Brief Report: The Negev Hospital-University-Based (HUB) Autism Database / Gal MEIRI in Journal of Autism and Developmental Disorders, 47-9 (September 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-9 (September 2017) . - p.2918-2926 Titre : Brief Report: The Negev Hospital-University-Based (HUB) Autism Database Type de document : texte imprimé Auteurs : Gal MEIRI, Auteur ; Ilan DINSTEIN, Auteur ; Analya MICHAELOWSKI, Auteur ; Hagit FLUSSER, Auteur ; Michal ILAN, Auteur ; Michal FAROY, Auteur ; Asif BAR-SINAI, Auteur ; Liora MANELIS, Auteur ; Dana STOLOWICZ, Auteur ; Lili Lea YOSEF, Auteur ; Nadav DAVIDOVITCH, Auteur ; Hava GOLAN, Auteur ; Shoshana ARBELLE, Auteur ; Idan MENASHE, Auteur Article en page(s) : p.2918-2926 Langues : Anglais (eng) Mots-clés : Autism  Epidemiology  Multidisciplinary  Child development  Preschool psychiatry Index. décimale : PER Périodiques Résumé : Elucidating the heterogeneous etiologies of autism will require investment in comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established a hospital-university-based (HUB) database of autism which incorporates prospective and retrospective data from a large and ethnically diverse population. The collected data includes social-demographic characteristics, standardized behavioral testing, detailed clinical history from electronic patient records, genetic samples, and various neurological measures. We describe the initial cohort characteristics following the first 18 months of data collection (188 children with autism). We believe that the Negev HUB autism database offers a unique and valuable resource for studying the heterogeneity of autism etiologies across different ethnic populations. En ligne : https://doi.org/10.1007/s10803-017-3207-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Brief Report: The Negev Hospital-University-Based (HUB) Autism Database [texte imprimé] / Gal MEIRI, Auteur ; Ilan DINSTEIN, Auteur ; Analya MICHAELOWSKI, Auteur ; Hagit FLUSSER, Auteur ; Michal ILAN, Auteur ; Michal FAROY, Auteur ; Asif BAR-SINAI, Auteur ; Liora MANELIS, Auteur ; Dana STOLOWICZ, Auteur ; Lili Lea YOSEF, Auteur ; Nadav DAVIDOVITCH, Auteur ; Hava GOLAN, Auteur ; Shoshana ARBELLE, Auteur ; Idan MENASHE, Auteur . - p.2918-2926. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-9 (September 2017) . - p.2918-2926 Mots-clés : Autism  Epidemiology  Multidisciplinary  Child development  Preschool psychiatry Index. décimale : PER Périodiques Résumé : Elucidating the heterogeneous etiologies of autism will require investment in comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established a hospital-university-based (HUB) database of autism which incorporates prospective and retrospective data from a large and ethnically diverse population. The collected data includes social-demographic characteristics, standardized behavioral testing, detailed clinical history from electronic patient records, genetic samples, and various neurological measures. We describe the initial cohort characteristics following the first 18 months of data collection (188 children with autism). We believe that the Negev HUB autism database offers a unique and valuable resource for studying the heterogeneity of autism etiologies across different ethnic populations. En ligne : https://doi.org/10.1007/s10803-017-3207-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Children with autism exhibit similar longitudinal changes in core symptoms when placed in special or mainstream education settings / Michal ILAN in Autism, 27-6 (August 2023)  

Public ISBD [article]  inAutism > 27-6 (August 2023) . - p.1628-1640 Titre : Children with autism exhibit similar longitudinal changes in core symptoms when placed in special or mainstream education settings Type de document : texte imprimé Auteurs : Michal ILAN, Auteur ; Michal FAROY, Auteur ; Ditza ZACHOR, Auteur ; Liora MANELIS, Auteur ; Danel WAISSENGREEN, Auteur ; Analya MICHAELOVSKI, Auteur ; Inbar AVNI, Auteur ; Idan MENASHE, Auteur ; Judah KOLLER, Auteur ; Ilan DINSTEIN, Auteur ; Gal MEIRI, Auteur Article en page(s) : p.1628-1640 Langues : Anglais (eng) Mots-clés : autism spectrum disorders;core symptoms;education services;inclusion;mainstream education;preschool children;special education Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) are often placed in inclusive mainstream education (ME) or exclusive special education (SE) settings. While ME settings usually offer less-intensive and structured intervention programs than SE settings, they offer more exposure to typically developing peers. A total of 121 children (2-5 years old) with ASD, 85 in SE and 36 in ME, completed two Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) assessments. Repeated-measures analysis of covariance (ANCOVA) analyses were used to assess longitudinal changes in ADOS-2 calibrated severity scores (CSS) and language production (estimated from the ADOS-2), while accounting for baseline cognitive scores, age of diagnosis, and parent-reported intensity of intervention. Longitudinal changes in ADOS CSS did not differ significantly across educational settings but were strongly associated with the age of diagnosis, demonstrating that children diagnosed earlier improved more regardless of educational settings. These findings suggest that children with ASD placed in SE and ME exhibit similar longitudinal changes in core ASD symptoms. Further studies comparing additional outcome measures such as cognitive abilities and adaptive behaviors are highly warranted for establishing placement recommendations and public health policies.Lay abstractToday, children with autism spectrum disorder (ASD) are placed in mainstream or special education settings somewhat arbitrarily with no clear clinical recommendations. Here, we compared changes in core ASD symptoms, as measured by the Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) clinical assessment, across ASD preschool children placed in special or mainstream education. Longitudinal changes in ADOS-2 scores did not differ significantly across settings over a 1- to 2-year period. While some children improved in core ASD symptoms, others deteriorated in both settings. This highlights the need to identify specific criteria for establishing meaningful placement recommendations. En ligne : http://dx.doi.org/10.1177/13623613221142394 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509 [article] Children with autism exhibit similar longitudinal changes in core symptoms when placed in special or mainstream education settings [texte imprimé] / Michal ILAN, Auteur ; Michal FAROY, Auteur ; Ditza ZACHOR, Auteur ; Liora MANELIS, Auteur ; Danel WAISSENGREEN, Auteur ; Analya MICHAELOVSKI, Auteur ; Inbar AVNI, Auteur ; Idan MENASHE, Auteur ; Judah KOLLER, Auteur ; Ilan DINSTEIN, Auteur ; Gal MEIRI, Auteur . - p.1628-1640. Langues : Anglais (eng) in Autism > 27-6 (August 2023) . - p.1628-1640 Mots-clés : autism spectrum disorders;core symptoms;education services;inclusion;mainstream education;preschool children;special education Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) are often placed in inclusive mainstream education (ME) or exclusive special education (SE) settings. While ME settings usually offer less-intensive and structured intervention programs than SE settings, they offer more exposure to typically developing peers. A total of 121 children (2-5 years old) with ASD, 85 in SE and 36 in ME, completed two Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) assessments. Repeated-measures analysis of covariance (ANCOVA) analyses were used to assess longitudinal changes in ADOS-2 calibrated severity scores (CSS) and language production (estimated from the ADOS-2), while accounting for baseline cognitive scores, age of diagnosis, and parent-reported intensity of intervention. Longitudinal changes in ADOS CSS did not differ significantly across educational settings but were strongly associated with the age of diagnosis, demonstrating that children diagnosed earlier improved more regardless of educational settings. These findings suggest that children with ASD placed in SE and ME exhibit similar longitudinal changes in core ASD symptoms. Further studies comparing additional outcome measures such as cognitive abilities and adaptive behaviors are highly warranted for establishing placement recommendations and public health policies.Lay abstractToday, children with autism spectrum disorder (ASD) are placed in mainstream or special education settings somewhat arbitrarily with no clear clinical recommendations. Here, we compared changes in core ASD symptoms, as measured by the Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) clinical assessment, across ASD preschool children placed in special or mainstream education. Longitudinal changes in ADOS-2 scores did not differ significantly across settings over a 1- to 2-year period. While some children improved in core ASD symptoms, others deteriorated in both settings. This highlights the need to identify specific criteria for establishing meaningful placement recommendations. En ligne : http://dx.doi.org/10.1177/13623613221142394 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509

Cognitive Abilities and Irritability Are the Main Factors Influencing Initial Placement of Autistic Preschoolers in Special or Mainstream Education in Israel / Moran BACHRACH in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70188 Titre : Cognitive Abilities and Irritability Are the Main Factors Influencing Initial Placement of Autistic Preschoolers in Special or Mainstream Education in Israel Type de document : texte imprimé Auteurs : Moran BACHRACH, Auteur ; Michal ILAN, Auteur ; Michal FAROY, Auteur ; Analya MICHAELOVSKY, Auteur ; Dikla ZAGDON, Auteur ; Yair SADAKA, Auteur ; Omer Bar YOSEF, Auteur ; Adi ARAN, Auteur ; Michal BEGIN, Auteur ; Ditza ZACHOR, Auteur ; Einat AVNI, Auteur ; Judah KOLLER, Auteur ; Idan MENASHE, Auteur ; Gal MEIRI, Auteur ; Ilan DINSTEIN, Auteur Article en page(s) : e70188 Langues : Anglais (eng) Mots-clés : autism  cognitive abilities  irritability  mainstream education  preschool placement  special education Index. décimale : PER Périodiques Résumé : ABSTRACT Following diagnosis, autistic children are often placed in preschool settings that vary along a continuum from exclusive special education to inclusive mainstream education. These settings differ in their staff composition and expertise, ability to implement structured autism interventions, ability to integrate autistic and typically developing children, and costs. Here, we examined whether there were significant differences in the behavioral abilities and developmental difficulties of children placed in special versus mainstream public education in Israel, where there is a systematic dichotomy between the two educational settings. We analyzed data from 165 autistic children, 120 in special and 45 in mainstream education, who completed comprehensive behavioral assessments at a mean age of 37.8?months, as they entered their first preschool setting. Children placed in special education exhibited significantly poorer cognitive abilities and higher irritability and hyperactivity than children in mainstream education while there were no significant differences in autism severity or adaptive behaviors across groups. Moreover, cognitive and irritability scores were sufficient for classifying children across the two settings with an average accuracy of 76.4% when using a pruned decision tree algorithm and a 5-fold cross-validation procedure. These findings extend previous research by demonstrating that cognitive abilities and irritability are the strongest predictors of preschool educational placement. Further longitudinal research is needed to determine whether these placement decisions benefit the children as they develop. En ligne : https://doi.org/10.1002/aur.70188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Cognitive Abilities and Irritability Are the Main Factors Influencing Initial Placement of Autistic Preschoolers in Special or Mainstream Education in Israel [texte imprimé] / Moran BACHRACH, Auteur ; Michal ILAN, Auteur ; Michal FAROY, Auteur ; Analya MICHAELOVSKY, Auteur ; Dikla ZAGDON, Auteur ; Yair SADAKA, Auteur ; Omer Bar YOSEF, Auteur ; Adi ARAN, Auteur ; Michal BEGIN, Auteur ; Ditza ZACHOR, Auteur ; Einat AVNI, Auteur ; Judah KOLLER, Auteur ; Idan MENASHE, Auteur ; Gal MEIRI, Auteur ; Ilan DINSTEIN, Auteur . - e70188. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70188 Mots-clés : autism  cognitive abilities  irritability  mainstream education  preschool placement  special education Index. décimale : PER Périodiques Résumé : ABSTRACT Following diagnosis, autistic children are often placed in preschool settings that vary along a continuum from exclusive special education to inclusive mainstream education. These settings differ in their staff composition and expertise, ability to implement structured autism interventions, ability to integrate autistic and typically developing children, and costs. Here, we examined whether there were significant differences in the behavioral abilities and developmental difficulties of children placed in special versus mainstream public education in Israel, where there is a systematic dichotomy between the two educational settings. We analyzed data from 165 autistic children, 120 in special and 45 in mainstream education, who completed comprehensive behavioral assessments at a mean age of 37.8?months, as they entered their first preschool setting. Children placed in special education exhibited significantly poorer cognitive abilities and higher irritability and hyperactivity than children in mainstream education while there were no significant differences in autism severity or adaptive behaviors across groups. Moreover, cognitive and irritability scores were sufficient for classifying children across the two settings with an average accuracy of 76.4% when using a pruned decision tree algorithm and a 5-fold cross-validation procedure. These findings extend previous research by demonstrating that cognitive abilities and irritability are the strongest predictors of preschool educational placement. Further longitudinal research is needed to determine whether these placement decisions benefit the children as they develop. En ligne : https://doi.org/10.1002/aur.70188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

Feasibility and initial outcomes of the social ABCs parent-mediated intervention for autistic toddlers in Israel: A pilot single-arm study / Tanya NITZAN in Research in Autism, 133 (May 2026)  

Public ISBD [article]  inResearch in Autism > 133 (May 2026) . - p.202906 Titre : Feasibility and initial outcomes of the social ABCs parent-mediated intervention for autistic toddlers in Israel: A pilot single-arm study Type de document : texte imprimé Auteurs : Tanya NITZAN, Auteur ; Tamar Matz VAISMAN, Auteur ; Tamar DAVID, Auteur ; Michal ILAN, Auteur ; Michal FAROY, Auteur ; Analya MICHAELOVSKI, Auteur ; Dikla ZIGDON, Auteur ; Gal MEIRI, Auteur ; Ilan DINSTEIN, Auteur ; Judah KOLLER, Auteur Article en page(s) : p.202906 Langues : Anglais (eng) Mots-clés : Autism  Parent-mediated intervention  Pilot feasibility  Early intervention  PRT  NDBI  Social ABCs Index. décimale : PER Périodiques Résumé : The Social ABCs is a parent-mediated Naturalistic Developmental Behavioral Intervention (NDBI) that promotes early verbal communication and affect sharing emphasizing child-led learning within natural routines. Here we conducted a six-week pilot single-arm study of the Social ABCs program with 17 autistic toddlers (19–39 months) and their parents in Israel, employing pre- and post-intervention assessments including language, social communication, and parenting stress measures. Results demonstrated significant gains in expressive and receptive vocabulary, improved social communication reduced social withdrawal, and enhanced parent-child interaction quality, with high parental satisfaction and engagement. No significant changes were observed in autism symptom severity or developmental scores. These findings suggest that the Social ABCs is a feasible, promising early intervention for autistic toddlers in Israel. Larger controlled trials are needed to confirm efficacy and assess long-term impact. En ligne : https://doi.org/10.1016/j.reia.2026.202906 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Feasibility and initial outcomes of the social ABCs parent-mediated intervention for autistic toddlers in Israel: A pilot single-arm study [texte imprimé] / Tanya NITZAN, Auteur ; Tamar Matz VAISMAN, Auteur ; Tamar DAVID, Auteur ; Michal ILAN, Auteur ; Michal FAROY, Auteur ; Analya MICHAELOVSKI, Auteur ; Dikla ZIGDON, Auteur ; Gal MEIRI, Auteur ; Ilan DINSTEIN, Auteur ; Judah KOLLER, Auteur . - p.202906. Langues : Anglais (eng) in Research in Autism > 133 (May 2026) . - p.202906 Mots-clés : Autism  Parent-mediated intervention  Pilot feasibility  Early intervention  PRT  NDBI  Social ABCs Index. décimale : PER Périodiques Résumé : The Social ABCs is a parent-mediated Naturalistic Developmental Behavioral Intervention (NDBI) that promotes early verbal communication and affect sharing emphasizing child-led learning within natural routines. Here we conducted a six-week pilot single-arm study of the Social ABCs program with 17 autistic toddlers (19–39 months) and their parents in Israel, employing pre- and post-intervention assessments including language, social communication, and parenting stress measures. Results demonstrated significant gains in expressive and receptive vocabulary, improved social communication reduced social withdrawal, and enhanced parent-child interaction quality, with high parental satisfaction and engagement. No significant changes were observed in autism symptom severity or developmental scores. These findings suggest that the Social ABCs is a feasible, promising early intervention for autistic toddlers in Israel. Larger controlled trials are needed to confirm efficacy and assess long-term impact. En ligne : https://doi.org/10.1016/j.reia.2026.202906 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Language regression is associated with faster early motor development in children with autism spectrum disorder / Liora MANELIS in Autism Research, 13-1 (January 2020)  

Public ISBD [article]  inAutism Research > 13-1 (January 2020) . - p.145-156 Titre : Language regression is associated with faster early motor development in children with autism spectrum disorder Type de document : texte imprimé Auteurs : Liora MANELIS, Auteur ; Gal MEIRI, Auteur ; Michal ILAN, Auteur ; Hagit FLUSSER, Auteur ; Analya MICHAELOVSKI, Auteur ; Michal FAROY, Auteur ; Orly KERUB, Auteur ; Ilan DINSTEIN, Auteur ; Idan MENASHE, Auteur Article en page(s) : p.145-156 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  early development  language regression  motor development Index. décimale : PER Périodiques Résumé : Language regression (LR) is a consistent and reproducible phenomenon that is reported by ~25% of parents who have children with autism spectrum disorder (ASD). However, there is controversy regarding the etiological and clinical significance of this phenomenon. Here, we examined data from a cohort of 218 children with ASD from the Negev Autism Center in Israel. We identified 36 children with ASD who were reported to exhibit clear LR by their parent on three independent occasions and compared them to 104 children whose parents did not report any concern of regression (NR). We compared a variety of key developmental characteristics across these two groups. We found that the age at which children with ASD in the LR group achieve key developmental milestones of crawling, walking, and use of first words is significantly younger than the age of children in the NR group, and comparable to the age of typically developing children. In contrast, no differences were observed in physical growth characteristics such as head circumference, weight, or height between the groups. Furthermore, almost all children with LR were born close to full term (>35 weeks) and none had a history of hypotonia. Notably, despite their apparently typical early development, children with LR were diagnosed with more severe symptoms of ASD than children with NR. These results strengthen the motivation to continue and study LR among children with ASD and suggest that early detection and intervention studies of ASD may benefit from stratifying children into LR and NR groups. Autism Res 2020, 13: 145-156. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The presence of language regression (LR) among children with autism is still a matter of scientific debate. Here, we show that children with autism and reported LR start to crawl, talk, and walk at the same age as other typically developing children and significantly earlier than other children with autism. These findings, along with other medical differences between these groups, suggest that children who experienced LR comprise a distinct subgroup within the autism spectrum. En ligne : http://dx.doi.org/10.1002/aur.2197 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Language regression is associated with faster early motor development in children with autism spectrum disorder [texte imprimé] / Liora MANELIS, Auteur ; Gal MEIRI, Auteur ; Michal ILAN, Auteur ; Hagit FLUSSER, Auteur ; Analya MICHAELOVSKI, Auteur ; Michal FAROY, Auteur ; Orly KERUB, Auteur ; Ilan DINSTEIN, Auteur ; Idan MENASHE, Auteur . - p.145-156. Langues : Anglais (eng) in Autism Research > 13-1 (January 2020) . - p.145-156 Mots-clés : autism spectrum disorder  early development  language regression  motor development Index. décimale : PER Périodiques Résumé : Language regression (LR) is a consistent and reproducible phenomenon that is reported by ~25% of parents who have children with autism spectrum disorder (ASD). However, there is controversy regarding the etiological and clinical significance of this phenomenon. Here, we examined data from a cohort of 218 children with ASD from the Negev Autism Center in Israel. We identified 36 children with ASD who were reported to exhibit clear LR by their parent on three independent occasions and compared them to 104 children whose parents did not report any concern of regression (NR). We compared a variety of key developmental characteristics across these two groups. We found that the age at which children with ASD in the LR group achieve key developmental milestones of crawling, walking, and use of first words is significantly younger than the age of children in the NR group, and comparable to the age of typically developing children. In contrast, no differences were observed in physical growth characteristics such as head circumference, weight, or height between the groups. Furthermore, almost all children with LR were born close to full term (>35 weeks) and none had a history of hypotonia. Notably, despite their apparently typical early development, children with LR were diagnosed with more severe symptoms of ASD than children with NR. These results strengthen the motivation to continue and study LR among children with ASD and suggest that early detection and intervention studies of ASD may benefit from stratifying children into LR and NR groups. Autism Res 2020, 13: 145-156. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The presence of language regression (LR) among children with autism is still a matter of scientific debate. Here, we show that children with autism and reported LR start to crawl, talk, and walk at the same age as other typically developing children and significantly earlier than other children with autism. These findings, along with other medical differences between these groups, suggest that children who experienced LR comprise a distinct subgroup within the autism spectrum. En ligne : http://dx.doi.org/10.1002/aur.2197 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Sleep Disturbances and Sensory Sensitivities Co-Vary in a Longitudinal Manner in Pre-School Children with Autism Spectrum Disorders / Liora MANELIS-BARAM in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

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Sleep disturbances are associated with greater healthcare utilization in children with autism spectrum disorder / Shirley SOLOMON in Journal of Neurodevelopmental Disorders, 16 (2024)  

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Sleep disturbances are associated with specific sensory sensitivities in children with autism / Orna TZISCHINSKY in Molecular Autism, 9 (2018)  

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The Importance of Language Delays as an Early Indicator of Subsequent ASD Diagnosis in Public Healthcare Settings / Judah KOLLER ; Michal ILAN ; Michal FAROY ; Analya MICHAELOVSKI ; Idan MENASHE ; Gal MEIRI ; Ilan DINSTEIN in Journal of Autism and Developmental Disorders, 53-12 (December 2023)  

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Young Autism Spectrum Disorder Children in Special and Mainstream Education Settings Have Similar Behavioral Characteristics / Michal ILAN in Autism Research, 14-4 (April 2021)  

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