auteur ; Takeo KATO, Auteur ; Takahiro IKEDA, Auteur ; Yoko HAKUNO, Auteur ; Ayaka IKEDA, Auteur ; Kanae MATSUSHIMA, Auteur ; Tomonari AWAYA, Auteur ; Shin OKAZAKI, Auteur ; Toshihiro KATO, Auteur ; Yasuko FUNABIKI, Auteur ; Toshiya MURAI, Auteur ; Toshio HEIKE, Auteur ; Masatoshi HAGIWARA, Auteur ; Takanori YAMAGATA, Auteur ; Kiyotaka TOMIWA, Auteur ; Ryo KIMURA, Auteur Article en page(s) : p.1737-1737 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-022-05810-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] Correction to: Comparison of the social responsiveness scale-2 among individuals with Autism Spectrum Disorder and Williams Syndrome in Japan [Texte imprimé et/ou numérique] / Masahiro HIRAI, Auteur ; Kosuke ASADA, Auteur ; Takeo KATO, Auteur ; Takahiro IKEDA, Auteur ; Yoko HAKUNO, Auteur ; Ayaka IKEDA, Auteur ; Kanae MATSUSHIMA, Auteur ; Tomonari AWAYA, Auteur ; Shin OKAZAKI, Auteur ; Toshihiro KATO, Auteur ; Yasuko FUNABIKI, Auteur ; Toshiya MURAI, Auteur ; Toshio HEIKE, Auteur ; Masatoshi HAGIWARA, Auteur ; Takanori YAMAGATA, Auteur ; Kiyotaka TOMIWA, Auteur ; Ryo KIMURA, Auteur . - p.1737-1737. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1737-1737 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-022-05810-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Hand-foot coordination is significantly influenced by motion direction in individuals with autism spectrum disorder / Kanae MATSUSHIMA ; Reiko FUKATSU ; Yasuo TERAO ; Masakazu IDE in Autism Research, 16-1 (January 2023)  

Public ISBD [article]  inAutism Research > 16-1 (January 2023) . - p.40-51 Titre : Hand-foot coordination is significantly influenced by motion direction in individuals with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kanae MATSUSHIMA, Auteur ; Reiko FUKATSU, Auteur ; Yasuo TERAO, Auteur ; Masakazu IDE, Auteur Article en page(s) : p.40-51 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Generally, when individuals attempt to move two limbs rhythmically in the opposite direction (e.g., flex the left hand and extend the left foot along the sagittal plane), the movements tend to be instead performed in the same direction. This phenomenon, known as directional constraint, can be harnessed to examine the difficulties in movement coordination exhibited by most individuals with autism spectrum disorder (ASD). While such difficulties have already been investigated through standardized clinical assessments, they have not been examined through kinematic methods. Thus, we employed a clinical assessment scale in an experimentally controlled environment to investigate whether stronger directional constraint during the rhythmic movement of two limbs is more pronounced and associated with decreased movement coordination in individuals with ASD. ASD and typically developing (TD) participants were asked to rhythmically move two limbs either in the same or opposite directions. In addition, the coordination skills of participants were assessed using the Bruininks-Oseretsky Test of Motor Proficiency Second Edition (BOT-2). Subjects with ASD showed significantly stronger directional constraint than TD participants during the contralateral and ipsilateral movement of the hand and foot. According to the pooled data from both groups, participants who showed stronger directional constraint during these two movement conditions also exhibited poorer coordinated movement skills in the BOT-2. These results suggest that people with ASD may have difficulties in inhibiting the neural signals that synchronize the direction of inter-limb movements, thus resulting in coordination disabilities. Lay Summary Individuals with autism spectrum disorder (ASD) often exhibit difficulties in coordinated movements. We asked those with ASD and typically developing (TD) participants to move two limbs (e.g., left hand and left foot) either in the same or the opposite direction. Results demonstrated that participants with ASD had more difficulties in counteracting the tendency of their hand and foot to synchronously move in the same direction. Our findings suggested that difficulties to suppress synchronized movements of the hand and foot result in coordination disabilities. En ligne : https://doi.org/10.1002/aur.2837 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Hand-foot coordination is significantly influenced by motion direction in individuals with autism spectrum disorder [Texte imprimé et/ou numérique] / Kanae MATSUSHIMA, Auteur ; Reiko FUKATSU, Auteur ; Yasuo TERAO, Auteur ; Masakazu IDE, Auteur . - p.40-51. Langues : Anglais (eng) in Autism Research > 16-1 (January 2023) . - p.40-51 Index. décimale : PER Périodiques Résumé : Abstract Generally, when individuals attempt to move two limbs rhythmically in the opposite direction (e.g., flex the left hand and extend the left foot along the sagittal plane), the movements tend to be instead performed in the same direction. This phenomenon, known as directional constraint, can be harnessed to examine the difficulties in movement coordination exhibited by most individuals with autism spectrum disorder (ASD). While such difficulties have already been investigated through standardized clinical assessments, they have not been examined through kinematic methods. Thus, we employed a clinical assessment scale in an experimentally controlled environment to investigate whether stronger directional constraint during the rhythmic movement of two limbs is more pronounced and associated with decreased movement coordination in individuals with ASD. ASD and typically developing (TD) participants were asked to rhythmically move two limbs either in the same or opposite directions. In addition, the coordination skills of participants were assessed using the Bruininks-Oseretsky Test of Motor Proficiency Second Edition (BOT-2). Subjects with ASD showed significantly stronger directional constraint than TD participants during the contralateral and ipsilateral movement of the hand and foot. According to the pooled data from both groups, participants who showed stronger directional constraint during these two movement conditions also exhibited poorer coordinated movement skills in the BOT-2. These results suggest that people with ASD may have difficulties in inhibiting the neural signals that synchronize the direction of inter-limb movements, thus resulting in coordination disabilities. Lay Summary Individuals with autism spectrum disorder (ASD) often exhibit difficulties in coordinated movements. We asked those with ASD and typically developing (TD) participants to move two limbs (e.g., left hand and left foot) either in the same or the opposite direction. Results demonstrated that participants with ASD had more difficulties in counteracting the tendency of their hand and foot to synchronously move in the same direction. Our findings suggested that difficulties to suppress synchronized movements of the hand and foot result in coordination disabilities. En ligne : https://doi.org/10.1002/aur.2837 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Unusual sensory features are related to resting-state cardiac vagus nerve activity in autism spectrum disorders / Kanae MATSUSHIMA in Research in Autism Spectrum Disorders, 25 (May 2016)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 25 (May 2016) . - p.37-46 Titre : Unusual sensory features are related to resting-state cardiac vagus nerve activity in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Kanae MATSUSHIMA, Auteur ; Jun MATSUBAYASHI, Auteur ; Motomi TOICHI, Auteur ; Yasuko FUNABIKI, Auteur ; Takeo KATO, Auteur ; Tomonari AWAYA, Auteur ; Toshihiro KATO, Auteur Article en page(s) : p.37-46 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Sensory features  Parasympathetic nervous system  Resting state  Heart rate variability Index. décimale : PER Périodiques Résumé : The relationship between unusual sensory features (hyper-reactivity, hypo-reactivity, and unusual sensory interests) and the parasympathetic nervous system in autism spectrum disorder (ASD) has recently garnered interest. The purpose of this study was to investigate whether unusual sensory features are associated with resting-state cardiac vagus nerve activity in ASD children. Electrocardiogram signals were recorded during three 2-min resting periods to quantify the high frequency (HF) component of heart rate variability (HRV) in 37 children with ASD aged 6–12 and 32 typically developing children. Parent-reported questionnaires (Short Sensory Profile, SSP; Social Responsiveness Scale-2, SRS-2) assessed atypical sensory behaviors in daily life and autistic traits. Children with ASD consistently showed lower HF-HRV than typically developing children across the three resting periods. The SSP “Visual/Auditory Sensitivity” score was correlated with resting-state HF-HRV in the ASD group, indicating that ASD children with more severe visual/auditory hyper-reactivity in daily life have lower vagus nerve activity. The SRS-2 “Restricted Interests and Repetitive Behavior” score was also correlated with resting-state HF-HRV in the ASD group. These findings suggest that ASD children with lower vagus nerve activity may have inadequate self-regulatory capacity and difficulty regulating behavioral responses to unpredictable and unavoidable visual/auditory stimuli in daily life. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 [article] Unusual sensory features are related to resting-state cardiac vagus nerve activity in autism spectrum disorders [Texte imprimé et/ou numérique] / Kanae MATSUSHIMA, Auteur ; Jun MATSUBAYASHI, Auteur ; Motomi TOICHI, Auteur ; Yasuko FUNABIKI, Auteur ; Takeo KATO, Auteur ; Tomonari AWAYA, Auteur ; Toshihiro KATO, Auteur . - p.37-46. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 25 (May 2016) . - p.37-46 Mots-clés : Autism spectrum disorders  Sensory features  Parasympathetic nervous system  Resting state  Heart rate variability Index. décimale : PER Périodiques Résumé : The relationship between unusual sensory features (hyper-reactivity, hypo-reactivity, and unusual sensory interests) and the parasympathetic nervous system in autism spectrum disorder (ASD) has recently garnered interest. The purpose of this study was to investigate whether unusual sensory features are associated with resting-state cardiac vagus nerve activity in ASD children. Electrocardiogram signals were recorded during three 2-min resting periods to quantify the high frequency (HF) component of heart rate variability (HRV) in 37 children with ASD aged 6–12 and 32 typically developing children. Parent-reported questionnaires (Short Sensory Profile, SSP; Social Responsiveness Scale-2, SRS-2) assessed atypical sensory behaviors in daily life and autistic traits. Children with ASD consistently showed lower HF-HRV than typically developing children across the three resting periods. The SSP “Visual/Auditory Sensitivity” score was correlated with resting-state HF-HRV in the ASD group, indicating that ASD children with more severe visual/auditory hyper-reactivity in daily life have lower vagus nerve activity. The SRS-2 “Restricted Interests and Repetitive Behavior” score was also correlated with resting-state HF-HRV in the ASD group. These findings suggest that ASD children with lower vagus nerve activity may have inadequate self-regulatory capacity and difficulty regulating behavioral responses to unpredictable and unavoidable visual/auditory stimuli in daily life. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285

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