Challenging the Developmental Substructure Model for Autism: A Perspective From Causal Statistics / Sean MCWEENY in Autism Research, 19-8 (August 2026)  

Public ISBD [article]  inAutism Research > 19-8 (August 2026) . - p.e70298 Titre : Challenging the Developmental Substructure Model for Autism: A Perspective From Causal Statistics Type de document : texte imprimé Auteurs : Sean MCWEENY, Auteur ; Joshua B. EWEN, Auteur Article en page(s) : p.e70298 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT The extent to which core autism traits?social interaction, communication, and restricted and repetitive behaviors (RRBs)?share a cause or have independent causes (e.g., fractionable triad model) has been a central debate in the field for decades. The latest iteration of this debate has reckoned with molecular genetic evidence that has largely failed to reproduce twin study heritability estimates. Against this backdrop, an alternative to the fractionable triad model?the developmental substructure model?was proposed by Constantino et al. in 2021. This model places a unitary, latent autism variable as the cause of the core phenotype. In the present Commentary, we showed that the developmental substructure model fails empirical tests derived from causal inference. Using published data, we demonstrated that correlations among core phenotype traits are largely the same in population samples as compared to autistic and non-autistic subsamples. Using simulations, we demonstrated that if latent autism were the cause of variance in core phenotype traits, then the correlations among the factors should reduce considerably after conditioning on autism. Although the developmental substructure model is well-reasoned and well-specified, it ultimately does not stand up to empirical evaluation. En ligne : https://doi.org/10.1002/aur.70298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Challenging the Developmental Substructure Model for Autism: A Perspective From Causal Statistics [texte imprimé] / Sean MCWEENY, Auteur ; Joshua B. EWEN, Auteur . - p.e70298. Langues : Anglais (eng) in Autism Research > 19-8 (August 2026) . - p.e70298 Index. décimale : PER Périodiques Résumé : ABSTRACT The extent to which core autism traits?social interaction, communication, and restricted and repetitive behaviors (RRBs)?share a cause or have independent causes (e.g., fractionable triad model) has been a central debate in the field for decades. The latest iteration of this debate has reckoned with molecular genetic evidence that has largely failed to reproduce twin study heritability estimates. Against this backdrop, an alternative to the fractionable triad model?the developmental substructure model?was proposed by Constantino et al. in 2021. This model places a unitary, latent autism variable as the cause of the core phenotype. In the present Commentary, we showed that the developmental substructure model fails empirical tests derived from causal inference. Using published data, we demonstrated that correlations among core phenotype traits are largely the same in population samples as compared to autistic and non-autistic subsamples. Using simulations, we demonstrated that if latent autism were the cause of variance in core phenotype traits, then the correlations among the factors should reduce considerably after conditioning on autism. Although the developmental substructure model is well-reasoned and well-specified, it ultimately does not stand up to empirical evaluation. En ligne : https://doi.org/10.1002/aur.70298 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Rates of Co-occurring Psychiatric Disorders in Autism Spectrum Disorder Using the Mini International Neuropsychiatric Interview / Maya G. MOSNER in Journal of Autism and Developmental Disorders, 49-9 (September 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3819-3832 Titre : Rates of Co-occurring Psychiatric Disorders in Autism Spectrum Disorder Using the Mini International Neuropsychiatric Interview Type de document : texte imprimé Auteurs : Maya G. MOSNER, Auteur ; Jessica L. KINARD, Auteur ; Jasmine S. SHAH, Auteur ; Sean MCWEENY, Auteur ; Rachel K. GREENE, Auteur ; Sarah C. LOWERY, Auteur ; Carla A. MAZEFSKY, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : p.3819-3832 Langues : Anglais (eng) Mots-clés : Assessment  Autism spectrum disorder  Co-occurring  Comorbidity Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) often meet criteria for at least one additional psychiatric disorder. The present study evaluated the utility of the Mini International Neuropsychiatric Interview (MINI) in assessing co-occurring psychiatric disorders in children, adolescents, and young adults with ASD. Ninety-one percent of children/adolescents and thirty-one percent of young adults were diagnosed with one or more co-occurring diagnoses using the MINI. MINI diagnostic rates were comparable to those found in the literature on children/adolescents with ASD; however, in young adults, MINI diagnostic rates were lower relative to rates found in the literature on young adults with ASD. Implications for treatment, transitioning to adulthood, and the need for instruments developed specifically to diagnose co-occurring disorders in ASD are discussed. En ligne : http://dx.doi.org/10.1007/s10803-019-04090-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Rates of Co-occurring Psychiatric Disorders in Autism Spectrum Disorder Using the Mini International Neuropsychiatric Interview [texte imprimé] / Maya G. MOSNER, Auteur ; Jessica L. KINARD, Auteur ; Jasmine S. SHAH, Auteur ; Sean MCWEENY, Auteur ; Rachel K. GREENE, Auteur ; Sarah C. LOWERY, Auteur ; Carla A. MAZEFSKY, Auteur ; Gabriel S. DICHTER, Auteur . - p.3819-3832. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3819-3832 Mots-clés : Assessment  Autism spectrum disorder  Co-occurring  Comorbidity Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) often meet criteria for at least one additional psychiatric disorder. The present study evaluated the utility of the Mini International Neuropsychiatric Interview (MINI) in assessing co-occurring psychiatric disorders in children, adolescents, and young adults with ASD. Ninety-one percent of children/adolescents and thirty-one percent of young adults were diagnosed with one or more co-occurring diagnoses using the MINI. MINI diagnostic rates were comparable to those found in the literature on children/adolescents with ASD; however, in young adults, MINI diagnostic rates were lower relative to rates found in the literature on young adults with ASD. Implications for treatment, transitioning to adulthood, and the need for instruments developed specifically to diagnose co-occurring disorders in ASD are discussed. En ligne : http://dx.doi.org/10.1007/s10803-019-04090-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Vicarious Effort-Based Decision-Making in Autism Spectrum Disorders / Maya G. MOSNER in Journal of Autism and Developmental Disorders, 47-10 (October 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-10 (October 2017) . - p.2992-3006 Titre : Vicarious Effort-Based Decision-Making in Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Maya G. MOSNER, Auteur ; Jessica L. KINARD, Auteur ; Sean MCWEENY, Auteur ; Jasmine S. SHAH, Auteur ; Nathan D. MARKIEWITZ, Auteur ; Cara R. DAMIANO-GOODWIN, Auteur ; Margaret R. BURCHINAL, Auteur ; Helena J.V. RUTHERFORD, Auteur ; Rachel K. GREENE, Auteur ; Michael T. TREADWAY, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : p.2992-3006 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Vicarious reward  Effort-based decision-making  Social motivation Index. décimale : PER Périodiques Résumé : This study investigated vicarious effort-based decision-making in 50 adolescents with autism spectrum disorders (ASD) compared to 32 controls using the Effort Expenditure for Rewards Task. Participants made choices to win money for themselves or for another person. When choosing for themselves, the ASD group exhibited relatively similar patterns of effort-based decision-making across reward parameters. However, when choosing for another person, the ASD group demonstrated relatively decreased sensitivity to reward magnitude, particularly in the high magnitude condition. Finally, patterns of responding in the ASD group were related to individual differences in consummatory pleasure capacity. These findings indicate atypical vicarious effort-based decision-making in ASD and more broadly add to the growing body of literature addressing social reward processing deficits in ASD. En ligne : https://doi.org/10.1007/s10803-017-3220-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319 [article] Vicarious Effort-Based Decision-Making in Autism Spectrum Disorders [texte imprimé] / Maya G. MOSNER, Auteur ; Jessica L. KINARD, Auteur ; Sean MCWEENY, Auteur ; Jasmine S. SHAH, Auteur ; Nathan D. MARKIEWITZ, Auteur ; Cara R. DAMIANO-GOODWIN, Auteur ; Margaret R. BURCHINAL, Auteur ; Helena J.V. RUTHERFORD, Auteur ; Rachel K. GREENE, Auteur ; Michael T. TREADWAY, Auteur ; Gabriel S. DICHTER, Auteur . - p.2992-3006. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-10 (October 2017) . - p.2992-3006 Mots-clés : Autism spectrum disorder  Vicarious reward  Effort-based decision-making  Social motivation Index. décimale : PER Périodiques Résumé : This study investigated vicarious effort-based decision-making in 50 adolescents with autism spectrum disorders (ASD) compared to 32 controls using the Effort Expenditure for Rewards Task. Participants made choices to win money for themselves or for another person. When choosing for themselves, the ASD group exhibited relatively similar patterns of effort-based decision-making across reward parameters. However, when choosing for another person, the ASD group demonstrated relatively decreased sensitivity to reward magnitude, particularly in the high magnitude condition. Finally, patterns of responding in the ASD group were related to individual differences in consummatory pleasure capacity. These findings indicate atypical vicarious effort-based decision-making in ASD and more broadly add to the growing body of literature addressing social reward processing deficits in ASD. En ligne : https://doi.org/10.1007/s10803-017-3220-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319

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