Dépouillements

Exploring autism via the retina: Comparative insights in children with autism spectrum disorder and typical development / Yuexuan WANG ; Huiyun GAO ; Zhengwang XIA ; Chaofan ZENG ; Kun HUANG ; Zhaoqi ZHU ; Jianfeng LU ; Qiang CHEN ; Xiaoyan KE ; Weiwei ZHANG in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1520-1533 Titre : Exploring autism via the retina: Comparative insights in children with autism spectrum disorder and typical development Type de document : Texte imprimé et/ou numérique Auteurs : Yuexuan WANG, Auteur ; Huiyun GAO, Auteur ; Zhengwang XIA, Auteur ; Chaofan ZENG, Auteur ; Kun HUANG, Auteur ; Zhaoqi ZHU, Auteur ; Jianfeng LU, Auteur ; Qiang CHEN, Auteur ; Xiaoyan KE, Auteur ; Weiwei ZHANG, Auteur Article en page(s) : p.1520-1533 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a widely recognized neurodevelopmental disorder, yet the identification of reliable imaging biomarkers for its early diagnosis remains a challenge. Considering the specific manifestations of ASD in the eyes and the interconnectivity between the brain and the eyes, this study investigates ASD through the lens of retinal analysis. We specifically examined differences in the macular region of the retina using optical coherence tomography (OCT)/optical coherence tomography angiography (OCTA) images between children diagnosed with ASD and those with typical development (TD). Our findings present potential novel characteristics of ASD: the thickness of the ellipsoid zone (EZ) with cone photoreceptors was significantly increased in ASD; the large-caliber arteriovenous of the inner retina was significantly reduced in ASD; these changes in the EZ and arteriovenous were more significant in the left eye than in the right eye. These observations of photoreceptor alterations, vascular function changes, and lateralization phenomena in ASD warrant further investigation, and we hope that this work can advance interdisciplinary understanding of ASD. En ligne : https://doi.org/10.1002/aur.3204 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Exploring autism via the retina: Comparative insights in children with autism spectrum disorder and typical development [Texte imprimé et/ou numérique] / Yuexuan WANG, Auteur ; Huiyun GAO, Auteur ; Zhengwang XIA, Auteur ; Chaofan ZENG, Auteur ; Kun HUANG, Auteur ; Zhaoqi ZHU, Auteur ; Jianfeng LU, Auteur ; Qiang CHEN, Auteur ; Xiaoyan KE, Auteur ; Weiwei ZHANG, Auteur . - p.1520-1533. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1520-1533 Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a widely recognized neurodevelopmental disorder, yet the identification of reliable imaging biomarkers for its early diagnosis remains a challenge. Considering the specific manifestations of ASD in the eyes and the interconnectivity between the brain and the eyes, this study investigates ASD through the lens of retinal analysis. We specifically examined differences in the macular region of the retina using optical coherence tomography (OCT)/optical coherence tomography angiography (OCTA) images between children diagnosed with ASD and those with typical development (TD). Our findings present potential novel characteristics of ASD: the thickness of the ellipsoid zone (EZ) with cone photoreceptors was significantly increased in ASD; the large-caliber arteriovenous of the inner retina was significantly reduced in ASD; these changes in the EZ and arteriovenous were more significant in the left eye than in the right eye. These observations of photoreceptor alterations, vascular function changes, and lateralization phenomena in ASD warrant further investigation, and we hope that this work can advance interdisciplinary understanding of ASD. En ligne : https://doi.org/10.1002/aur.3204 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

An alpha 5-GABA receptor positive allosteric modulator attenuates social and cognitive deficits without changing dopamine system hyperactivity in rats exposed to valproic acid in utero / Ícaro Silva FREITAS ; Dishary SHARMIN ; James M. COOK ; Francisco S. GUIMARÃES ; Felipe V. GOMES in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1534-1544 Titre : An alpha 5-GABA receptor positive allosteric modulator attenuates social and cognitive deficits without changing dopamine system hyperactivity in rats exposed to valproic acid in utero Type de document : Texte imprimé et/ou numérique Auteurs : Ícaro Silva FREITAS, Auteur ; Dishary SHARMIN, Auteur ; James M. COOK, Auteur ; Francisco S. GUIMARÃES, Auteur ; Felipe V. GOMES, Auteur Article en page(s) : p.1534-1544 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorders (ASDs) are characterized by core behavioral symptoms in the domains of sociability, language/communication, and repetitive or stereotyped behaviors. Deficits in the prefrontal and hippocampal excitatory/inhibitory balance due to a functional loss of GABAergic interneurons are proposed to underlie these symptoms. Increasing the postsynaptic effects of GABA with compounds that selectively modulate GABAergic receptors could be a potential target for treating ASD symptoms. In addition, deficits in GABAergic interneurons have been linked to dopamine (DA) system dysregulation, and, despite conflicting evidence, abnormalities in the DA system activity may underly some ASD symptoms. Here, we investigated whether the positive allosteric modulator of ?5-containing GABAA receptors (?5-GABAARs) SH-053-2?F-R-CH3 (10?mg/kg) attenuates behavioral abnormalities in rats exposed to valproic acid (VPA) in utero, an established risk factor for autism. We also evaluated if animals exposed to VPA in utero present changes in the ventral tegmental area (VTA) DA system activity using in vivo electrophysiology and if SH-053-2?F-R-CH3 could attenuate these changes. SH-053-2?F-R-CH3 was administered intraperitoneally 30?min before each behavioral test and electrophysiology. In utero VPA exposure caused male and female rats to present increased repetitive behavior (self-grooming) in early adolescence and deficits in social interaction in adulthood. Male, but not female VPA rats, also presented deficits in recognition memory as adults. SH-053-2?F-R-CH3 attenuated the impairments in sociability and cognitive function in male VPA-exposed rats without attenuating the decreased social interaction in females. Adult male and female VPA-exposed rats also showed an increased VTA DA neuron population activity, which was not changed by SH-053-2?F-R-CH3. Despite sex differences, our findings indicate that ?5-GABAARs positive allosteric modulators may effectively attenuate some core ASD symptoms. En ligne : https://doi.org/10.1002/aur.3178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] An alpha 5-GABA receptor positive allosteric modulator attenuates social and cognitive deficits without changing dopamine system hyperactivity in rats exposed to valproic acid in utero [Texte imprimé et/ou numérique] / Ícaro Silva FREITAS, Auteur ; Dishary SHARMIN, Auteur ; James M. COOK, Auteur ; Francisco S. GUIMARÃES, Auteur ; Felipe V. GOMES, Auteur . - p.1534-1544. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1534-1544 Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorders (ASDs) are characterized by core behavioral symptoms in the domains of sociability, language/communication, and repetitive or stereotyped behaviors. Deficits in the prefrontal and hippocampal excitatory/inhibitory balance due to a functional loss of GABAergic interneurons are proposed to underlie these symptoms. Increasing the postsynaptic effects of GABA with compounds that selectively modulate GABAergic receptors could be a potential target for treating ASD symptoms. In addition, deficits in GABAergic interneurons have been linked to dopamine (DA) system dysregulation, and, despite conflicting evidence, abnormalities in the DA system activity may underly some ASD symptoms. Here, we investigated whether the positive allosteric modulator of ?5-containing GABAA receptors (?5-GABAARs) SH-053-2?F-R-CH3 (10?mg/kg) attenuates behavioral abnormalities in rats exposed to valproic acid (VPA) in utero, an established risk factor for autism. We also evaluated if animals exposed to VPA in utero present changes in the ventral tegmental area (VTA) DA system activity using in vivo electrophysiology and if SH-053-2?F-R-CH3 could attenuate these changes. SH-053-2?F-R-CH3 was administered intraperitoneally 30?min before each behavioral test and electrophysiology. In utero VPA exposure caused male and female rats to present increased repetitive behavior (self-grooming) in early adolescence and deficits in social interaction in adulthood. Male, but not female VPA rats, also presented deficits in recognition memory as adults. SH-053-2?F-R-CH3 attenuated the impairments in sociability and cognitive function in male VPA-exposed rats without attenuating the decreased social interaction in females. Adult male and female VPA-exposed rats also showed an increased VTA DA neuron population activity, which was not changed by SH-053-2?F-R-CH3. Despite sex differences, our findings indicate that ?5-GABAARs positive allosteric modulators may effectively attenuate some core ASD symptoms. En ligne : https://doi.org/10.1002/aur.3178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Balance and motor skills differences between children and teenagers with autism spectrum disorder and neurotypically developing / Alicia CUESTA-GÓMEZ ; Pilar FERNÁDEZ-GONZÁLEZ ; María CARRATLÁ-TEJADA in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1545-1555 Titre : Balance and motor skills differences between children and teenagers with autism spectrum disorder and neurotypically developing Type de document : Texte imprimé et/ou numérique Auteurs : Alicia CUESTA-GÓMEZ, Auteur ; Pilar FERNÁDEZ-GONZÁLEZ, Auteur ; María CARRATLÁ-TEJADA, Auteur Article en page(s) : p.1545-1555 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study examined the differences between children and adolescents with autism spectrum disorder (ASD) and neurotypically developing (NTD) in terms of balance, postural control, and motor skills. It also examined which motor skills are most affected and whether scores on different assessment tests in ASD children are correlated. A cross-sectional observational study with two research groups was conducted. Timed up and go test (TUG), short form of Bruininks-Oseretsky test of Motor Proficiency version 2 (SFBOT-2), and pediatric balance scale (PBS) were used. A total of 100 participants 50 with ASD and 50 with NTD engaged in the research. Statistically significant differences were obtained between control group and ASD group in TUG test and in SFBOT-2 standard score and total score (p-value = <0.01). A statistically significant difference (p-value = <0.01) was seen between ASD group's and control group's PBS scores. Poor correlation was noted between TUG and SFBOT-2, as well as between PBS and TUG. A moderate correlation was also found between SFBOT-2 and PBS. Children with ASD present difficulties in motor skills and in static and dynamic balance compared to children with NTD. Differences were observed in the motor skills of strength followed by manual dexterity, running speed and agility, fine motor precision, fine motor integration, and balance. The PBS item that showed the greatest difference between the ASD group and control group was maintaining monopodial support with hands on hips. Finally, poor to moderate correlations were obtained between the different tests with statistically significant differences. En ligne : https://doi.org/10.1002/aur.3181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Balance and motor skills differences between children and teenagers with autism spectrum disorder and neurotypically developing [Texte imprimé et/ou numérique] / Alicia CUESTA-GÓMEZ, Auteur ; Pilar FERNÁDEZ-GONZÁLEZ, Auteur ; María CARRATLÁ-TEJADA, Auteur . - p.1545-1555. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1545-1555 Index. décimale : PER Périodiques Résumé : Abstract This study examined the differences between children and adolescents with autism spectrum disorder (ASD) and neurotypically developing (NTD) in terms of balance, postural control, and motor skills. It also examined which motor skills are most affected and whether scores on different assessment tests in ASD children are correlated. A cross-sectional observational study with two research groups was conducted. Timed up and go test (TUG), short form of Bruininks-Oseretsky test of Motor Proficiency version 2 (SFBOT-2), and pediatric balance scale (PBS) were used. A total of 100 participants 50 with ASD and 50 with NTD engaged in the research. Statistically significant differences were obtained between control group and ASD group in TUG test and in SFBOT-2 standard score and total score (p-value = <0.01). A statistically significant difference (p-value = <0.01) was seen between ASD group's and control group's PBS scores. Poor correlation was noted between TUG and SFBOT-2, as well as between PBS and TUG. A moderate correlation was also found between SFBOT-2 and PBS. Children with ASD present difficulties in motor skills and in static and dynamic balance compared to children with NTD. Differences were observed in the motor skills of strength followed by manual dexterity, running speed and agility, fine motor precision, fine motor integration, and balance. The PBS item that showed the greatest difference between the ASD group and control group was maintaining monopodial support with hands on hips. Finally, poor to moderate correlations were obtained between the different tests with statistically significant differences. En ligne : https://doi.org/10.1002/aur.3181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Impaired inhibitory control when processing real but not cartoon emotional faces in autistic children: Evidence from an event-related potential study / Shelley Xiuli TONG in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1556-1571 Titre : Impaired inhibitory control when processing real but not cartoon emotional faces in autistic children: Evidence from an event-related potential study Type de document : Texte imprimé et/ou numérique Auteurs : Shelley Xiuli TONG, Auteur Article en page(s) : p.1556-1571 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Impaired socioemotional functioning characterizes autistic children, but does weak inhibition control underlie their socioemotional difficulty? This study addressed this question by examining whether and, if so, how inhibition control is affected by face realism and emotional valence in school-age autistic and neurotypical children. Fifty-two autistic and 52 age-matched neurotypical controls aged 10-12?years completed real and cartoon emotional face Go/Nogo tasks while event-related potentials (ERPs) were recorded. The analyses of inhibition-emotion components (i.e., N2, P3, and LPP) and a face-specific N170 revealed that autistic children elicited greater N2 while inhibiting Nogo trials and greater P3/LPP and late LPP for real but not cartoon emotional faces. Moreover, autistic children exhibited a reduced N170 to real face emotions only. Furthermore, correlation results showed that better behavioral inhibition and emotion recognition in autistic children were associated with a reduced N170. These findings suggest that neural mechanisms of inhibitory control in autistic children are less efficient and more disrupted during real face processing, which may affect their age-appropriate socio-emotional development. En ligne : https://doi.org/10.1002/aur.3176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Impaired inhibitory control when processing real but not cartoon emotional faces in autistic children: Evidence from an event-related potential study [Texte imprimé et/ou numérique] / Shelley Xiuli TONG, Auteur . - p.1556-1571. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1556-1571 Index. décimale : PER Périodiques Résumé : Abstract Impaired socioemotional functioning characterizes autistic children, but does weak inhibition control underlie their socioemotional difficulty? This study addressed this question by examining whether and, if so, how inhibition control is affected by face realism and emotional valence in school-age autistic and neurotypical children. Fifty-two autistic and 52 age-matched neurotypical controls aged 10-12?years completed real and cartoon emotional face Go/Nogo tasks while event-related potentials (ERPs) were recorded. The analyses of inhibition-emotion components (i.e., N2, P3, and LPP) and a face-specific N170 revealed that autistic children elicited greater N2 while inhibiting Nogo trials and greater P3/LPP and late LPP for real but not cartoon emotional faces. Moreover, autistic children exhibited a reduced N170 to real face emotions only. Furthermore, correlation results showed that better behavioral inhibition and emotion recognition in autistic children were associated with a reduced N170. These findings suggest that neural mechanisms of inhibitory control in autistic children are less efficient and more disrupted during real face processing, which may affect their age-appropriate socio-emotional development. En ligne : https://doi.org/10.1002/aur.3176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Atypical and variable attention patterns reveal reduced contextual priors in children with autism spectrum disorder / Rong CHENG ; Zhong ZHAO ; Haotian LIAO ; Jing LI in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1572-1585 Titre : Atypical and variable attention patterns reveal reduced contextual priors in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rong CHENG, Auteur ; Zhong ZHAO, Auteur ; Haotian LIAO, Auteur ; Jing LI, Auteur Article en page(s) : p.1572-1585 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Accumulating evidence suggests that individuals with autism spectrum disorder (ASD) show impairments in using contextual priors to predict others'actions and make intention inference. Yet less is known about whether and how children with ASD acquire contextual priors during action observation and how contextual priors relate to their action prediction and intention inference. To form proper contextual priors, individuals need to observe the social scenes in a reliable manner and focus on socially relevant information. By employing a data-driven scan path method and areas of interest (AOI)-based analysis, the current study investigated how contextual priors would relate to action prediction and intention understanding in 4-to-9-year-old children with ASD (N = 56) and typically developing (TD) children (N = 50) during free viewing of dynamic social scenes with different intentions. Results showed that children with ASD exhibited higher intra-subject variability when scanning social scenes and reduced attention to socially relevant areas. Moreover, children with high-level action prediction and intention understanding showed lower intra-subject variability and increased attention to socially relevant areas. These findings suggest that altered fixation patterns might restrain children with ASD from acquiring proper contextual priors, which has cascading downstream effects on their action prediction and intention understanding. En ligne : https://doi.org/10.1002/aur.3194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Atypical and variable attention patterns reveal reduced contextual priors in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Rong CHENG, Auteur ; Zhong ZHAO, Auteur ; Haotian LIAO, Auteur ; Jing LI, Auteur . - p.1572-1585. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1572-1585 Index. décimale : PER Périodiques Résumé : Abstract Accumulating evidence suggests that individuals with autism spectrum disorder (ASD) show impairments in using contextual priors to predict others'actions and make intention inference. Yet less is known about whether and how children with ASD acquire contextual priors during action observation and how contextual priors relate to their action prediction and intention inference. To form proper contextual priors, individuals need to observe the social scenes in a reliable manner and focus on socially relevant information. By employing a data-driven scan path method and areas of interest (AOI)-based analysis, the current study investigated how contextual priors would relate to action prediction and intention understanding in 4-to-9-year-old children with ASD (N = 56) and typically developing (TD) children (N = 50) during free viewing of dynamic social scenes with different intentions. Results showed that children with ASD exhibited higher intra-subject variability when scanning social scenes and reduced attention to socially relevant areas. Moreover, children with high-level action prediction and intention understanding showed lower intra-subject variability and increased attention to socially relevant areas. These findings suggest that altered fixation patterns might restrain children with ASD from acquiring proper contextual priors, which has cascading downstream effects on their action prediction and intention understanding. En ligne : https://doi.org/10.1002/aur.3194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Characteristics and correlates of aggressive behavior in autistic youths / Charles M. BORDUIN ; Kaitlin M. SHEERIN ; Stephen M. KANNE in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1586-1600 Titre : Characteristics and correlates of aggressive behavior in autistic youths Type de document : Texte imprimé et/ou numérique Auteurs : Charles M. BORDUIN, Auteur ; Kaitlin M. SHEERIN, Auteur ; Stephen M. KANNE, Auteur Article en page(s) : p.1586-1600 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study aimed to characterize aggressive behaviors in autistic youths and to identify the social environment variables most strongly linked with aggression in this clinical population. Participants were 2142 caregivers of autistic youths (ages 6.0-17.9) recruited from autism research centers across the United States. Caregivers completed self-report and behavior rating inventories that assessed both verbal and physical aggression as well as characteristics of the individual youths (sleep quality, gastrointestinal [GI] symptoms, and autism characteristics) and their families (caregiver stress, global family functioning, and sibling relations), peers (emotional bonding, number of friends), schools (academic functioning), and neighborhoods (perceived community safety). We used descriptive analyses to identify which aggressive acts were most common among autistic youths, and we performed bivariate correlations and multiple linear regression analyses to determine which characteristics of the youths and their social environments were most strongly linked with youth aggression. Verbally aggressive youth behaviors were endorsed by caregivers most frequently. Youth age and sex were not associated with verbal or physical aggression. A combination of youth and social environment characteristics accounted for 42.6% of the variance in verbal aggression and 26.0% of the variance in physical aggression. Thus, those characteristics most strongly linked with verbal and physical aggression were strained sibling relations, caregiver stress, youth sleep problems, and youth repetitive and restrictive behaviors. Viewed together, the results suggest that aggressive behaviors in autistic youths are associated with multiple characteristics pertaining to the individual youths and their immediate social environments. Implications for treatment and research are discussed. En ligne : https://doi.org/10.1002/aur.3199 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Characteristics and correlates of aggressive behavior in autistic youths [Texte imprimé et/ou numérique] / Charles M. BORDUIN, Auteur ; Kaitlin M. SHEERIN, Auteur ; Stephen M. KANNE, Auteur . - p.1586-1600. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1586-1600 Index. décimale : PER Périodiques Résumé : Abstract This study aimed to characterize aggressive behaviors in autistic youths and to identify the social environment variables most strongly linked with aggression in this clinical population. Participants were 2142 caregivers of autistic youths (ages 6.0-17.9) recruited from autism research centers across the United States. Caregivers completed self-report and behavior rating inventories that assessed both verbal and physical aggression as well as characteristics of the individual youths (sleep quality, gastrointestinal [GI] symptoms, and autism characteristics) and their families (caregiver stress, global family functioning, and sibling relations), peers (emotional bonding, number of friends), schools (academic functioning), and neighborhoods (perceived community safety). We used descriptive analyses to identify which aggressive acts were most common among autistic youths, and we performed bivariate correlations and multiple linear regression analyses to determine which characteristics of the youths and their social environments were most strongly linked with youth aggression. Verbally aggressive youth behaviors were endorsed by caregivers most frequently. Youth age and sex were not associated with verbal or physical aggression. A combination of youth and social environment characteristics accounted for 42.6% of the variance in verbal aggression and 26.0% of the variance in physical aggression. Thus, those characteristics most strongly linked with verbal and physical aggression were strained sibling relations, caregiver stress, youth sleep problems, and youth repetitive and restrictive behaviors. Viewed together, the results suggest that aggressive behaviors in autistic youths are associated with multiple characteristics pertaining to the individual youths and their immediate social environments. Implications for treatment and research are discussed. En ligne : https://doi.org/10.1002/aur.3199 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Diurnal cortisol profiles in autistic adolescents and young adults: Associations with social difficulties and internalizing mental health symptoms / Farnaz DELAVARI ; Clémence FELLER ; Olivia ZANOLETTI ; Carmen SANDI ; Maude SCHNEIDER in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1601-1615 Titre : Diurnal cortisol profiles in autistic adolescents and young adults: Associations with social difficulties and internalizing mental health symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Farnaz DELAVARI, Auteur ; Clémence FELLER, Auteur ; Olivia ZANOLETTI, Auteur ; Carmen SANDI, Auteur ; Maude SCHNEIDER, Auteur Article en page(s) : p.1601-1615 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Several autism-related characteristics, such as social difficulties, may contribute to high perceived stress and increased exposure to stressful life events in some autistic individuals. Repeated exposure to stress might lead to the dysfunction of the hypothalamic-pituitary-adrenocortical-axis and be a vulnerability factor for developing mental health difficulties. Previous studies show contradictory findings on salivary cortisol in autism. In the current study, we investigated diurnal cortisol profiles in autistic adolescents and young adults, as well as their associations with social difficulties, stress exposure, and mental health symptoms. Autistic (n = 48, Mage = 17.6) and nonautistic (n = 51, Mage = 18.4) participants collected salivary cortisol at home six times a day for 2?days. Social difficulties, exposure to stressful life events/bullying, and mental health symptoms were assessed with questionnaires and clinical interviews. Similar diurnal cortisol slopes (DCS) and cortisol awakening responses were observed between the groups, but autistic participants showed higher total cortisol output (AUCG, area under the curve with respect to ground) during the day (b = 19.09, p = 0.009). In the autistic group, more severe social difficulties were associated with flatter DCS (b = 0.01, p = 0.007). Finally, cortisol alterations were associated with self-reported mental health symptoms, especially in autistic females in analyses uncorrected for multiple comparisons. In conclusion, our results do not indicate autism-related group-level alterations in most diurnal cortisol measures, but autistic youth showed higher total cortisol (AUCG) compared with nonautistic peers. More detailed investigation of interindividual variability in cortisol profiles within autistic people might give us important insights into vulnerability to developing stress-related mental health difficulties. En ligne : https://doi.org/10.1002/aur.3184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Diurnal cortisol profiles in autistic adolescents and young adults: Associations with social difficulties and internalizing mental health symptoms [Texte imprimé et/ou numérique] / Farnaz DELAVARI, Auteur ; Clémence FELLER, Auteur ; Olivia ZANOLETTI, Auteur ; Carmen SANDI, Auteur ; Maude SCHNEIDER, Auteur . - p.1601-1615. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1601-1615 Index. décimale : PER Périodiques Résumé : Abstract Several autism-related characteristics, such as social difficulties, may contribute to high perceived stress and increased exposure to stressful life events in some autistic individuals. Repeated exposure to stress might lead to the dysfunction of the hypothalamic-pituitary-adrenocortical-axis and be a vulnerability factor for developing mental health difficulties. Previous studies show contradictory findings on salivary cortisol in autism. In the current study, we investigated diurnal cortisol profiles in autistic adolescents and young adults, as well as their associations with social difficulties, stress exposure, and mental health symptoms. Autistic (n = 48, Mage = 17.6) and nonautistic (n = 51, Mage = 18.4) participants collected salivary cortisol at home six times a day for 2?days. Social difficulties, exposure to stressful life events/bullying, and mental health symptoms were assessed with questionnaires and clinical interviews. Similar diurnal cortisol slopes (DCS) and cortisol awakening responses were observed between the groups, but autistic participants showed higher total cortisol output (AUCG, area under the curve with respect to ground) during the day (b = 19.09, p = 0.009). In the autistic group, more severe social difficulties were associated with flatter DCS (b = 0.01, p = 0.007). Finally, cortisol alterations were associated with self-reported mental health symptoms, especially in autistic females in analyses uncorrected for multiple comparisons. In conclusion, our results do not indicate autism-related group-level alterations in most diurnal cortisol measures, but autistic youth showed higher total cortisol (AUCG) compared with nonautistic peers. More detailed investigation of interindividual variability in cortisol profiles within autistic people might give us important insights into vulnerability to developing stress-related mental health difficulties. En ligne : https://doi.org/10.1002/aur.3184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Early developmental milestone clusters of autistic children based on electronic health records / Joshua GUEDALIA ; Keren ILAN ; Galit SHEFER ; Roe COHEN ; Lidia V. GABIS in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1616-1627 Titre : Early developmental milestone clusters of autistic children based on electronic health records Type de document : Texte imprimé et/ou numérique Auteurs : Joshua GUEDALIA, Auteur ; Keren ILAN, Auteur ; Galit SHEFER, Auteur ; Roe COHEN, Auteur ; Lidia V. GABIS, Auteur Article en page(s) : p.1616-1627 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autistic children vary in symptoms, co-morbidities, and response to interventions. This study aimed to identify clusters of autistic children with a distinct pattern of attaining early developmental milestones (EDMs). The clustering of 5836 autistic children was based on the attainment of 43 gross motor, fine motor, language, and social developmental milestones during the first 3?years of life as recorded in baby wellness visits. K-means cluster analysis detected four EDM clusters: mild (n = 1686); moderate (n = 1691); severe (n = 2265); and global (n = 194). The most prominent cluster differences were in the language domain. The global cluster showed earlier and greater developmental delay across domains, unique early gross motor delays, and more were born preterm via cesarean section. The severe cluster had poor language development prominently in the second year of life, and later fine motor delays. Moderate cluster had mainly language delays in the third year of life. The mild cluster mostly passed milestones. EDM clusters differed demographically, with higher socioeconomic status in mild cluster and lowest in global cluster. However, the severe cluster had more immigrant and non-Jewish mothers followed by the moderate cluster. The rates of parental concerns and provider developmental referrals were significantly higher in the global, followed by the severe, moderate, and mild EDM clusters. Autistic children's language and motor delay in the first 3?years can be grouped by common magnitude and onset profiles as distinct groups that may link to specific etiologies (like prematurity or genetics) and specific intervention programs. Early autism screening should be tailored to these different developmental profiles. En ligne : https://doi.org/10.1002/aur.3177 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Early developmental milestone clusters of autistic children based on electronic health records [Texte imprimé et/ou numérique] / Joshua GUEDALIA, Auteur ; Keren ILAN, Auteur ; Galit SHEFER, Auteur ; Roe COHEN, Auteur ; Lidia V. GABIS, Auteur . - p.1616-1627. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1616-1627 Index. décimale : PER Périodiques Résumé : Abstract Autistic children vary in symptoms, co-morbidities, and response to interventions. This study aimed to identify clusters of autistic children with a distinct pattern of attaining early developmental milestones (EDMs). The clustering of 5836 autistic children was based on the attainment of 43 gross motor, fine motor, language, and social developmental milestones during the first 3?years of life as recorded in baby wellness visits. K-means cluster analysis detected four EDM clusters: mild (n = 1686); moderate (n = 1691); severe (n = 2265); and global (n = 194). The most prominent cluster differences were in the language domain. The global cluster showed earlier and greater developmental delay across domains, unique early gross motor delays, and more were born preterm via cesarean section. The severe cluster had poor language development prominently in the second year of life, and later fine motor delays. Moderate cluster had mainly language delays in the third year of life. The mild cluster mostly passed milestones. EDM clusters differed demographically, with higher socioeconomic status in mild cluster and lowest in global cluster. However, the severe cluster had more immigrant and non-Jewish mothers followed by the moderate cluster. The rates of parental concerns and provider developmental referrals were significantly higher in the global, followed by the severe, moderate, and mild EDM clusters. Autistic children's language and motor delay in the first 3?years can be grouped by common magnitude and onset profiles as distinct groups that may link to specific etiologies (like prematurity or genetics) and specific intervention programs. Early autism screening should be tailored to these different developmental profiles. En ligne : https://doi.org/10.1002/aur.3177 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Empathy among autistic and non-autistic adolescents: The importance of informant effects / Florina UZEFOVSKY in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1628-1639 Titre : Empathy among autistic and non-autistic adolescents: The importance of informant effects Type de document : Texte imprimé et/ou numérique Auteurs : Florina UZEFOVSKY, Auteur Article en page(s) : p.1628-1639 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Empathy is the ability to recognize the emotions of others (cognitive empathy) and to share in those emotions while maintaining a self-other distinction (emotional empathy). Previous research often, but not always, showed that autistic adults and children have lower levels of overall and cognitive empathy than non-autistic individuals. Yet how empathy manifests during adolescence, a developmental period marked by physiological, social, and cognitive change, is largely unclear. As well, we aimed to compare self versus parents'perceptions regarding adolescents'empathy. To do so, parents (N = 157) of 10-16-year-olds (N = 59 autistic) and their children (N = 133) completed empathy questionnaires. Adolescents also completed a measure of mental state recognition (Reading the Mind in the Eyes Test; RMET) and parents reported on their child's autistic traits. The tasks were completed twice ~six months apart. We found that autistic adolescents reported having lower empathic concern and higher personal distress than their non-autistic peers, whereas parents of autistic adolescents perceived them as having overall lower levels of empathy. Performance on the mental state recognition task of autistic and non-autistic adolescents'was comparable. The gap between self and parent reports regarding adolescents'empathy was explainable by parent-reported autistic traits, mainly communication difficulties. Empathy remains stable across the study's two time points. Thus, the findings do not support previous views of autistic people as having less empathy and these are possibly explainable by informant effects. En ligne : https://doi.org/10.1002/aur.3197 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Empathy among autistic and non-autistic adolescents: The importance of informant effects [Texte imprimé et/ou numérique] / Florina UZEFOVSKY, Auteur . - p.1628-1639. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1628-1639 Index. décimale : PER Périodiques Résumé : Abstract Empathy is the ability to recognize the emotions of others (cognitive empathy) and to share in those emotions while maintaining a self-other distinction (emotional empathy). Previous research often, but not always, showed that autistic adults and children have lower levels of overall and cognitive empathy than non-autistic individuals. Yet how empathy manifests during adolescence, a developmental period marked by physiological, social, and cognitive change, is largely unclear. As well, we aimed to compare self versus parents'perceptions regarding adolescents'empathy. To do so, parents (N = 157) of 10-16-year-olds (N = 59 autistic) and their children (N = 133) completed empathy questionnaires. Adolescents also completed a measure of mental state recognition (Reading the Mind in the Eyes Test; RMET) and parents reported on their child's autistic traits. The tasks were completed twice ~six months apart. We found that autistic adolescents reported having lower empathic concern and higher personal distress than their non-autistic peers, whereas parents of autistic adolescents perceived them as having overall lower levels of empathy. Performance on the mental state recognition task of autistic and non-autistic adolescents'was comparable. The gap between self and parent reports regarding adolescents'empathy was explainable by parent-reported autistic traits, mainly communication difficulties. Empathy remains stable across the study's two time points. Thus, the findings do not support previous views of autistic people as having less empathy and these are possibly explainable by informant effects. En ligne : https://doi.org/10.1002/aur.3197 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Empathy in autistic children: Emotional overarousal in response to others'physical pain / Jean DECETY ; Zihui HUA ; Guoxiang LI ; Li YI in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1640-1650 Titre : Empathy in autistic children: Emotional overarousal in response to others'physical pain Type de document : Texte imprimé et/ou numérique Auteurs : Jean DECETY, Auteur ; Zihui HUA, Auteur ; Guoxiang LI, Auteur ; Li YI, Auteur Article en page(s) : p.1640-1650 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Different empathic responses are often reported in autism but remain controversial. To investigate which component of empathy is most affected by autism, we examined the affective, cognitive, and motivational components of empathy in 25 5- to 8-year-old autistic and 27 neurotypical children. Participants were presented with visual stimuli depicting people's limbs in painful or nonpainful situations while their eye movements, pupillary responses, and verbal ratings of pain intensity and empathic concern were recorded. The results indicate an emotional overarousal and reduced empathic concern to others'pain in autism. Compared with neurotypical children, autistic children displayed larger pupil dilation accompanied by attentional avoidance to others'pain. Moreover, even though autistic children rated others in painful situations as painful, they felt less sorry than neurotypical children. Interestingly, autistic children felt more sorry in nonpainful situations compared with neurotypical children. These findings demonstrated an emotional overarousal in response to others'pain in autistic children, and provide important implications for clinical practice aiming to promote socio-emotional understanding in autistic children. En ligne : https://doi.org/10.1002/aur.3200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Empathy in autistic children: Emotional overarousal in response to others'physical pain [Texte imprimé et/ou numérique] / Jean DECETY, Auteur ; Zihui HUA, Auteur ; Guoxiang LI, Auteur ; Li YI, Auteur . - p.1640-1650. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1640-1650 Index. décimale : PER Périodiques Résumé : Abstract Different empathic responses are often reported in autism but remain controversial. To investigate which component of empathy is most affected by autism, we examined the affective, cognitive, and motivational components of empathy in 25 5- to 8-year-old autistic and 27 neurotypical children. Participants were presented with visual stimuli depicting people's limbs in painful or nonpainful situations while their eye movements, pupillary responses, and verbal ratings of pain intensity and empathic concern were recorded. The results indicate an emotional overarousal and reduced empathic concern to others'pain in autism. Compared with neurotypical children, autistic children displayed larger pupil dilation accompanied by attentional avoidance to others'pain. Moreover, even though autistic children rated others in painful situations as painful, they felt less sorry than neurotypical children. Interestingly, autistic children felt more sorry in nonpainful situations compared with neurotypical children. These findings demonstrated an emotional overarousal in response to others'pain in autistic children, and provide important implications for clinical practice aiming to promote socio-emotional understanding in autistic children. En ligne : https://doi.org/10.1002/aur.3200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program / Aisha S. DICKERSON ; Tingju HSU ; Aseel AL-JADIRI ; Carlos A. CAMARGO ; Julie B. SCHWEITZER ; Coral L. SHUSTER ; Margaret R. KARAGAS ; Juliette C. MADAN ; Bibiana RESTREPO ; Rebecca J. SCHMIDT ; Claudia LUGO-CANDELAS ; Jenae NEIDERHISER ; Sheela SATHYANARAYANA ; Anne L. DUNLOP ; Patricia A. BRENNAN ; program collaborators for Environmental influences on Child Health OUTCOMES in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1651-1664 Titre : Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program Type de document : Texte imprimé et/ou numérique Auteurs : Aisha S. DICKERSON, Auteur ; Tingju HSU, Auteur ; Aseel AL-JADIRI, Auteur ; Carlos A. CAMARGO, Auteur ; Julie B. SCHWEITZER, Auteur ; Coral L. SHUSTER, Auteur ; Margaret R. KARAGAS, Auteur ; Juliette C. MADAN, Auteur ; Bibiana RESTREPO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Claudia LUGO-CANDELAS, Auteur ; Jenae NEIDERHISER, Auteur ; Sheela SATHYANARAYANA, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Article en page(s) : p.1651-1664 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1-18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on child health outcomes consortium were included in analyses. Results from generalized linear mixed models replicated previous studies showing that associations between prenatal cannabis exposure and ASD traits in children are not significant when controlling for relevant covariates, particularly tobacco exposure. Child biological sex did not moderate the association between prenatal cannabis exposure and ASD. In a large sample and measuring ASD traits continuously, there was no evidence that prenatal cannabis exposure increases the risk for ASD. This work helps to clarify previous mixed findings by addressing concerns about statistical power and ASD measurement. En ligne : https://doi.org/10.1002/aur.3185 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program [Texte imprimé et/ou numérique] / Aisha S. DICKERSON, Auteur ; Tingju HSU, Auteur ; Aseel AL-JADIRI, Auteur ; Carlos A. CAMARGO, Auteur ; Julie B. SCHWEITZER, Auteur ; Coral L. SHUSTER, Auteur ; Margaret R. KARAGAS, Auteur ; Juliette C. MADAN, Auteur ; Bibiana RESTREPO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Claudia LUGO-CANDELAS, Auteur ; Jenae NEIDERHISER, Auteur ; Sheela SATHYANARAYANA, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur . - p.1651-1664. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1651-1664 Index. décimale : PER Périodiques Résumé : Abstract This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1-18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on child health outcomes consortium were included in analyses. Results from generalized linear mixed models replicated previous studies showing that associations between prenatal cannabis exposure and ASD traits in children are not significant when controlling for relevant covariates, particularly tobacco exposure. Child biological sex did not moderate the association between prenatal cannabis exposure and ASD. In a large sample and measuring ASD traits continuously, there was no evidence that prenatal cannabis exposure increases the risk for ASD. This work helps to clarify previous mixed findings by addressing concerns about statistical power and ASD measurement. En ligne : https://doi.org/10.1002/aur.3185 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Family history of psychiatric conditions and development of siblings of children with autism / Joseph CHANG ; Zeyan LIEW ; Angelina VERNETTI ; Suzanne MACARI ; Kelly POWELL ; Katarzyna CHAWARSKA in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1665-1676 Titre : Family history of psychiatric conditions and development of siblings of children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Joseph CHANG, Auteur ; Zeyan LIEW, Auteur ; Angelina VERNETTI, Auteur ; Suzanne MACARI, Auteur ; Kelly POWELL, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.1665-1676 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Younger siblings (SIBS) of children with autism exhibit a wide range of clinical and subclinical symptoms including social, cognitive, language, and adaptive functioning delays. Identifying factors linked with this phenotypic heterogeneity is essential for improving understanding of the underlying biology of the heterogenous outcomes and for early identification of the most vulnerable SIBS. Prevalence of neurodevelopmental (NDD) and neuropsychiatric disorders (NPD) is significantly elevated in families of children with autism. It remains unknown, however, if the family history associates with the developmental outcomes among the SIBS. We quantified history of the NDDs and NPDs commonly reported in families of children with autism using a parent interview and assessed autism symptoms, verbal, nonverbal, and adaptive skills in a sample of 229 SIBS. Multiple regression analyses were used to examine links between family history and phenotypic outcomes, whereas controlling for birth year, age, sex, demographics, and parental education. Results suggest that family history of schizophrenia, depression, anxiety, bipolar disorder, and intellectual disability associate robustly with dimensional measures of social affect, verbal and nonverbal IQ, and adaptive functioning in the SIBS. Considering family history of these disorders may improve efforts to predict long-term outcomes in younger siblings of children with autism and inform about familial factors contributing to high phenotypic heterogenetity in this cohort. En ligne : https://doi.org/10.1002/aur.3175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Family history of psychiatric conditions and development of siblings of children with autism [Texte imprimé et/ou numérique] / Joseph CHANG, Auteur ; Zeyan LIEW, Auteur ; Angelina VERNETTI, Auteur ; Suzanne MACARI, Auteur ; Kelly POWELL, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.1665-1676. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1665-1676 Index. décimale : PER Périodiques Résumé : Abstract Younger siblings (SIBS) of children with autism exhibit a wide range of clinical and subclinical symptoms including social, cognitive, language, and adaptive functioning delays. Identifying factors linked with this phenotypic heterogeneity is essential for improving understanding of the underlying biology of the heterogenous outcomes and for early identification of the most vulnerable SIBS. Prevalence of neurodevelopmental (NDD) and neuropsychiatric disorders (NPD) is significantly elevated in families of children with autism. It remains unknown, however, if the family history associates with the developmental outcomes among the SIBS. We quantified history of the NDDs and NPDs commonly reported in families of children with autism using a parent interview and assessed autism symptoms, verbal, nonverbal, and adaptive skills in a sample of 229 SIBS. Multiple regression analyses were used to examine links between family history and phenotypic outcomes, whereas controlling for birth year, age, sex, demographics, and parental education. Results suggest that family history of schizophrenia, depression, anxiety, bipolar disorder, and intellectual disability associate robustly with dimensional measures of social affect, verbal and nonverbal IQ, and adaptive functioning in the SIBS. Considering family history of these disorders may improve efforts to predict long-term outcomes in younger siblings of children with autism and inform about familial factors contributing to high phenotypic heterogenetity in this cohort. En ligne : https://doi.org/10.1002/aur.3175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Hyper-focus, sticky attention, and springy attention in young autistic children: Associations with sensory behaviors and cognitive ability / Andre SILLAS ; Melanie PRIETO ; Emily CAMP ; Christine Wu NORDAHL ; Susan M. RIVERA in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1677-1695 Titre : Hyper-focus, sticky attention, and springy attention in young autistic children: Associations with sensory behaviors and cognitive ability Type de document : Texte imprimé et/ou numérique Auteurs : Andre SILLAS, Auteur ; Melanie PRIETO, Auteur ; Emily CAMP, Auteur ; Christine Wu NORDAHL, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : p.1677-1695 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The autistic-developed monotropism account suggests that atypical, domain-general attentional hyper-focus on interests is a central aspect of autism, but domain-general attention differences in autism can manifest differently. Prior research suggests autistic children are often slow to disengage attention from stimuli-a pattern often called "sticky attention"-and that they can show reduced novelty preference. These attentional patterns could influence sensory experiences and learning. We used eye-tracking to investigate novelty preference and "sticky attention" in young autistic children; we also examined whether attentional patterns were related to cognitive abilities and caregiver-reported sensory responsiveness. A total of 46 autistic and 28 nonautistic participants, aged between 2 and 4?years, provided usable data. We found no evidence that autistic children exhibited greater "sticky attention" than nonautistics, but "sticky attention" in autism was associated with more caregiver-reported sensory hyper-responsiveness, seeking/interests, and enhanced perception. Autistic children also nonsignificantly trended toward exhibiting reduced novelty preference. Unexpectedly, the time-course of this trending novelty preference difference implied it was not driven by reduced orienting to novelty, but increased returning to already-familiarized stimuli: what we call "springy attention." Exploratory analyses of data from the attentional disengagement task suggest autistic participants may have exhibited greater "springy attention," though further research with paradigms optimized for measuring this construct should confirm this. Importantly, "springy attention" was robustly related to reduced cognitive abilities and greater caregiver-reported hypo-responsiveness. Thus, this study illuminates two distinct domain-general attentional patterns, each with distinct correlates in young autistic children, which could have important implications for understanding autistic children's learning, development, and experiences. En ligne : https://doi.org/10.1002/aur.3174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Hyper-focus, sticky attention, and springy attention in young autistic children: Associations with sensory behaviors and cognitive ability [Texte imprimé et/ou numérique] / Andre SILLAS, Auteur ; Melanie PRIETO, Auteur ; Emily CAMP, Auteur ; Christine Wu NORDAHL, Auteur ; Susan M. RIVERA, Auteur . - p.1677-1695. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1677-1695 Index. décimale : PER Périodiques Résumé : Abstract The autistic-developed monotropism account suggests that atypical, domain-general attentional hyper-focus on interests is a central aspect of autism, but domain-general attention differences in autism can manifest differently. Prior research suggests autistic children are often slow to disengage attention from stimuli-a pattern often called "sticky attention"-and that they can show reduced novelty preference. These attentional patterns could influence sensory experiences and learning. We used eye-tracking to investigate novelty preference and "sticky attention" in young autistic children; we also examined whether attentional patterns were related to cognitive abilities and caregiver-reported sensory responsiveness. A total of 46 autistic and 28 nonautistic participants, aged between 2 and 4?years, provided usable data. We found no evidence that autistic children exhibited greater "sticky attention" than nonautistics, but "sticky attention" in autism was associated with more caregiver-reported sensory hyper-responsiveness, seeking/interests, and enhanced perception. Autistic children also nonsignificantly trended toward exhibiting reduced novelty preference. Unexpectedly, the time-course of this trending novelty preference difference implied it was not driven by reduced orienting to novelty, but increased returning to already-familiarized stimuli: what we call "springy attention." Exploratory analyses of data from the attentional disengagement task suggest autistic participants may have exhibited greater "springy attention," though further research with paradigms optimized for measuring this construct should confirm this. Importantly, "springy attention" was robustly related to reduced cognitive abilities and greater caregiver-reported hypo-responsiveness. Thus, this study illuminates two distinct domain-general attentional patterns, each with distinct correlates in young autistic children, which could have important implications for understanding autistic children's learning, development, and experiences. En ligne : https://doi.org/10.1002/aur.3174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Breastfeeding patterns in infants are associated with a later diagnosis of autism Spectrum disorder / Rewaa BALAUM ; Einav ALHOZYEL ; Gal MEIRI ; Dikla ZIGDON ; Analya MICHAELOVSKI ; Orly KERUB ; Idan MENASHE in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1696-1704 Titre : Breastfeeding patterns in infants are associated with a later diagnosis of autism Spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rewaa BALAUM, Auteur ; Einav ALHOZYEL, Auteur ; Gal MEIRI, Auteur ; Dikla ZIGDON, Auteur ; Analya MICHAELOVSKI, Auteur ; Orly KERUB, Auteur ; Idan MENASHE, Auteur Article en page(s) : p.1696-1704 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Breastfeeding is associated with medical and developmental benefits. This study aimed to assess associations between nutritional patterns in the first year of life and the likelihood of autism spectrum disorder (ASD). 270 children diagnosed with ASD (cases) and 500 neurotypical children (controls) matched to cases by sex, ethnicity, and birth date (+?3?months) were included in this retrospective case-control study. Both groups were ascertained from children born between 2014 and 2017 whose development/nutrition were monitored at mother-child health clinics in southern Israel. Conditional logistic regression was used to determine the independent association of nutritional patterns with ASD while adjusting for socio-demographic and clinical characteristics. Both exclusive and partial breastfeeding modes were associated with decreased odds of ASD diagnosis (aOR = 0.221, 95%CI = 0.136-0.360; aOR = 0.494, 95%CI = 0.328-0.743, respectively). A breastfeeding duration of >12?months was associated with lower ASD odds (aOR = 0.418, 95%CI = 0.204-0.855), while the introduction of solids after 6?months of age was associated with higher ASD odds than the introduction of solids at 6?months (aOR = 2.455, 95%CI = 1.116-4.201). These findings suggest that a longer period of exclusive breastfeeding is associated with a subsequent reduced likelihood of ASD diagnosis, thus reiterating the importance of proper post-natal nutrition for infant neurodevelopment. En ligne : https://doi.org/10.1002/aur.3211 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Breastfeeding patterns in infants are associated with a later diagnosis of autism Spectrum disorder [Texte imprimé et/ou numérique] / Rewaa BALAUM, Auteur ; Einav ALHOZYEL, Auteur ; Gal MEIRI, Auteur ; Dikla ZIGDON, Auteur ; Analya MICHAELOVSKI, Auteur ; Orly KERUB, Auteur ; Idan MENASHE, Auteur . - p.1696-1704. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1696-1704 Index. décimale : PER Périodiques Résumé : Abstract Breastfeeding is associated with medical and developmental benefits. This study aimed to assess associations between nutritional patterns in the first year of life and the likelihood of autism spectrum disorder (ASD). 270 children diagnosed with ASD (cases) and 500 neurotypical children (controls) matched to cases by sex, ethnicity, and birth date (+?3?months) were included in this retrospective case-control study. Both groups were ascertained from children born between 2014 and 2017 whose development/nutrition were monitored at mother-child health clinics in southern Israel. Conditional logistic regression was used to determine the independent association of nutritional patterns with ASD while adjusting for socio-demographic and clinical characteristics. Both exclusive and partial breastfeeding modes were associated with decreased odds of ASD diagnosis (aOR = 0.221, 95%CI = 0.136-0.360; aOR = 0.494, 95%CI = 0.328-0.743, respectively). A breastfeeding duration of >12?months was associated with lower ASD odds (aOR = 0.418, 95%CI = 0.204-0.855), while the introduction of solids after 6?months of age was associated with higher ASD odds than the introduction of solids at 6?months (aOR = 2.455, 95%CI = 1.116-4.201). These findings suggest that a longer period of exclusive breastfeeding is associated with a subsequent reduced likelihood of ASD diagnosis, thus reiterating the importance of proper post-natal nutrition for infant neurodevelopment. En ligne : https://doi.org/10.1002/aur.3211 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

A preliminary randomized controlled study of the PEERS® program for Taiwanese autistic adolescents: The effectiveness on reducing school bullying and enhancing social function / Yi-Ling CHIEN ; Yueh-Ming TAI ; Heng-Man CHEN ; Hsien-Hsueh SHIH ; Li-Wei CHEN ; Yu-Ying CHEN ; Wei-Tsuen SOONG ; Yen-Nan CHIU ; Wen-Che TSAI ; Elizabeth LAUGESON ; Mei-Hui TSENG ; Susan Shur-Fen GAU in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1705-1720 Titre : A preliminary randomized controlled study of the PEERS® program for Taiwanese autistic adolescents: The effectiveness on reducing school bullying and enhancing social function Type de document : Texte imprimé et/ou numérique Auteurs : Yi-Ling CHIEN, Auteur ; Yueh-Ming TAI, Auteur ; Heng-Man CHEN, Auteur ; Hsien-Hsueh SHIH, Auteur ; Li-Wei CHEN, Auteur ; Yu-Ying CHEN, Auteur ; Wei-Tsuen SOONG, Auteur ; Yen-Nan CHIU, Auteur ; Wen-Che TSAI, Auteur ; Elizabeth LAUGESON, Auteur ; Mei-Hui TSENG, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.1705-1720 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Individuals with autism spectrum disorder (ASD) often experience lifelong social communication challenges and are more vulnerable to school bullying. Addressing their social difficulties and school bullying requires evidence-based interventions. PEERS® (Program for the Education and Enrichment of Relational Skills) was adapted and translated for Taiwanese adolescents. This randomized controlled study aimed to examine the effectiveness of the Taiwanese version of PEERS® in reducing school bullying and enhancing social function among autistic adolescents. Twenty-one autistic adolescents (mean age 14.29?+?1.67?years; female n = 733.33%) were randomized to a treatment group (TG, n = 10) or a delayed treatment control group (DTG, n = 11). The outcome measures (school bullying, social challenges, social skills knowledge, and social skills performance) were assessed at baseline, post-treatment, and follow-up. The group and time interaction analyses revealed greater magnitudes of reduction in general school bullying (p < 0.001), victimization (p < 0.001), perpetration (p = 0.012), social challenges (p = 0.001), and peer conflicts (p < 0.001), and improvement in social knowledge (p < 0.001) in the TG group than the DTG group. The findings suggest that the PEERS® program tailored for Taiwanese adolescents is effective in reducing school bullying, decreasing social challenges, and enhancing social skills among autistic adolescents, with very large effect sizes (Cohen's d ranging from 1.19 to 2.88). Consequently, participation in the PEERS® program is recommended for adolescents with social difficulties to improve their social communication and interactions to offset school bullying and other social challenges related to adverse outcomes. En ligne : https://doi.org/10.1002/aur.3213 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] A preliminary randomized controlled study of the PEERS® program for Taiwanese autistic adolescents: The effectiveness on reducing school bullying and enhancing social function [Texte imprimé et/ou numérique] / Yi-Ling CHIEN, Auteur ; Yueh-Ming TAI, Auteur ; Heng-Man CHEN, Auteur ; Hsien-Hsueh SHIH, Auteur ; Li-Wei CHEN, Auteur ; Yu-Ying CHEN, Auteur ; Wei-Tsuen SOONG, Auteur ; Yen-Nan CHIU, Auteur ; Wen-Che TSAI, Auteur ; Elizabeth LAUGESON, Auteur ; Mei-Hui TSENG, Auteur ; Susan Shur-Fen GAU, Auteur . - p.1705-1720. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1705-1720 Index. décimale : PER Périodiques Résumé : Abstract Individuals with autism spectrum disorder (ASD) often experience lifelong social communication challenges and are more vulnerable to school bullying. Addressing their social difficulties and school bullying requires evidence-based interventions. PEERS® (Program for the Education and Enrichment of Relational Skills) was adapted and translated for Taiwanese adolescents. This randomized controlled study aimed to examine the effectiveness of the Taiwanese version of PEERS® in reducing school bullying and enhancing social function among autistic adolescents. Twenty-one autistic adolescents (mean age 14.29?+?1.67?years; female n = 733.33%) were randomized to a treatment group (TG, n = 10) or a delayed treatment control group (DTG, n = 11). The outcome measures (school bullying, social challenges, social skills knowledge, and social skills performance) were assessed at baseline, post-treatment, and follow-up. The group and time interaction analyses revealed greater magnitudes of reduction in general school bullying (p < 0.001), victimization (p < 0.001), perpetration (p = 0.012), social challenges (p = 0.001), and peer conflicts (p < 0.001), and improvement in social knowledge (p < 0.001) in the TG group than the DTG group. The findings suggest that the PEERS® program tailored for Taiwanese adolescents is effective in reducing school bullying, decreasing social challenges, and enhancing social skills among autistic adolescents, with very large effect sizes (Cohen's d ranging from 1.19 to 2.88). Consequently, participation in the PEERS® program is recommended for adolescents with social difficulties to improve their social communication and interactions to offset school bullying and other social challenges related to adverse outcomes. En ligne : https://doi.org/10.1002/aur.3213 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Autologous umbilical cord blood infusion for the treatment of autism in young children: A within-subjects open label study on safety (assessed via caregiver report) and efficacy / Charmain Samantha TAN ; Natasha RIARD ; Yeleswarapu Sita PADMINI ; Lourdes Mary DANIEL ; Arun PRASATH ; Ah. Moy TAN ; Thiam Chye TAN ; Rehena SULTANA ; Joyce Ching Mei LAM in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1721-1734 Titre : Autologous umbilical cord blood infusion for the treatment of autism in young children: A within-subjects open label study on safety (assessed via caregiver report) and efficacy Type de document : Texte imprimé et/ou numérique Auteurs : Charmain Samantha TAN, Auteur ; Natasha RIARD, Auteur ; Yeleswarapu Sita PADMINI, Auteur ; Lourdes Mary DANIEL, Auteur ; Arun PRASATH, Auteur ; Ah. Moy TAN, Auteur ; Thiam Chye TAN, Auteur ; Rehena SULTANA, Auteur ; Joyce Ching Mei LAM, Auteur Article en page(s) : p.1721-1734 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study aimed to document the safety and efficacy of a single infusion of autologous umbilical cord blood (UCB) in 20 autistic children aged 24-72?months. A pre-post treatment within-subjects open label design was used. At T = 0, 6, 12, and 18?months, participants underwent detailed and structured safety evaluations (via caregiver report), Vineland Adaptive Behavior Scale (Vineland-3), Stanford Binet Intelligence Scale (SB-5), Expressive One-Word Picture Vocabulary Test, Brief Observation of Social Communication Change (BOSCC), Pervasive Developmental Disorder-Behavior Inventory, Repetitive Behavior Scale-Revised, Sensory Experience Questionnaire (SEQ-2.1), Child Behavior Checklist, Clinical Global Impression-Severity and Improvement (CGI-I) Scales, and eye-gaze tracking. UCB infusion was conducted at T = 6?months, hence, 0-6?months was the control period, and 6-18?months the follow-up period. Of 20 children recruited, 19 completed the study and 1 was withdrawn due to UCB not meeting quality control criteria for infusion. There were 15 males and 4 females with an overall mean (SD) age of 4.15 (0.62)?years. Mean (SD) cell dose administered was 38.16 (9.82) million cells/kg. None suffered serious adverse events although there were mild behavioral side effects and one unit grew coagulase negative staphylococcus from a post-thaw sample. There were no significant differences in Vineland-3, SB-5, BOSCC, and SEQ-2.1 scores at T = 12 and T = 18?months. Twelve participants had T = 18 CGI-I scores of 2-3 (minimally to much improved), seven participants had scores of 4 (no change). Autologous UCB infusion in autistic children is generally safe but not without risks, including that of infection. In this within-subjects study, some children showed global symptom improvements while others showed no change. Stem cell therapies for autism should only be conducted under strict clinical trial conditions with clear risk discussions. En ligne : https://doi.org/10.1002/aur.3187 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Autologous umbilical cord blood infusion for the treatment of autism in young children: A within-subjects open label study on safety (assessed via caregiver report) and efficacy [Texte imprimé et/ou numérique] / Charmain Samantha TAN, Auteur ; Natasha RIARD, Auteur ; Yeleswarapu Sita PADMINI, Auteur ; Lourdes Mary DANIEL, Auteur ; Arun PRASATH, Auteur ; Ah. Moy TAN, Auteur ; Thiam Chye TAN, Auteur ; Rehena SULTANA, Auteur ; Joyce Ching Mei LAM, Auteur . - p.1721-1734. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1721-1734 Index. décimale : PER Périodiques Résumé : Abstract This study aimed to document the safety and efficacy of a single infusion of autologous umbilical cord blood (UCB) in 20 autistic children aged 24-72?months. A pre-post treatment within-subjects open label design was used. At T = 0, 6, 12, and 18?months, participants underwent detailed and structured safety evaluations (via caregiver report), Vineland Adaptive Behavior Scale (Vineland-3), Stanford Binet Intelligence Scale (SB-5), Expressive One-Word Picture Vocabulary Test, Brief Observation of Social Communication Change (BOSCC), Pervasive Developmental Disorder-Behavior Inventory, Repetitive Behavior Scale-Revised, Sensory Experience Questionnaire (SEQ-2.1), Child Behavior Checklist, Clinical Global Impression-Severity and Improvement (CGI-I) Scales, and eye-gaze tracking. UCB infusion was conducted at T = 6?months, hence, 0-6?months was the control period, and 6-18?months the follow-up period. Of 20 children recruited, 19 completed the study and 1 was withdrawn due to UCB not meeting quality control criteria for infusion. There were 15 males and 4 females with an overall mean (SD) age of 4.15 (0.62)?years. Mean (SD) cell dose administered was 38.16 (9.82) million cells/kg. None suffered serious adverse events although there were mild behavioral side effects and one unit grew coagulase negative staphylococcus from a post-thaw sample. There were no significant differences in Vineland-3, SB-5, BOSCC, and SEQ-2.1 scores at T = 12 and T = 18?months. Twelve participants had T = 18 CGI-I scores of 2-3 (minimally to much improved), seven participants had scores of 4 (no change). Autologous UCB infusion in autistic children is generally safe but not without risks, including that of infection. In this within-subjects study, some children showed global symptom improvements while others showed no change. Stem cell therapies for autism should only be conducted under strict clinical trial conditions with clear risk discussions. En ligne : https://doi.org/10.1002/aur.3187 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

RETRACTION: Auditory perceptual learning in autistic adults in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1735-1735 Titre : RETRACTION: Auditory perceptual learning in autistic adults Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1735-1735 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : RETRACTION: S. Alispahic, E. Pellicano, A. Cutler, and M. Antoniou, "Auditory perceptual learning in autistic adults," Autism Research 15, no. 8 (2022): 1495-1507, https://doi.org/10.1002/aur.2778. The above article, published online on 05 July 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; journal Editor-in-Chief, David G. Amaral; International Society for Autism Research; and Wiley Periodicals, LLC. The authors received notice from a third party regarding methodological errors which affected participant data. The authors shared this information with the journal and have confirmed that the errors confound the results and conclusions of the article. As the results are fundamentally impacted by the errors, all parties agree that the article must be retracted. The authors have stated that they are preparing a revised version of their article to be submitted in a future publication. En ligne : https://doi.org/10.1002/aur.3198 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] RETRACTION: Auditory perceptual learning in autistic adults [Texte imprimé et/ou numérique] . - p.1735-1735. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1735-1735 Index. décimale : PER Périodiques Résumé : RETRACTION: S. Alispahic, E. Pellicano, A. Cutler, and M. Antoniou, "Auditory perceptual learning in autistic adults," Autism Research 15, no. 8 (2022): 1495-1507, https://doi.org/10.1002/aur.2778. The above article, published online on 05 July 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; journal Editor-in-Chief, David G. Amaral; International Society for Autism Research; and Wiley Periodicals, LLC. The authors received notice from a third party regarding methodological errors which affected participant data. The authors shared this information with the journal and have confirmed that the errors confound the results and conclusions of the article. As the results are fundamentally impacted by the errors, all parties agree that the article must be retracted. The authors have stated that they are preparing a revised version of their article to be submitted in a future publication. En ligne : https://doi.org/10.1002/aur.3198 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533