Commentary: sex difference differences? A reply to Constantino / D. S. MESSINGER in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 31p. Titre : Commentary: sex difference differences? A reply to Constantino Type de document : Texte imprimé et/ou numérique Auteurs : D. S. MESSINGER, Auteur ; Gregory S. YOUNG, Auteur ; S. J. WEBB, Auteur ; S. OZONOFF, Auteur ; Susan E. BRYSON, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Tony CHARMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; S. CURTIN, Auteur ; K. DOBKINS, Auteur ; I. HERTZ-PICCIOTTO, Auteur ; T. HUTMAN, Auteur ; J. M. IVERSON, Auteur ; R. LANDA, Auteur ; C. A. NELSON, Auteur ; W. L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur Article en page(s) : 31p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Female protective effect  High-risk siblings  Sex differences Index. décimale : PER Périodiques Résumé : Messinger et al. found a 3.18 odds ratio of male to female ASD recurrence in 1241 prospectively followed high-risk (HR) siblings. Among high-risk siblings (with and without ASD), as well as among 583 low-risk controls, girls exhibited higher performance on the Mullen Scales of Early Learning, as well as lower restricted and repetitive behavior severity scores on the Autism Diagnostic Observation Schedule (ADOS) than boys. That is, female-favoring sex differences in developmental performance and autism traits were evident among low-risk and non-ASD high-risk children, as well as those with ASD. Constantino (Mol Autism) suggests that sex differences in categorical ASD outcomes in Messinger et al. should be understood as a female protective effect. We are receptive to Constantino's (Mol Autism) suggestion, and propose that quantitative sex differences in autism-related features are keys to understanding this female protective effect. En ligne : http://dx.doi.org/10.1186/s13229-016-0093-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Commentary: sex difference differences? A reply to Constantino [Texte imprimé et/ou numérique] / D. S. MESSINGER, Auteur ; Gregory S. YOUNG, Auteur ; S. J. WEBB, Auteur ; S. OZONOFF, Auteur ; Susan E. BRYSON, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Tony CHARMAN, Auteur ; Katarzyna CHAWARSKA, Auteur ; S. CURTIN, Auteur ; K. DOBKINS, Auteur ; I. HERTZ-PICCIOTTO, Auteur ; T. HUTMAN, Auteur ; J. M. IVERSON, Auteur ; R. LANDA, Auteur ; C. A. NELSON, Auteur ; W. L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - 31p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 31p. Mots-clés : Autism spectrum disorder  Female protective effect  High-risk siblings  Sex differences Index. décimale : PER Périodiques Résumé : Messinger et al. found a 3.18 odds ratio of male to female ASD recurrence in 1241 prospectively followed high-risk (HR) siblings. Among high-risk siblings (with and without ASD), as well as among 583 low-risk controls, girls exhibited higher performance on the Mullen Scales of Early Learning, as well as lower restricted and repetitive behavior severity scores on the Autism Diagnostic Observation Schedule (ADOS) than boys. That is, female-favoring sex differences in developmental performance and autism traits were evident among low-risk and non-ASD high-risk children, as well as those with ASD. Constantino (Mol Autism) suggests that sex differences in categorical ASD outcomes in Messinger et al. should be understood as a female protective effect. We are receptive to Constantino's (Mol Autism) suggestion, and propose that quantitative sex differences in autism-related features are keys to understanding this female protective effect. En ligne : http://dx.doi.org/10.1186/s13229-016-0093-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder / M. MILLER in Journal of Child Psychology and Psychiatry, 60-5 (May 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-5 (May 2019) . - p.516-523 Titre : The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. MILLER, Auteur ; A. M. IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; L. J. BELL, Auteur ; A. J. SCHWICHTENBERG, Auteur ; T. HUTMAN, Auteur ; S. OZONOFF, Auteur Article en page(s) : p.516-523 Langues : Anglais (eng) Mots-clés : Dysregulation  autism spectrum disorder  high risk  preschool  siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: The 'dysregulation profile' (DP) is a measure of emotional and behavioral dysregulation that may cut across diagnostic boundaries. Siblings of children with autism spectrum disorder (ASD) who do not develop ASD themselves are at risk for atypical outcomes including behavioral challenges and therefore may be a useful population in which to investigate the structure of the DP in preschoolers. METHODS: We sought to examine the factor structure and predictors of the DP in a sample enriched for a wide range of phenotypic variation-36-month-olds with and without family histories of ASD-and to determine whether children with genetic liability for ASD are at risk for a phenotype characterized by elevated dysregulation. Data were collected from 415 children with (n = 253) and without (n = 162) an older sibling with ASD, all without ASD themselves, at 18, 24, and 36 months of age. RESULTS: Our findings replicate prior reports, conducted in predominantly clinically referred and older samples, supporting the superiority of a bifactor model of the DP in the preschool period compared to the second-order and one-factor models. Examiner ratings were longitudinally and concurrently associated with the DP at 36 months of age. Family history of ASD was associated with higher dysregulation in the Anxious/Depressed dimension. CONCLUSIONS: These findings support the relevance of examining the structure of psychopathology in preschoolers and suggest that examiner observations as early as 18 months of age, particularly of overactivity, may help identify risk for later DP-related concerns. Non-ASD preschoolers with family histories of ASD may be at risk for a phenotype characterized by elevated dysregulation particularly in the Anxious/Depressed dimension by age 3. En ligne : http://dx.doi.org/10.1111/jcpp.13003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392 [article] The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder [Texte imprimé et/ou numérique] / M. MILLER, Auteur ; A. M. IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; L. J. BELL, Auteur ; A. J. SCHWICHTENBERG, Auteur ; T. HUTMAN, Auteur ; S. OZONOFF, Auteur . - p.516-523. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-5 (May 2019) . - p.516-523 Mots-clés : Dysregulation  autism spectrum disorder  high risk  preschool  siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: The 'dysregulation profile' (DP) is a measure of emotional and behavioral dysregulation that may cut across diagnostic boundaries. Siblings of children with autism spectrum disorder (ASD) who do not develop ASD themselves are at risk for atypical outcomes including behavioral challenges and therefore may be a useful population in which to investigate the structure of the DP in preschoolers. METHODS: We sought to examine the factor structure and predictors of the DP in a sample enriched for a wide range of phenotypic variation-36-month-olds with and without family histories of ASD-and to determine whether children with genetic liability for ASD are at risk for a phenotype characterized by elevated dysregulation. Data were collected from 415 children with (n = 253) and without (n = 162) an older sibling with ASD, all without ASD themselves, at 18, 24, and 36 months of age. RESULTS: Our findings replicate prior reports, conducted in predominantly clinically referred and older samples, supporting the superiority of a bifactor model of the DP in the preschool period compared to the second-order and one-factor models. Examiner ratings were longitudinally and concurrently associated with the DP at 36 months of age. Family history of ASD was associated with higher dysregulation in the Anxious/Depressed dimension. CONCLUSIONS: These findings support the relevance of examining the structure of psychopathology in preschoolers and suggest that examiner observations as early as 18 months of age, particularly of overactivity, may help identify risk for later DP-related concerns. Non-ASD preschoolers with family histories of ASD may be at risk for a phenotype characterized by elevated dysregulation particularly in the Anxious/Depressed dimension by age 3. En ligne : http://dx.doi.org/10.1111/jcpp.13003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392

Theory of Mind Indexes the Broader Autism Phenotype in Siblings of Children with Autism at School Age / T. TSANG in Autism Research and Treatment, 2016 (2016)  

Public ISBD [article]  inAutism Research and Treatment > 2016 (2016) Titre : Theory of Mind Indexes the Broader Autism Phenotype in Siblings of Children with Autism at School Age Type de document : Texte imprimé et/ou numérique Auteurs : T. TSANG, Auteur ; K. GILLESPIE-LYNCH, Auteur ; T. HUTMAN, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Subclinical variants of the social-communicative challenges and rigidity that define autism spectrum disorder (ASD) are known as the broader autism phenotype (BAP). The BAP has been conceptualized categorically (as specific to a subset of relatives of individuals with ASD) and dimensionally (as continuously distributed within the general population). The current study examined the compatibility of these two approaches by assessing associations among autism symptoms and social-communicative skills in young school-age children with ASD, children who have a sibling with ASD, and children without a sibling with ASD. Autism symptoms were associated with reduced Theory of Mind (ToM), adaptive skills, cognitive empathy, and language skills across the full sample. Reduced ToM was a core aspect of the BAP in the current sample regardless of whether the BAP was defined categorically (in terms of siblings of children with ASD who exhibited atypical developmental) or dimensionally (in terms of associations with autism symptoms across the entire sample). Early language skills predicted school-age ToM. Findings support the compatibility of categorical and dimensional approaches to the BAP, highlight reduced ToM as a core aspect of the school-age BAP, and suggest that narrative-based approaches to promoting ToM may be beneficial for siblings of children with ASD. En ligne : http://dx.doi.org/10.1155/2016/6309189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=332 [article] Theory of Mind Indexes the Broader Autism Phenotype in Siblings of Children with Autism at School Age [Texte imprimé et/ou numérique] / T. TSANG, Auteur ; K. GILLESPIE-LYNCH, Auteur ; T. HUTMAN, Auteur. Langues : Anglais (eng) in Autism Research and Treatment > 2016 (2016) Index. décimale : PER Périodiques Résumé : Subclinical variants of the social-communicative challenges and rigidity that define autism spectrum disorder (ASD) are known as the broader autism phenotype (BAP). The BAP has been conceptualized categorically (as specific to a subset of relatives of individuals with ASD) and dimensionally (as continuously distributed within the general population). The current study examined the compatibility of these two approaches by assessing associations among autism symptoms and social-communicative skills in young school-age children with ASD, children who have a sibling with ASD, and children without a sibling with ASD. Autism symptoms were associated with reduced Theory of Mind (ToM), adaptive skills, cognitive empathy, and language skills across the full sample. Reduced ToM was a core aspect of the BAP in the current sample regardless of whether the BAP was defined categorically (in terms of siblings of children with ASD who exhibited atypical developmental) or dimensionally (in terms of associations with autism symptoms across the entire sample). Early language skills predicted school-age ToM. Findings support the compatibility of categorical and dimensional approaches to the BAP, highlight reduced ToM as a core aspect of the school-age BAP, and suggest that narrative-based approaches to promoting ToM may be beneficial for siblings of children with ASD. En ligne : http://dx.doi.org/10.1155/2016/6309189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=332

---

1 (1 - 3 / 3)