Association between irritability and bias in attention orienting to threat in children and adolescents / Giovanni A. SALUM in Journal of Child Psychology and Psychiatry, 58-5 (May 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-5 (May 2017) . - p.595-602 Titre : Association between irritability and bias in attention orienting to threat in children and adolescents Type de document : texte imprimé Auteurs : Giovanni A. SALUM, Auteur ; Karin MOGG, Auteur ; Brendan P. BRADLEY, Auteur ; Argyris STRINGARIS, Auteur ; Ary GADELHA, Auteur ; Pedro M. PAN, Auteur ; Luis Augusto ROHDE, Auteur ; Guilherme V. POLANCZYK, Auteur ; Gisele G. MANFRO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur Article en page(s) : p.595-602 Langues : Anglais (eng) Mots-clés : Irritability  anger  attention  bias  cognition  emotion Index. décimale : PER Périodiques Résumé : Background Irritability, a frequent complaint in children with psychiatric disorders, reflects increased predisposition to anger. Preliminary work in pediatric clinical samples links irritability to attention bias to threat, and the current study examines this association in a large population-based sample. Methods We studied 1,872 children (ages 6–14) using the Development and Well-Being Assessment (DAWBA), Childhood Behavior Checklist (CBCL), and dot-probe tasks. Irritability was defined using CBCL items that assessed temper tantrums and hot temper. The dot-probe task assessed attention biases for threat-related (angry face) stimuli. Multiple regression analysis was used to assess specificity of associations to irritability when adjusting for demographic variables and co-occurring psychiatric traits. Propensity score matching analysis was used to increase causal inference when matching for demographic variables and co-occurring psychiatric traits. Results Irritability was associated with increased attention bias toward threat-related cues. Multiple regression analysis suggests associations between irritability and threat bias are independent from demographic variables, anxiety, and externalizing traits (attention-deficit/hyperactivity, conduct, and headstrong/hurtful), but not from broad internalizing symptoms. Propensity score matching analysis indicated that this association was found for irritable versus nonirritable groups matched on demographic and co-occurring traits including internalizing symptoms. Conclusions Irritability in children is associated with biased attention toward threatening information. This finding, if replicated, warrants further investigation to examine the extent to which it contributes to chronic irritability and to explore possible treatment implications. En ligne : http://dx.doi.org/10.1111/jcpp.12659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=306 [article] Association between irritability and bias in attention orienting to threat in children and adolescents [texte imprimé] / Giovanni A. SALUM, Auteur ; Karin MOGG, Auteur ; Brendan P. BRADLEY, Auteur ; Argyris STRINGARIS, Auteur ; Ary GADELHA, Auteur ; Pedro M. PAN, Auteur ; Luis Augusto ROHDE, Auteur ; Guilherme V. POLANCZYK, Auteur ; Gisele G. MANFRO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur . - p.595-602. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-5 (May 2017) . - p.595-602 Mots-clés : Irritability  anger  attention  bias  cognition  emotion Index. décimale : PER Périodiques Résumé : Background Irritability, a frequent complaint in children with psychiatric disorders, reflects increased predisposition to anger. Preliminary work in pediatric clinical samples links irritability to attention bias to threat, and the current study examines this association in a large population-based sample. Methods We studied 1,872 children (ages 6–14) using the Development and Well-Being Assessment (DAWBA), Childhood Behavior Checklist (CBCL), and dot-probe tasks. Irritability was defined using CBCL items that assessed temper tantrums and hot temper. The dot-probe task assessed attention biases for threat-related (angry face) stimuli. Multiple regression analysis was used to assess specificity of associations to irritability when adjusting for demographic variables and co-occurring psychiatric traits. Propensity score matching analysis was used to increase causal inference when matching for demographic variables and co-occurring psychiatric traits. Results Irritability was associated with increased attention bias toward threat-related cues. Multiple regression analysis suggests associations between irritability and threat bias are independent from demographic variables, anxiety, and externalizing traits (attention-deficit/hyperactivity, conduct, and headstrong/hurtful), but not from broad internalizing symptoms. Propensity score matching analysis indicated that this association was found for irritable versus nonirritable groups matched on demographic and co-occurring traits including internalizing symptoms. Conclusions Irritability in children is associated with biased attention toward threatening information. This finding, if replicated, warrants further investigation to examine the extent to which it contributes to chronic irritability and to explore possible treatment implications. En ligne : http://dx.doi.org/10.1111/jcpp.12659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=306

Default mode network maturation and psychopathology in children and adolescents / João Ricardo SATO in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.55-64 Titre : Default mode network maturation and psychopathology in children and adolescents Type de document : texte imprimé Auteurs : João Ricardo SATO, Auteur ; Giovanni A. SALUM, Auteur ; Ary GADELHA, Auteur ; Nicolas CROSSLEY, Auteur ; Gilson VIEIRA, Auteur ; Gisele G. MANFRO, Auteur ; André ZUGMAN, Auteur ; Felipe A. PICON, Auteur ; Pedro M. PAN, Auteur ; Marcelo Queiroz HOEXTER, Auteur ; Mauricio ANÉS, Auteur ; Luciana Monteiro MOURA, Auteur ; Marco Antonio Gomes DEL'AQUILLA, Auteur ; Edson Jr AMARO, Auteur ; Philip MCGUIRE, Auteur ; Acioly Luiz Tavares LACERDA, Auteur ; Luis Augusto ROHDE, Auteur ; Euripedes Constantino MIGUEL, Auteur ; Andrea Parolin JACKOWSKI, Auteur ; Rodrigo Affonseca BRESSAN, Auteur Article en page(s) : p.55-64 Langues : Anglais (eng) Mots-clés : Neurodevelopment  default mode network  neuroimaging  psychopathology  MVPA Index. décimale : PER Périodiques Résumé : Background The human default mode (DMN) is involved in a wide array of mental disorders. Current knowledge suggests that mental health disorders may reflect deviant trajectories of brain maturation. Method We studied 654 children using functional magnetic resonance imaging (fMRI) scans under a resting-state protocol. A machine-learning method was used to obtain age predictions of children based on the average coefficient of fractional amplitude of low frequency fluctuations (fALFFs) of the DMN, a measure of spontaneous local activity. The chronological ages of the children and fALFF measures from regions of this network, the response and predictor variables were considered respectively in a Gaussian Process Regression. Subsequently, we computed a network maturation status index for each subject (actual age minus predicted). We then evaluated the association between this maturation index and psychopathology scores on the Child Behavior Checklist (CBCL). Results Our hypothesis was that the maturation status of the DMN would be negatively associated with psychopathology. Consistent with previous studies, fALFF significantly predicted the age of participants (p < .001). Furthermore, as expected, we found an association between the DMN maturation status (precocious vs. delayed) and general psychopathology scores (p = .011). Conclusions Our findings suggest that child psychopathology seems to be associated with delayed maturation of the DMN. This delay in the neurodevelopmental trajectory may offer interesting insights into the pathophysiology of mental health disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Default mode network maturation and psychopathology in children and adolescents [texte imprimé] / João Ricardo SATO, Auteur ; Giovanni A. SALUM, Auteur ; Ary GADELHA, Auteur ; Nicolas CROSSLEY, Auteur ; Gilson VIEIRA, Auteur ; Gisele G. MANFRO, Auteur ; André ZUGMAN, Auteur ; Felipe A. PICON, Auteur ; Pedro M. PAN, Auteur ; Marcelo Queiroz HOEXTER, Auteur ; Mauricio ANÉS, Auteur ; Luciana Monteiro MOURA, Auteur ; Marco Antonio Gomes DEL'AQUILLA, Auteur ; Edson Jr AMARO, Auteur ; Philip MCGUIRE, Auteur ; Acioly Luiz Tavares LACERDA, Auteur ; Luis Augusto ROHDE, Auteur ; Euripedes Constantino MIGUEL, Auteur ; Andrea Parolin JACKOWSKI, Auteur ; Rodrigo Affonseca BRESSAN, Auteur . - p.55-64. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.55-64 Mots-clés : Neurodevelopment  default mode network  neuroimaging  psychopathology  MVPA Index. décimale : PER Périodiques Résumé : Background The human default mode (DMN) is involved in a wide array of mental disorders. Current knowledge suggests that mental health disorders may reflect deviant trajectories of brain maturation. Method We studied 654 children using functional magnetic resonance imaging (fMRI) scans under a resting-state protocol. A machine-learning method was used to obtain age predictions of children based on the average coefficient of fractional amplitude of low frequency fluctuations (fALFFs) of the DMN, a measure of spontaneous local activity. The chronological ages of the children and fALFF measures from regions of this network, the response and predictor variables were considered respectively in a Gaussian Process Regression. Subsequently, we computed a network maturation status index for each subject (actual age minus predicted). We then evaluated the association between this maturation index and psychopathology scores on the Child Behavior Checklist (CBCL). Results Our hypothesis was that the maturation status of the DMN would be negatively associated with psychopathology. Consistent with previous studies, fALFF significantly predicted the age of participants (p < .001). Furthermore, as expected, we found an association between the DMN maturation status (precocious vs. delayed) and general psychopathology scores (p = .011). Conclusions Our findings suggest that child psychopathology seems to be associated with delayed maturation of the DMN. This delay in the neurodevelopmental trajectory may offer interesting insights into the pathophysiology of mental health disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

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