Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 55 (November 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 55 (November 2018) . - p.50-63 Titre : Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium Type de document : texte imprimé Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; MacKinsey A. CHRISTIAN, Auteur ; Jan BRESSLER, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Charlene COORE-DESAI, Auteur ; Jody-Ann REECE, Auteur ; Katherine A. LOVELAND, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.50-63 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Heavy metals  Interaction  Weighted quantile sum (WQS) regression Index. décimale : PER Périodiques Résumé : Background We previously reported a significant interactive association between polymorphisms of GSTP1 and blood manganese concentrations (BMC) with autism spectrum disorder (ASD) in Jamaican children. In this paper, we investigate the same interactive association with ASD while adjusting for the mixture of four metals (lead, mercury, cadmium, and arsenic). Method We used data from 163 case-control pairs of children 2–8 years of age from our autism project in Jamaica, in which we collected blood for heavy metals analysis at enrollment. To minimize potential multicollinearity between concentrations of the four metals, we generated a mixture index using generalized weighted quantile sum regression, which was used in conditional logistic regression models to control for the four metals while assessing the interactive association between GSTP1 and BMC with ASD. Results Similar to the findings we reported previously, we found that in co-dominant and dominant models for GSTP1, among children with the Ile/Ile genotype, those with BMC ≥ 12 μg/L had 4.6 and 4.27 times higher odds of ASD compared to those with BMC < 12 μg/L (adjusted Matched Odds Ratio (MOR) = 4.6, 95% CI: 1.21–17.42 and adjusted MOR = 4.27, 95% CI: 1.15–15.85, respectively). In the co-dominant model, for children with the Ile/Val and Val/Val genotypes, the adjusted MORs were 1.26 (95% CI: 0.32, 5.01) and 0.26 (95% CI: 0.05, 1.42), respectively. Conclusions After adjusting for the mixture of four metals, the interactive association of BMC and GSTP1 with ASD remained significant with similar magnitude of associations. Results should be interpreted cautiously. En ligne : https://doi.org/10.1016/j.rasd.2018.08.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium [texte imprimé] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; MacKinsey A. CHRISTIAN, Auteur ; Jan BRESSLER, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Charlene COORE-DESAI, Auteur ; Jody-Ann REECE, Auteur ; Katherine A. LOVELAND, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur . - p.50-63. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 55 (November 2018) . - p.50-63 Mots-clés : Autism spectrum disorder (ASD)  Heavy metals  Interaction  Weighted quantile sum (WQS) regression Index. décimale : PER Périodiques Résumé : Background We previously reported a significant interactive association between polymorphisms of GSTP1 and blood manganese concentrations (BMC) with autism spectrum disorder (ASD) in Jamaican children. In this paper, we investigate the same interactive association with ASD while adjusting for the mixture of four metals (lead, mercury, cadmium, and arsenic). Method We used data from 163 case-control pairs of children 2–8 years of age from our autism project in Jamaica, in which we collected blood for heavy metals analysis at enrollment. To minimize potential multicollinearity between concentrations of the four metals, we generated a mixture index using generalized weighted quantile sum regression, which was used in conditional logistic regression models to control for the four metals while assessing the interactive association between GSTP1 and BMC with ASD. Results Similar to the findings we reported previously, we found that in co-dominant and dominant models for GSTP1, among children with the Ile/Ile genotype, those with BMC ≥ 12 μg/L had 4.6 and 4.27 times higher odds of ASD compared to those with BMC < 12 μg/L (adjusted Matched Odds Ratio (MOR) = 4.6, 95% CI: 1.21–17.42 and adjusted MOR = 4.27, 95% CI: 1.15–15.85, respectively). In the co-dominant model, for children with the Ile/Val and Val/Val genotypes, the adjusted MORs were 1.26 (95% CI: 0.32, 5.01) and 0.26 (95% CI: 0.05, 1.42), respectively. Conclusions After adjusting for the mixture of four metals, the interactive association of BMC and GSTP1 with ASD remained significant with similar magnitude of associations. Results should be interpreted cautiously. En ligne : https://doi.org/10.1016/j.rasd.2018.08.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children / MacKinsey A. CHRISTIAN in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2766-2778 Titre : Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children Type de document : texte imprimé Auteurs : MacKinsey A. CHRISTIAN, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Michelle LEE, Auteur ; Jan BRESSLER, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Charlene COORE-DESAI, Auteur ; Jody-Ann REECE, Auteur ; Katherine A. LOVELAND, Auteur ; Eric BOERWINKLE, Auteur ; Mohammad H. RAHBAR, Auteur Article en page(s) : p.2766-2778 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Fever  Jamaica  Pesticides  Physical trauma  Volatile organic compounds Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3537-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children [texte imprimé] / MacKinsey A. CHRISTIAN, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Michelle LEE, Auteur ; Jan BRESSLER, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Charlene COORE-DESAI, Auteur ; Jody-Ann REECE, Auteur ; Katherine A. LOVELAND, Auteur ; Eric BOERWINKLE, Auteur ; Mohammad H. RAHBAR, Auteur . - p.2766-2778. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2766-2778 Mots-clés : Autism spectrum disorder  Fever  Jamaica  Pesticides  Physical trauma  Volatile organic compounds Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3537-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

The diagnosis of autism and autism spectrum disorder in low- and middle-income countries: Experience from Jamaica / Maureen SAMMS-VAUGHAN in Autism, 21-5 (July 2017)  

Public ISBD [article]  inAutism > 21-5 (July 2017) . - p.564-572 Titre : The diagnosis of autism and autism spectrum disorder in low- and middle-income countries: Experience from Jamaica Type de document : texte imprimé Auteurs : Maureen SAMMS-VAUGHAN, Auteur ; Mohammad H. RAHBAR, Auteur ; Aisha S. DICKERSON, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr HESSABI, Auteur ; Deborah A. PEARSON, Auteur ; Jan BRESSLER, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Charlene COORE-DESAI, Auteur ; Jody-Ann REECE, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.564-572 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The administration requirements of the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview?Revised, widely used in high-income countries, make them less feasible for diagnosis of autism spectrum disorder in low- and middle-income countries. The flexible administration requirements of the Childhood Autism Rating Scale have resulted in its use in both high-income countries and low- and middle-income countries. This study examines the agreement between assessments using the Childhood Autism Rating Scale with those using the Autism Diagnostic Observation Schedule or Autism Diagnostic Observation Schedule, Second Edition and Autism Diagnostic Interview?Revised in Jamaica. Children aged 2 8 years (n=149) diagnosed with autism by an experienced clinician using the Childhood Autism Rating Scale were re-evaluated using the Autism Diagnostic Observation Schedule and Autism Diagnostic Interview?Revised. The proportion diagnosed with autism spectrum disorder using the Autism Diagnostic Observation Schedule, Autism Diagnostic Observation Schedule, Second Edition, and Autism Diagnostic Interview?Revised was determined and mean domain scores compared using analysis of variance (ANOVA). The mean age was 64.4 (standard deviation=21.6)?months; the male:female ratio was 6:1. The diagnostic agreement of the Childhood Autism Rating Scale with the Autism Diagnostic Observation Schedule and Autism Diagnostic Observation Schedule, Second Edition was 100.0% and 98.0%, respectively. Agreement with the Autism Diagnostic Interview?Revised was 94.6%. Domain scores were highest for children with more severe symptoms (p?< 0.01). Despite a high level of agreement of the Childhood Autism Rating Scale with the Autism Diagnostic Observation Schedule, Autism Diagnostic Observation Schedule, Second Edition, and Autism Diagnostic Interview?Revised, the Childhood Autism Rating Scale should be evaluated further with a broader range of autism spectrum disorder symptomatology, and by clinicians with varying experience before recommendation for use in low- and middle-income countries. En ligne : http://dx.doi.org/10.1177/1362361317698938 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 [article] The diagnosis of autism and autism spectrum disorder in low- and middle-income countries: Experience from Jamaica [texte imprimé] / Maureen SAMMS-VAUGHAN, Auteur ; Mohammad H. RAHBAR, Auteur ; Aisha S. DICKERSON, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr HESSABI, Auteur ; Deborah A. PEARSON, Auteur ; Jan BRESSLER, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Charlene COORE-DESAI, Auteur ; Jody-Ann REECE, Auteur ; Eric BOERWINKLE, Auteur . - p.564-572. Langues : Anglais (eng) in Autism > 21-5 (July 2017) . - p.564-572 Index. décimale : PER Périodiques Résumé : The administration requirements of the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview?Revised, widely used in high-income countries, make them less feasible for diagnosis of autism spectrum disorder in low- and middle-income countries. The flexible administration requirements of the Childhood Autism Rating Scale have resulted in its use in both high-income countries and low- and middle-income countries. This study examines the agreement between assessments using the Childhood Autism Rating Scale with those using the Autism Diagnostic Observation Schedule or Autism Diagnostic Observation Schedule, Second Edition and Autism Diagnostic Interview?Revised in Jamaica. Children aged 2 8 years (n=149) diagnosed with autism by an experienced clinician using the Childhood Autism Rating Scale were re-evaluated using the Autism Diagnostic Observation Schedule and Autism Diagnostic Interview?Revised. The proportion diagnosed with autism spectrum disorder using the Autism Diagnostic Observation Schedule, Autism Diagnostic Observation Schedule, Second Edition, and Autism Diagnostic Interview?Revised was determined and mean domain scores compared using analysis of variance (ANOVA). The mean age was 64.4 (standard deviation=21.6)?months; the male:female ratio was 6:1. The diagnostic agreement of the Childhood Autism Rating Scale with the Autism Diagnostic Observation Schedule and Autism Diagnostic Observation Schedule, Second Edition was 100.0% and 98.0%, respectively. Agreement with the Autism Diagnostic Interview?Revised was 94.6%. Domain scores were highest for children with more severe symptoms (p?< 0.01). Despite a high level of agreement of the Childhood Autism Rating Scale with the Autism Diagnostic Observation Schedule, Autism Diagnostic Observation Schedule, Second Edition, and Autism Diagnostic Interview?Revised, the Childhood Autism Rating Scale should be evaluated further with a broader range of autism spectrum disorder symptomatology, and by clinicians with varying experience before recommendation for use in low- and middle-income countries. En ligne : http://dx.doi.org/10.1177/1362361317698938 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310

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