Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study / Ting CHOW in Autism Research, 18-8 (August 2025)  

Public ISBD [article]  inAutism Research > 18-8 (August 2025) . - p.1664-1673 Titre : Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study Type de document : texte imprimé Auteurs : Ting CHOW, Auteur ; Qi MENG, Auteur ; Jingyuan XIAO, Auteur ; Karl O'SHARKEY, Auteur ; Zeyan LIEW, Auteur ; Beate RITZ, Auteur Article en page(s) : p.1664-1673 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  grandfather's age  grandmother's age  multigenerational  race/ethnicity Index. décimale : PER Périodiques Résumé : ABSTRACT We investigated associations between maternal grandparents' age and autism spectrum disorders (ASD) in grandchildren, exploring differences by race/ethnicity. In a multigenerational California birth cohort study including 1,743,998 and 1,630,722 mother?child pairs (with 27,975 and 25,816 ASD cases, respectively), we examined ASD risk by grandmother's and grandfather's age at the time when their daughter was born. Logistic regression was used to obtain odds ratios (ORs) and 95% CIs. The odds of ASD in grandchildren were higher among White grandmothers (OR, 1.14; 95% CI, 1.08 1.20) and grandfathers (OR, 1.18; 95% CI, 1.11 1.25) who had daughters at younger ages (18 24 years) compared to the 25 29 year reference, while inverse associations were observed for younger Black grandmothers (OR, 0.85; 95% CI, 0.78 0.94). At older ages (35 55 years), ASD risks were higher among Hispanic grandmothers (OR, 1.13; 95% CI, 1.06 1.21) and Hispanic (OR, 1.12; 95% CI, 1.06 1.18) and Black grandfathers (OR, 1.18; 95% CI, 1.05 1.32). The risk of ASD in grandchildren was higher among older grandparents of several races/ethnicities but among the youngest grandparents only among those of White race. Differences by race/ethnicity may imply different mechanisms operating in younger and older grandparents. Studies exploring the contributions of biological as well as social, occupational, and environmental factors on the influence of age at pregnancy with ASD are needed. En ligne : https://doi.org/10.1002/aur.70074 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566 [article] Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study [texte imprimé] / Ting CHOW, Auteur ; Qi MENG, Auteur ; Jingyuan XIAO, Auteur ; Karl O'SHARKEY, Auteur ; Zeyan LIEW, Auteur ; Beate RITZ, Auteur . - p.1664-1673. Langues : Anglais (eng) in Autism Research > 18-8 (August 2025) . - p.1664-1673 Mots-clés : autism spectrum disorders  grandfather's age  grandmother's age  multigenerational  race/ethnicity Index. décimale : PER Périodiques Résumé : ABSTRACT We investigated associations between maternal grandparents' age and autism spectrum disorders (ASD) in grandchildren, exploring differences by race/ethnicity. In a multigenerational California birth cohort study including 1,743,998 and 1,630,722 mother?child pairs (with 27,975 and 25,816 ASD cases, respectively), we examined ASD risk by grandmother's and grandfather's age at the time when their daughter was born. Logistic regression was used to obtain odds ratios (ORs) and 95% CIs. The odds of ASD in grandchildren were higher among White grandmothers (OR, 1.14; 95% CI, 1.08 1.20) and grandfathers (OR, 1.18; 95% CI, 1.11 1.25) who had daughters at younger ages (18 24 years) compared to the 25 29 year reference, while inverse associations were observed for younger Black grandmothers (OR, 0.85; 95% CI, 0.78 0.94). At older ages (35 55 years), ASD risks were higher among Hispanic grandmothers (OR, 1.13; 95% CI, 1.06 1.21) and Hispanic (OR, 1.12; 95% CI, 1.06 1.18) and Black grandfathers (OR, 1.18; 95% CI, 1.05 1.32). The risk of ASD in grandchildren was higher among older grandparents of several races/ethnicities but among the youngest grandparents only among those of White race. Differences by race/ethnicity may imply different mechanisms operating in younger and older grandparents. Studies exploring the contributions of biological as well as social, occupational, and environmental factors on the influence of age at pregnancy with ASD are needed. En ligne : https://doi.org/10.1002/aur.70074 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566

Family history of psychiatric conditions and development of siblings of children with autism / Joseph T. CHANG ; Zeyan LIEW ; Angelina VERNETTI ; Suzanne L. MACARI ; Kelly POWELL ; Katarzyna CHAWARSKA in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1665-1676 Titre : Family history of psychiatric conditions and development of siblings of children with autism Type de document : texte imprimé Auteurs : Joseph T. CHANG, Auteur ; Zeyan LIEW, Auteur ; Angelina VERNETTI, Auteur ; Suzanne L. MACARI, Auteur ; Kelly POWELL, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.1665-1676 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Younger siblings (SIBS) of children with autism exhibit a wide range of clinical and subclinical symptoms including social, cognitive, language, and adaptive functioning delays. Identifying factors linked with this phenotypic heterogeneity is essential for improving understanding of the underlying biology of the heterogenous outcomes and for early identification of the most vulnerable SIBS. Prevalence of neurodevelopmental (NDD) and neuropsychiatric disorders (NPD) is significantly elevated in families of children with autism. It remains unknown, however, if the family history associates with the developmental outcomes among the SIBS. We quantified history of the NDDs and NPDs commonly reported in families of children with autism using a parent interview and assessed autism symptoms, verbal, nonverbal, and adaptive skills in a sample of 229 SIBS. Multiple regression analyses were used to examine links between family history and phenotypic outcomes, whereas controlling for birth year, age, sex, demographics, and parental education. Results suggest that family history of schizophrenia, depression, anxiety, bipolar disorder, and intellectual disability associate robustly with dimensional measures of social affect, verbal and nonverbal IQ, and adaptive functioning in the SIBS. Considering family history of these disorders may improve efforts to predict long-term outcomes in younger siblings of children with autism and inform about familial factors contributing to high phenotypic heterogenetity in this cohort. En ligne : https://doi.org/10.1002/aur.3175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Family history of psychiatric conditions and development of siblings of children with autism [texte imprimé] / Joseph T. CHANG, Auteur ; Zeyan LIEW, Auteur ; Angelina VERNETTI, Auteur ; Suzanne L. MACARI, Auteur ; Kelly POWELL, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.1665-1676. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1665-1676 Index. décimale : PER Périodiques Résumé : Abstract Younger siblings (SIBS) of children with autism exhibit a wide range of clinical and subclinical symptoms including social, cognitive, language, and adaptive functioning delays. Identifying factors linked with this phenotypic heterogeneity is essential for improving understanding of the underlying biology of the heterogenous outcomes and for early identification of the most vulnerable SIBS. Prevalence of neurodevelopmental (NDD) and neuropsychiatric disorders (NPD) is significantly elevated in families of children with autism. It remains unknown, however, if the family history associates with the developmental outcomes among the SIBS. We quantified history of the NDDs and NPDs commonly reported in families of children with autism using a parent interview and assessed autism symptoms, verbal, nonverbal, and adaptive skills in a sample of 229 SIBS. Multiple regression analyses were used to examine links between family history and phenotypic outcomes, whereas controlling for birth year, age, sex, demographics, and parental education. Results suggest that family history of schizophrenia, depression, anxiety, bipolar disorder, and intellectual disability associate robustly with dimensional measures of social affect, verbal and nonverbal IQ, and adaptive functioning in the SIBS. Considering family history of these disorders may improve efforts to predict long-term outcomes in younger siblings of children with autism and inform about familial factors contributing to high phenotypic heterogenetity in this cohort. En ligne : https://doi.org/10.1002/aur.3175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study / Zeyan LIEW in Autism Research, 9-9 (September 2016)  

Public ISBD [article]  inAutism Research > 9-9 (September 2016) . - p.951-958 Titre : Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study Type de document : texte imprimé Auteurs : Zeyan LIEW, Auteur ; Beate RITZ, Auteur ; Jasveer VIRK, Auteur ; Jørn OLSEN, Auteur Article en page(s) : p.951-958 Langues : Anglais (eng) Mots-clés : acetaminophen  autism spectrum disorders  infantile autism  childhood behavior  prenatal exposure  pregnancy cohort Index. décimale : PER Périodiques Résumé : Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996–2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring. Information on acetaminophen use was collected prospectively from three computer-assisted telephone interviews. We used records from the Danish hospital and psychiatric registries to identify diagnoses of ASD. At the end of follow up, 1,027 (1.6%) children were diagnosed with ASD, 345 (0.5%) with infantile autism. We found that 31% of ASD (26% of infantile autism) have also been diagnosed with hyperkinetic disorders. More than 50% women reported ever using acetaminophen in pregnancy. We used Cox proportional hazards model to estimate hazard ratio (HR) and 95% confident interval (CI). Prenatal use of acetaminophen was associated with an increased risk of ASD accompanied by hyperkinetic symptoms (HR = 1.51 95% CI 1.19–1.92), but not with other ASD cases (HR = 1.06 95% CI 0.92–1.24). Longer duration of use (i.e., use for >20 weeks in gestation) increased the risk of ASD or infantile autism with hyperkinetic symptoms almost twofold. Maternal use of acetaminophen in pregnancy was associated with ASD with hyperkinetic symptoms only, suggesting acetaminophen exposure early in fetal life may specifically impact this hyperactive behavioral phenotype. Autism Res 2016, 9: 951–958. En ligne : http://dx.doi.org/10.1002/aur.1591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study [texte imprimé] / Zeyan LIEW, Auteur ; Beate RITZ, Auteur ; Jasveer VIRK, Auteur ; Jørn OLSEN, Auteur . - p.951-958. Langues : Anglais (eng) in Autism Research > 9-9 (September 2016) . - p.951-958 Mots-clés : acetaminophen  autism spectrum disorders  infantile autism  childhood behavior  prenatal exposure  pregnancy cohort Index. décimale : PER Périodiques Résumé : Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996–2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring. Information on acetaminophen use was collected prospectively from three computer-assisted telephone interviews. We used records from the Danish hospital and psychiatric registries to identify diagnoses of ASD. At the end of follow up, 1,027 (1.6%) children were diagnosed with ASD, 345 (0.5%) with infantile autism. We found that 31% of ASD (26% of infantile autism) have also been diagnosed with hyperkinetic disorders. More than 50% women reported ever using acetaminophen in pregnancy. We used Cox proportional hazards model to estimate hazard ratio (HR) and 95% confident interval (CI). Prenatal use of acetaminophen was associated with an increased risk of ASD accompanied by hyperkinetic symptoms (HR = 1.51 95% CI 1.19–1.92), but not with other ASD cases (HR = 1.06 95% CI 0.92–1.24). Longer duration of use (i.e., use for >20 weeks in gestation) increased the risk of ASD or infantile autism with hyperkinetic symptoms almost twofold. Maternal use of acetaminophen in pregnancy was associated with ASD with hyperkinetic symptoms only, suggesting acetaminophen exposure early in fetal life may specifically impact this hyperactive behavioral phenotype. Autism Res 2016, 9: 951–958. En ligne : http://dx.doi.org/10.1002/aur.1591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Preconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders / Jasveer VIRK in Autism, 20-6 (August 2016)  

Public ISBD [article]  inAutism > 20-6 (August 2016) . - p.710-718 Titre : Preconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders Type de document : texte imprimé Auteurs : Jasveer VIRK, Auteur ; Zeyan LIEW, Auteur ; Jørn OLSEN, Auteur ; Ellen A NOHR, Auteur ; Janet M CATOV, Auteur ; Beate RITZ, Auteur Article en page(s) : p.710-718 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  environmental factors Index. décimale : PER Périodiques Résumé : Objective: To evaluate whether early folic acid supplementation during pregnancy prevents diagnosis of autism spectrum disorders in offspring.Methods: Information on autism spectrum disorder diagnosis was obtained from the National Hospital Register and the Central Psychiatric Register. We estimated risk ratios for autism spectrum disorders for children whose mothers took folate or multivitamin supplements from 4 weeks prior from the last menstrual period through to 8 weeks after the last menstrual period (−4 to 8 weeks) by three 4-week periods.Results: We did not find an association between early folate or multivitamin intake for autism spectrum disorder (folic acid—adjusted risk ratio: 1.06, 95% confidence interval: 0.82–1.36; multivitamin—adjusted risk ratio: 1.00, 95% confidence interval: 0.82–1.22), autistic disorder (folic acid—adjusted risk ratio: 1.18, 95% confidence interval: 0.76–1.84; multivitamin—adjusted risk ratio: 1.22, 95% confidence interval: 0.87–1.69), Asperger’s syndrome (folic acid—adjusted risk ratio: 0.85, 95% confidence interval: 0.46–1.53; multivitamin—adjusted risk ratio: 0.95, 95% confidence interval: 0.62–1.46), or pervasive developmental disorder–not otherwise specified (folic acid—adjusted risk ratio: 1.07, 95% confidence interval: 0.75–1.54; multivitamin: adjusted risk ratio: 0.87, 95% confidence interval: 0.65–1.17) compared with women reporting no supplement use in the same period.Conclusion: We did not find any evidence to corroborate previous reports of a reduced risk for autism spectrum disorders in offspring of women using folic acid supplements in early pregnancy. En ligne : http://dx.doi.org/10.1177/1362361315604076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] Preconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders [texte imprimé] / Jasveer VIRK, Auteur ; Zeyan LIEW, Auteur ; Jørn OLSEN, Auteur ; Ellen A NOHR, Auteur ; Janet M CATOV, Auteur ; Beate RITZ, Auteur . - p.710-718. Langues : Anglais (eng) in Autism > 20-6 (August 2016) . - p.710-718 Mots-clés : autism spectrum disorders  environmental factors Index. décimale : PER Périodiques Résumé : Objective: To evaluate whether early folic acid supplementation during pregnancy prevents diagnosis of autism spectrum disorders in offspring.Methods: Information on autism spectrum disorder diagnosis was obtained from the National Hospital Register and the Central Psychiatric Register. We estimated risk ratios for autism spectrum disorders for children whose mothers took folate or multivitamin supplements from 4 weeks prior from the last menstrual period through to 8 weeks after the last menstrual period (−4 to 8 weeks) by three 4-week periods.Results: We did not find an association between early folate or multivitamin intake for autism spectrum disorder (folic acid—adjusted risk ratio: 1.06, 95% confidence interval: 0.82–1.36; multivitamin—adjusted risk ratio: 1.00, 95% confidence interval: 0.82–1.22), autistic disorder (folic acid—adjusted risk ratio: 1.18, 95% confidence interval: 0.76–1.84; multivitamin—adjusted risk ratio: 1.22, 95% confidence interval: 0.87–1.69), Asperger’s syndrome (folic acid—adjusted risk ratio: 0.85, 95% confidence interval: 0.46–1.53; multivitamin—adjusted risk ratio: 0.95, 95% confidence interval: 0.62–1.46), or pervasive developmental disorder–not otherwise specified (folic acid—adjusted risk ratio: 1.07, 95% confidence interval: 0.75–1.54; multivitamin: adjusted risk ratio: 0.87, 95% confidence interval: 0.65–1.17) compared with women reporting no supplement use in the same period.Conclusion: We did not find any evidence to corroborate previous reports of a reduced risk for autism spectrum disorders in offspring of women using folic acid supplements in early pregnancy. En ligne : http://dx.doi.org/10.1177/1362361315604076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

Sex-specific pathways from early irritability trajectories to later suicidal ideations and behaviors: Findings from the ABCD study® / Nellia BELLAERT in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.673-685 Titre : Sex-specific pathways from early irritability trajectories to later suicidal ideations and behaviors: Findings from the ABCD study® Type de document : texte imprimé Auteurs : Nellia BELLAERT, Auteur ; Angelique SIMEONE, Auteur ; Lanting ZHANG, Auteur ; Haoran ZHUO, Auteur ; Massimiliano ORRI, Auteur ; Zeyan LIEW, Auteur ; Wan-Ling TSENG, Auteur Article en page(s) : p.673-685 Langues : Anglais (eng) Mots-clés : Irritability  developmental trajectories  suicidal ideations and behaviors  sex differences Index. décimale : PER Périodiques Résumé : Background Previous studies have demonstrated that children with high irritability are at increased risk for suicidal ideations and behaviors. However, they have mostly relied on teacher reports and shown mixed findings regarding sex differences. We aimed to identify developmental trajectories of childhood irritability, test their direct and indirect (through psychopathology) associations with adolescent suicidal ideations and behaviors, and examine whether these associations differed by sex. Methods This study used five waves of data from the adolescent brain cognitive development (ABCD) Study (N?=?4,583). Parents rated their children's irritability yearly from ages 9?10 to ages 11?12, internalizing (e.g. depression) and externalizing (e.g. aggression) symptoms at ages 12?13, and suicidal ideations and behaviors (SIBs) at ages 13?14 using the child behavior checklist. Subgroups of irritability trajectories were derived using growth mixture modeling. Path analysis was conducted to test the total, direct, and indirect pathways from irritability trajectories to SIBs through internalizing and externalizing symptoms, and sex differences in those paths. Results Four irritability trajectories were identified: low-stable (73.01%), rising (12.04%), declining (10.28%), and high-stable (4.67%). Compared with the other trajectories, children on the high-stable irritability trajectory were at higher risk for suicidal ideations (??=?.13, p? En ligne : https://doi.org/10.1111/jcpp.70044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Sex-specific pathways from early irritability trajectories to later suicidal ideations and behaviors: Findings from the ABCD study® [texte imprimé] / Nellia BELLAERT, Auteur ; Angelique SIMEONE, Auteur ; Lanting ZHANG, Auteur ; Haoran ZHUO, Auteur ; Massimiliano ORRI, Auteur ; Zeyan LIEW, Auteur ; Wan-Ling TSENG, Auteur . - p.673-685. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.673-685 Mots-clés : Irritability  developmental trajectories  suicidal ideations and behaviors  sex differences Index. décimale : PER Périodiques Résumé : Background Previous studies have demonstrated that children with high irritability are at increased risk for suicidal ideations and behaviors. However, they have mostly relied on teacher reports and shown mixed findings regarding sex differences. We aimed to identify developmental trajectories of childhood irritability, test their direct and indirect (through psychopathology) associations with adolescent suicidal ideations and behaviors, and examine whether these associations differed by sex. Methods This study used five waves of data from the adolescent brain cognitive development (ABCD) Study (N?=?4,583). Parents rated their children's irritability yearly from ages 9?10 to ages 11?12, internalizing (e.g. depression) and externalizing (e.g. aggression) symptoms at ages 12?13, and suicidal ideations and behaviors (SIBs) at ages 13?14 using the child behavior checklist. Subgroups of irritability trajectories were derived using growth mixture modeling. Path analysis was conducted to test the total, direct, and indirect pathways from irritability trajectories to SIBs through internalizing and externalizing symptoms, and sex differences in those paths. Results Four irritability trajectories were identified: low-stable (73.01%), rising (12.04%), declining (10.28%), and high-stable (4.67%). Compared with the other trajectories, children on the high-stable irritability trajectory were at higher risk for suicidal ideations (??=?.13, p? En ligne : https://doi.org/10.1111/jcpp.70044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Untargeted Metabolomics Screen of Mid-pregnancy Maternal Serum and Autism in Offspring / Beate RITZ in Autism Research, 13-8 (August 2020)  

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